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Article

Anesthetic drug propofol inhibits the expression of interleukin‑6, interleukin‑8 and cyclooxygenase‑2, a potential mechanism for propofol in suppressing tumor development and metastasis

  • Authors:
    • Xuefeng Li
    • Longyun Li
    • Feng Liang
    • Guifeng Liu
    • Guoqing Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China, Department of Radiology, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China
  • Pages: 9523-9528
    |
    Published online on: April 17, 2018
       https://doi.org/10.3892/ol.2018.8515
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Abstract

Previous studies have indicated that anesthesia‑associated drugs may directly inhibit cellular immunity and humoral immunity, which may be associated with tumor recurrence. The present study demonstrated that propofol may suppress the proliferation of MCF‑7 cells and inhibit the expression of interleukin (IL)‑6 and IL‑8. Subsequent to treatment with propofol, MCF‑7 cells demonstrated downregulated cyclooxygenase‑2 (COX‑2) protein expression and decreased levels of vascular endothelial growth factor and prostaglandin E2 in the supernatant. Therefore, the mechanism of propofol in suppressing tumor development and metastasis may be associated with the inhibition of IL‑6, IL‑8 and COX‑2.
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1 

Jemal A, Siegel R, Ward E, Murray T, Xu J and Thun MJ: Cancer statistic, 2007. CA Cancer J Clin. 57:43–66. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Eschwège P, Dumas F, Blanchet P, Le Maire V, Benoit G, Jardin A, Lacour B and Loric S: Haematogenous dissemination of prostatic epithelial cells during radical prostatectomy. Lancet. 346:1528–1530. 1995. View Article : Google Scholar : PubMed/NCBI

3 

Holmgren L, O'Reilly MS and Folkman J: Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression. Nat Med. 1:149–153. 1995. View Article : Google Scholar : PubMed/NCBI

4 

Shapiro J, Jersky J, Katzav S, Feldman M and Segal S: Anesthetic drugs accelerate the progression of postoperative metastases of mouse tumors. J Clin Invest. 68:678–685. 1981. View Article : Google Scholar : PubMed/NCBI

5 

Page GG, Blakely WP and Ben-Eliyahu S: Evidence that post-operative pain is a mediator of the tumor-promoting effects of surgery in rats. Pain. 90:191–199. 2001. View Article : Google Scholar : PubMed/NCBI

6 

Ben-Eliyahu S: The price of anticancer intervention. Does surgery promote metastasis? Lancet Oncol. 3:578–579. 2002.PubMed/NCBI

7 

Biki B, Mascha E, Moriarty DC, Fitzpatrick JM, Sessler DI and Buggy DJ: Anesthetic technique for radical prostatectomy surgery affects cancer recurrence: A retrospective analysis. Anesthesiology. 109:180–187. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Tsui BC, Rashiq S, Schopflocher D, Murtha A, Broemling S, Pillay J and Finucane BT: Epidural anesthesia and cancer recurrence rates after radical prostatectomy. Can J Anaesth. 57:107–112. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Forget P, Vandenhende J, Berliere M, Machiels JP, Nussbaum B, Legrand C and De Kock M: Do intraoperative analgesics influence breast cancer recurrence after mastectomy? A retrospective analysis. Anesth Analg. 110:1163–1635. 2010. View Article : Google Scholar

10 

Chen X, Lu P, Chen L, Yang SJ, Shen HY, Yu DD, Zhang XH, Zhong SL, Zhao JH and Tang JH: Perioperative propofol-paravertebral anesthesia decreases the metastasis and progression of breast cancer. Tumour Biol. 36:8259–8266. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Melamed R, Bar-Yosef S, Shakhar G, Shakhar K and Ben-Eliyahu S: Suppression of natural killer cell activity and promotion of tumor metastasis by ketamine, thiopental, and halothane, but not by propofol: Mediating mechanisms and prophylactic measures. Anesth Analg. 97:1331–1339. 2003. View Article : Google Scholar : PubMed/NCBI

12 

Kirkpatrick K, Ogunkolade W, Elkak A, Bustin S, Jenkins P, Ghilchik M and Mokbel K: The mRNA expression of cyclo-oxygenase-2 (COX-2) and vascular endothelia growth factor (VEGF) in human breast cancer. Curr Med Res Opin. 18:237–241. 2002. View Article : Google Scholar : PubMed/NCBI

13 

Chang SH, Liu CH, Conway R, Han DK, Nithipatikom K, Trifan OC, Lane TF and Hla T: Role of prostaglandin E2-dependent angiogenic switch in cyclooxygenase 2-induced breast cancer progression. Proc Natl Acad Sci USA. 101:591–596. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Simeone AM, Li YJ, Broemeling LD, Johnson MM, Tuna M and Tari AM: Cyclooxygenase-2 is essential for HER-2/neu to suppress N-(4-hydroxyphenyl)retinamide apoptotic effects in breast cancer cells. Cancer Res. 64:1224–1228. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Barnes N, Haywood P, Flint P, Knox WF and Bundred NJ: Survivin expression in in situ and invasive breast cancer relates to COX-2 expression and DCIS recurrence. Br J Cancer. 94:253–258. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Harris RE: Cyclooxygenase-2 (cox-2) blockade in the chemoprevention of cancers of the colon, breast, prostate, and lung. Inflammopharmacology. 17:55–67. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Qin G, Xu F, Qin T, Zheng Q, Shi D, Xia W, Tian Y, Tang Y, Wang J, Xiao X, et al: Palbociclib inhibits epithelial-mesenchymal transition and metastasis in breast cancer via c-Jun/COX-2 signaling pathway. Oncotarget. 6:41794–41808. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Hugo HJ, Saunders C, Ramsay RG and Thompson EW: New insights on COX-2 in chronic inflammation driving breast cancer growth and metastasis. J Mammary Gland Biol Neoplasia. 20:109–119. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Liu CH, Chang SH, Narko K, Trifan OC, Wu MT, Smith E, Haudenschild C, Lane TF and Hla T: Overexpression of cyclooxygenase-2 is sufficient to induce tumorigenesis in transgenic mice. J Biol Chem. 267:18563–18569. 2001. View Article : Google Scholar

20 

Harris RE, Kasbari S and Farrar WB: Prospective study of nonsteroidal anti-inflammatory drugs and breast cancer. Oncol Rep. 6:71–73. 1999.PubMed/NCBI

21 

Joo YE, Rew JS, Seo YH, Choi SK, Kim YJ, Park CS and Kim SJ: Cyclooxygenase-2 overexpression correlates with vascular endothelial growth factor expression and tumor angiogenesis in gastric cancer. J Clin Gastroenterol. 37:28–33. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Wise H: Lack of interaction between prostaglandin E2 receptor subtypes in regulating adenylyl cyclase activity in cultured rat dorsal root ganglion cells. Eur J Pharmacol. 535:69–77. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Komuro M, Kamiyama M, Furuya Y, Takihana Y, Araki I and Takeda M: Gene and protein expression profiles of prostaglandin E2 receptor subtypes in the human corpus cavernosum. Int J Impot Res. 18:275–281. 2006. View Article : Google Scholar : PubMed/NCBI

24 

Deasy BM, O'Sullivan-Coyne G, O'Donovan TR, McKenna SL and O'Sullivan GC: Cyclooxygenase-2 inhibitors demonstrate anti-proliferative effects in oesophageal cancer cells by prostaglandin E(2)-independent mechanisms. Cancer Lett. 256:246–258. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Kellesarian SV, Al-Kheraif AA, Vohra F, Ghanem A, Malmstrom H, Romanos GE and Javed F: Cytokine profile in the synovial fluid of patients with temporomandibular joint disorders: A systematic review. Cytokine. 77:98–106. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Ren XF, Li WZ, Meng FY and Lin CF: Differential effects of propofol and isoflurane on the activation of T-helper cells in lung cancer patients. Anaesthesia. 65:478–482. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Miyata T, Kodama T, Honma R, Nezu Y, Harada Y, Yogo T, Hara Y and Tagawa M: Influence of general anesthesia with isoflurane following propofol-induction on natural killer cell cytotoxic activities of peripheral blood lymphocytes in dogs. J Vet Med Sci. 75:917–921. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Mammoto T, Mukai M, Mammoto A, Yamanaka Y, Hayashi Y, Mashimo T, Kishi Y and Nakamura H: Intravenous anesthetic, propofol inhibits invasion of cancer cells. Cancer Lett. 184:165–170. 2002. View Article : Google Scholar : PubMed/NCBI

29 

Tsuchiya M, Asada A, Arita K, Utsumi T, Yoshida T, Sato EF, Utsumi K and Inoue M: Induction and mechanism of apoptotic cell death by propofol in HL-60 cells. Acta Anaesthesiol Scand. 46:1068–1074. 2002. View Article : Google Scholar : PubMed/NCBI

30 

Miao Y, Zhang Y, Wan H, Chen L and Wang F: GABA-receptor agonist, propofol inhibits invasion of colon carcinoma cells. Biomed Pharmacother. 64:583–588. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Kushida A, Inada T and Shingu K: Enhancement of antitumor immunity after propofol treatment in mice. Immunopharmacol Immunotoxicol. 29:477–486. 2007. View Article : Google Scholar : PubMed/NCBI

32 

Inada T, Kubo K and Shingu K: Possible link between cyclooxygenase-inhibiting and antitumor properties of propofol. J Anesth. 25:569–575. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Tchirkov A, Khalil T, Chautard E, Mokhtari K, Véronèse L, Irthum B, Vago P, Kémény JL and Verrelle P: Interleukin-6 gene amplification and shortened survival in glioblastoma patients. Br J Cancer. 96:474–476. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Singh B, Berry JA, Vincent LE and Lucci A: Involvement of IL-8 in COX-2-mediated bone metastases from breast cancer. J Surg Res. 134:44–51. 2006. View Article : Google Scholar : PubMed/NCBI

35 

Chou WY, Chuang KH, Sun D, Lee YH, Kao PH, Lin YY, Wang HW and Wu YL: Inhibition of PKC-Induced COX-2 and IL-8 expression in human breast cancer cells by glucosamine. J Cell Physiol. 230:2240–2251. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Simeone AM, Nieves-Alicea R, McMurtry VC, Colella S, Krahe R and Tari AM: Cyclooxygenase-2 uses the protein kinase C/interleukin-8/urokinase-type plasminogen activator pathway to increase the invasiveness of breast cancer cells. Int J Oncol. 30:785–792. 2007.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li X, Li L, Liang F, Liu G and Zhao G: Anesthetic drug propofol inhibits the expression of interleukin‑6, interleukin‑8 and cyclooxygenase‑2, a potential mechanism for propofol in suppressing tumor development and metastasis. Oncol Lett 15: 9523-9528, 2018.
APA
Li, X., Li, L., Liang, F., Liu, G., & Zhao, G. (2018). Anesthetic drug propofol inhibits the expression of interleukin‑6, interleukin‑8 and cyclooxygenase‑2, a potential mechanism for propofol in suppressing tumor development and metastasis. Oncology Letters, 15, 9523-9528. https://doi.org/10.3892/ol.2018.8515
MLA
Li, X., Li, L., Liang, F., Liu, G., Zhao, G."Anesthetic drug propofol inhibits the expression of interleukin‑6, interleukin‑8 and cyclooxygenase‑2, a potential mechanism for propofol in suppressing tumor development and metastasis". Oncology Letters 15.6 (2018): 9523-9528.
Chicago
Li, X., Li, L., Liang, F., Liu, G., Zhao, G."Anesthetic drug propofol inhibits the expression of interleukin‑6, interleukin‑8 and cyclooxygenase‑2, a potential mechanism for propofol in suppressing tumor development and metastasis". Oncology Letters 15, no. 6 (2018): 9523-9528. https://doi.org/10.3892/ol.2018.8515
Copy and paste a formatted citation
x
Spandidos Publications style
Li X, Li L, Liang F, Liu G and Zhao G: Anesthetic drug propofol inhibits the expression of interleukin‑6, interleukin‑8 and cyclooxygenase‑2, a potential mechanism for propofol in suppressing tumor development and metastasis. Oncol Lett 15: 9523-9528, 2018.
APA
Li, X., Li, L., Liang, F., Liu, G., & Zhao, G. (2018). Anesthetic drug propofol inhibits the expression of interleukin‑6, interleukin‑8 and cyclooxygenase‑2, a potential mechanism for propofol in suppressing tumor development and metastasis. Oncology Letters, 15, 9523-9528. https://doi.org/10.3892/ol.2018.8515
MLA
Li, X., Li, L., Liang, F., Liu, G., Zhao, G."Anesthetic drug propofol inhibits the expression of interleukin‑6, interleukin‑8 and cyclooxygenase‑2, a potential mechanism for propofol in suppressing tumor development and metastasis". Oncology Letters 15.6 (2018): 9523-9528.
Chicago
Li, X., Li, L., Liang, F., Liu, G., Zhao, G."Anesthetic drug propofol inhibits the expression of interleukin‑6, interleukin‑8 and cyclooxygenase‑2, a potential mechanism for propofol in suppressing tumor development and metastasis". Oncology Letters 15, no. 6 (2018): 9523-9528. https://doi.org/10.3892/ol.2018.8515
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