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Article

Identification of key genes and pathways in uterine leiomyosarcoma through bioinformatics analysis

  • Authors:
    • Yuqin Zang
    • Lina Gu
    • Yanfang Zhang
    • Yingmei Wang
    • Fengxia Xue
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China
  • Pages: 9361-9368
    |
    Published online on: April 16, 2018
       https://doi.org/10.3892/ol.2018.8503
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Abstract

Uterine leiomyosarcoma (uLMS) is a rare but malignant gynaecological tumour with a poor survival outcome. The present study was aimed at identifying the key genes and pathways in the development of uLMS through bioinformatics analysis. To minimize the frequency of false‑positive results of the bioinformatics analysis, 3 microarrays including GSE764, GSE64763 and GSE68312 were downloaded from Gene Expression Omnibus (GEO). Differentially expressed genes (DEGs) were screened out using the online tool GEO2R. Then, Gene Ontology and Kyoto Encyclopaedia of Genes and Genomes pathway enrichment analyses were performed using the Database for Annotation, Visualization and Integrated Discovery. Finally, a protein‑protein interaction (PPI) network of the DEGs was constructed using Cytoscape, and module analysis was conducted using the plug‑in MCODE. A total of 95 DEGs including 21 upregulated genes and 74 downregulated genes were identified. The upregulated DEGs were annotated with ‘DNA metabolic process’, ‘nucleobase‑containing compound biosynthetic process’ and ‘cellular macromolecule biosynthetic process’, while the downregulated DEGs were annotated with ‘cellular response to chemical stimulus’, ‘movement of cell or subcellular component’ and ‘response to inorganic substances’. The results of the PPI network analysis demonstrated that matrix metallopeptidase 9, apolipoprotein E, cyclin E1 and syndecan 1 were the predominant upregulated genes in uLMS. Additionally, the genes in the main module were enriched in ‘proteoglycans in cancer’, ‘p53 signalling pathway’ and ‘extracellular matrix‑receptor interaction’. The key genes and pathways identified in the present study may provide valuable clues for clarifying the molecular mechanism underlying the development of uLMS and demonstrate promise for use as diagnostic markers and therapeutic targets.
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1 

Ricci S, Stone RL and Fader AN: Uterine leiomyosarcoma: Epidemiology, contemporary treatment strategies and the impact of uterine morcellation. Gynecol Oncol. 145:208–216. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Park JY, Lee JW, Lee HJ, Lee JJ, Moon SH, Kang SY, Cheon GJ and Chung HH: Prognostic significance of preoperative 18F-FDG PET/CT in uterine leiomyosarcoma. J Gynecol Oncol. 28:e282017. View Article : Google Scholar : PubMed/NCBI

3 

Ducie JA and Leitao MM Jr: The role of adjuvant therapy in uterine leiomyosarcoma. Expert Rev Anticancer Ther. 16:45–55. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Cui RR, Wright JD and Hou JY: Uterine leiomyosarcoma: A review of recent advances in molecular biology, clinical management and outcome. BJOG. 124:1028–1037. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Barlin JN, Zhou QC, Leitao MM, Bisogna M, Olvera N, Shih KK, Jacobsen A, Schultz N, Tap WD, Hensley ML, et al: Molecular subtypes of uterine leiomyosarcoma and correlation with clinical outcome. Neoplasia. 17:183–189. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Lee TI and Young RA: Transcriptional regulation and its misregulation in disease. Cell. 152:1237–1251. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Anastas JN and Moon RT: WNT signalling pathways as therapeutic targets in cancer. Nat Rev Cancer. 13:11–26. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Cuppens T, Moisse M, Depreeuw J, Annibali D, Colas E, Gil-Moreno A, Huvila J, Carpén O, Zikán M, Matias-Guiu X, et al: Integrated genome analysis of uterine leiomyosarcoma to identify novel driver genes and targetable pathways. Int J Cancer. 142:1230–1243. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Iozzo RV and Sanderson RD: Proteoglycans in cancer biology, tumor microenvironment and angiogenesis. J Cell Mol Med. 15:1013–1031. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Purushothaman A, Babitz SK and Sanderson RD: Heparanase enhances the insulin receptor signaling pathway to activate extracellular signal-regulated kinase in multiple myeloma. J Biol Chem. 287:41288–41296. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Brule S, Charnaux N, Sutton A, Ledoux D, Chaigneau T, Saffar L and Gattegno L: The shedding of syndecan-4 and syndecan-1 from HeLa cells and human primary macrophages is accelerated by SDF-1/CXCL12 and mediated by the matrix metalloproteinase-9. Glycobiology. 16:488–501. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Asuthkar S, Velpula KK, Nalla AK, Gogineni VR, Gondi CS and Rao JS: Irradiation-induced angiogenesis is associated with an MMP-9-miR-494-syndecan-1 regulatory loop in medulloblastoma cells. Oncogene. 33:1922–1933. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Wen N, Wang Y, Wen L, Zhao SH, Ai ZH, Wang Y, Wu B, Lu HX, Yang H, Liu WC and Li Y: Overexpression of FOXM1 predicts poor prognosis and promotes cancer cell proliferation, migration and invasion in epithelial ovarian cancer. J Transl Med. 12:1342014. View Article : Google Scholar : PubMed/NCBI

14 

Tzeng HT, Tsai CH, Yen YT, Cheng HC, Chen YC, Pu SW, Wang YS, Shan YS, Tseng YL, Su WC, et al: Dysregulation of Rab37-mediated cross-talk between cancer cells and endothelial cells via thrombospondin-1 promotes tumor neovasculature and metastasis. Clin Cancer Res. 23:2335–2345. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Limoge M, Safina A, Beattie A, Kapus L, Truskinovsky AM and Bakin AV: Tumor-fibroblast interactions stimulate tumor vascularization by enhancing cytokine-driven production of MMP9 by tumor cells. Oncotarget. 8:35592–35608. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Lorenc Z, Waniczek D, Lorenc-Podgórska K, Krawczyk W, Domagała M, Majewski M and Mazurek U: Profile of expression of genes encoding matrix metallopeptidase 9 (MMP9), matrix metallopeptidase 28 (MMP28) and TIMP metallopeptidase inhibitor 1 (TIMP1) in colorectal cancer: Assessment of the role in diagnosis and prognostication. Med Sci Monit. 23:1305–1311. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Roomi MW, Kalinovsky T, Niedzwiecki A and Rath M: Modulation of u-PA, MMPs and their inhibitors by a novel nutrient mixture in adult human sarcoma cell lines. Int J Oncol. 43:39–49. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Lusby K, Savannah KB, Demicco EG, Zhang Y, Ghadimi MP, Young ED, Colombo C, Lam R, Dogan TE, Hornick JL, et al: Uterine leiomyosarcoma management, outcome, and associated molecular biomarkers: A single institution's experience. Ann Surg Oncol. 20:2364–2372. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Zhu XQ, Shi YF, Cheng XD and Wu YZ: The differential diagnosis between uterine leiomyosarcoma and the special subtypes of leiomyoma. Zhonghua Yi Xue Za Zhi. 83:1419–1421. 2003.(In Chinese). PubMed/NCBI

20 

Koivisto-Korander R, Butzow R, Koivisto AM and Leminen A: Immunohistochemical studies on uterine carcinosarcoma, leiomyosarcoma, and endometrial stromal sarcoma: Expression and prognostic importance of ten different markers. Tumour Biol. 32:451–459. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Garcia C, Kubat JS, Fulton RS, Anthony AT, Combs M, Powell CB and Littell RD: Clinical outcomes and prognostic markers in uterine leiomyosarcoma: A population-based cohort. Int J Gynecol Cancer. 25:622–628. 2015. View Article : Google Scholar : PubMed/NCBI

22 

George S, Feng Y, Manola J, Nucci MR, Butrynski JE, Morgan JA, Ramaiya N, Quek R, Penson RT, Wagner AJ, et al: Phase 2 trial of aromatase inhibition with letrozole in patients with uterine leiomyosarcomas expressing estrogen and/or progesterone receptors. Cancer. 120:738–743. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Cho YL, Bae S, Koo MS, Kim KM, Chun HJ, Kim CK, Ro DY, Kim JH, Lee CH, Kim YW and Ahn WS: Array comparative genomic hybridization analysis of uterine leiomyosarcoma. Gynecol Oncol. 99:545–551. 2005. View Article : Google Scholar : PubMed/NCBI

24 

Uluer ET, Inan S, Ozbilgin K, Karaca F, Dicle N and Sanci M: The role of hypoxia related angiogenesis in uterine smooth muscle tumors. Biotech Histochem. 90:102–110. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Bodner-Adler B, Nather A, Bodner K, Czerwenka K, Kimberger O, Leodolter S and Mayerhofer K: Expression of thrombospondin 1 (TSP 1) in patients with uterine smooth muscle tumors: An immunohistochemical study. Gynecol Oncol. 103:186–189. 2006. View Article : Google Scholar : PubMed/NCBI

26 

Hulsurkar M, Li Z, Zhang Y, Li X, Zheng D and Li W: Beta-adrenergic signaling promotes tumor angiogenesis and prostate cancer progression through HDAC2-mediated suppression of thrombospondin-1. Oncogene. 36:1525–1536. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Adams JC, Kureishy N and Taylor AL: A role for syndecan-1 in coupling fascin spike formation by thrombospondin-1. J Cell Biol. 152:1169–1182. 2001. View Article : Google Scholar : PubMed/NCBI

28 

Alexander CM, Reichsman F, Hinkes MT, Lincecum J, Becker KA, Cumberledge S and Bernfield M: Syndecan-1 is required for Wnt-1-induced mammary tumorigenesis in mice. Nat Genet. 25:329–332. 2000. View Article : Google Scholar : PubMed/NCBI

29 

Marinkovich MP: Tumor microenvironment: Laminin 332 in squamous-cell carcinoma. Nat Rev Cancer. 7:370–380. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Jary M, Lecomte T, Bouché O, Kim S, Dobi E, Queiroz L, Ghiringhelli F, Etienne H, Léger J, Godet Y, et al: Prognostic value of baseline seric Syndecan-1 in initially unresectable metastatic colorectal cancer patients: A simple biological score. Int J Cancer. 139:2325–2335. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Wilsie LC, Gonzales AM and Orlando RA: Syndecan-1 mediates internalization of apoE-VLDL through a low density lipoprotein receptor-related protein (LRP)-independent, non-clathrin-mediated pathway. Lipids Health Dis. 5:232006. View Article : Google Scholar : PubMed/NCBI

32 

Huang YA, Zhou B, Wernig M and Südhof TC: ApoE2, ApoE3, and ApoE4 differentially stimulate APP transcription and Aβ secretion. Cell. 168:427–441.e21. 2017. View Article : Google Scholar : PubMed/NCBI

33 

Luo J, Song J, Feng P, Wang Y, Long W, Liu M and Li L: Elevated serum apolipoprotein E is associated with metastasis and poor prognosis of non-small cell lung cancer. Tumour Biol. 37:10715–10721. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Xu X, Wan J, Yuan L, Ba J, Feng P, Long W, Huang H, Liu P, Cai Y, Liu M, et al: Serum levels of apolipoprotein E correlates with disease progression and poor prognosis in breast cancer. Tumour Biol. Oct 5–2016.(Epub ahead of print). View Article : Google Scholar

35 

Shi X, Xu J, Wang J, Cui M, Gao Y, Niu H and Jin H: Expression analysis of apolipoprotein E and its associated genes in gastric cancer. Oncol Lett. 10:1309–1314. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Roy I, Zimmerman NP, Mackinnon AC, Tsai S, Evans DB and Dwinell MB: CXCL12 chemokine expression suppresses human pancreatic cancer growth and metastasis. PLoS One. 9:e904002014. View Article : Google Scholar : PubMed/NCBI

37 

Jiang YP and Wu XH: Correlations of chemokine CXCL12 and its receptor to tumor metastasis. Ai Zheng. 26:220–224. 2007.(In Chinese). PubMed/NCBI

38 

Wu Y, Guo X, Brandt Y, Hathaway HJ and Hartley RS: Three-dimensional collagen represses cyclin E1 via β1 integrin in invasive breast cancer cells. Breast Cancer Res Treat. 127:397–406. 2011. View Article : Google Scholar : PubMed/NCBI

39 

Nakayama N, Nakayama K, Shamima Y, Ishikawa M, Katagiri A, Iida K and Miyazaki K: Gene amplification CCNE1 is related to poor survival and potential therapeutic target in ovarian cancer. Cancer. 116:2621–2634. 2010.PubMed/NCBI

40 

Kanska J, Zakhour M, Taylor-Harding B, Karlan BY and Wiedemeyer WR: Cyclin E as a potential therapeutic target in high grade serous ovarian cancer. Gynecol Oncol. 143:152–158. 2016. View Article : Google Scholar : PubMed/NCBI

41 

Lin SC, Kao CY, Lee HJ, Creighton CJ, Ittmann MM, Tsai SJ, Tsai SY and Tsai MJ: Dysregulation of miRNAs-COUP-TFII-FOXM1-CENPF axis contributes to the metastasis of prostate cancer. Nat Commun. 7:114182016. View Article : Google Scholar : PubMed/NCBI

42 

Gormally MV, Dexheimer TS, Marsico G, Sanders DA, Lowe C, Matak-Vinković D, Michael S, Jadhav A, Rai G, Maloney DJ, et al: Suppression of the FOXM1 transcriptional programme via novel small molecule inhibition. Nat Commun. 5:51652014. View Article : Google Scholar : PubMed/NCBI

43 

Leitao MM, Soslow RA, Nonaka D, Olshen AB, Aghajanian C, Sabbatini P, Dupont J, Hensley M, Sonoda Y, Barakat RR and Anderson S: Tissue microarray immunohistochemical expression of estrogen, progesterone, and androgen receptors in uterine leiomyomata and leiomyosarcoma. Cancer. 101:1455–1462. 2004. View Article : Google Scholar : PubMed/NCBI

44 

Nachtigal MW, Hirokawa Y, Enyeart-VanHouten DL, Flanagan JN, Hammer GD and Ingraham HA: Wilms' tumor 1 and Dax-1 modulate the orphan nuclear receptor SF-1 in sex-specific gene expression. Cell. 93:445–454. 1998. View Article : Google Scholar : PubMed/NCBI

45 

Patil DT, Laskin WB, Fetsch JF and Miettinen M: Inguinal smooth muscle tumors in women-a dichotomous group consisting of Müllerian-type leiomyomas and soft tissue leiomyosarcomas: An analysis of 55 cases. Am J Surg Pathol. 35:315–324. 2011. View Article : Google Scholar : PubMed/NCBI

46 

Coosemans A, Van Calster B, Verbist G, Moerman P, Vergote I, Van Gool SW and Amant F: Wilms tumor gene 1 (WT1) is a prognostic marker in high-grade uterine sarcoma. Int J Gynecol Cancer. 21:302–308. 2011.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zang Y, Gu L, Zhang Y, Wang Y and Xue F: Identification of key genes and pathways in uterine leiomyosarcoma through bioinformatics analysis. Oncol Lett 15: 9361-9368, 2018.
APA
Zang, Y., Gu, L., Zhang, Y., Wang, Y., & Xue, F. (2018). Identification of key genes and pathways in uterine leiomyosarcoma through bioinformatics analysis. Oncology Letters, 15, 9361-9368. https://doi.org/10.3892/ol.2018.8503
MLA
Zang, Y., Gu, L., Zhang, Y., Wang, Y., Xue, F."Identification of key genes and pathways in uterine leiomyosarcoma through bioinformatics analysis". Oncology Letters 15.6 (2018): 9361-9368.
Chicago
Zang, Y., Gu, L., Zhang, Y., Wang, Y., Xue, F."Identification of key genes and pathways in uterine leiomyosarcoma through bioinformatics analysis". Oncology Letters 15, no. 6 (2018): 9361-9368. https://doi.org/10.3892/ol.2018.8503
Copy and paste a formatted citation
x
Spandidos Publications style
Zang Y, Gu L, Zhang Y, Wang Y and Xue F: Identification of key genes and pathways in uterine leiomyosarcoma through bioinformatics analysis. Oncol Lett 15: 9361-9368, 2018.
APA
Zang, Y., Gu, L., Zhang, Y., Wang, Y., & Xue, F. (2018). Identification of key genes and pathways in uterine leiomyosarcoma through bioinformatics analysis. Oncology Letters, 15, 9361-9368. https://doi.org/10.3892/ol.2018.8503
MLA
Zang, Y., Gu, L., Zhang, Y., Wang, Y., Xue, F."Identification of key genes and pathways in uterine leiomyosarcoma through bioinformatics analysis". Oncology Letters 15.6 (2018): 9361-9368.
Chicago
Zang, Y., Gu, L., Zhang, Y., Wang, Y., Xue, F."Identification of key genes and pathways in uterine leiomyosarcoma through bioinformatics analysis". Oncology Letters 15, no. 6 (2018): 9361-9368. https://doi.org/10.3892/ol.2018.8503
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