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Analyzing EGFR mutations and their association with clinicopathological characteristics and prognosis of patients with lung adenocarcinoma

  • Authors:
    • Xiuzhi Zhou
    • Li Cai
    • Junjie Liu
    • Xiaomin Hua
    • Ying Zhang
    • Huilin Zhao
    • Bin Wang
    • Boqing Li
    • Pengzhou Gai
  • View Affiliations / Copyright

    Affiliations: Department of Microbiology, Qingdao University, Qingdao, Shandong 266071, P.R. China, Department of Pathology and Medicine, Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong 264000, P.R. China, School of Basic Medical Sciences, Binzhou Medical University, Yantai, Shandong 264003, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 362-370
    |
    Published online on: May 9, 2018
       https://doi.org/10.3892/ol.2018.8681
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Abstract

Epidermal growth factor receptor (EGFR) is an important gene in the development of lung adenocarcinoma. However, there is controversy regarding the association between EGFR mutations and survival time of patients with lung adenocarcinoma. In the present study, tissue specimens and clinical data were collected from 219 patients with lung adenocarcinoma who had not undergone prior radiotherapy or chemotherapy. EGFR mutations were detected using a fluorescence polymerase chain reaction method, and the association between EGFR mutations and clinicopathological characteristics was analyzed. Overall survival (OS) curves were constructed using the Kaplan‑Meier method and the influence of clinicopathological characteristics on OS was analyzed using the Cox regression model. The EGFR mutation rate was 50.7%, and the most common mutations were the L858R substitution mutation in exon 21 (L858R; 54.9%) and the deletion mutation in exon 19 (19‑Del; 36%). The presence of EGFR mutations varied significantly with sex, smoking history, T stage, vascular invasion and adenocarcinoma subtypes (P<0.05). The survival time was significantly longer for female, young (<60 years‑old), non‑smokers or patients exhibiting EGFR mutations (G719X, 19‑Del, L858R and L861Q). The survival time was also significantly longer for patients with a 19‑Del mutation, early stage tumors, tyrosine kinase inhibitors targeted therapy‑treated patients, for those not exhibiting nerve or vascular invasion, and for those without disease recurrence (P<0.05). Multivariate analysis revealed that tumor pathological Tumor‑Node‑Metastasis (pTNM) stage, nerve invasion, vascular invasion, EGFR mutation and the 19‑Del mutation were independent predictors (P<0.05). Therefore, tumor pTNM stage, nerve invasion, vascular invasion and EGFR mutation status, particularly that of 19‑Del, were independent prognostic factors for patients with lung adenocarcinoma.
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1 

Jia Y, Li F, Liu YF, Zhao JP, Leng MM and Chen L: Depression and cancer risk: A systematic review and meta-analysis. Public Health. 149:138–148. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Chen Z, Fillmore CM, Hammerman PS, Kim CF and Wong KK: Non-small-cell lung cancers: A heterogeneous set of diseases. Nat Rev Cancer. 14:535–546. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Devarakonda S, Morgensztern D and Govindan R: Genomic alterations in lung adenocarcinoma. Lancet Oncol. 16:e342–e351. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Pao W and Miller VA: Epidermal growth factor receptor mutations, small-molecule kinase inhibitors, and non-small-cell lung cancer: Current knowledge and future directions. J Clin Oncol. 23:2556–2568. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Cho J, Choi SM, Lee J, Lee CH, Lee SM, Yim JJ, Chung DH, Yoo CG, Kim YW, Han SK and Park YS: The association of EGFR mutations with stage at diagnosis in lung adenocarcinomas. PLoS One. 11:e01668212016. View Article : Google Scholar : PubMed/NCBI

7 

Lin JH, Lin D, Xu L, Wang Q, Hu HH, Xu HP and He ZY: The association between clinical prognostic factors and epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) efficacy in advanced non-small-cell lung cancer patients: A retrospective assessment of 94 cases with EGFR mutations. Oncotarget. 8:3412–3421. 2017.PubMed/NCBI

8 

Na II, Rho JK, Choi YJ, Kim CH, Park JH, Koh JS, Ryoo BY, Yang SH and Lee JC: The survival outcomes of patients with resected non-small cell lung cancer differ according to EGFR mutations and the P21 expression. Lung Cancer. 57:96–102. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Eichler AF, Kahle KT, Wang DL, Joshi VA, Willers H, Engelman JA, Lynch TJ and Sequist LV: EGFR mutation status and survival after diagnosis of brain metastasis in nonsmall cell lung cancer. Neuro Oncol. 12:1193–1199. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Isaka T, Nakayama H, Yokose T, Ito H, Miyagi Y, Matsuzaki T, Nagata M, Furumoto H, Nishii T, Katayama K, et al: Epidermal growth factor receptor mutations and prognosis in pathologic N1-N2 pulmonary adenocarcinoma. Ann Thorac Surg. 102:1821–1828. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Dancey JE: Epidermal growth factor receptor inhibitors in non-small cell lung cancer. Drugs. 67:1125–1138. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Matsumura Y, Owada Y, Yamaura T, Muto S, Osugi J, Hoshino M, Higuchi M, Ohira T, Suzuki H and Gotoh M: Epidermal growth factor receptor gene mutation as risk factor for recurrence in patients with surgically resected lung adenocarcinoma: A matched-pair analysis. Interact Cardiovasc Thorac Surg. 23:216–222. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Yoshizawa A, Sumiyoshi S, Sonobe M, Kobayashi M, Fujimoto M, Kawakami F, Tsuruyama T, Travis WD, Date H and Haga H: Validation of the IASLC/ATS/ERS lung adenocarcinoma classification for prognosis and association with EGFR and KRAS gene mutations: Analysis of 440 Japanese patients. J Thorac Oncol. 8:52–61. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Memon AA, Zhang H, Gu Y, Luo Q, Shi J, Deng Z, Ma J and Ma W: EGFR with TKI-sensitive mutations in exon 19 is highly expressed and frequently detected in Chinese patients with lung squamous carcinoma. Onco Targets Ther. 10:4607–4613. 2017. View Article : Google Scholar : PubMed/NCBI

15 

Russell PA, Barnett SA, Walkiewicz M, Wainer Z, Conron M, Wright GM, Gooi J, Knight S, Wynne R, Liew D and John T: Correlation of mutation status and survival with predominant histologic subtype according to the new IASLC/ATS/ERS lung adenocarcinoma classification in stage III (N2) patients. J Thorac Oncol. 8:461–468. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Sun Y, Hou L, Yang Y, Xie H, Yang Y, Li Z, Zhao H, Gao W and Su B: Two-gene signature improves the discriminatory power of IASLC/ATS/ERS classification to predict the survival of patients with early-stage lung adenocarcinoma. Onco Targets Ther. 9:4583–4591. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Kim D, Kim HK, Kim SH, Lee HY, Cho JH, Choi YS, Kim K, Kim J, Zo JI and Shim YM: Prognostic significance of histologic classification and tumor disappearance rate by computed tomography in lung cancer. J Thorac Dis. 10:388–397. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Abdollah F, Sun M, Suardi N, Gallina A, Capitanio U, Bianchi M, Tutolo M, Passoni N, Karakiewicz PI, Rigatti P, et al: National Comprehensive Cancer Network practice guidelines 2011: Need for more accurate recommendations for pelvic lymph node dissection in prostate cancer. J Urol. 188:423–428. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger K, Yatabe Y, Powell CA, Beer D, Riely G, Garg K, et al: International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma. J Thorac Oncol. 6:244–285. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Warth A, Muley T, Meister M, Stenzinger A, Thomas M, Schirmacher P, Schnabel PA, Budczies J, Hoffmann H and Weichert W: The novel histologic International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification system of lung adenocarcinoma is a stage-independent predictor of survival. J Clin Oncol. 30:1438–1446. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Mok TS, Wu YL, Thongprasert S, Yang CH, Chu DT, Saijo N, Sunpaweravong P, Han B, Margono B, Ichinose Y, et al: Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med. 361:947–957. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Angulo B, Conde E, Suárez-Gauthier A, Plaza C, Martínez R, Redondo P, Izquierdo E, Rubio-Viqueira B, Paz-Ares L, Hidalgo M, et al: A comparison of EGFR mutation testing methods in lung carcinoma: Direct sequencing, real-time PCR and immunohistochemistry. PLoS One. 7:e438422012. View Article : Google Scholar : PubMed/NCBI

23 

Wang J, Cai Y, Dong Y, Nong J, Zhou L, Liu G, Su D, Li X, Wu S, Chen X, et al: Clinical characteristics and outcomes of patients with primary lung adenocarcinoma harboring ALK rearrangements detected by FISH, IHC, and RT-PCR. PLoS One. 9:e1015512014. View Article : Google Scholar : PubMed/NCBI

24 

Kim EK, Kim KA, Lee CY and Shim HS: The frequency and clinical impact of HER2 alterations in lung adenocarcinoma. PLoS One. 12:e01712802017. View Article : Google Scholar : PubMed/NCBI

25 

Shi Y, Au JS, Thongprasert S, Srinivasan S, Tsai CM, Khoa MT, Heeroma K, Itoh Y, Cornelio G and Yang PC: A prospective, molecular epidemiology study of EGFR mutations in Asian patients with advanced non-small-cell lung cancer of adenocarcinoma histology (PIONEER). J Thorac Oncol. 9:154–162. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Midha A, Dearden S and McCormack R: EGFR mutation incidence in non-small-cell lung cancer of adenocarcinoma histology: A systematic review and global map by ethnicity (mutMapII). Am J Cancer Res. 5:2892–2911. 2015.PubMed/NCBI

27 

Martin P, Shiau CJ, Pasic M, Tsao M, Kamel-Reid S, Lin S, Tudor R, Cheng S, Higgins B, Burkes R, et al: Clinical impact of mutation fraction in epidermal growth factor receptor mutation positive NSCLC patients. Br J Cancer. 114:616–622. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Wei WE, Mao NQ, Ning SF, Li JL, Liu HZ, Xie T, Zhong JH, Feng Y, Wei CH and Zhang LT: An analysis of EGFR mutations among 1506 cases of non-small cell lung cancer patients in Guangxi, China. PLoS One. 11:e01687952016. View Article : Google Scholar : PubMed/NCBI

29 

Won YW, Han JY, Lee GK, Park SY, Lim KY, Yoon KA, Yun T, Kim HT and Lee JS: Comparison of clinical outcome of patients with non-small-cell lung cancer harbouring epidermal growth factor receptor exon 19 or exon 21 mutations. J Clin Pathol. 64:947–952. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Lai Y, Zhang Z, Li J, Sun D, Zhou Y, Jiang T, Han Y, Huang L, Zhu Y, Li X and Yan X: EGFR mutations in surgically resected fresh specimens from 697 consecutive Chinese patients with non-small cell lung cancer and their relationships with clinical features. Int J Mol Sci. 14:24549–24559. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Riely GJ, Pao W, Pham D, Li AR, Rizvi N, Venkatraman ES, Zakowski MF, Kris MG, Ladanyi M and Miller VA: Clinical course of patients with non-small cell lung cancer and epidermal growth factor receptor exon 19 and exon 21 mutations treated with gefitinib or erlotinib. Clin Cancer Res. 12:839–844. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Lee VH, Tin VP, Choy TS, Lam KO, Choi CW, Chung LP, Tsang JW, Ho PP, Leung DK, Ma ES, et al: Association of exon 19 and 21 EGFR mutation patterns with treatment outcome after first-line tyrosine kinase inhibitor in metastatic non-small-cell lung cancer. J Thorac Oncol. 8:1148–1155. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Gazdar AF and Minna JD: Inhibition of EGFR signaling: All mutations are not created equal. PLoS Med. 2:e3772005. View Article : Google Scholar : PubMed/NCBI

34 

Carey KD, Garton AJ, Romero MS, Kahler J, Thomson S, Ross S, Park F, Haley JD, Gibson N and Sliwkowski MX: Kinetic analysis of epidermal growth factor receptor somatic mutant proteins shows increased sensitivity to the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib. Cancer Res. 66:8163–8171. 2006. View Article : Google Scholar : PubMed/NCBI

35 

Beau-Faller M, Prim N, Ruppert AM, Nanni-Metéllus I, Lacave R, Lacroix L, Escande F, Lizard S, Pretet JL, Rouquette I, et al: Rare EGFR exon 18 and exon 20 mutations in non-small-cell lung cancer on 10 117 patients: A multicentre observational study by the French ERMETIC-IFCT network. Ann Oncol. 25:126–131. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Watanabe S, Minegishi Y, Yoshizawa H, Maemondo M, Inoue A, Sugawara S, Isobe H, Harada M, Ishii Y, Gemma A, et al: Effectiveness of gefitinib against non-small-cell lung cancer with the uncommon EGFR mutations G719X and L861Q. J Thorac Oncol. 9:189–194. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Zhang Q, Ke E, Niu F, Deng W, Chen Z, Xu C, Zhang X, Zhao N, Su J, Yang J, et al: The role of T790M mutation in EGFR-TKI re-challenge for patients with EGFR-mutant advanced lung adenocarcinoma. Oncotarget. 8:4994–5002. 2017.PubMed/NCBI

38 

Su KY, Chen HY, Li KC, Kuo ML, Yang JC, Chan WK, Ho BC, Chang GC, Shih JY, Yu SL and Yang PC: Pretreatment epidermal growth factor receptor (EGFR) T790M mutation predicts shorter EGFR tyrosine kinase inhibitor response duration in patients with non-small-cell lung cancer. J Clin Oncol. 30:433–440. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Sumiyoshi S, Yoshizawa A, Sonobe M, Kobayashi M, Fujimoto M, Tsuruyama T, Date H and Haga H: Pulmonary adenocarcinomas with micropapillary component significantly correlate with recurrence, but can be well controlled with EGFR tyrosine kinase inhibitors in the early stages. Lung Cancer-J Iaslc. 81:53–59. 2013. View Article : Google Scholar

40 

Ohtaki Y, Shimizu K, Kakegawa S, Nagashima T, Nakano T, Atsumi J, Enokida Y, Igai H, Ibe T, Sugano M, et al: Postrecurrence survival of surgically resected pulmonary adenocarcinoma patients according to EGFR and KRAS mutation status. Mol Clin Oncol. 2:187–196. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Li J, Yang X, Xia T, Guan Y and Zhong N: Stage I synchronous multiple primary non-small cell lung cancer: CT findings and the effect of TNM staging with the 7th and 8th editions on prognosis. J Thorac Dis. 9:5335–5344. 2017. View Article : Google Scholar : PubMed/NCBI

42 

Ramlau R, Krawczyk P, Dziadziuszko R, Chmielewska I, Milanowski J, Olszewski W, Stencel K, Ramlau-Piątek K, Segiet A, Skroński M, et al: Predictors of EGFR mutation and factors associated with clinical tumor stage at diagnosis: Experience of the INSIGHT study in Poland. Oncol Lett. 14:5611–5618. 2017.PubMed/NCBI

43 

Saji H, Tsuboi M, Shimada Y, Kato Y, Yoshida K, Nomura M, Matsubayashi J, Nagao T, Kakihana M, Usuda J, et al: A proposal for combination of total number and anatomical location of involved lymph nodes for nodal classification in non-small cell lung cancer. Chest. 143:1618–1625. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhou X, Cai L, Liu J, Hua X, Zhang Y, Zhao H, Wang B, Li B and Gai P: Analyzing EGFR mutations and their association with clinicopathological characteristics and prognosis of patients with lung adenocarcinoma. Oncol Lett 16: 362-370, 2018.
APA
Zhou, X., Cai, L., Liu, J., Hua, X., Zhang, Y., Zhao, H. ... Gai, P. (2018). Analyzing EGFR mutations and their association with clinicopathological characteristics and prognosis of patients with lung adenocarcinoma. Oncology Letters, 16, 362-370. https://doi.org/10.3892/ol.2018.8681
MLA
Zhou, X., Cai, L., Liu, J., Hua, X., Zhang, Y., Zhao, H., Wang, B., Li, B., Gai, P."Analyzing EGFR mutations and their association with clinicopathological characteristics and prognosis of patients with lung adenocarcinoma". Oncology Letters 16.1 (2018): 362-370.
Chicago
Zhou, X., Cai, L., Liu, J., Hua, X., Zhang, Y., Zhao, H., Wang, B., Li, B., Gai, P."Analyzing EGFR mutations and their association with clinicopathological characteristics and prognosis of patients with lung adenocarcinoma". Oncology Letters 16, no. 1 (2018): 362-370. https://doi.org/10.3892/ol.2018.8681
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou X, Cai L, Liu J, Hua X, Zhang Y, Zhao H, Wang B, Li B and Gai P: Analyzing EGFR mutations and their association with clinicopathological characteristics and prognosis of patients with lung adenocarcinoma. Oncol Lett 16: 362-370, 2018.
APA
Zhou, X., Cai, L., Liu, J., Hua, X., Zhang, Y., Zhao, H. ... Gai, P. (2018). Analyzing EGFR mutations and their association with clinicopathological characteristics and prognosis of patients with lung adenocarcinoma. Oncology Letters, 16, 362-370. https://doi.org/10.3892/ol.2018.8681
MLA
Zhou, X., Cai, L., Liu, J., Hua, X., Zhang, Y., Zhao, H., Wang, B., Li, B., Gai, P."Analyzing EGFR mutations and their association with clinicopathological characteristics and prognosis of patients with lung adenocarcinoma". Oncology Letters 16.1 (2018): 362-370.
Chicago
Zhou, X., Cai, L., Liu, J., Hua, X., Zhang, Y., Zhao, H., Wang, B., Li, B., Gai, P."Analyzing EGFR mutations and their association with clinicopathological characteristics and prognosis of patients with lung adenocarcinoma". Oncology Letters 16, no. 1 (2018): 362-370. https://doi.org/10.3892/ol.2018.8681
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