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Triple primary malignancies of surface osteosarcoma of jaw, myelodysplastic syndrome and colorectal cancer as a second primary cancer detected by PET2‑[18F]‑fluoro‑2‑deoxy‑D‑glucose positron emission tomography: A case report

  • Authors:
    • Nobuyuki Maruyama
    • Kazuhide Nishihara
    • Toshiyuki Nakasone
    • Masanao Saio
    • Tessho Maruyama
    • Iori Tedokon
    • Tetsuya Ohira
    • Fumikazu Nimura
    • Akira Matayoshi
    • Ken‑Nosuke Karube
    • Naoki Yoshimi
    • Akira Arasaki
  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial Functional Rehabilitation, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa 903‑0215, Japan, Department of Oral and Maxillofacial Surgery, University Hospital of the Ryukyus, Nishihara, Okinawa 903‑0215, Japan, Department of Pathology and Oncology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa 903‑0215, Japan, Division of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology (Second Department of Internal Medicine), Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa 903‑0215, Japan, Department of Endoscopy, University of the Ryukyus, Nishihara, Okinawa 903‑0215, Japan, Department of Pathology and Cell Biology, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa 903‑0215, Japan
    Copyright: © Maruyama et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 9901-9907
    |
    Published online on: April 27, 2018
       https://doi.org/10.3892/ol.2018.8594
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Abstract

Second primary malignancy (SPM) is a severe issue for cancer survivors, particularly for osteosarcoma (OS) survivors. To date, the associations between subsequent SPM and OS have been well reported. Hematogenic and solid malignancies tend to occur following OS treatment. Reportedly, 2‑[18F]‑fluoro‑2‑deoxy‑D‑glucose positron emission tomography (FDG‑PET) is mainly used in OS patients for initial cancer staging, to evaluate the response of neoadjuvant chemotherapy, and when recurrence or metastasis is clinically suspected. The present case report describes a 70‑year‑old man diagnosed with three primary malignancies: jaw OS, myelodysplastic syndrome and colorectal adenocarcinoma. To the best of our knowledge, this combination of malignancies has not been reported previously. Until now, there is no specific protocol of postoperative FDG‑PET for OS patients. Few studies have described OS follow‑up methods; therefore, there is no consensus on proper follow‑up methods. In the present case report, the colorectal early‑stage SPM was observed, without any symptoms, by FDG‑PET/computed tomography. To avoid overlooking solid SPMs, it is suggested that FDG‑PET should be performed in the long‑term follow‑up of OS patients.
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Spandidos Publications style
Maruyama N, Nishihara K, Nakasone T, Saio M, Maruyama T, Tedokon I, Ohira T, Nimura F, Matayoshi A, Karube KN, Karube KN, et al: Triple primary malignancies of surface osteosarcoma of jaw, myelodysplastic syndrome and colorectal cancer as a second primary cancer detected by PET2‑[18F]‑fluoro‑2‑deoxy‑D‑glucose positron emission tomography: A case report. Oncol Lett 15: 9901-9907, 2018.
APA
Maruyama, N., Nishihara, K., Nakasone, T., Saio, M., Maruyama, T., Tedokon, I. ... Arasaki, A. (2018). Triple primary malignancies of surface osteosarcoma of jaw, myelodysplastic syndrome and colorectal cancer as a second primary cancer detected by PET2‑[18F]‑fluoro‑2‑deoxy‑D‑glucose positron emission tomography: A case report. Oncology Letters, 15, 9901-9907. https://doi.org/10.3892/ol.2018.8594
MLA
Maruyama, N., Nishihara, K., Nakasone, T., Saio, M., Maruyama, T., Tedokon, I., Ohira, T., Nimura, F., Matayoshi, A., Karube, K., Yoshimi, N., Arasaki, A."Triple primary malignancies of surface osteosarcoma of jaw, myelodysplastic syndrome and colorectal cancer as a second primary cancer detected by PET2‑[18F]‑fluoro‑2‑deoxy‑D‑glucose positron emission tomography: A case report". Oncology Letters 15.6 (2018): 9901-9907.
Chicago
Maruyama, N., Nishihara, K., Nakasone, T., Saio, M., Maruyama, T., Tedokon, I., Ohira, T., Nimura, F., Matayoshi, A., Karube, K., Yoshimi, N., Arasaki, A."Triple primary malignancies of surface osteosarcoma of jaw, myelodysplastic syndrome and colorectal cancer as a second primary cancer detected by PET2‑[18F]‑fluoro‑2‑deoxy‑D‑glucose positron emission tomography: A case report". Oncology Letters 15, no. 6 (2018): 9901-9907. https://doi.org/10.3892/ol.2018.8594
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Spandidos Publications style
Maruyama N, Nishihara K, Nakasone T, Saio M, Maruyama T, Tedokon I, Ohira T, Nimura F, Matayoshi A, Karube KN, Karube KN, et al: Triple primary malignancies of surface osteosarcoma of jaw, myelodysplastic syndrome and colorectal cancer as a second primary cancer detected by PET2‑[18F]‑fluoro‑2‑deoxy‑D‑glucose positron emission tomography: A case report. Oncol Lett 15: 9901-9907, 2018.
APA
Maruyama, N., Nishihara, K., Nakasone, T., Saio, M., Maruyama, T., Tedokon, I. ... Arasaki, A. (2018). Triple primary malignancies of surface osteosarcoma of jaw, myelodysplastic syndrome and colorectal cancer as a second primary cancer detected by PET2‑[18F]‑fluoro‑2‑deoxy‑D‑glucose positron emission tomography: A case report. Oncology Letters, 15, 9901-9907. https://doi.org/10.3892/ol.2018.8594
MLA
Maruyama, N., Nishihara, K., Nakasone, T., Saio, M., Maruyama, T., Tedokon, I., Ohira, T., Nimura, F., Matayoshi, A., Karube, K., Yoshimi, N., Arasaki, A."Triple primary malignancies of surface osteosarcoma of jaw, myelodysplastic syndrome and colorectal cancer as a second primary cancer detected by PET2‑[18F]‑fluoro‑2‑deoxy‑D‑glucose positron emission tomography: A case report". Oncology Letters 15.6 (2018): 9901-9907.
Chicago
Maruyama, N., Nishihara, K., Nakasone, T., Saio, M., Maruyama, T., Tedokon, I., Ohira, T., Nimura, F., Matayoshi, A., Karube, K., Yoshimi, N., Arasaki, A."Triple primary malignancies of surface osteosarcoma of jaw, myelodysplastic syndrome and colorectal cancer as a second primary cancer detected by PET2‑[18F]‑fluoro‑2‑deoxy‑D‑glucose positron emission tomography: A case report". Oncology Letters 15, no. 6 (2018): 9901-9907. https://doi.org/10.3892/ol.2018.8594
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