Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
June-2018 Volume 15 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2018 Volume 15 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Tremella polysaccharides inhibit cellular apoptosis and autophagy induced by Pseudomonas aeruginosa lipopolysaccharide in A549 cells through sirtuin 1 activation

Retraction in: /10.3892/ol.2024.14384
  • Authors:
    • Xiaolan Shi
    • Wenfeng Wei
    • Ning Wang
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory and Asthma, Xi'an Children's Hospital, Xi'an, Shanxi 710043, P.R. China, Department of Paediatrics, Xianyang Central Hospital, Xi'an, Shanxi 712000, P.R. China
    Copyright: © Shi et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 4.0].
  • Pages: 9609-9616
    |
    Published online on: April 23, 2018
       https://doi.org/10.3892/ol.2018.8554
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

In the present study, the role of Tremella polysaccharides in cellular apoptosis and autophagy induced by Pseudomonas aeruginosa lipopolysaccharide (LPS) in human epithelial A549 lung‑cancer cells was investigated. Initially, it was demonstrated that LPS attenuated A549 cell viability in a time‑ and dose‑dependent manner. Furthermore, LPS induced apoptotic cell death and autophagy in A549 cells and increased reactive oxygen species (ROS) production in a time‑dependent manner. In addition, LPS treatment was demonstrated to markedly suppress sirtuin 1 (SIRT1) protein expression in A549 cells. Notably, it was demonstrated that Tremella polysaccharides activate SIRT1, leading to increased p62 expression, decreased p53 acetylation and B‑cell lymphoma 2‑associated X protein expression, and subsequently attenuate LPS‑induced apoptotic cell death and autophagy. The results of the present study demonstrated that Tremella polysaccharides activate SIRT1 and inhibit LPS‑induced ROS production, apoptosis and autophagy. This may have critical implications for the treatment of Pseudomonas aeruginosa infection.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Van Oosten B and Harroun TA: A MARTINI extension for Pseudomonas aeruginosa PAO1 lipopolysaccharide. J Mol Graph Model. 63:125–133. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Alshalchi SA and Anderson GG: Expression of the lipopolysaccharide biosynthesis gene lpxD affects biofilm formation of Pseudomonas aeruginosa. Arch Microbiol. 197:135–145. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Bollati M, Villa R, Gourlay LJ, Benedet M, Dehò G, Polissi A, Barbiroli A, Martorana AM, Sperandeo P, Bolognesi M and Nardini M: Crystal structure of LptH, the periplasmic component of the lipopolysaccharide transport machinery from Pseudomonas aeruginosa. FEBS J. 282:1980–1997. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Hao Y, Murphy K, Lo RY, Khursigara CM and Lam JS: Single-nucleotide polymorphisms found in the migA and wbpX Glycosyltransferase genes account for the intrinsic lipopolysaccharide defects exhibited by pseudomonas aeruginosa PA14. J Bacteriol. 197:2780–2791. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Ruhal R, Antti H, Rzhepishevska O, Boulanger N, Barbero DR, Wai SN, Uhlin BE and Ramstedt M: A multivariate approach to correlate bacterial surface properties to biofilm formation by lipopolysaccharide mutants of Pseudomonas aeruginosa. Colloids Surf B Biointerfaces. 127:182–191. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Sardar RK, Kavita K and Jha B: Lipopolysaccharide of Marinobacter litoralis inhibits swarming motility and biofilm formation in Pseudomonas aeruginosa PA01. Carbohydr Polym. 123:468–475. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Li Z, Qin B, Qi X, Mao J and Wu D: Isoalantolactone induces apoptosis in human breast cancer cells via ROS-mediated mitochondrial pathway and downregulation of SIRT1. Arch Pharm Res. 39:1441–1453. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Suzuki M, Bandoski C and Bartlett JD: Fluoride induces oxidative damage and SIRT1/autophagy through ROS-mediated JNK signaling. Free Radic Biol Med. 89:369–378. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Wang T, Gu J, Wu PF, Wang F, Xiong Z, Yang YJ, Wu WN, Dong LD and Chen JG: Protection by tetrahydroxystilbene glucoside against cerebral ischemia: Involvement of JNK, SIRT1 and NF-kappaB pathways and inhibition of intracellular ROS/RNS generation. Free Radic Biol Med. 47:229–240. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Xie Y, Tu W, Zhang J, He M, Ye S, Dong C and Shao C: SirT1 knockdown potentiates radiation-induced bystander effect through promoting c-Myc activity and thus facilitating ROS accumulation. Mutat Res. 772:23–29. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Yang LJ, Chen Y, He J, Yi S, Wen L, Zhao S and Cui GH: Effects of gambogic acid on the activation of caspase-3 and downregulation of SIRT1 in RPMI-8226 multiple myeloma cells via the accumulation of ROS. Oncol Lett. 3:1159–1165. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Zhou Y, Chen X, Yi R, Li G, Sun P, Qian Y and Zhao X: Immunomodulatory effect of tremella polysaccharides against cyclophosphamide-induced immunosuppression in mice. Molecules. 23:E2392018. View Article : Google Scholar : PubMed/NCBI

13 

Du XJ, Zhang JS, Yang Y, Tang QJ, Jia W and Pan YJ: Purification, chemical modification and immunostimulating activity of polysaccharides from Tremella aurantialba fruit bodies. J Zhejiang Univ Sci B. 11:437–442. 2010. View Article : Google Scholar : PubMed/NCBI

14 

Khondka P: Composition and partial structure characterization of tremella polysaccharides. Mycobiology. 37:286–294. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Jin Y, Hu X, Zhang Y and Liu T: Studies on the purification of polysaccharides separated from Tremella fuciformis and their neuroprotective effect. Mol Med Rep. 13:3985–3992. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Dong Y, Bao C, Yu J and Liu X: Receptor-interacting protein kinase 3-mediated programmed cell necrosis in rats subjected to focal cerebral ischemia-reperfusion injury. Mol Med Rep. 14:728–736. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Biedenbach DJ, Giao PT, Van Hung P, Su Minh Tuyet N, Thi Thanh Nga T, Phuong DM, Trung Vu N and Badal RE: Antimicrobial-resistant pseudomonas aeruginosa and acinetobacter baumannii from patients with hospital-acquired or ventilator-associated pneumonia in vietnam. Clin Ther. 38:2098–2105. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Li Y, Qu HP, Liu JL and Wan HY: Correlation between group behavior and quorum sensing in Pseudomonas aeruginosa isolated from patients with hospital-acquired pneumonia. J Thorac Dis. 6:810–817. 2014.PubMed/NCBI

19 

Fujii A, Seki M, Higashiguchi M, Tachibana I, Kumanogoh A and Tomono K: Community-acquired, hospital-acquired and healthcare-associated pneumonia caused by Pseudomonas aeruginosa. Respir Med Case Rep. 12:30–33. 2014.PubMed/NCBI

20 

Furtado GH, Gales AC, Perdiz LB, Santos AE, Wey SB and Medeiros EA: Risk factors for hospital-acquired pneumonia caused by imipenem-resistant Pseudomonas aeruginosa in an intensive care unit. Anaesth Intensive Care. 38:994–1001. 2010.PubMed/NCBI

21 

Xu Y, Duan C, Kuang Z, Hao Y, Jeffries JL and Lau GW: Pseudomonas aeruginosa pyocyanin activates NRF2-ARE-mediated transcriptional response via the ROS-EGFR-PI3K-AKT/MEK-ERK MAP kinase signaling in pulmonary epithelial cells. PLoS One. 8:e725282013. View Article : Google Scholar : PubMed/NCBI

22 

Yan F, Li W, Jono H, Li Q, Zhang S, Li JD and Shen H: Reactive oxygen species regulate Pseudomonas aeruginosa lipopolysaccharide-induced MUC5AC mucin expression via PKC-NADPH oxidase-ROS-TGF-alpha signaling pathways in human airway epithelial cells. Biochem Biophys Res Commun. 366:513–519. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Zeng R, Chen Y, Zhao S and Cui GH: Autophagy counteracts apoptosis in human multiple myeloma cells exposed to oridonin in vitro via regulating intracellular ROS and SIRT1. Acta Pharmacol Sin. 33:91–100. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Vaziri H, Dessain SK, Eaton Ng E, Imai SI, Frye RA, Pandita TK, Guarente L and Weinberg RA: hSIR2 (SIRT1) functions as an NAD-dependent p53 deacetylase. Cell. 107:149–159. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Zhang ZC, Lian B, Huang DM and Cui FJ: Compare activities on regulating lipid-metabolism and reducing oxidative stress of diabetic rats of Tremella aurantialba broth's extract (TBE) with its mycelia polysaccharides (TMP). J Food Sci. 74:H15–H21. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Khondkar P, Aidoo KE and Tester RF: Sugar profile of extracellular polysaccharides from different Tremella species. Int J Food Microbiol. 79:121–129. 2002. View Article : Google Scholar : PubMed/NCBI

27 

Kiho T, Morimoto H, Sakushima M, Usui S and Ukai S: Polysaccharides in fungi. XXXV. Anti diabetic activity of an acidic polysaccharide from the fruiting bodies of Tremella aurantia. Biol Pharm Bull. 18:1627–1629. 1995. View Article : Google Scholar : PubMed/NCBI

28 

Keta O, Bulat T, Golić I, Incerti S, Korać A, Petrović I and Ristić-Fira A: The impact of autophagy on cell death modalities in CRL-5876 lung adenocarcinoma cells after their exposure to gamma-rays and/or erlotinib. Cell Biol Toxicol. 32:83–101. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Ryter SW, Mizumura K and Choi AM: The impact of autophagy on cell death modalities. Int J Cell Biol. 2014:5026762014. View Article : Google Scholar : PubMed/NCBI

30 

Gump JM and Thorburn A: Autophagy and apoptosis: What is the connection? Trends Cell Biol. 21:387–392. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Su M, Mei Y and Sinha S: Role of the crosstalk between autophagy and apoptosis in cancer. J Oncol. 2013:1027352013. View Article : Google Scholar : PubMed/NCBI

32 

Pattingre S, Bauvy C, Carpentier S, Levade T, Levine B and Codogno P: Role of JNK1-dependent Bcl-2 phosphorylation in ceramide-induced macroautophagy. J Biol Chem. 284:2719–2728. 2009. View Article : Google Scholar : PubMed/NCBI

33 

Cao B, Li J, Zhou X, Juan J, Han K, Zhang Z, Kong Y, Wang J and Mao X: Clioquinol induces pro-death autophagy in leukemia and myeloma cells by disrupting the mTOR signaling pathway. Sci Rep. 4:57492014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Shi X, Wei W and Wang N: Tremella polysaccharides inhibit cellular apoptosis and autophagy induced by Pseudomonas aeruginosa lipopolysaccharide in A549 cells through sirtuin 1 activation Retraction in /10.3892/ol.2024.14384. Oncol Lett 15: 9609-9616, 2018.
APA
Shi, X., Wei, W., & Wang, N. (2018). Tremella polysaccharides inhibit cellular apoptosis and autophagy induced by Pseudomonas aeruginosa lipopolysaccharide in A549 cells through sirtuin 1 activation Retraction in /10.3892/ol.2024.14384. Oncology Letters, 15, 9609-9616. https://doi.org/10.3892/ol.2018.8554
MLA
Shi, X., Wei, W., Wang, N."Tremella polysaccharides inhibit cellular apoptosis and autophagy induced by Pseudomonas aeruginosa lipopolysaccharide in A549 cells through sirtuin 1 activation Retraction in /10.3892/ol.2024.14384". Oncology Letters 15.6 (2018): 9609-9616.
Chicago
Shi, X., Wei, W., Wang, N."Tremella polysaccharides inhibit cellular apoptosis and autophagy induced by Pseudomonas aeruginosa lipopolysaccharide in A549 cells through sirtuin 1 activation Retraction in /10.3892/ol.2024.14384". Oncology Letters 15, no. 6 (2018): 9609-9616. https://doi.org/10.3892/ol.2018.8554
Copy and paste a formatted citation
x
Spandidos Publications style
Shi X, Wei W and Wang N: Tremella polysaccharides inhibit cellular apoptosis and autophagy induced by Pseudomonas aeruginosa lipopolysaccharide in A549 cells through sirtuin 1 activation Retraction in /10.3892/ol.2024.14384. Oncol Lett 15: 9609-9616, 2018.
APA
Shi, X., Wei, W., & Wang, N. (2018). Tremella polysaccharides inhibit cellular apoptosis and autophagy induced by Pseudomonas aeruginosa lipopolysaccharide in A549 cells through sirtuin 1 activation Retraction in /10.3892/ol.2024.14384. Oncology Letters, 15, 9609-9616. https://doi.org/10.3892/ol.2018.8554
MLA
Shi, X., Wei, W., Wang, N."Tremella polysaccharides inhibit cellular apoptosis and autophagy induced by Pseudomonas aeruginosa lipopolysaccharide in A549 cells through sirtuin 1 activation Retraction in /10.3892/ol.2024.14384". Oncology Letters 15.6 (2018): 9609-9616.
Chicago
Shi, X., Wei, W., Wang, N."Tremella polysaccharides inhibit cellular apoptosis and autophagy induced by Pseudomonas aeruginosa lipopolysaccharide in A549 cells through sirtuin 1 activation Retraction in /10.3892/ol.2024.14384". Oncology Letters 15, no. 6 (2018): 9609-9616. https://doi.org/10.3892/ol.2018.8554
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team