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Resveratrol suppresses human cervical carcinoma cell proliferation and elevates apoptosis via the mitochondrial and p53 signaling pathways

  • Authors:
    • Lin Li
    • Rong‑Li Qiu
    • Yu Lin
    • Ying Cai
    • Yong Bian
    • Yan Fan
    • Xiao‑Jun Gao
  • View Affiliations / Copyright

    Affiliations: Institute of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, P.R. China, CAS Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P.R. China, Nanjing General Hospital of Nanjing Military Command, Nanjing, Jiangsu 210002, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 9845-9851
    |
    Published online on: April 25, 2018
       https://doi.org/10.3892/ol.2018.8571
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Abstract

Numerous studies have demonstrated the apoptotic and anti‑proliferative effects of resveratrol, a natural polyphenolic phytoalexin, on various cancer cell lines. However, the effects of resveratrol on the regulation of human cervical carcinoma, and the mechanisms underlying these effects, remain to be elucidated. In the present study, the potential mechanisms underlying the effects of resveratrol in HeLa cervical carcinoma cells were investigated. The results revealed that resveratrol inhibited proliferation and induced apoptosis in HeLa human cervical cancer cells in a dose‑dependent and time‑dependent manner. Resveratrol induced cell shrinkage in HeLa cells and apoptosis accompanied by the activation of caspase‑3 and ‑9. Furthermore, resveratrol upregulated the expression of the pro‑apoptotic B‑cell lymphoma (Bcl)‑2‑associated X protein and downregulated the expression of the anti‑apoptotic proteins Bcl‑2 and Bcl‑extra large in HeLa cells. In addition, p53, a protein that is essential for cell survival and cell cycle progression, exhibited elevated expression levels in resveratrol‑treated HeLa cells. Therefore, resveratrol may be a promising novel inhibitor of human cervical cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Li L, Qiu RL, Lin Y, Cai Y, Bian Y, Fan Y and Gao XJ: Resveratrol suppresses human cervical carcinoma cell proliferation and elevates apoptosis via the mitochondrial and p53 signaling pathways. Oncol Lett 15: 9845-9851, 2018.
APA
Li, L., Qiu, R., Lin, Y., Cai, Y., Bian, Y., Fan, Y., & Gao, X. (2018). Resveratrol suppresses human cervical carcinoma cell proliferation and elevates apoptosis via the mitochondrial and p53 signaling pathways. Oncology Letters, 15, 9845-9851. https://doi.org/10.3892/ol.2018.8571
MLA
Li, L., Qiu, R., Lin, Y., Cai, Y., Bian, Y., Fan, Y., Gao, X."Resveratrol suppresses human cervical carcinoma cell proliferation and elevates apoptosis via the mitochondrial and p53 signaling pathways". Oncology Letters 15.6 (2018): 9845-9851.
Chicago
Li, L., Qiu, R., Lin, Y., Cai, Y., Bian, Y., Fan, Y., Gao, X."Resveratrol suppresses human cervical carcinoma cell proliferation and elevates apoptosis via the mitochondrial and p53 signaling pathways". Oncology Letters 15, no. 6 (2018): 9845-9851. https://doi.org/10.3892/ol.2018.8571
Copy and paste a formatted citation
x
Spandidos Publications style
Li L, Qiu RL, Lin Y, Cai Y, Bian Y, Fan Y and Gao XJ: Resveratrol suppresses human cervical carcinoma cell proliferation and elevates apoptosis via the mitochondrial and p53 signaling pathways. Oncol Lett 15: 9845-9851, 2018.
APA
Li, L., Qiu, R., Lin, Y., Cai, Y., Bian, Y., Fan, Y., & Gao, X. (2018). Resveratrol suppresses human cervical carcinoma cell proliferation and elevates apoptosis via the mitochondrial and p53 signaling pathways. Oncology Letters, 15, 9845-9851. https://doi.org/10.3892/ol.2018.8571
MLA
Li, L., Qiu, R., Lin, Y., Cai, Y., Bian, Y., Fan, Y., Gao, X."Resveratrol suppresses human cervical carcinoma cell proliferation and elevates apoptosis via the mitochondrial and p53 signaling pathways". Oncology Letters 15.6 (2018): 9845-9851.
Chicago
Li, L., Qiu, R., Lin, Y., Cai, Y., Bian, Y., Fan, Y., Gao, X."Resveratrol suppresses human cervical carcinoma cell proliferation and elevates apoptosis via the mitochondrial and p53 signaling pathways". Oncology Letters 15, no. 6 (2018): 9845-9851. https://doi.org/10.3892/ol.2018.8571
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