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Case Report Open Access

A report of amelanotic malignant melanoma of the esophagus diagnosed appropriately with novel markers: A case report

  • Authors:
    • Junya Kobayashi
    • Daisuke Fujimoto
    • Makoto Murakami
    • Yasuo Hirono
    • Takanori Goi
  • View Affiliations / Copyright

    Affiliations: Department of Surgery 1, Faculty of Medicine, University of Fukui, Fukui 910‑1193, Japan, Department of Surgery, Teikyo University Hospital, Kawasaki, Kanagawa 213‑8507, Japan
    Copyright: © Kobayashi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 9087-9092
    |
    Published online on: April 12, 2018
       https://doi.org/10.3892/ol.2018.8479
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Abstract

The present case study reported of amelanotic malignant melanoma of the esophagus. A 68‑year‑old man underwent laparoscopic distal gastrectomy for early gastric cancer diagnosis. After gastrectomy, endoscopic examination revealed a protruded lesion lying adjacent to the melanosis area of the esophagus. Histology of the biopsy specimen suggested malignancy, but the diagnosis could not be made. The patient underwent trans‑thoraco‑abdominal curative subtotal esophagectomy. Immunohistochemical examination of the resected specimen was negative for HBM‑45 and Melan‑A. However, immunohistochemical examinations of SOX10 (Sry‑related HMg‑Box gene 10) and KBA.62, which are not associated with melanosome, were strongly positive, and tyrosinase was notably positive. A diagnosis primary of amelanotic malignant melanoma of the esophagus that consisted of only premelanosomes was made. The present findings suggest that, in the diagnosis of malignant melanoma, SOX10 and KBA.62 may be useful, particularly in diagnosing amelanotic malignant melanoma.
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Copy and paste a formatted citation
Spandidos Publications style
Kobayashi J, Fujimoto D, Murakami M, Hirono Y and Goi T: A report of amelanotic malignant melanoma of the esophagus diagnosed appropriately with novel markers: A case report. Oncol Lett 15: 9087-9092, 2018.
APA
Kobayashi, J., Fujimoto, D., Murakami, M., Hirono, Y., & Goi, T. (2018). A report of amelanotic malignant melanoma of the esophagus diagnosed appropriately with novel markers: A case report. Oncology Letters, 15, 9087-9092. https://doi.org/10.3892/ol.2018.8479
MLA
Kobayashi, J., Fujimoto, D., Murakami, M., Hirono, Y., Goi, T."A report of amelanotic malignant melanoma of the esophagus diagnosed appropriately with novel markers: A case report". Oncology Letters 15.6 (2018): 9087-9092.
Chicago
Kobayashi, J., Fujimoto, D., Murakami, M., Hirono, Y., Goi, T."A report of amelanotic malignant melanoma of the esophagus diagnosed appropriately with novel markers: A case report". Oncology Letters 15, no. 6 (2018): 9087-9092. https://doi.org/10.3892/ol.2018.8479
Copy and paste a formatted citation
x
Spandidos Publications style
Kobayashi J, Fujimoto D, Murakami M, Hirono Y and Goi T: A report of amelanotic malignant melanoma of the esophagus diagnosed appropriately with novel markers: A case report. Oncol Lett 15: 9087-9092, 2018.
APA
Kobayashi, J., Fujimoto, D., Murakami, M., Hirono, Y., & Goi, T. (2018). A report of amelanotic malignant melanoma of the esophagus diagnosed appropriately with novel markers: A case report. Oncology Letters, 15, 9087-9092. https://doi.org/10.3892/ol.2018.8479
MLA
Kobayashi, J., Fujimoto, D., Murakami, M., Hirono, Y., Goi, T."A report of amelanotic malignant melanoma of the esophagus diagnosed appropriately with novel markers: A case report". Oncology Letters 15.6 (2018): 9087-9092.
Chicago
Kobayashi, J., Fujimoto, D., Murakami, M., Hirono, Y., Goi, T."A report of amelanotic malignant melanoma of the esophagus diagnosed appropriately with novel markers: A case report". Oncology Letters 15, no. 6 (2018): 9087-9092. https://doi.org/10.3892/ol.2018.8479
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