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Article

miR‑449c inhibits migration and invasion of gastric cancer cells by targeting PFKFB3

  • Authors:
    • Xin Chen
    • Anping Wang
    • Xinxia Yue
  • View Affiliations / Copyright

    Affiliations: Department of Digestive Disease, People’s Hospital Xinjiang Autonomous Republic, Urumqi, Xinjiang 830001, P.R. China, Department of Anesthesia, The Second Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, P.R. China, Department of Digestive Disease, People’s Hospital Xinjiang Autonomous Republic, North Hospital,Urumqi, Xinjiang 830001, P.R. China
  • Pages: 417-424
    |
    Published online on: May 2, 2018
       https://doi.org/10.3892/ol.2018.8609
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Abstract

microRNAs (miRNAs) are important regulators in the development and progression of human gastric cancer (GC). However, the expression and biological function of miR‑449c in GC remains unknown. In the present study, miR‑449c was demonstrated to be downregulated in GC tissues and cell lines compared with normal. Decreased miR‑449c levels were associated with poor prognosis in GC patients. Overexpression of miR‑449c inhibited migration and invasion in SGC‑7901 cells, while inhibition of miR‑449c enhanced migration and invasion in MGC‑803 cells. Furthermore, 6‑phosphofructo‑2‑kinase (PFKFB3) was identified to be a downstream target of miR‑449c in GC cells. miR‑449c directly regulated the expression of PFKFB3 in GC cells. Overexpression of PFKFB3 abrogated the inhibitory effect of miR‑449c on the migration and invasion of GC cells. In conclusion, the present study suggests that miR‑449c may be a novel biomarker and potential therapeutic target in GC.
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Copy and paste a formatted citation
Spandidos Publications style
Chen X, Wang A and Yue X: miR‑449c inhibits migration and invasion of gastric cancer cells by targeting PFKFB3. Oncol Lett 16: 417-424, 2018.
APA
Chen, X., Wang, A., & Yue, X. (2018). miR‑449c inhibits migration and invasion of gastric cancer cells by targeting PFKFB3. Oncology Letters, 16, 417-424. https://doi.org/10.3892/ol.2018.8609
MLA
Chen, X., Wang, A., Yue, X."miR‑449c inhibits migration and invasion of gastric cancer cells by targeting PFKFB3". Oncology Letters 16.1 (2018): 417-424.
Chicago
Chen, X., Wang, A., Yue, X."miR‑449c inhibits migration and invasion of gastric cancer cells by targeting PFKFB3". Oncology Letters 16, no. 1 (2018): 417-424. https://doi.org/10.3892/ol.2018.8609
Copy and paste a formatted citation
x
Spandidos Publications style
Chen X, Wang A and Yue X: miR‑449c inhibits migration and invasion of gastric cancer cells by targeting PFKFB3. Oncol Lett 16: 417-424, 2018.
APA
Chen, X., Wang, A., & Yue, X. (2018). miR‑449c inhibits migration and invasion of gastric cancer cells by targeting PFKFB3. Oncology Letters, 16, 417-424. https://doi.org/10.3892/ol.2018.8609
MLA
Chen, X., Wang, A., Yue, X."miR‑449c inhibits migration and invasion of gastric cancer cells by targeting PFKFB3". Oncology Letters 16.1 (2018): 417-424.
Chicago
Chen, X., Wang, A., Yue, X."miR‑449c inhibits migration and invasion of gastric cancer cells by targeting PFKFB3". Oncology Letters 16, no. 1 (2018): 417-424. https://doi.org/10.3892/ol.2018.8609
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