Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
June-2018 Volume 15 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2018 Volume 15 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Mitoxantrone induces apoptosis in osteosarcoma cells through regulation of the Akt/FOXO3 pathway

  • Authors:
    • See‑Hyoung Park
    • Jongsung Lee
    • Mi‑Ae Kang
    • Kyu Yun Jang
    • Jung Ryul Kim
  • View Affiliations / Copyright

    Affiliations: Department of Bio and Chemical Engineering, Hongik University, Sejong, Chungcheong 30016, Republic of Korea, Department of Genetic Engineering, Sungkyunkwan University, Suwon, Gyeonggi 16419, Republic of Korea, Department of Life Science, Gachon University, Seongnam, Gyeonggi 13120, Republic of Korea, Department of Pathology, Chonbuk National University Medical School, Research Institute of Clinical Medicine of Chonbuk National University‑Biomedical Research Institute of Chonbuk National University Hospital and Research Institute for Endocrine Sciences, Jeonju, Jeollabuk 54896, Republic of Korea, Department of Orthopedic Surgery, Chonbuk National University Medical School, Research Institute of Clinical Medicine of Chonbuk National University‑Biomedical Research Institute of Chonbuk National University Hospital and Research Institute for Endocrine Sciences, Jeonju, Jeollabuk 54896, Republic of Korea
    Copyright: © Park et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 9687-9696
    |
    Published online on: April 20, 2018
       https://doi.org/10.3892/ol.2018.8547
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The outcome of chemotherapy for osteosarcoma have improved during the past decade and more patients have access to combination chemotherapy, but there has been no significant clinical progress in the patient survival rate. Recently, forkhead‑box O3 (FOXO3) was identified as a pivotal transcription factor responsible for the transcriptional regulation of genes associated with suppression of cancer. The purpose of the present study was to screen small chemicals activating FOXO3 and elucidate their underlying mechanism. Using a drug discovery platform based on the phosphorylation status of FOXO3 in osteosarcoma cells, mitoxantrone (MTZ), a type of DNA‑damaging agent, was selected as a possible FOXO3 activator from the food and drug administration‑approved drug library. MTZ treatments significantly inhibited the phosphorylation level of Akt‑pS473 and caused nuclear localization of FOXO3 in osteosarcoma cells. MTZ treatment inhibited proliferation in osteosarcoma cells in vitro, whereas silencing FOXO3 potently attenuates MTZ‑mediated apoptosis in osteosarcoma cells. Taken together, the results indicated that MTZ induces apoptosis in osteosarcoma cells through an Akt/FOXO3‑dependent mechanism.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Moore DD and Luu HH: Osteosarcoma. Cancer Treat Res. 162:65–92. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Lamoureux F, Trichet V, Chipoy C, Blanchard F, Gouin F and Redini F: Recent advances in the management of osteosarcoma and forthcoming therapeutic strategies. Expert Rev Anticancer Ther. 7:169–181. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Luetke A, Meyers PA, Lewis I and Juergens H: Osteosarcoma treatment-where do we stand? A state of the art review. Cancer Treat Rev. 40:523–532. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Sakamoto A and Iwamoto Y: Current status and perspectives regarding the treatment of osteo-sarcoma: Chemotherapy. Rev Recent Clin Trials. 3:228–231. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Chou AJ and Gorlick R: Chemotherapy resistance in osteosarcoma: Current challenges and future directions. Expert Rev Anticancer Ther. 6:1075–1085. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Katoh M and Katoh M: Human FOX gene family (Review). Int J Oncol. 25:1495–1500. 2004.PubMed/NCBI

7 

Alvarez B, Martinez-A C, Burgering BM and Carrera AC: Forkhead transcription factors contribute to execution of the mitotic programme in mammals. Nature. 413:744–747. 2001. View Article : Google Scholar : PubMed/NCBI

8 

Furukawa-Hibi Y, Kobayashi Y, Chen C and Motoyama N: FOXO transcription factors in cell-cycle regulation and the response to oxidative stress. Antioxid Redox Signal. 7:752–760. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Fu Z and Tindall DJ: FOXOs, cancer and regulation of apoptosis. Oncogene. 27:2312–2319. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J and Greenberg ME: Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor. Cell. 96:857–868. 1999. View Article : Google Scholar : PubMed/NCBI

11 

Park SH, Chung YM, Ma J, Yang Q, Berek JS and Hu MC: Pharmacological activation of FOXO3 suppresses triple-negative breast cancer in vitro and in vivo. Oncotarget. 7:42110–42125. 2016.PubMed/NCBI

12 

Park SH, Lee JH, Berek JS and Hu MC: Auranofin displays anticancer activity against ovarian cancer cells through FOXO3 activation independent of p53. Int J Oncol. 45:1691–1698. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Fei M, Zhao Y, Wang Y, Lu M, Cheng C, Huang X, Zhang D, Lu J, He S and Shen A: Low expression of Foxo3a is associated with poor prognosis in ovarian cancer patients. Cancer Invest. 27:52–59. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Lu M, Zhao Y, Xu F, Wang Y, Xiang J and Chen D: The expression and prognosis of FOXO3a and Skp2 in human ovarian cancer. Med Oncol. 29:3409–3415. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Jancic J, Nikolic B, Ivancevic N, Djuric V, Zaletel I, Stevanovic D, Peric S, van den Anker JN and Samardzic J: Multiple sclerosis in pediatrics: Current concepts and treatment options. Neurol Ther. 5:131–143. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Atwal M, Lishman EL, Austin CA and Cowell IG: Myeloperoxidase enhances etoposide and mitoxantrone-mediated DNA damage: A target for myeloprotection in cancer chemotherapy. Mol Pharmacol. 91:49–57. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Casadei B, Pellegrini C, Pulsoni A, Annechini G, De Renzo A, Stefoni V, Broccoli A, Gandolfi L, Quirini F, Tonialini L, et al: 90-yttrium-ibritumomab tiuxetan consolidation of fludarabine, mitoxantrone, rituximab in intermediate/high-risk follicular lymphoma: Updated long-term results after a median follow-up of 7 years. Cancer Med. 5:1093–1097. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Nussbaum N, George DJ, Abernethy AP, Dolan CM, Oestreicher N, Flanders S and Dorff TB: Patient experience in the treatment of metastatic castration-resistant prostate cancer: State of the science. Prostate Cancer Prostatic Dis. 19:111–121. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Hasinoff BB, Wu X, Patel D, Kanagasabai R, Karmahapatra S and Yalowich JC: Mechanisms of action and reduced cardiotoxicity of pixantrone; a topoisomerase II targeting agent with cellular selectivity for the topoisomerase IIα isoform. J Pharmacol Exp Ther. 356:397–409. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Ferrer A, Marce S, Bellosillo B, Marcé S, Bellosillo B, Villamor N, Bosch F, López-Guillermo A, Espinet B, Solé F, Montserrat E, Campo E and Colomer D: Activation of mitochondrial apoptotic pathway in mantle cell lymphoma: High sensitivity to mitoxantrone in cases with functional DNA-damage response genes. Oncogene. 23:8941–8949. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Chong CR and Sullivan DJ Jr: New uses for old drugs. Nature. 448:645–646. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Rena G, Woods YL, Prescott AR, Peggie M, Unterman TG, Williams MR and Cohen P: Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion. EMBO J. 21:2263–2271. 2002. View Article : Google Scholar : PubMed/NCBI

23 

Bae JS, Lee J, Park Y, Park K, Kim JR, Cho DH, Jang KY and Park SH: Attenuation of MUC4 potentiates the anticancer activity of auranofin via regulation of the Her2/Akt/FOXO3 pathway in ovarian cancer cells. Oncol Rep. 38:2417–2425. 2017. View Article : Google Scholar : PubMed/NCBI

24 

ESMO/European Sarcoma Network Working Group: Bone sarcomas: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 25:iii113–iii123. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Zambo I and Veselý K: WHO classification of tumours of soft tissue and bone 2013: The main changes compared to the 3rd edition. Cesk Patol. 50:64–70. 2014.(In Czech). PubMed/NCBI

26 

Schajowicz F, McGuire MH, Araujo Santini E, Muscolo DL and Gitelis S: Osteosarcomas arising on the surfaces of long bones. J Bone Joint Surg Am. 70:555–564. 1988. View Article : Google Scholar : PubMed/NCBI

27 

Grimer RJ, Bielack S, Flege S, Cannon SR, Foleras G, Andreeff I, Sokolov T, Taminiau A, Dominkus M, San-Julian M, et al: Periosteal osteosarcoma-a European review of outcome. Eur J Cancer. 41:2806–2811. 2005. View Article : Google Scholar : PubMed/NCBI

28 

Cesari M, Alberghini M, Vanel D, Palmerini E, Staals EL, Longhi A, Abate M, Ferrari C, Balladelli A and Ferrari S: Periosteal osteosarcoma: A single-institution experience. Cancer. 117:1731–1735. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Bernthal NM, Federman N, Eilber FR, Nelson SD, Eckardt JJ, Eilber FC and Tap WD: Long-term results (>25 years) of a randomized, prospective clinical trial evaluating chemotherapy in patients with high-grade, operable osteosarcoma. Cancer. 118:5888–5893. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Bielack SS, Smeland S, Whelan JS, Marina N, Jovic G, Hook JM, Krailo MD, Gebhardt M, Pápai Z, Meyer J, et al: Methotrexate, doxorubicin, and cisplatin (MAP) plus maintenance pegylated interferon Alfa-2b versus MAP alone in patients with resectable high-grade osteosarcoma and good histologic response to preoperative MAP: First results of the EURAMOS-1 good response randomized controlled trial. J Clin Oncol. 33:2279–2287. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Benjamin RS, Wagner MJ, Livingston JA, Ravi V and Patel SR: Chemotherapy for bone sarcomas in adults: The MD anderson experience. Am Soc Clin Oncol Educ Book. e656–e660. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Su W, Lai Z, Wu F, Lin Y, Mo Y, Yang Z and Wu J: Clinical efficacy of preoperative chemotherapy with or without ifosfamide in patients with osteosarcoma of the extremity: Meta-analysis of randomized controlled trials. Med Oncol. 32:4812015. View Article : Google Scholar : PubMed/NCBI

33 

Navid F, Willert JR, McCarville MB, Furman W, Watkins A, Roberts W and Daw NC: Combination of gemcitabine and docetaxel in the treatment of children and young adults with refractory bone sarcoma. Cancer. 113:419–425. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Rodriguez-Galindo C, Daw NC, Kaste SC, Meyer WH, Dome JS, Pappo AS, Rao BN and Pratt CB: Treatment of refractory osteosarcoma with fractionated cyclophosphamide and etoposide. J Pediatr Hematol Oncol. 24:250–255. 2002. View Article : Google Scholar : PubMed/NCBI

35 

Saylors RL 3rd, Stine KC, Sullivan J, Kepner JL, Wall DA, Bernstein ML, Harris MB, Hayashi R and Vietti TJ: Pediatric Oncology Group: Cyclophosphamide plus topotecan in children with recurrent or refractory solid tumors: A pediatric oncology group phase II study. J Clin Oncol. 19:3463–3469. 2001. View Article : Google Scholar : PubMed/NCBI

36 

Merimsky O, Meller I, Kollender Y, Issakov J, Flusser G and Inbar M: Gemcitabine in bone sarcoma resistant to doxorubicin-based chemotherapy. Sarcoma. 4:7–10. 2000. View Article : Google Scholar : PubMed/NCBI

37 

Goorin AM, Harris MB, Bernstein M, Ferguson W, Devidas M, Siegal GP, Gebhardt MC, Schwartz CL, Link M and Grier HE: Phase II/III trial of etoposide and high-dose ifosfamide in newly diagnosed metastatic osteosarcoma: A pediatric oncology group trial. J Clin Oncol. 20:426–433. 2002. View Article : Google Scholar : PubMed/NCBI

38 

Van Winkle P, Angiolillo A, Krailo M, Cheung YK, Anderson B, Davenport V, Reaman G and Cairo MS: Ifosfamide, carboplatin, and etoposide (ICE) reinduction chemotherapy in a large cohort of children and adolescents with recurrent/refractory sarcoma: The children's cancer group (CCG) experience. Pediatr Blood Cancer. 44:338–347. 2005. View Article : Google Scholar : PubMed/NCBI

39 

Michelagnoli MP, Lewis IJ, Gattamaneni HR, Bailey CC and Lashford LS: Ifosfamide/etoposide alternating with high-dose methotrexate: Evaluation of a chemotherapy regimen for poor-risk osteosarcoma. Br J Cancer. 79:1174–1178. 1999. View Article : Google Scholar : PubMed/NCBI

40 

Anderson PM, Wiseman GA, Dispenzieri A, Arndt CA, Hartmann LC, Smithson WA, Mullan BP and Bruland OS: High-dose samarium-153 ethylene diamine tetramethylene phosphonate: Low toxicity of skeletal irradiation in patients with osteosarcoma and bone metastases. J Clin Oncol. 20:189–196. 2002. View Article : Google Scholar : PubMed/NCBI

41 

Hattinger CM, Vella S, Tavanti E, Fanelli M, Picci P and Serra M: Pharmacogenomics of second-line drugs used for treatment of unresponsive or relapsed osteosarcoma patients. Pharmacogenomics. 17:2097–2114. 2016. View Article : Google Scholar : PubMed/NCBI

42 

Liu T, Li Z, Zhang Q, De Amorim Bernstein K, Lozano-Calderon S, Choy E, Hornicek FJ and Duan Z: Targeting ABCB1 (MDR1) in multi-drug resistant osteosarcoma cells using the CRISPR-Cas9 system to reverse drug resistance. Oncotarget. 7:83502–83513. 2016. View Article : Google Scholar : PubMed/NCBI

43 

Buondonno I, Gazzano E, Jean SR, Audrito V, Kopecka J, Fanelli M, Salaroglio IC, Costamagna C, Roato I, Mungo E, et al: Mitochondria-targeted doxorubicin: A new therapeutic strategy against doxorubicin-resistant osteosarcoma. Mol Cancer Ther. 15:2640–2652. 2016. View Article : Google Scholar : PubMed/NCBI

44 

Chen Z, Guo J, Zhang K and Guo Y: TP53 mutations and survival in osteosarcoma patients: A meta-analysis of published data. Dis Markers. 2016:46395752016. View Article : Google Scholar : PubMed/NCBI

45 

Ru JY, Cong Y, Kang WB, Yu L, Guo T and Zhao JN: Polymorphisms in TP53 are associated with risk and survival of osteosarcoma in a Chinese population. Int J Clin Exp Pathol. 8:3198–3203. 2015.PubMed/NCBI

46 

Yao D, Cai GH, Chen J, Ling R, Wu SX and Li YP: Prognostic value of p53 alterations in human osteosarcoma: A meta analysis. Int J Clin Exp Pathol. 7:6725–6733. 2014.PubMed/NCBI

47 

Pakos EE, Kyzas PA and Ioannidis JP: Prognostic significance of TP53 tumor suppressor gene expression and mutations in human osteosarcoma: A meta-analysis. Clin Cancer Res. 10:6208–6214. 2004. View Article : Google Scholar : PubMed/NCBI

48 

Ozaki T, Wu D, Sugimoto H, Nagase H and Nakagawara A: Runt-related transcription factor 2 (RUNX2) inhibits p53-dependent apoptosis through the collaboration with HDAC6 in response to DNA damage. Cell Death Dis. 4:e6102013. View Article : Google Scholar : PubMed/NCBI

49 

Tarrado-Castellarnau M, Cortes R, Zanuy M, Tarragó-Celada J, Polat IH, Hill R, Fan TW, Link W and Cascante M: Methylseleninic acid promotes antitumour effects via nuclear FOXO3a translocation through Akt inhibition. Pharmacol Res. 102:218–234. 2015. View Article : Google Scholar : PubMed/NCBI

50 

Guzman-Perez V, Bumke-Vogt C, Schreiner M, Mewis I, Borchert A and Pfeiffer AF: Benzylglucosinolate Derived Isothiocyanate from Tropaeolum majus Reduces Gluconeogenic Gene and Protein Expression in Human Cells. PLoS One. 11:e01623972016. View Article : Google Scholar : PubMed/NCBI

51 

Jin S, Pang RP, Shen JN, Huang G, Wang J and Zhou JG: Grifolin induces apoptosis via inhibition of PI3K/AKT signalling pathway in human osteosarcoma cells. Apoptosis. 12:1317–1326. 2007. View Article : Google Scholar : PubMed/NCBI

52 

Pei H, Jin Z, Chen S, Sun X, Yu J and Guo W: MiR-135b promotes proliferation and invasion of osteosarcoma cells via targeting FOXO1. Mol Cell Biochem. 400:245–252. 2015. View Article : Google Scholar : PubMed/NCBI

53 

Toker A and Marmiroli S: Signaling specificity in the Akt pathway in biology and disease. Adv Biol Regul. 55:28–38. 2014. View Article : Google Scholar : PubMed/NCBI

54 

Yuan CL, Lin SW and Cheng MH: Inhibition of Molecular Signaling in Huh-7 Cells by AM3: A Novel Chemotherapeutic Agent for Hepatocellular Carcinoma. Med Chem. 49–56. 2016. View Article : Google Scholar : PubMed/NCBI

55 

Hu T, Cao H, Yang C, Zhang L, Jiang X, Gao X, Yang F, He G, Song X, Tong A, et al: LHD-modified mechanism-based liposome coencapsulation of Mitoxantrone and Prednisolone using novel lipid bilayer fusion for tissue-specific colocalization and synergistic antitumor effects. ACS App Mater Interfaces. 8:6586–6601. 2016. View Article : Google Scholar

56 

Matsuda T, Kato T, Kiyotani K, Tarhan YE, Saloura V, Chung S, Ueda K, Nakamura Y and Park JH: p53-independent p21 induction by MELK inhibition. Oncotarget. 8:57938–57947. 2017. View Article : Google Scholar : PubMed/NCBI

57 

Liu H, Yin J, Wang C, Gu Y, Deng M and He Z: FOXO3a mediates the cytotoxic effects of cisplatin in lung cancer cells. Anticancer Drugs. 25:898–907. 2014. View Article : Google Scholar : PubMed/NCBI

58 

Zhang YX, Liu XM, Wang J, Li J, Liu Y, Zhang H, Yu XW and Wei N: Inhibition of AKT/FoxO3a signaling induced PUMA expression in response to p53-independent cytotoxic effects of H1: A derivative of tetrandrine. Cancer Biol Ther. 16:965–975. 2015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Park SH, Lee J, Kang MA, Jang KY and Kim JR: Mitoxantrone induces apoptosis in osteosarcoma cells through regulation of the Akt/FOXO3 pathway. Oncol Lett 15: 9687-9696, 2018.
APA
Park, S., Lee, J., Kang, M., Jang, K.Y., & Kim, J.R. (2018). Mitoxantrone induces apoptosis in osteosarcoma cells through regulation of the Akt/FOXO3 pathway. Oncology Letters, 15, 9687-9696. https://doi.org/10.3892/ol.2018.8547
MLA
Park, S., Lee, J., Kang, M., Jang, K. Y., Kim, J. R."Mitoxantrone induces apoptosis in osteosarcoma cells through regulation of the Akt/FOXO3 pathway". Oncology Letters 15.6 (2018): 9687-9696.
Chicago
Park, S., Lee, J., Kang, M., Jang, K. Y., Kim, J. R."Mitoxantrone induces apoptosis in osteosarcoma cells through regulation of the Akt/FOXO3 pathway". Oncology Letters 15, no. 6 (2018): 9687-9696. https://doi.org/10.3892/ol.2018.8547
Copy and paste a formatted citation
x
Spandidos Publications style
Park SH, Lee J, Kang MA, Jang KY and Kim JR: Mitoxantrone induces apoptosis in osteosarcoma cells through regulation of the Akt/FOXO3 pathway. Oncol Lett 15: 9687-9696, 2018.
APA
Park, S., Lee, J., Kang, M., Jang, K.Y., & Kim, J.R. (2018). Mitoxantrone induces apoptosis in osteosarcoma cells through regulation of the Akt/FOXO3 pathway. Oncology Letters, 15, 9687-9696. https://doi.org/10.3892/ol.2018.8547
MLA
Park, S., Lee, J., Kang, M., Jang, K. Y., Kim, J. R."Mitoxantrone induces apoptosis in osteosarcoma cells through regulation of the Akt/FOXO3 pathway". Oncology Letters 15.6 (2018): 9687-9696.
Chicago
Park, S., Lee, J., Kang, M., Jang, K. Y., Kim, J. R."Mitoxantrone induces apoptosis in osteosarcoma cells through regulation of the Akt/FOXO3 pathway". Oncology Letters 15, no. 6 (2018): 9687-9696. https://doi.org/10.3892/ol.2018.8547
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team