Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
July-2018 Volume 16 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2018 Volume 16 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Exploring the molecular pathogenesis associated with T‑cell prolymphocytic leukemia based on a comprehensive bioinformatics analysis

  • Authors:
    • Zhangzhen Shi
    • Jing Yu
    • Hui Shao
    • Kailiang Cheng
    • Jingjie Zhai
    • Qi Jiang
    • Hongjun Li
  • View Affiliations / Copyright

    Affiliations: Department of Hematology and Oncology, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China, Department of Nephrology, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China, Department of Radiology, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China, Department of Implantology, Jilin University Stomatology Hospital, Changchun, Jilin 130021, P.R. China, Medical Examination Center, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China
    Copyright: © Shi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 301-307
    |
    Published online on: May 2, 2018
       https://doi.org/10.3892/ol.2018.8615
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

As a rare hematological malignancy, T‑cell prolymphocytic leukemia (T‑PLL) has a high mortality rate. However, the comprehensive mechanisms of the underlying pathogenesis of T‑PLL are unknown. The purpose of the present study was to investigate the pathogenesis of T‑PLL based on a comprehensive bioinformatics analysis. The differentially expressed genes (DEGs) between T‑PLL blood cell samples and normal peripheral blood cell samples were investigated using the GSE5788 Affymetrix microarray data from the Gene Expression Omnibus database. To investigate the functional changes associated with tumor progression, Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses were used on the identified DEGs, followed by protein‑protein interaction (PPI) and sub‑PPI analysis. Transcription factors and tumor‑associated genes (TAGs) were investigated further. The results identified 84 upregulated genes and 354 downregulated genes in T‑PLL samples when compared with healthy samples. These DEGs featured in various functions including cell death and various pathways including apoptosis. The functional analysis of DEGs revealed 17 dysregulated transcription factors and 37 dysregulated TAGs. Furthermore, the PPI network analysis based on node degree (a network topology attribute) identified 61 genes, including the core downregulated gene of the sub‑PPI network, signal transducer and activator of transcription 3 (STAT3; degree, 13) and the core upregulated gene, insulin receptor substrate‑1 (IRS1; degree, 5), that may have important associations with the progression of T‑PLL. Alterations to cell functions, including cell death, and pathways, including apoptosis, may contribute to the process of T‑PLL. Candidate genes identified in the present study, including STAT3 and IRS1, should be targets for additional studies.
View Figures

Figure 1

Figure 2

View References

1 

Herling M, Khoury JD, Washington LT, Duvic M, Keating MJ and Jones D: A systematic approach to diagnosis of mature T-cell leukemias reveals heterogeneity among WHO categories. Blood. 104:328–335. 2004. View Article : Google Scholar : PubMed/NCBI

2 

Matutes E, Brito-Babapulle V, Swansbury J, Ellis J, Morilla R, Dearden C, Sempere A and Catovsky D: Clinical and laboratory features of 78 cases of T-prolymphocytic leukemia. Blood. 78:3269–3274. 1991.PubMed/NCBI

3 

Soulier J, Pierron G, Vecchione D, Garand R, Brizard F, Sigaux F, Stern MH and Aurias A: A complex pattern of recurrent chromosomal losses and gains in T-cell prolymphocytic leukemia. Genes Chromosomes Cancer. 31:248–254. 2001. View Article : Google Scholar : PubMed/NCBI

4 

Vivekanandarajah A, Atallah JP and Gupta S: T-cell prolymphocytic leukaemia (T-PLL): A rare disease with a grave prognosis. BMJ Case Rep. 2013:pii: bcr2013009808. 2013. View Article : Google Scholar : PubMed/NCBI

5 

K A and D C: T-cell prolymphocytic leukemia. Clin Lymph Myelom. 9 Suppl 3:S239–S243. 2009. View Article : Google Scholar

6 

Brito-Babapulle V, Pomfret M, Matutes E and Catovsky D: Cytogenetic studies on prolymphocytic leukemia. II. T cell prolymphocytic leukemia. Blood. 70:926–931. 1987.PubMed/NCBI

7 

Kiel MJ, Velusamy T, Rolland D, Sahasrabuddhe AA, Chung F, Bailey NG, Schrader A, Li B, Li JZ, Ozel AB, et al: Integrated genomic sequencing reveals mutational landscape of T-cell prolymphocytic leukemia. Blood. 124:1460–1472. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Bergmann AK, Schneppenheim S, Seifert M, Betts MJ, Haake A, Lopez C, Maria Murga Penas E, Vater I, Jayne S, Dyer MJ, et al: Recurrent mutation of JAK3 in T-cell prolymphocytic leukemia. Genes Chromosomes Cancer. 53:309–316. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Yokohama A, Saitoh A, Nakahashi H, Mitsui T, Koiso H, Kim Y, Uchiumi H, Saitoh T, Handa H, Jimbo T, et al: TCL1A gene involvement in T-cell prolymphocytic leukemia in Japanese patients. Int J Hematol. 95:77–85. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Bug S, Dürig J, Oyen F, Klein-Hitpass L, Martin-Subero JI, Harder L, Baudis M, Arnold N, Kordes U, Dührsen U, et al: Recurrent loss, but lack of mutations, of the SMARCB1 tumor suppressor gene in T-cell prolymphocytic leukemia with TCL1A-TCRAD juxtaposition. Cancer Genet Cytogenet. 192:44–47. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Ozpuyan F, Meyer P, Ni H, Al-Masri H and Alkan S: Bortezomib induces apoptosis in T-cell prolymphocytic leukemia (T-PLL). Leuk Lymphoma. 48:2247–2250. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Wang J, Hasui K, Utsunomiya A, Jia X, Matsuyama T and Murata F: Association of high proliferation in adult T-cell leukemia cells with apoptosis, and expression of p53 protein in acute type ATL. J Clin Exp Hematop. 48:1–10. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Dürig J, Bug S, Klein-Hitpass L, Boes T, Jöns T, Martin-Subero JI, Harder L, Baudis M, Dührsen U and Siebert R: Combined single nucleotide polymorphism-based genomic mapping and global gene expression profiling identifies novel chromosomal imbalances, mechanisms and candidate genes important in the pathogenesis of T-cell prolymphocytic leukemia with inv(14)(q11q32). Leukemia. 21:2153–2163. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Irizarry RA, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, Scherf U and Speed TP: Exploration, normalization and summaries of high density oligonucleotide array probe level data. Biostatistics. 4:249–264. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Gautier L, Cope L, Bolstad BM and Irizarry RA: Affy-analysis of Affymetrix GeneChip data at the probe level. Bioinformatics. 20:307–315. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Wang P, Ding F, Chiang H, Thompson RC, Watson SJ and Meng F: ProbeMatchDB-a web database for finding equivalent probes across microarray platforms and species. Bioinformatics. 18:488–489. 2002. View Article : Google Scholar : PubMed/NCBI

17 

Smyth GK: Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol. 3:Article32004. View Article : Google Scholar : PubMed/NCBI

18 

Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, et al: Gene ontology: Tool for the unification of biology. The Gene Ontology Consortium. Nat Genet. 25:25–29. 2000. View Article : Google Scholar : PubMed/NCBI

19 

Kanehisa M and Goto S: KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28:27–30. 2000. View Article : Google Scholar : PubMed/NCBI

20 

da Huang W, Sherman BT and Lempicki RA: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 4:44–57. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Zhao M, Sun J and Zhao Z: TSGene: A web resource for tumor suppressor genes. Nucleic Acids Res. 41:(Database Issue). D970–D976. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Chen JS, Hung WS, Chan HH, Tsai SJ and Sun HS: In silico identification of oncogenic potential of fyn-related kinase in hepatocellular carcinoma. Bioinformatics. 29:420–427. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Franceschini A, Szklarczyk D, Frankild S, Kuhn M, Simonovic M, Roth A, Lin J, Minguez P, Bork P, von Mering C and Jensen LJ: STRING v9.1: Protein-protein interaction networks, with increased coverage and integration. Nucleic Acids Res. 41:(Database Issue). D808–D815. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Beisser D, Klau GW, Dandekar T, Müller T and Dittrich MT: BioNet: An R-Package for the functional analysis of biological networks. Bioinformatics. 26:1129–1130. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Kibbe WA, Arze C, Felix V, Mitraka E, Bolton E, Fu G, Mungall CJ, Binder JX, Malone J, Vasant D, et al: Disease Ontology 2015 update: An expanded and updated database of human diseases for linking biomedical knowledge through disease data. Nucleic Acids Res. 43:(Database Issue). D1071–D1078. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Liu YJ, Zhu Y, Yuan HX, Zhang JP, Guo JM and Lin ZM: Overexpression of HOXC11 homeobox gene in clear cell renal cell carcinoma induces cellular proliferation and is associated with poor prognosis. Tumour Biol. 36:2821–2829. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Li W, Li K, Zhao L and Zou H: Bioinformatics analysis reveals disturbance mechanism of MAPK signaling pathway and cell cycle in Glioblastoma multiforme. Gene. 547:346–350. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Verstrepen L and Beyaert R: Receptor proximal kinases in NF-κB signaling as potential therapeutic targets in cancer and inflammation. Biochem Pharmacol. 92:519–529. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Liu J, Li J, Li H, Li A, Liu B and Han L: A comprehensive analysis of candidate genes and pathways in pancreatic cancer. Tumour Biol. 36:1849–1857. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Kim HS, Li A, Ahn S, Song H and Zhang W: Inositol Polyphosphate-5-Phosphatase F (INPP5F) inhibits STAT3 activity and suppresses gliomas tumorigenicity. Sci Rep. 4:73302014. View Article : Google Scholar : PubMed/NCBI

31 

Tell RW and Horvath CM: Bioinformatic analysis reveals a pattern of STAT3-associated gene expression specific to basal-like breast cancers in human tumors. Proc Natl Acad Sci USA. 111:12787–12792. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Santillán-Benítez JG, Mendieta-Zerón H, Gómez-Oliván LM, Quiroz Ordóñez A, Torres-Juárez JJ and González-Bañales JM: JAK2, STAT3 and SOCS3 gene expression in women with and without breast cancer. Gene. 547:70–76. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Gao SM, Chen CQ, Wang LY, Hong LL, Wu JB, Dong PH and Yu FJ: Histone deacetylases inhibitor sodium butyrate inhibits JAK2/STAT signaling through upregulation of SOCS1 and SOCS3 mediated by HDAC8 inhibition in myeloproliferative neoplasms. Exp Hematol. 41:261–270.e4. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Grozovsky R, Begonja AJ, Liu K, Visner G, Hartwig JH, Falet H and Hoffmeister KM: The Ashwell-Morell receptor regulates hepatic thrombopoietin production via JAK2-STAT3 signaling. Nat Med. 21:47–54. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Jorvig JE and Chakraborty A: Zerumbone inhibits growth of hormone refractory prostate cancer cells by inhibiting JAK2/STAT3 pathway and increases paclitaxel sensitivity. Anticancer Drugs. 26:160–166. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Ozoe A, Sone M, Fukushima T, Kataoka N, Arai T, Chida K, Asano T, Hakuno F and Takahashi S: Insulin receptor substrate-1 (IRS-1) forms a ribonucleoprotein complex associated with polysomes. FEBS Lett. 587:2319–2324. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Hu Y, He K, Wang D, Yuan X, Liu Y, Ji H and Song J: TMEPAI regulates EMT in lung cancer cells by modulating the ROS and IRS-1 signaling pathways. Carcinogenesis. 34:1764–1772. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Li P, Wang L, Liu L, Jiang H, Ma C and Hao T: Association between IRS-1 Gly972Arg polymorphism and colorectal cancer risk. Tumour Biol. 35:6581–6585. 2014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Shi Z, Yu J, Shao H, Cheng K, Zhai J, Jiang Q and Li H: Exploring the molecular pathogenesis associated with T‑cell prolymphocytic leukemia based on a comprehensive bioinformatics analysis. Oncol Lett 16: 301-307, 2018.
APA
Shi, Z., Yu, J., Shao, H., Cheng, K., Zhai, J., Jiang, Q., & Li, H. (2018). Exploring the molecular pathogenesis associated with T‑cell prolymphocytic leukemia based on a comprehensive bioinformatics analysis. Oncology Letters, 16, 301-307. https://doi.org/10.3892/ol.2018.8615
MLA
Shi, Z., Yu, J., Shao, H., Cheng, K., Zhai, J., Jiang, Q., Li, H."Exploring the molecular pathogenesis associated with T‑cell prolymphocytic leukemia based on a comprehensive bioinformatics analysis". Oncology Letters 16.1 (2018): 301-307.
Chicago
Shi, Z., Yu, J., Shao, H., Cheng, K., Zhai, J., Jiang, Q., Li, H."Exploring the molecular pathogenesis associated with T‑cell prolymphocytic leukemia based on a comprehensive bioinformatics analysis". Oncology Letters 16, no. 1 (2018): 301-307. https://doi.org/10.3892/ol.2018.8615
Copy and paste a formatted citation
x
Spandidos Publications style
Shi Z, Yu J, Shao H, Cheng K, Zhai J, Jiang Q and Li H: Exploring the molecular pathogenesis associated with T‑cell prolymphocytic leukemia based on a comprehensive bioinformatics analysis. Oncol Lett 16: 301-307, 2018.
APA
Shi, Z., Yu, J., Shao, H., Cheng, K., Zhai, J., Jiang, Q., & Li, H. (2018). Exploring the molecular pathogenesis associated with T‑cell prolymphocytic leukemia based on a comprehensive bioinformatics analysis. Oncology Letters, 16, 301-307. https://doi.org/10.3892/ol.2018.8615
MLA
Shi, Z., Yu, J., Shao, H., Cheng, K., Zhai, J., Jiang, Q., Li, H."Exploring the molecular pathogenesis associated with T‑cell prolymphocytic leukemia based on a comprehensive bioinformatics analysis". Oncology Letters 16.1 (2018): 301-307.
Chicago
Shi, Z., Yu, J., Shao, H., Cheng, K., Zhai, J., Jiang, Q., Li, H."Exploring the molecular pathogenesis associated with T‑cell prolymphocytic leukemia based on a comprehensive bioinformatics analysis". Oncology Letters 16, no. 1 (2018): 301-307. https://doi.org/10.3892/ol.2018.8615
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team