A report of amelanotic malignant melanoma of the esophagus diagnosed appropriately with novel markers: A case report

Kobayashi,Junya; Fujimoto,Daisuke; Murakami,Makoto; Hirono,Yasuo; Goi,Takanori

doi:10.3892/ol.2018.8479

A report of amelanotic malignant melanoma of the esophagus diagnosed appropriately with novel markers: A case report

Authors:
- Junya Kobayashi
- Daisuke Fujimoto
- Makoto Murakami
- Yasuo Hirono
- Takanori Goi
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Affiliations: Department of Surgery 1, Faculty of Medicine, University of Fukui, Fukui 910‑1193, Japan, Department of Surgery, Teikyo University Hospital, Kawasaki, Kanagawa 213‑8507, Japan
Published online on: April 12, 2018 https://doi.org/10.3892/ol.2018.8479
Pages: 9087-9092
Copyright: © Kobayashi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present case study reported of amelanotic malignant melanoma of the esophagus. A 68‑year‑old man underwent laparoscopic distal gastrectomy for early gastric cancer diagnosis. After gastrectomy, endoscopic examination revealed a protruded lesion lying adjacent to the melanosis area of the esophagus. Histology of the biopsy specimen suggested malignancy, but the diagnosis could not be made. The patient underwent trans‑thoraco‑abdominal curative subtotal esophagectomy. Immunohistochemical examination of the resected specimen was negative for HBM‑45 and Melan‑A. However, immunohistochemical examinations of SOX10 (Sry‑related HMg‑Box gene 10) and KBA.62, which are not associated with melanosome, were strongly positive, and tyrosinase was notably positive. A diagnosis primary of amelanotic malignant melanoma of the esophagus that consisted of only premelanosomes was made. The present findings suggest that, in the diagnosis of malignant melanoma, SOX10 and KBA.62 may be useful, particularly in diagnosing amelanotic malignant melanoma.

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1	Stringa O, Valdez R, Beguerie JR, Abbruzzese M, Lioni M, Nadales A, Iudica F, Venditti J and Roman San A: Primary amelanotic melanoma of the esophagus. Int J Dermatol. 45:1207–1210. 2006. View Article : Google Scholar : PubMed/NCBI
2	Slominski A, Tobin DJ, Shibahara S and Wortsman J: Melanin pigmentation in mammalian skin and its hormonal regulation. Physiol Rev. 84:1155–1228. 2004. View Article : Google Scholar : PubMed/NCBI
3	Naoki O and Akira K: The stage of melanogenesis in amelanotic melanomaMelanoma in the clinic-diagnosis, management and complications of malignancy. Mandi M: InTech; London: pp. 277–286. 2011
4	Japan esophageal society: Japanese classification of esophageal cancer, 11th edition: Part I. Esopahgus. 14:1–36. 2017. View Article : Google Scholar
5	Ordóñez NG: Value of melanocytic-associated immunohistochemical markers in the diagnosis of malignant melanoma: A review and update. Hum Pathol. 45:191–205. 2014. View Article : Google Scholar : PubMed/NCBI
6	Hirayama Y, Masahiro T, Tanaka T, Ishihara M, Ohnishi S, Hara K, Mizuno N, Hijioka S, Okuno N, Abe T, et al: Slow-growing amelanotic malignant melanoma of the esophagus with long survival: A case report and review of the literature. Endosc Int Open. 5:E1076–E1080. 2017. View Article : Google Scholar : PubMed/NCBI
7	Ramaswamy B, Bhandarkar AM, Venkitachalam S and Trivedi S: Amelanotic malignant melanoma of the cervical oesophagus. BMJ Case Rep 2014: pii: bcr2014204182. 2014.
8	Terada T: Amelanotic malignant melanoma of the esophagus: Report of two cases with immunohistochemical and molecular genetic study of KIT and PDGFRA. World J Gastroenterol. 15:2679–2683. 2009. View Article : Google Scholar : PubMed/NCBI
9	Wang S, Thamboo TP, Nga ME, Zin T, Cheng A and Tan KB: C-kit positive amelanotic melanoma of the oesophagus: A potential diagnostic pitfall. Pathology. 40:527–530. 2008. View Article : Google Scholar : PubMed/NCBI
10	Kranzfelder M, Seidl S, Dobritz M and Brücher BL: Amelanotic esophageal malignant melanoma: Case report and short review of the literature. Case Rep Gastroenterol. 2:224–231. 2008. View Article : Google Scholar : PubMed/NCBI
11	Stringa O, Valdez R, Beguerie JR, Abbruzzese M, Lioni M, Nadales A, Iudica F, Venditti J and Roman San A: Primary amelanotic melanoma of the esophagus. Int J Dermatol. 45:1207–1210. 2006. View Article : Google Scholar : PubMed/NCBI
12	De Simone P, Gelin M and El Nakadi I: Amelanotic malignant melanoma of the esophagus. Report of a case. Minerva Chir. 61:45–49. 2006.PubMed/NCBI
13	Suzuki Y, Aoyama N, Minamide J, Takata K and Ogata T: Amelanotic malignant melanoma of the esophagus: Report of a patient with recurrence successfully treated with chemoendocrine therapy. Int J Clin Oncol. 10:204–207. 2005. View Article : Google Scholar : PubMed/NCBI
14	Heidemann J, Lebiedz P, Herbst H, Spahn TW, Domagk D, Domschke W and Kucharzik T: Amelanotic malignant melanoma of the esophagus: Case report. Z Gastroenterol. 43:597–600. 2005. View Article : Google Scholar : PubMed/NCBI
15	Lee SH, Park SH, Kim HG and Kim CB: Primary malignant melanoma of the esophagus. Yonsei Med J. 39:468–473. 1998. View Article : Google Scholar : PubMed/NCBI
16	Volpin E, Sauvanet A, Couvelard A and Belghiti J: Primary malignant melanoma of the esophagus: A case report and review of the literature. Dis Esophagus. 15:244–249. 2002. View Article : Google Scholar : PubMed/NCBI
17	Allen AC and Spitz S: Malignant melanoma; a clinicopathological analysis of criteria for diagnosis and prognosis. Cancer. 6:1–45. 1953. View Article : Google Scholar : PubMed/NCBI
18	Levene A: On the histological diagnosis and prognosis of malignant melanoma. J Clin Pathol. 33:101–124. 1980. View Article : Google Scholar : PubMed/NCBI
19	Miettinen M, McCue PA, Sarlomo-Rikala M, Biernat W, Czapiewski P, Kopczynski J, Thompson LD, Lasota J, Wang Z and Fetsch JF: Sox10-a marker for not only schwannian and melanocytic neoplasms but also myoepithelial cell tumors of soft tissue: A systematic analysis of 5134 tumors. Am J Surg Pathol. 39:826–835. 2015. View Article : Google Scholar : PubMed/NCBI
20	Kaufmann O, Koch S, Burghardt J, Audring H and Dietel M: Tyrosinase, melan-A, and KBA62 as markers for the immunohistochemical identification of metastatic amelanotic melanomas on paraffin sections. Mod Pathol. 11:740–746. 1998.PubMed/NCBI
21	Shibahara S, Takeda K, Yasumoto K, Udono T, Watanabe K, Saito H and Takahashi K: Microphthalmia-associated transcription factor (MITF): Multiplicity in structure, function, and regulation. J Investig Dermatol Symp Proc. 6:99–104. 2001. View Article : Google Scholar : PubMed/NCBI
22	Tudrej KB, Czepielewska E and Kozłowska-Wojciechowska M: SOX10-MITF pathway activity in melanoma cells. Arch Med Sci. 13:1493–1503. 2017. View Article : Google Scholar : PubMed/NCBI
23	Nonaka D, Chiriboga L and Rubin BP: Sox10: A pan-schwannian and melanocytic marker. Am J Surg Pathol. 32:1291–1298. 2008. View Article : Google Scholar : PubMed/NCBI
24	Cohen-Kanfo E, al Saati T, Aziza J, Ralfkiaer E, Selves J, Gorgiet B and Delsol G: Production and characterisation of an antimelanoma monoclonal antibody KBA.62 using a new melanoma cell line reactive on paraffin wax embedded sections. J Clin Pathol. 48:826–831. 1995. View Article : Google Scholar : PubMed/NCBI
25	Pagès C, Rochaix P, al Saati T, Valmary-Degano S, Boulinguez S, Launay F, Carle P, Lauwers F, Payoux P, Le Guellec S, et al: KBA.62: A useful marker for primary and metastatic melanomas. Hum Pathol. 39:1136–1142. 2008. View Article : Google Scholar : PubMed/NCBI
26	Chen KG, Leapman RD, Zhang G, Lai B, Valencia JC, Cardarelli CO, Vieira WD, Hearing VJ and Gotttesman MM: Influence of melanosome dynamics on melanoma drug sensitivity. J Natl Cancer Inst. 101:1259–1271. 2009. View Article : Google Scholar : PubMed/NCBI
27	Tief K, Hahne M, Schmidt A and Beermann F: Tyrosinase, the key enzyme in melanin synthesis, is expressed in murine brain. Eur J Biochem. 241:12–16. 1996. View Article : Google Scholar : PubMed/NCBI
28	Hearing VJ and Tsukamoto K: Enzymatic control of pigmentation in mammals. FASEB J. 5:2902–2909. 1991. View Article : Google Scholar : PubMed/NCBI
29	Hofbauer GF, Kamarashev J, Geertsen R, Böni R and Dummer R: Tyrosinase immunoreactivity in formalin-fixed, paraffin-embedded primary and metastatic melanoma: Frequency and distribution. J Cutan Pathol. 25:204–209. 1998. View Article : Google Scholar : PubMed/NCBI
30	Orchard GE: Comparison of immunohistochemical labelling of melanocyte differentiation antibodies melan-A, tyrosinase and HMB 45 with NKIC3 and S100 protein in the evaluation of benign naevi and malignant melanoma. Histochem J. 32:475–481. 2000. View Article : Google Scholar : PubMed/NCBI
31	Jungbluth AA, Iversen K, Coplan K, Kolb D, Stockert E, Chen YT, Old LJ and Busam K: T311-an anti-tyrosinase monoclonal antibody for the detection of melanocytic lesions in paraffin embedded tissues. Pathol Res Pract. 196:235–242. 2000. View Article : Google Scholar : PubMed/NCBI
32	Paterson EK, Fielder TJ, MacGregor GR, Ito S, Wakamatsu K, Gillen DL, Eby V, Boissy RE and Ganesan AK: Tyrosinase depletion prevents the maturation of melanosomes in the mouse hair follicle. PLoS One. 10:e01437022015. View Article : Google Scholar : PubMed/NCBI
33	Słominski A, Moellmann G, Kuklinska E, Bomirski A and Pawelek J: Positive regulation of melanin pigmentation by two key substrates of the melanogenic pathway, L-tyrosine and L-dopa. J Cell Sci. 89:287–296. 1988.PubMed/NCBI
34	Slominski A, Moellmann G and Kuklinska E: L-tyrosine, L-dopa, and tyrosinase as positive regulators of the subcellular apparatus of melanogenesis in Bomirski Ab amelanotic melanoma cells. Pigment Cell Res. 2:109–116. 1989. View Article : Google Scholar : PubMed/NCBI
35	Fuller BB, Iman DS and Lunsford JB: Comparison of tyrosinase levels in amelanotic and melanotic melanoma cell cultures by a competitive enzyme-linked immunoadsorbent assay and by immunotitration analysis. J Cell Physiol. 134:149–154. 1988. View Article : Google Scholar : PubMed/NCBI