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Downregulation of COUP‑TFII inhibits glioblastoma growth via targeting MPC1

  • Authors:
    • Bing Xiao
    • Yanghua Fan
    • Minhua Ye
    • Shigang Lv
    • Bin Xu
    • Yi Chai
    • Miaojin Wu
    • Xingen Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China
    Copyright: © Xiao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 9697-9702
    |
    Published online on: April 27, 2018
       https://doi.org/10.3892/ol.2018.8601
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Abstract

Chicken ovalbumin upstream promoter transcription factor II (COUP‑TFII) is a steroid receptor that is broadly expressed in many tissues throughout embryonic development. Previous studies indicated that COUP‑TFII is dysregulated in multiple types of cancer and serves crucial roles in cancer development. The mitochondrial pyruvate carrier 1 (MPC1) is involved in transporting pyruvate for entry into the citric acid cycle, an important event in cancer progression. However, the roles of COUP‑TFII and MPC1 in glioma remain unknown. In the present study, it was demonstrated that MPC1 is downregulated in glioblastoma. Furthermore, the inhibition of COUP‑TFII was able to increase MPC1 expression and inhibit the growth of glioblastoma cells in vitro and in vivo. The findings from the present study demonstrated that downregulation of COUP‑TFII inhibits glioblastoma growth via targeting MPC1. Therefore, COUP‑TFII is a potential therapeutic target for glioma.
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Copy and paste a formatted citation
Spandidos Publications style
Xiao B, Fan Y, Ye M, Lv S, Xu B, Chai Y, Wu M and Zhu X: Downregulation of COUP‑TFII inhibits glioblastoma growth via targeting MPC1. Oncol Lett 15: 9697-9702, 2018.
APA
Xiao, B., Fan, Y., Ye, M., Lv, S., Xu, B., Chai, Y. ... Zhu, X. (2018). Downregulation of COUP‑TFII inhibits glioblastoma growth via targeting MPC1. Oncology Letters, 15, 9697-9702. https://doi.org/10.3892/ol.2018.8601
MLA
Xiao, B., Fan, Y., Ye, M., Lv, S., Xu, B., Chai, Y., Wu, M., Zhu, X."Downregulation of COUP‑TFII inhibits glioblastoma growth via targeting MPC1". Oncology Letters 15.6 (2018): 9697-9702.
Chicago
Xiao, B., Fan, Y., Ye, M., Lv, S., Xu, B., Chai, Y., Wu, M., Zhu, X."Downregulation of COUP‑TFII inhibits glioblastoma growth via targeting MPC1". Oncology Letters 15, no. 6 (2018): 9697-9702. https://doi.org/10.3892/ol.2018.8601
Copy and paste a formatted citation
x
Spandidos Publications style
Xiao B, Fan Y, Ye M, Lv S, Xu B, Chai Y, Wu M and Zhu X: Downregulation of COUP‑TFII inhibits glioblastoma growth via targeting MPC1. Oncol Lett 15: 9697-9702, 2018.
APA
Xiao, B., Fan, Y., Ye, M., Lv, S., Xu, B., Chai, Y. ... Zhu, X. (2018). Downregulation of COUP‑TFII inhibits glioblastoma growth via targeting MPC1. Oncology Letters, 15, 9697-9702. https://doi.org/10.3892/ol.2018.8601
MLA
Xiao, B., Fan, Y., Ye, M., Lv, S., Xu, B., Chai, Y., Wu, M., Zhu, X."Downregulation of COUP‑TFII inhibits glioblastoma growth via targeting MPC1". Oncology Letters 15.6 (2018): 9697-9702.
Chicago
Xiao, B., Fan, Y., Ye, M., Lv, S., Xu, B., Chai, Y., Wu, M., Zhu, X."Downregulation of COUP‑TFII inhibits glioblastoma growth via targeting MPC1". Oncology Letters 15, no. 6 (2018): 9697-9702. https://doi.org/10.3892/ol.2018.8601
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