Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
June-2018 Volume 15 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2018 Volume 15 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Comprehensive identification of microRNA arm selection preference in lung cancer: miR‑324‑5p and ‑3p serve oncogenic functions in lung cancer

  • Authors:
    • Min‑Hsi Lin
    • You‑Zuo Chen
    • Mei‑Yu Lee
    • Ken‑Pen Weng
    • Hong‑Tai Chang
    • Shou‑Yu Yu
    • Bo‑Jhu Dong
    • Fan‑Rong Kuo
    • Li‑Tzu Hung
    • Li‑Feng Liu
    • Wei‑Shone Chen
    • Kuo‑Wang Tsai
  • View Affiliations / Copyright

    Affiliations: Division of Chest Medicine, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan, R.O.C., Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan, R.O.C., School of Medicine, National Yang‑Ming University, Taipei 112, Taiwan, R.O.C., Center for Geriatrics and Gerontology, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan, R.O.C., Department of Chemical Biology, National Pingtung University of Education, Pingtung 900, Taiwan, R.O.C., Department of Biological Science and Technology, I‑Shou University, Kaohsiung 813, Taiwan, R.O.C.
    Copyright: © Lin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 9818-9826
    |
    Published online on: April 24, 2018
       https://doi.org/10.3892/ol.2018.8557
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

MicroRNA (miRNA/miR) dysfunction is a hallmark of lung cancer, and results in the dysregulation of tumor suppressors and oncogenes during lung cancer progression. Selection of the 5p and 3p arms of miRNA is a mechanism that improves the modulation of miRNA biological functions and complicates the regulatory network in human types of cancer. However, the involvement of arm selection preference of miRNA in lung cancer remains unclear. In the present study, changes in miRNA arm selection preference were comprehensively identified in lung cancer and corresponding adjacent normal tissues by analyzing The Cancer Genome Atlas. Arm selection was revealed to be consistent in the majority of miRNAs in lung cancer. Only a few miRNAs had significantly altered arm selection preference in lung cancer. Among these, the biological functions of the individual arms of miR‑324 were investigated further. The data revealed that miR‑324‑5p and ‑3p were significantly overexpressed in lung cancer cells. Ectopic expression of miR‑324‑5p significantly promoted cell proliferation and invasion in lung cancer cells, while miR‑324‑3p overexpression significantly increased cell proliferation but did not alter the invasion of lung cancer cells. In conclusion, the arm selection preference of miRNA may be an additional mechanism through which biological functions are modulated. The results of the present study provide a novel insight into the underlying mechanisms of lung cancer and may direct research into future therapies.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Siegel R, Ma J, Zou Z and Jemal A: Cancer statistics, 2014. CA Cancer J Clin. 64:9–29. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Ferlay J, Shin HR, Bray F, Forman D, Mathers C and Parkin DM: Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 127:2893–2917. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Socinski MA, Crowell R, Hensing TE, Langer CJ, Lilenbaum R, Sandler AB and Morris D: American College of Chest Physicians: Treatment of non-small cell lung cancer, stage IV: ACCP evidence-based clinical practice guidelines (2nd edition). Chest. 132 Suppl 3:277S–289S. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Hanahan D and Weinberg RA: The hallmarks of cancer. Cell. 100:57–70. 2000. View Article : Google Scholar : PubMed/NCBI

5 

Nowell PC: The clonal evolution of tumor cell populations. Science. 194:23–28. 1976. View Article : Google Scholar : PubMed/NCBI

6 

Wu HH, Lin WC and Tsai KW: Advances in molecular biomarkers for gastric cancer: miRNAs as emerging novel cancer markers. Expert Rev Mol Med. 16:e12014. View Article : Google Scholar : PubMed/NCBI

7 

Yekta S, Shih IH and Bartel DP: MicroRNA-directed cleavage of HOXB8 mRNA. Science. 304:594–596. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Trabucchi M, Briata P, Filipowicz W, Rosenfeld MG, Ramos A and Gherzi R: How to control miRNA maturation? RNA Biol. 6:536–540. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Newman MA and Hammond SM: Emerging paradigms of regulated microRNA processing. Genes Dev. 24:1086–1092. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Chen WS, Chen TW, Yang TH, Hu LY, Pan HW, Leung CM, Li SC, Ho MR, Shu CW, Liu PF, et al: Co-modulated behavior and effects of differentially expressed miRNA in colorectal cancer. BMC Genomics. 14 Suppl 5:S122013. View Article : Google Scholar : PubMed/NCBI

11 

Hayashita Y, Osada H, Tatematsu Y, Yamada H, Yanagisawa K, Tomida S, Yatabe Y, Kawahara K, Sekido Y and Takahashi T: A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation. Cancer Res. 65:9628–9632. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Lee YS and Dutta A: The tumor suppressor microRNA let-7 represses the HMGA2 oncogene. Genes Dev. 21:1025–1030. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Matsubara H, Takeuchi T, Nishikawa E, Yanagisawa K, Hayashita Y, Ebi H, Yamada H, Suzuki M, Nagino M, Nimura Y, et al: Apoptosis induction by antisense oligonucleotides against miR-17-5p and miR-20a in lung cancers overexpressing miR-17-92. Oncogene. 26:6099–6105. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Fabbri M, Garzon R, Cimmino A, Liu Z, Zanesi N, Callegari E, Liu S, Alder H, Costinean S, Fernandez-Cymering C, et al: MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proc Natl Acad Sci USA. 104:15805–15810. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Liu B, Peng XC, Zheng XL, Wang J and Qin YW: MiR-126 restoration down-regulate VEGF and inhibit the growth of lung cancer cell lines in vitro and in vivo. Lung Cancer. 66:169–175. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Takahashi Y, Forrest AR, Maeno E, Hashimoto T, Daub CO and Yasuda J: miR-107 and MiR-185 can induce cell cycle arrest in human non small cell lung cancer cell lines. PLoS One. 4:e66772009. View Article : Google Scholar : PubMed/NCBI

17 

Xiao L, Zhou H, Li XP, Chen J, Fang C, Mao CX, Cui JJ, Zhang W, Zhou HH, Yin JY and Liu ZQ: MicroRNA-138 acts as a tumor suppressor in non small cell lung cancer via targeting YAP1. Oncotarget. 7:40038–40046. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Leung CM, Li SC, Chen TW, Ho MR, Hu LY, Liu WS, Wu TT, Hsu PC, Chang HT and Tsai KW: Comprehensive microRNA profiling of prostate cancer cells after ionizing radiation treatment. Oncol Rep. 31:1067–1078. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Cheng WC, Chung IF, Huang TS, Chang ST, Sun HJ, Tsai CF, Liang ML, Wong TT and Wang HW: YM500: A small RNA sequencing (smRNA-seq) database for microRNA research. Nucleic Acids Res. 41:(Database Issue). D285–D294. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Li SC, Liao YL, Ho MR, Tsai KW, Lai CH and Lin WC: miRNA arm selection and isomiR distribution in gastric cancer. BMC Genomics. 13 Suppl 1:S132012. View Article : Google Scholar : PubMed/NCBI

21 

Chang HT, Li SC, Ho MR, Pan HW, Ger LP, Hu LY, Yu SY, Li WH and Tsai KW: Comprehensive analysis of microRNAs in breast cancer. BMC Genomics. 13 Suppl 7:S182012.PubMed/NCBI

22 

Li SC, Liao YL, Chan WC, Ho MR, Tsai KW, Hu LY, Lai CH, Hsu CN and Lin WC: Interrogation of rabbit miRNAs and their isomiRs. Genomics. 98:453–459. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Griffiths-Jones S, Hui JH, Marco A and Ronshaugen M: MicroRNA evolution by arm switching. EMBO Rep. 12:172–177. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Cloonan N, Wani S, Xu Q, Gu J, Lea K, Heater S, Barbacioru C, Steptoe AL, Martin HC, Nourbakhsh E, et al: MicroRNAs and their isomiRs function cooperatively to target common biological pathways. Genome Biol. 12:R1262011. View Article : Google Scholar : PubMed/NCBI

25 

Marco A, Hui JH, Ronshaugen M and Griffiths-Jones S: Functional shifts in insect microRNA evolution. Genome Biol Evol. 2:686–696. 2010.PubMed/NCBI

26 

Guo L, Li H, Liang T, Lu J, Yang Q, Ge Q and Lu Z: Consistent isomiR expression patterns and 3′ addition events in miRNA gene clusters and families implicate functional and evolutionary relationships. Mol Biol Rep. 39:6699–6706. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Tsai KW, Leung CM, Lo YH, Chen TW, Chan WC, Yu SY, Tu YT, Lam HC, Li SC, Ger LP, et al: Arm selection preference of MicroRNA-193a varies in breast cancer. Sci Rep. 6:281762016. View Article : Google Scholar : PubMed/NCBI

28 

Kuo WT, Yu SY, Li SC, Lam HC, Chang HT, Chen WS, Yeh CY, Hung SF, Liu TC, Wu T, et al: MicroRNA-324 in Human cancer: miR-324-5p and miR-324-3p have distinct biological functions in human cancer. Anticancer Res. 36:5189–5196. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Lewis BP, Burge CB and Bartel DP: Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell. 120:15–20. 2005. View Article : Google Scholar : PubMed/NCBI

30 

Oliveros JC: Venny. An interactive tool for comparing lists with Venn's diagrams. http://bioinfogp.cnb.csic.es/tools/venny/index.html2007–2015.

31 

Griffiths-Jones S, Saini HK, van Dongen S and Enright AJ: miRBase: Tools for microRNA genomics. Nucleic Acids Res. 36:(Database issue). D154–D158. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Griffiths-Jones S, Grocock RJ, van Dongen S, Bateman A and Enright AJ: miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res. 34:(Database issue). D140–D144. 2006. View Article : Google Scholar : PubMed/NCBI

33 

Kozomara A and Griffiths-Jones S: miRBase: Annotating high confidence microRNAs using deep sequencing data. Nucleic Acids Res. 42:(Database issue). D68–D73. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Kozomara A and Griffiths-Jones S: miRBase: Integrating microRNA annotation and deep-sequencing data. Nucleic Acids Res. 39:(Database issue). D152–D157. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Griffiths-Jones S: The microRNA registry. Nucleic Acids Res. 32:(Database issue). D109–D111. 2004. View Article : Google Scholar : PubMed/NCBI

36 

Liu C, Zheng L, Wang H, Ran X, Liu H and Sun X: The RCAN1 inhibits NF-κB and suppresses lymphoma growth in mice. Cell Death Dis. 6:e19292015. View Article : Google Scholar : PubMed/NCBI

37 

Kohler RS, Anugraham M, López MN, Xiao C, Schoetzau A, Hettich T, Schlotterbeck G, Fedier A, Jacob F and Heinzelmann-Schwarz V: Epigenetic activation of MGAT3 and corresponding bisecting GlcNAc shortens the survival of cancer patients. Oncotarget. 7:51674–51686. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Chang SN, Lee JM, Oh H and Park JH: Glutathione peroxidase 3 inhibits prostate tumorigenesis in TRAMP mice. Prostate. 76:1387–1398. 2016. View Article : Google Scholar : PubMed/NCBI

39 

An BC, Jung NK, Park CY, Oh IJ, Choi YD, Park JI and Lee SW: Epigenetic and glucocorticoid receptor-mediated regulation of glutathione peroxidase 3 in lung cancer cells. Mol Cells. 39:631–638. 2016. View Article : Google Scholar : PubMed/NCBI

40 

Slezak-Prochazka I, Durmus S, Kroesen BJ and van den Berg A: MicroRNAs, macrocontrol: Regulation of miRNA processing. Rna. 16:1087–1095. 2010. View Article : Google Scholar : PubMed/NCBI

41 

Li SC, Tsai KW, Pan HW, Jeng YM, Ho MR and Li WH: MicroRNA 3′ end nucleotide modification patterns and arm selection preference in liver tissues. BMC Syst Biol. 6 Suppl 2:S142012. View Article : Google Scholar

42 

Dixon-McIver A, East P, Mein CA, Cazier JB, Molloy G, Chaplin T, Lister Andrew T, Young BD and Debernardi S: Distinctive patterns of microRNA expression associated with karyotype in acute myeloid leukaemia. PLoS One. 3:e21412008. View Article : Google Scholar : PubMed/NCBI

43 

Ferretti E, De Smaele E, Miele E, Laneve P, Po A, Pelloni M, Paganelli A, Di Marcotullio L, Caffarelli E, Screpanti I, et al: Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells. EMBO J. 27:2616–2627. 2008. View Article : Google Scholar : PubMed/NCBI

44 

Schultz J, Lorenz P, Gross G, Ibrahim S and Kunz M: MicroRNA let-7b targets important cell cycle molecules in malignant melanoma cells and interferes with anchorage-independent growth. Cell Res. 18:549–557. 2008. View Article : Google Scholar : PubMed/NCBI

45 

Wang Y, Lee AT, Ma JZ, Wang J, Ren J, Yang Y, Tantoso E, Li KB, Ooi LL, Tan P and Lee CG: Profiling microRNA expression in hepatocellular carcinoma reveals microRNA-224 up-regulation and apoptosis inhibitor-5 as a microRNA-224-specific target. J Biol Chem. 283:13205–13215. 2008. View Article : Google Scholar : PubMed/NCBI

46 

Crawford M, Batte K, Yu L, Wu X, Nuovo GJ, Marsh CB, Otterson GA and Nana-Sinkam SP: MicroRNA 133B targets pro-survival molecules MCL-1 and BCL2L2 in lung cancer. Biochem Biophys Res Commun. 388:483–489. 2009. View Article : Google Scholar : PubMed/NCBI

47 

Xu HS, Zong HL, Shang M, Ming X, Zhao JP, Ma C and Cao L: MiR-324-5p inhibits proliferation of glioma by target regulation of GLI1. Eur Rev Med Pharmacol Sci. 18:828–832. 2014.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Lin MH, Chen YZ, Lee MY, Weng KP, Chang HT, Yu SY, Dong BJ, Kuo FR, Hung LT, Liu LF, Liu LF, et al: Comprehensive identification of microRNA arm selection preference in lung cancer: miR‑324‑5p and ‑3p serve oncogenic functions in lung cancer. Oncol Lett 15: 9818-9826, 2018.
APA
Lin, M., Chen, Y., Lee, M., Weng, K., Chang, H., Yu, S. ... Tsai, K. (2018). Comprehensive identification of microRNA arm selection preference in lung cancer: miR‑324‑5p and ‑3p serve oncogenic functions in lung cancer. Oncology Letters, 15, 9818-9826. https://doi.org/10.3892/ol.2018.8557
MLA
Lin, M., Chen, Y., Lee, M., Weng, K., Chang, H., Yu, S., Dong, B., Kuo, F., Hung, L., Liu, L., Chen, W., Tsai, K."Comprehensive identification of microRNA arm selection preference in lung cancer: miR‑324‑5p and ‑3p serve oncogenic functions in lung cancer". Oncology Letters 15.6 (2018): 9818-9826.
Chicago
Lin, M., Chen, Y., Lee, M., Weng, K., Chang, H., Yu, S., Dong, B., Kuo, F., Hung, L., Liu, L., Chen, W., Tsai, K."Comprehensive identification of microRNA arm selection preference in lung cancer: miR‑324‑5p and ‑3p serve oncogenic functions in lung cancer". Oncology Letters 15, no. 6 (2018): 9818-9826. https://doi.org/10.3892/ol.2018.8557
Copy and paste a formatted citation
x
Spandidos Publications style
Lin MH, Chen YZ, Lee MY, Weng KP, Chang HT, Yu SY, Dong BJ, Kuo FR, Hung LT, Liu LF, Liu LF, et al: Comprehensive identification of microRNA arm selection preference in lung cancer: miR‑324‑5p and ‑3p serve oncogenic functions in lung cancer. Oncol Lett 15: 9818-9826, 2018.
APA
Lin, M., Chen, Y., Lee, M., Weng, K., Chang, H., Yu, S. ... Tsai, K. (2018). Comprehensive identification of microRNA arm selection preference in lung cancer: miR‑324‑5p and ‑3p serve oncogenic functions in lung cancer. Oncology Letters, 15, 9818-9826. https://doi.org/10.3892/ol.2018.8557
MLA
Lin, M., Chen, Y., Lee, M., Weng, K., Chang, H., Yu, S., Dong, B., Kuo, F., Hung, L., Liu, L., Chen, W., Tsai, K."Comprehensive identification of microRNA arm selection preference in lung cancer: miR‑324‑5p and ‑3p serve oncogenic functions in lung cancer". Oncology Letters 15.6 (2018): 9818-9826.
Chicago
Lin, M., Chen, Y., Lee, M., Weng, K., Chang, H., Yu, S., Dong, B., Kuo, F., Hung, L., Liu, L., Chen, W., Tsai, K."Comprehensive identification of microRNA arm selection preference in lung cancer: miR‑324‑5p and ‑3p serve oncogenic functions in lung cancer". Oncology Letters 15, no. 6 (2018): 9818-9826. https://doi.org/10.3892/ol.2018.8557
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team