Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
July-2018 Volume 16 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2018 Volume 16 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

CITED1 gene promotes proliferation, migration and invasion in papillary thyroid cancer

  • Authors:
    • Erjie Xia
    • Yinghao Wang
    • Adheesh Bhandari
    • Jizhao Niu
    • Fan Yang
    • Zhihan Yao
    • Ouchen Wang
  • View Affiliations / Copyright

    Affiliations: Department of Surgical Oncology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China
    Copyright: © Xia et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 105-112
    |
    Published online on: May 7, 2018
       https://doi.org/10.3892/ol.2018.8653
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Thyroid cancer is the most common malignancy of the endocrine organs. In order to further understand the tumorigenesis and progression of papillary thyroid carcinoma (PTC), the present study performed whole transcriptome sequence analysis. It was found that Cbp/p300‑interacting transactivators with glutamic acid [E] and aspartic acid [D]‑rich C‑terminal domain 1 (CITED1) was a novel potential PTC‑associated gene in thyroid cancer. The expression level and clinicopathological features of CITED1 were then assessed in The Cancer Genome Atlas (TCGA) database. The expression of CITED1 was knocked down and the biological function of CITED1 in PTC cell lines was examined. The results showed that upregulated CITED1 was associated with lymph node metastasis (P=0.006) and clinical stage (P=0.003). In order to differentiate PTC tissues and normal tissues, an area under the curve was constructed of a receiver operating characteristic of 91.3% for the TCGA cohort and 85.3% for a validated cohort. The downregulated expression of CITED1 significantly inhibited cell proliferation, colony formation, migration and invasion in the PTC cell lines. The present study demonstrated that CITED1 is important in the tumorigenesis and metastasis of PTC and may be a potential therapeutic target in PTC.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T and Thun MJ: Cancer statistics, 2008. CA Cancer J Clin. 58:71–96. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Smith RA, Manassaram-Baptiste D, Brooks D, Doroshenk M, Fedewa S, Saslow D, Brawley OW and Wender R: Cancer screening in the United States, 2015: A review of current American cancer society guidelines and current issues in cancer screening. CA Cancer J Clin. 65:30–54. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Cabanillas ME, McFadden DG and Durante C: Thyroid cancer. Lancet. 388:2783–2795. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Cha YJ and Koo JS: Next-generation sequencing in thyroid cancer. J Transl Med. 14:3222016. View Article : Google Scholar : PubMed/NCBI

5 

Hunt J: Understanding the genotype of follicular thyroid tumors. Endocr Pathol. 16:311–321. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Wang QX, Chen ED, Cai YF, Li Q, Jin YX, Jin WX, Wang YH, Zheng ZC, Xue L, Wang OC and Zhang XH: A panel of four genes accurately differentiates benign from malignant thyroid nodules. J Exp Clin Cancer Res. 35:1692016. View Article : Google Scholar : PubMed/NCBI

7 

Watanabe R, Hayashi Y, Sassa M, Kikumori T, Imai T, Kiuchi T and Murata Y: Possible involvement of BRAFV600E in altered gene expression in papillary thyroid cancer. Endocr J. 56:407–414. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Nikiforova MN and Nikiforov YE: Molecular diagnostics and predictors in thyroid cancer. Thyroid. 19:1351–1361. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Tang KT and Lee CH: BRAF mutation in papillary thyroid carcinoma: Pathogenic role and clinical implications. J Chin Med Assoc. 73:113–128. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Huang Y, Prasad M, Lemon WJ, Hampel H, Wright FA, Kornacker K, LiVolsi V, Frankel W, Kloos RT, Eng C, et al: Gene expression in papillary thyroid carcinoma reveals highly consistent profiles. Proc Natl Acad Sci USA. 98:15044–15049. 2001. View Article : Google Scholar : PubMed/NCBI

11 

Prasad ML, Pellegata NS, Kloos RT, Barbacioru C, Huang Y and de la Chapelle A: CITED1 protein expression suggests Papillary Thyroid Carcinoma in high throughput tissue microarray-based study. Thyroid. 14:169–175. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Shioda T, Fenner MH and Isselbacher KJ: MSG1, a novel melanocyte-specific gene, encodes a nuclear protein and is associated with pigmentation. Proc Natl Acad Sci USA. 93:12298–12303. 1996. View Article : Google Scholar : PubMed/NCBI

13 

Yahata T, Shao W, Endoh H, Hur J, Coser KR, Sun H, Ueda Y, Kato S, Isselbacher KJ, Brown M and Shioda T: Selective coactivation of estrogen-dependent transcription by CITED1 CBP/p300-binding protein. Genes Dev. 15:2598–2612. 2001. View Article : Google Scholar : PubMed/NCBI

14 

Shioda T, Fenner MH and Isselbacher KJ: MSG1 and its related protein MRG1 share a transcription activating domain. Gene. 204:235–241. 1997. View Article : Google Scholar : PubMed/NCBI

15 

Prasad ML, Pellegata NS, Huang Y, Nagaraja HN, de la Chapelle A and Kloos RT: Galectin-3, fibronectin-1, CITED-1, HBME1 and cytokeratin-19 immunohistochemistry is useful for the differential diagnosis of thyroid tumors. Mod Pathol. 18:48–57. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Li H, Ahmed NU, Fenner MH, Ueda M, Isselbacher KJ and Shioda T: Regulation of expression of MSG1 melanocyte-specific nuclear protein in human melanocytes and melanoma cells. Exp Cell Res. 242:478–486. 1998. View Article : Google Scholar : PubMed/NCBI

17 

Sedghizadeh PP, Williams JD, Allen CM and Prasad ML: MSG-1 expression in benign and malignant melanocytic lesions of cutaneous and mucosal epithelium. Med Sci Monit. 11:BR189–BR194. 2005.PubMed/NCBI

18 

Lovvorn HN III, Boyle S, Shi G, Shyr Y, Wills ML, Perantoni AO and de Caestecker M: Wilms' tumorigenesis is altered by misexpression of the transcriptional co-activator, CITED1. J Pediatr Surg. 42:474–481. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Schweppe RE, Klopper JP, Korch C, Pugazhenthi U, Benezra M, Knauf JA, Fagin JA, Marlow LA, Copland JA, Smallridge RC and Haugen BR: Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification. J Clin Endocrinol Metab. 93:4331–4341. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

21 

Kuo SF, Lin SF, Chao TC, Hsueh C, Lin KJ and Lin JD: Prognosis of multifocal papillary thyroid carcinoma. Int J Endocrinol. 2013:8093822013. View Article : Google Scholar : PubMed/NCBI

22 

Sancho JJ, Lennard TW, Paunovic I, Triponez F and Sitges-Serra A: Prophylactic central neck disection in papillary thyroid cancer: A consensus report of the European society of endocrine surgeons (ESES). Langenbecks Arch Surg. 399:155–163. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Pereira JA, Jimeno J, Miquel J, Iglesias M, Munné A, Sancho JJ and Sitges-Serra A: Nodal yield, morbidity, and recurrence after central neck dissection for papillary thyroid carcinoma. Surgery. 138:1095–1101. 2005. View Article : Google Scholar : PubMed/NCBI

24 

Machens A, Hinze R, Thomusch O and Dralle H: Pattern of nodal metastasis for primary and reoperative thyroid cancer. World J Surg. 26:22–28. 2002. View Article : Google Scholar : PubMed/NCBI

25 

Zaydfudim V, Feurer ID, Griffin MR and Phay JE: The impact of lymph node involvement on survival in patients with papillary and follicular thyroid carcinoma. Surgery. 144:1070–1078. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Leboulleux S, Rubino C, Baudin E, Caillou B, Hartl DM, Bidart JM, Travagli JP and Schlumberger M: Prognostic factors for persistent or recurrent disease of papillary thyroid carcinoma with neck lymph node metastases and/or tumor extension beyond the thyroid capsule at initial diagnosis. J Clin Endocrinol Metab. 90:5723–5729. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Cancer Genome Atlas Research Network: Integrated genomic characterization of papillary thyroid carcinoma. Cell. 159:676–690. 2014. View Article : Google Scholar : PubMed/NCBI

28 

McBryan J, Howlin J, Kenny PA, Shioda T and Martin F: ERalpha-CITED1 co-regulated genes expressed during pubertal mammary gland development: Implications for breast cancer prognosis. Oncogene. 26:6406–6419. 2007. View Article : Google Scholar : PubMed/NCBI

29 

Murphy AJ, de Caestecker C, Pierce J, Boyle SC, Ayers GD, Zhao Z, Libes JM, Correa H, Walter T, Huppert SS, et al: CITED1 expression in liver development and hepatoblastoma. Neoplasia. 14:1153–1163. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Sassa M, Hayashi Y, Watanabe R, Kikumori T, Imai T, Kurebayashi J, Kiuchi T and Murata Y: Aberrant promoter methylation in overexpression of CITED1 in papillary thyroid cancer. Thyroid. 21:511–517. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Nasu T, Oku Y, Takifuji K, Hotta T, Yokoyama S, Matsuda K, Tamura K, Ieda J, Yamamoto N, Takemura S, et al: Predicting lymph node metastasis in early colorectal cancer using the CITED1 expression. J Surg Res. 185:136–142. 2013. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Xia E, Wang Y, Bhandari A, Niu J, Yang F, Yao Z and Wang O: CITED1 gene promotes proliferation, migration and invasion in papillary thyroid cancer. Oncol Lett 16: 105-112, 2018.
APA
Xia, E., Wang, Y., Bhandari, A., Niu, J., Yang, F., Yao, Z., & Wang, O. (2018). CITED1 gene promotes proliferation, migration and invasion in papillary thyroid cancer. Oncology Letters, 16, 105-112. https://doi.org/10.3892/ol.2018.8653
MLA
Xia, E., Wang, Y., Bhandari, A., Niu, J., Yang, F., Yao, Z., Wang, O."CITED1 gene promotes proliferation, migration and invasion in papillary thyroid cancer". Oncology Letters 16.1 (2018): 105-112.
Chicago
Xia, E., Wang, Y., Bhandari, A., Niu, J., Yang, F., Yao, Z., Wang, O."CITED1 gene promotes proliferation, migration and invasion in papillary thyroid cancer". Oncology Letters 16, no. 1 (2018): 105-112. https://doi.org/10.3892/ol.2018.8653
Copy and paste a formatted citation
x
Spandidos Publications style
Xia E, Wang Y, Bhandari A, Niu J, Yang F, Yao Z and Wang O: CITED1 gene promotes proliferation, migration and invasion in papillary thyroid cancer. Oncol Lett 16: 105-112, 2018.
APA
Xia, E., Wang, Y., Bhandari, A., Niu, J., Yang, F., Yao, Z., & Wang, O. (2018). CITED1 gene promotes proliferation, migration and invasion in papillary thyroid cancer. Oncology Letters, 16, 105-112. https://doi.org/10.3892/ol.2018.8653
MLA
Xia, E., Wang, Y., Bhandari, A., Niu, J., Yang, F., Yao, Z., Wang, O."CITED1 gene promotes proliferation, migration and invasion in papillary thyroid cancer". Oncology Letters 16.1 (2018): 105-112.
Chicago
Xia, E., Wang, Y., Bhandari, A., Niu, J., Yang, F., Yao, Z., Wang, O."CITED1 gene promotes proliferation, migration and invasion in papillary thyroid cancer". Oncology Letters 16, no. 1 (2018): 105-112. https://doi.org/10.3892/ol.2018.8653
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team