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Article

Prognostic value of glypican‑1 for patients with advanced pancreatic cancer following regional intra‑arterial chemotherapy

  • Authors:
    • Jing‑Yu Qian
    • Yu‑Lin Tan
    • Yang Zhang
    • Yong‑Fei Yang
    • Xiao‑Qiang Li
  • View Affiliations / Copyright

    Affiliations: Department of Vascular Surgery, The Second Affiliated Hospital, Soochow University, Suzhou, Jiangsu 215004, P.R. China, Department of Interventional Radiology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, P.R. China, School of Life Science, Beijing Institute of Technology, Beijing 100081, P.R. China
  • Pages: 1253-1258
    |
    Published online on: May 11, 2018
       https://doi.org/10.3892/ol.2018.8701
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Abstract

Regional intra‑arterial chemotherapy (RIAC) is a potential alternative treatment for advanced pancreatic cancer (APC) with fewer adverse effects than other treatment options. However, specific biomarkers to determine the prognosis of patients with APC have thus far, been unsatisfactory. Glypican‑1 (GPC1) in exosomes has been identified as an early diagnostic biomarker for pancreatic adenocarcinoma. The aim of the present study was to investigate whether the presence of GPC1 in extracellular vesicles (EVs) could serve as a predictor of RIAC outcome for patients with APC. EVs in circulation were isolated and the percentage of GPC1+ EVs was measured using flow cytometry. Compared with healthy individuals, the levels of GPC1+ EVs were significantly increased in patients with APC (P<0.01). Following RIAC treatment, the percentage of GPC1+ EVs was decreased (P=0.023). Furthermore, patients with APC exhibiting a greater decrease of GPC1+ EVs experienced improved overall survival (OS) rates. In summary, the present study provides insights into identifying GPC1 as a novel prognostic biomarker for patients with APC following RIAC treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Qian JY, Tan YL, Zhang Y, Yang YF and Li XQ: Prognostic value of glypican‑1 for patients with advanced pancreatic cancer following regional intra‑arterial chemotherapy. Oncol Lett 16: 1253-1258, 2018.
APA
Qian, J., Tan, Y., Zhang, Y., Yang, Y., & Li, X. (2018). Prognostic value of glypican‑1 for patients with advanced pancreatic cancer following regional intra‑arterial chemotherapy. Oncology Letters, 16, 1253-1258. https://doi.org/10.3892/ol.2018.8701
MLA
Qian, J., Tan, Y., Zhang, Y., Yang, Y., Li, X."Prognostic value of glypican‑1 for patients with advanced pancreatic cancer following regional intra‑arterial chemotherapy". Oncology Letters 16.1 (2018): 1253-1258.
Chicago
Qian, J., Tan, Y., Zhang, Y., Yang, Y., Li, X."Prognostic value of glypican‑1 for patients with advanced pancreatic cancer following regional intra‑arterial chemotherapy". Oncology Letters 16, no. 1 (2018): 1253-1258. https://doi.org/10.3892/ol.2018.8701
Copy and paste a formatted citation
x
Spandidos Publications style
Qian JY, Tan YL, Zhang Y, Yang YF and Li XQ: Prognostic value of glypican‑1 for patients with advanced pancreatic cancer following regional intra‑arterial chemotherapy. Oncol Lett 16: 1253-1258, 2018.
APA
Qian, J., Tan, Y., Zhang, Y., Yang, Y., & Li, X. (2018). Prognostic value of glypican‑1 for patients with advanced pancreatic cancer following regional intra‑arterial chemotherapy. Oncology Letters, 16, 1253-1258. https://doi.org/10.3892/ol.2018.8701
MLA
Qian, J., Tan, Y., Zhang, Y., Yang, Y., Li, X."Prognostic value of glypican‑1 for patients with advanced pancreatic cancer following regional intra‑arterial chemotherapy". Oncology Letters 16.1 (2018): 1253-1258.
Chicago
Qian, J., Tan, Y., Zhang, Y., Yang, Y., Li, X."Prognostic value of glypican‑1 for patients with advanced pancreatic cancer following regional intra‑arterial chemotherapy". Oncology Letters 16, no. 1 (2018): 1253-1258. https://doi.org/10.3892/ol.2018.8701
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