Anesthetic drug propofol inhibits the expression of interleukin‑6, interleukin‑8 and cyclooxygenase‑2, a potential mechanism for propofol in suppressing tumor development and metastasis

  • Authors:
    • Xuefeng Li
    • Longyun Li
    • Feng Liang
    • Guifeng Liu
    • Guoqing Zhao
  • View Affiliations

  • Published online on: April 17, 2018     https://doi.org/10.3892/ol.2018.8515
  • Pages: 9523-9528
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Abstract

Previous studies have indicated that anesthesia‑associated drugs may directly inhibit cellular immunity and humoral immunity, which may be associated with tumor recurrence. The present study demonstrated that propofol may suppress the proliferation of MCF‑7 cells and inhibit the expression of interleukin (IL)‑6 and IL‑8. Subsequent to treatment with propofol, MCF‑7 cells demonstrated downregulated cyclooxygenase‑2 (COX‑2) protein expression and decreased levels of vascular endothelial growth factor and prostaglandin E2 in the supernatant. Therefore, the mechanism of propofol in suppressing tumor development and metastasis may be associated with the inhibition of IL‑6, IL‑8 and COX‑2.
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June-2018
Volume 15 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Li X, Li L, Liang F, Liu G and Zhao G: Anesthetic drug propofol inhibits the expression of interleukin‑6, interleukin‑8 and cyclooxygenase‑2, a potential mechanism for propofol in suppressing tumor development and metastasis. Oncol Lett 15: 9523-9528, 2018
APA
Li, X., Li, L., Liang, F., Liu, G., & Zhao, G. (2018). Anesthetic drug propofol inhibits the expression of interleukin‑6, interleukin‑8 and cyclooxygenase‑2, a potential mechanism for propofol in suppressing tumor development and metastasis. Oncology Letters, 15, 9523-9528. https://doi.org/10.3892/ol.2018.8515
MLA
Li, X., Li, L., Liang, F., Liu, G., Zhao, G."Anesthetic drug propofol inhibits the expression of interleukin‑6, interleukin‑8 and cyclooxygenase‑2, a potential mechanism for propofol in suppressing tumor development and metastasis". Oncology Letters 15.6 (2018): 9523-9528.
Chicago
Li, X., Li, L., Liang, F., Liu, G., Zhao, G."Anesthetic drug propofol inhibits the expression of interleukin‑6, interleukin‑8 and cyclooxygenase‑2, a potential mechanism for propofol in suppressing tumor development and metastasis". Oncology Letters 15, no. 6 (2018): 9523-9528. https://doi.org/10.3892/ol.2018.8515