Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
July-2018 Volume 16 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2018 Volume 16 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Presence of cancer cells in the periarterial tissues of patients with advanced gastric cancer

  • Authors:
    • Hiroshi Yamamoto
    • Satoshi Murata
    • Sachiko Kaida
    • Tsuyoshi Yamaguchi
    • Mitsuaki Ishida
    • Ryoji Kushima
    • Masaji Tani
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Surgery, Kusatsu General Hospital, Kusatsu, Shiga 525‑8585, Japan, Department of Surgery, Shiga University of Medical Science, Otsu, Shiga 520‑2192, Japan, Division of Diagnostic Pathology, Kansai Medical University, Hirakata, Osaka 573‑1191, Japan, Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Otsu, Shiga 520‑2192, Japan
  • Pages: 1226-1230
    |
    Published online on: May 11, 2018
       https://doi.org/10.3892/ol.2018.8704
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Lymphadenectomy with gastrectomy is considered a curative surgical treatment for gastric cancer. Periarterial connective tissue‑preserving lymphadenectomy has become a common procedure following developments in laparoscopic surgery. However, the presence of cancer cells in the periarterial tissue, including neural invasion, has not been examined. In the present study, the periarterial tissues from the vessel roots of the left gastric artery (LGA) and right gastroepiploic artery (RGEA) after gastrectomy were evaluated for the presence of cancer cells. The study included 28 consecutive patients who underwent gastrectomy for gastric cancer. The vessel roots of the RGEA and LGA were obtained from surgically resected specimens and examined by two independent pathologists to determine the presence of cancer cells in the periarterial tissues. The collected specimens included 23 RGEA roots and 26 LGA roots from 28 patients. In 8 cases of early gastric cancer, no cancer cells were indicated in the periarterial tissues. By contrast, cancer cells, including neural invasion in 2 cases, were identified in the periarterial tissues from the roots of examined gastric arteries in 3/20 (15%) cases of advanced gastric cancer. Notably, all 3 cases featured multiple regional lymph node (LN) metastases. Cancer cells were detected in the perivascular tissue of the major gastric arteries from cases with advanced gastric cancer with LN metastases, suggesting the requirement for oncologic evaluation to ensure adequate vascular tissue margins and an adequate periarterial layer during lymphadenectomy.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Koeda K, Nishizuka S and Wakabayashi G: Minimally invasive surgery for gastric cancer: The future standard of care. World J Surg. 35:1469–1477. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Funabiki T: Extended radical subtotal gastrectomy with R3 lymphnodal dissection as well as saccate bursctomy. Jpn J Gastroenterol Surg. 24:162–166. 1991. View Article : Google Scholar

3 

Kanaya S, Haruta S, Kawamura Y, Yoshimura F, Inaba K, Hiramatsu Y, Ishida Y, Taniguchi K, Isogaki J and Uyama I: Video: Laparoscopy distinctive technique for suprapancreatic lymph node dissection: Medial approach for laparoscopic gastric cancer surgery. Surg Endosc. 25:3928–3929. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Uyama I, Suda K and Satoh S: Laparoscopic surgery for advanced gastric cancer: Current status and future perspectives. J Gastric Cancer. 13:19–25. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Liu B and Lu KY: Neural invasion in pancreatic carcinoma. Hepatobiliary Pancreat Dis Int. 1:469–476. 2002.PubMed/NCBI

6 

Shinohara T, Satoh S, Kanaya S, Ishida Y, Taniguchi K, Isogaki J, Inaba K, Yanaga K and Uyama I: Laparoscopic versus open D2 gastrectomy for advanced gastric cancer: A retrospective cohort study. Surg Endosc. 27:286–294. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Liebl F, Demir IE, Mayer K, Schuster T, D'Haese JG, Becker K, Langer R, Bergmann F, Wang K, Rosenberg R, et al: The impact of neural invasion severity in gastrointestinal malignancies: A clinicopathological study. Ann Surg. 260:900–907. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Tanaka A, Yoshikawa H, Okuno K, Koh K, Watatani M, Matsumura E and Yasutomi M: The importance of neural invasion (NI) as a prognostic factor in diffuse invasive gastric cancer. Surg Today. 27:692–695. 1997. View Article : Google Scholar : PubMed/NCBI

9 

Bilici A, Seker M, Ustaalioglu BB, Kefeli U, Yildirim E, Yavuzer D, Aydin FM, Salepci T, Oncel M and Gumus M: Prognostic significance of perineural invasion in patients with gastric cancer who underwent curative resection. Ann Surg Oncol. 17:2037–2044. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Japanese Gastric Cancer Association: Japanese Classification of gastric carcinoma: 3rd English edition. Gastric Cancer. 14:101–112. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Littenberg B and MacLean CD: Passive consent for clinical research in the age of HIPAA. J Gen Intern Med. 21:207–211. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Vellinga A, Cormican M, Hanahoe B, Bennett K and Murphy AW: Opt-out as an acceptable method of obtaining consent in medical research: A short report. BMC Med Res Methodol. 11:402011. View Article : Google Scholar : PubMed/NCBI

13 

Sakuramoto S, Sasako M, Yamaguchi T, Kinoshita T, Fujii M, Nashimoto A, Furukawa H, Nakajima T, Ohashi Y, Imamura H, et al: Adjuvant chemotherapy for gastric cancer with S-1, an oral fluoropyrimidine. N Engl J Med. 357:1810–1820. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Katai H, Sasako M, Fukuda H, Nakamura K, Hiki N, Saka M, Yamaue H, Yoshikawa T and Kojima K: JCOG Gastric Cancer Surgical Study Group: Safety and feasibility of laparoscopy-assisted distal gastrectomy with suprapancreatic nodal dissection for clinical stage I gastric cancer: A multicenter phase II trial (JCOG 0703). Gastric Cancer. 13:238–244. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Kim HI, Hur H, Kim YN, Lee HJ, Kim MC, Han SU and Hyung WJ: Standardization of D2 lymphadenectomy and surgical quality control (KLASS-02-QC): A prospective, observational, multicenter study [NCT01283893]. BMC Cancer. 14:2092014. View Article : Google Scholar : PubMed/NCBI

16 

Fukunaga T, Hiki N, Kubota T, Nunobe S, Tokunaga M, Nohara K, Sano T and Yamaguchi T: Oncologic outcomes of laparoscopy-assisted distal gastrectomy for gastric cancer. Ann Surg Oncol. 20:2676–2682. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Facchetti F, Lonardi S, Gentili F, Bercich L, Falchetti M, Tardanico R, Baronchelli C, Lucini L, Santin A and Murer B: Claudin 4 identifies a wide spectrum of epithelial neoplasms and represents a very useful marker for carcinoma versus mesothelioma diagnosis in pleural and peritoneal biopsies and effusions. Virchows Arch. 451:669–680. 2007. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yamamoto H, Murata S, Kaida S, Yamaguchi T, Ishida M, Kushima R and Tani M: Presence of cancer cells in the periarterial tissues of patients with advanced gastric cancer. Oncol Lett 16: 1226-1230, 2018.
APA
Yamamoto, H., Murata, S., Kaida, S., Yamaguchi, T., Ishida, M., Kushima, R., & Tani, M. (2018). Presence of cancer cells in the periarterial tissues of patients with advanced gastric cancer. Oncology Letters, 16, 1226-1230. https://doi.org/10.3892/ol.2018.8704
MLA
Yamamoto, H., Murata, S., Kaida, S., Yamaguchi, T., Ishida, M., Kushima, R., Tani, M."Presence of cancer cells in the periarterial tissues of patients with advanced gastric cancer". Oncology Letters 16.1 (2018): 1226-1230.
Chicago
Yamamoto, H., Murata, S., Kaida, S., Yamaguchi, T., Ishida, M., Kushima, R., Tani, M."Presence of cancer cells in the periarterial tissues of patients with advanced gastric cancer". Oncology Letters 16, no. 1 (2018): 1226-1230. https://doi.org/10.3892/ol.2018.8704
Copy and paste a formatted citation
x
Spandidos Publications style
Yamamoto H, Murata S, Kaida S, Yamaguchi T, Ishida M, Kushima R and Tani M: Presence of cancer cells in the periarterial tissues of patients with advanced gastric cancer. Oncol Lett 16: 1226-1230, 2018.
APA
Yamamoto, H., Murata, S., Kaida, S., Yamaguchi, T., Ishida, M., Kushima, R., & Tani, M. (2018). Presence of cancer cells in the periarterial tissues of patients with advanced gastric cancer. Oncology Letters, 16, 1226-1230. https://doi.org/10.3892/ol.2018.8704
MLA
Yamamoto, H., Murata, S., Kaida, S., Yamaguchi, T., Ishida, M., Kushima, R., Tani, M."Presence of cancer cells in the periarterial tissues of patients with advanced gastric cancer". Oncology Letters 16.1 (2018): 1226-1230.
Chicago
Yamamoto, H., Murata, S., Kaida, S., Yamaguchi, T., Ishida, M., Kushima, R., Tani, M."Presence of cancer cells in the periarterial tissues of patients with advanced gastric cancer". Oncology Letters 16, no. 1 (2018): 1226-1230. https://doi.org/10.3892/ol.2018.8704
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team