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Article Open Access

KDM3A is not associated with metastasis and prognosis of breast cancer

  • Authors:
    • Juan Yao
    • Shutao Zheng
    • Baiyan Li
    • Xinxin Li
    • Wenya Liu
  • View Affiliations / Copyright

    Affiliations: The Imaging Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uyghur Autonomous Region 830054, P.R. China, Clinical Medical Research Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uyghur Autonomous Region 830054, P.R. China
    Copyright: © Yao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 9751-9756
    |
    Published online on: April 25, 2018
       https://doi.org/10.3892/ol.2018.8578
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Abstract

Lysine demethylase 3A (KDM3A), also known as JMJD1A, has been associated with metastasis and poor prognosis in several cancer types, including renal cell carcinoma, prostate cancer and Ewing sarcoma. However, little is known regarding the clinicopathological significance of KDM3A expression in breast cancer (BCa). To investigate the clinical relevance of KDM3A expression in the setting of BCa, immunohistochemistry was performed on a tissue microarray consisting of 150 commercially available BCa samples. No significant correlation was identified between KDM3A expression and various clinicopathological variables, including clinical stage, pathological grade, tumor size and the expression statuses of human epidermal growth factor receptor 2, estrogen receptor, and progesterone receptor. In addition, no significant association between KDM3A expression and overall prognosis was observed. Taken together, these findings suggest that there is no significant association between KDM3A expression and clinicopathological variables, indicating that KDM3A may not be associated with the malignant behavior of BCa.
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1 

Bozorgi A, Khazaei M and Khazaei MR: New findings on breast cancer stem cells: A review. J Breast Cancer. 18:303–312. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Siegel R, Ma J, Zou Z and Jemal A: Cancer statistics, 2014. CA Cancer J Clin. 64:9–29. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Kim SJ, Kim YS, Jang ED, Seo KJ and Kim JS: Prognostic impact and clinicopathological correlation of CD133 and ALDH1 expression in invasive breast cancer. J Breast Cancer. 18:347–355. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Weigelt B, Peterse JL and van't Veer LJ: Breast cancer metastasis: Markers and models. Nat Rev Cancer. 5:591–602. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Wade MA, Jones D, Wilson L, Stockley J, Coffey K, Robson CN and Gaughan L: The histone demethylase enzyme KDM3A is a key estrogen receptor regulator in breast cancer. Nucleic Acids Res. 43:196–207. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Ramadoss S, Guo G and Wang CY: Lysine demethylase KDM3A regulates breast cancer cell invasion and apoptosis by targeting histone and the non-histone protein p53. Oncogene. 36:47–59. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Yamane K, Toumazou C, Tsukada Y, Erdjument-Bromage H, Tempst P, Wong J and Zhang Y: JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor. Cell. 125:483–495. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Wellmann S, Bettkober M, Zelmer A, Seeger K, Faigle M, Eltzschig HK and Bührer C: Hypoxia upregulates the histone demethylase JMJD1A via HIF-1. Biochem Biophys Res Commun. 372:892–897. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Parrish JK, Sechler M, Winn RA and Jedlicka P: The histone demethylase KDM3A is a microRNA-22-regulated tumor promoter in Ewing Sarcoma. Oncogene. 34:257–262. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Cho HS, Toyokawa G, Daigo Y, Hayami S, Masuda K, Ikawa N, Yamane Y, Maejima K, Tsunoda T, Field HI, et al: The JmjC domain-containing histone demethylase KDM3A is a positive regulator of the G1/S transition in cancer cells via transcriptional regulation of the HOXA1 gene. Int J Cancer. 131:E179–E189. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Tee AE, Ling D, Nelson C, Atmadibrata B, Dinger ME, Xu N, Mizukami T, Liu PY, Liu B, Cheung B, et al: The histone demethylase JMJD1A induces cell migration and invasion by up-regulating the expression of the long noncoding RNA MALAT1. Oncotarget. 5:1793–1804. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Yamada D, Kobayashi S, Yamamoto H, Tomimaru Y, Noda T, Uemura M, Wada H, Marubashi S, Eguchi H, Tanemura M, et al: Role of the hypoxia-related gene, JMJD1A, in hepatocellular carcinoma: Clinical impact on recurrence after hepatic resection. Ann Surg Oncol. 3 Suppl 19:S355–S364. 2012. View Article : Google Scholar

14 

Guo X, Shi M, Sun L, Wang Y, Gui Y, Cai Z and Duan X: The expression of histone demethylase JMJD1A in renal cell carcinoma. Neoplasma. 58:153–157. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Hewitt SM, Baskin DG, Frevert CW, Stahl WL and Rosa-Molinar E: Controls for immunohistochemistry: The Histochemical Society's standards of practice for validation of immunohistochemical assays. J Histochem Cytochem. 62:693–697. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Burry RW: Controls for immunocytochemistry: An update. J Histochem Cytochem. 59:6–12. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Okada Y, Scott G, Ray MK, Mishina Y and Zhang Y: Histone demethylase JHDM2A is critical for Tnp1 and Prm1 transcription and spermatogenesis. Nature. 450:119–123. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Beyer S, Kristensen MM, Jensen KS, Johansen JV and Staller P: The histone demethylases JMJD1A and JMJD2B are transcriptional targets of hypoxia-inducible factor HIF. J Biol Chem. 283:36542–36552. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Pollard PJ, Loenarz C, Mole DR, McDonough MA, Gleadle JM, Schofield CJ and Ratcliffe PJ: Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha. Biochem J. 416:387–394. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Zhou X, Sun H, Ellen TP, Chen H and Costa M: Arsenite alters global histone H3 methylation. Carcinogenesis. 29:1831–1836. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Krieg AJ, Rankin EB, Chan D, Razorenova O, Fernandez S and Giaccia AJ: Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 alpha enhances hypoxic gene expression and tumor growth. Mol Cell Biol. 30:344–353. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Osawa T, Tsuchida R, Muramatsu M, Shimamura T, Wang F, Suehiro J, Kanki Y, Wada Y, Yuasa Y, Aburatani H, et al: Inhibition of histone demethylase JMJD1A improves anti-angiogenic therapy and reduces tumor-associated macrophages. Cancer Res. 73:3019–3028. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Yang H, Liu Z, Yuan C, Zhao Y, Wang L, Hu J, Xie D, Wang L and Chen D: Elevated JMJD1A is a novel predictor for prognosis and a potential therapeutic target for gastric cancer. Int J Clin Exp Pathol. 8:11092–11099. 2015.PubMed/NCBI

24 

Suikki HE, Kujala PM, Tammela TL, van Weerden WM, Vessella RL and Visakorpi T: Genetic alterations and changes in expression of histone demethylases in prostate cancer. Prostate. 70:889–898. 2010.PubMed/NCBI

25 

Zhao QY, Lei PJ, Zhang X, Zheng JY, Wang HY, Zhao J, Li YM, Ye M, Li L, Wei G and Wu M: Global histone modification profiling reveals the epigenomic dynamics during malignant transformation in a four-stage breast cancer model. Clin Epigenetics. 8:342016. View Article : Google Scholar : PubMed/NCBI

26 

Wang L, Chang J, Varghese D, Dellinger M, Kumar S, Best AM, Ruiz J, Bruick R, Peña-Llopis S, Xu J, et al: A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth. Nat Commun. 4:20352013. View Article : Google Scholar : PubMed/NCBI

27 

Baker M: Reproducibility crisis: Blame it on the antibodies. Nature. 521:274–276. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Sar A, Ponjevic D, Nguyen M, Box AH and Demetrick DJ: Identification and characterization of demethylase JMJD1A as a gene upregulated in the human cellular response to hypoxia. Cell Tissue Res. 337:223–234. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Khouja MH, Baekelandt M, Sarab A, Nesland JM and Holm R: Limitations of tissue microarrays compared with whole tissue sections in survival analysis. Oncol Lett. 1:827–831. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Merseburger AS, Kuczyk MA, Serth J, Bokemeyer C, Young DY, Sun L, Connelly RR, McLeod DG, Mostofi FK, Srivastava SK, et al: Limitations of tissue microarrays in the evaluation of focal alterations of bcl-2 and p53 in whole mount derived prostate tissues. Oncol Rep. 10:223–228. 2003.PubMed/NCBI

31 

Mirlacher M, Kasper M, Storz M, Knecht Y, Dürmüller U, Simon R, Mihatsch MJ and Sauter G: Influence of slide aging on results of translational research studies using immunohistochemistry. Mod Pathol. 17:1414–1420. 2004. View Article : Google Scholar : PubMed/NCBI

32 

Dressler LG, Geradts J, Burroughs M, Cowan D, Millikan RC and Newman B: Policy guidelines for the utilization of formalin-fixed, paraffin-embedded tissue sections: The UNC SPORE experience. University of North Carolina Specialized Program of Research Excellence. Breast Cancer Res Treat. 58:31–39. 1999. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yao J, Zheng S, Li B, Li X and Liu W: KDM3A is not associated with metastasis and prognosis of breast cancer. Oncol Lett 15: 9751-9756, 2018.
APA
Yao, J., Zheng, S., Li, B., Li, X., & Liu, W. (2018). KDM3A is not associated with metastasis and prognosis of breast cancer. Oncology Letters, 15, 9751-9756. https://doi.org/10.3892/ol.2018.8578
MLA
Yao, J., Zheng, S., Li, B., Li, X., Liu, W."KDM3A is not associated with metastasis and prognosis of breast cancer". Oncology Letters 15.6 (2018): 9751-9756.
Chicago
Yao, J., Zheng, S., Li, B., Li, X., Liu, W."KDM3A is not associated with metastasis and prognosis of breast cancer". Oncology Letters 15, no. 6 (2018): 9751-9756. https://doi.org/10.3892/ol.2018.8578
Copy and paste a formatted citation
x
Spandidos Publications style
Yao J, Zheng S, Li B, Li X and Liu W: KDM3A is not associated with metastasis and prognosis of breast cancer. Oncol Lett 15: 9751-9756, 2018.
APA
Yao, J., Zheng, S., Li, B., Li, X., & Liu, W. (2018). KDM3A is not associated with metastasis and prognosis of breast cancer. Oncology Letters, 15, 9751-9756. https://doi.org/10.3892/ol.2018.8578
MLA
Yao, J., Zheng, S., Li, B., Li, X., Liu, W."KDM3A is not associated with metastasis and prognosis of breast cancer". Oncology Letters 15.6 (2018): 9751-9756.
Chicago
Yao, J., Zheng, S., Li, B., Li, X., Liu, W."KDM3A is not associated with metastasis and prognosis of breast cancer". Oncology Letters 15, no. 6 (2018): 9751-9756. https://doi.org/10.3892/ol.2018.8578
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