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Article Open Access

Identification of endothelial selectin as a potential prognostic marker in breast cancer

  • Authors:
    • Wei Zhang
    • Zhichao Zuo
    • Xiangyang Huang
    • Junjie Liu
    • Guanqiao Jin
    • Danke Su
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China, Department of Ultrasound, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 9908-9916
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    Published online on: April 25, 2018
       https://doi.org/10.3892/ol.2018.8570
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Abstract

Endothelial selectin (ELAM1 or CD62E) has been previously reported as being associated with the prognosis of multiple types of cancer. However, its prognostic value in breast cancer (BC) remains unclear. The aim of the present study was to investigate the prognostic value of ELAM1 mRNA expression in BC tissue. The prognostic value of ELAM1 mRNA was assessed in patients with BC using the Kaplan‑Meier plotter (KM‑plot) database. The KM‑plot generated updated ELAM1 mRNA expression data and survival analysis from a total of 3,951 patients with BC, gathered from 35 datasets. Low expression of ELAM1 mRNA was correlated with a poorer overall survival in 1,402 patients with BC followed for 20 years [hazard ratio (HR), 0.71; 95% confidence interval (CI), 0.57‑0.88; log‑rank P=0.0016]. Low expression of ELAM1 was also correlated with poorer relapse‑free survival (HR, 0.69; 95% CI, 0.62‑0.77; log‑rank P=2.2e‑11) in 3,951 patients and poorer distant metastasis‑free survival (HR, 0.79; 95% CI, 0.65‑0.96; log‑rank P=0.02) in 1,746 patients with BC followed for 20 years. Results from the Metabolic gEne RApid visualizer database indicated that ELAM1 mRNA expression was elevated in normal tissue. The results of the present study suggest that ELAM1 mRNA is a potential prognostic and metastatic marker in patients with BC.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang W, Zuo Z, Huang X, Liu J, Jin G and Su D: Identification of endothelial selectin as a potential prognostic marker in breast cancer. Oncol Lett 15: 9908-9916, 2018.
APA
Zhang, W., Zuo, Z., Huang, X., Liu, J., Jin, G., & Su, D. (2018). Identification of endothelial selectin as a potential prognostic marker in breast cancer. Oncology Letters, 15, 9908-9916. https://doi.org/10.3892/ol.2018.8570
MLA
Zhang, W., Zuo, Z., Huang, X., Liu, J., Jin, G., Su, D."Identification of endothelial selectin as a potential prognostic marker in breast cancer". Oncology Letters 15.6 (2018): 9908-9916.
Chicago
Zhang, W., Zuo, Z., Huang, X., Liu, J., Jin, G., Su, D."Identification of endothelial selectin as a potential prognostic marker in breast cancer". Oncology Letters 15, no. 6 (2018): 9908-9916. https://doi.org/10.3892/ol.2018.8570
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang W, Zuo Z, Huang X, Liu J, Jin G and Su D: Identification of endothelial selectin as a potential prognostic marker in breast cancer. Oncol Lett 15: 9908-9916, 2018.
APA
Zhang, W., Zuo, Z., Huang, X., Liu, J., Jin, G., & Su, D. (2018). Identification of endothelial selectin as a potential prognostic marker in breast cancer. Oncology Letters, 15, 9908-9916. https://doi.org/10.3892/ol.2018.8570
MLA
Zhang, W., Zuo, Z., Huang, X., Liu, J., Jin, G., Su, D."Identification of endothelial selectin as a potential prognostic marker in breast cancer". Oncology Letters 15.6 (2018): 9908-9916.
Chicago
Zhang, W., Zuo, Z., Huang, X., Liu, J., Jin, G., Su, D."Identification of endothelial selectin as a potential prognostic marker in breast cancer". Oncology Letters 15, no. 6 (2018): 9908-9916. https://doi.org/10.3892/ol.2018.8570
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