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Article

Insulin‑like growth factor‑1 receptor knockdown enhances radiosensitivity via the HIF‑1α pathway and attenuates ATM/H2AX/53BP1 DNA repair activation in human lung squamous carcinoma cells

  • Authors:
    • Xiaoxing Liu
    • Haiyan Chen
    • Xin Xu
    • Ming Ye
    • Hongbin Cao
    • Lei Xu
    • Yanli Hou
    • Jianmin Tang
    • Di Zhou
    • Yongrui Bai
    • Xiumei Ma
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, P.R. China
  • Pages: 1332-1340
    |
    Published online on: May 11, 2018
       https://doi.org/10.3892/ol.2018.8705
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Abstract

Insulin‑like growth factor‑1 receptor (IGF‑1R) is a cell membrane receptor involved in cell proliferation and apoptosis, which is highly expressed in lung squamous cell carcinoma (SCC). The present study aimed to observe the influence of IGF‑1R silencing on the radiosensitivity of SCC and investigate the potential mechanisms involved. Human lung SCC H520 cells with relatively high expression of IGF‑1R were used. IGF‑1R expression was silenced using short hairpin RNA. The influence of IGF‑1R silencing on radiosensitivity and apoptosis was assessed using a clone formation assay and flow cytometry. The expression levels of proteins relevant in DNA damage repair and hypoxic signaling pathways were analyzed using western blotting. Decreased expression of IGF‑1R led to an increase in the sensitivity of H520 cells to irradiation. Molecular analysis showed that the reduced expression of IGF‑1R decreased the protein expression of ataxia‑telangiectasia mutated (ATM), H2A histone family member X (H2AX) and p53 binding protein 1 (53BP1), which are associated with the DNA repair pathway. Furthermore, 53BP1 is also known to be involved in apoptosis. Proteins involved in the hypoxic pathway, including hypoxia inducible factor 1 α (HIF‑1α), matrix metallopeptidase 9 (MMP‑9) and vascular endothelial growth factor A (VEGFA) were also involved in the radiosensitivity. In conclusion, decreased expression of IGF‑1R leads to improved radiosensitivity of SCC cells, and the underlying mechanism may be associated with the decreased expression of proteins involved in ATM/H2AX/53BP1 DNA damage repair and the HIF‑1α/MMP‑9 hypoxic pathway, which results in the induction of apoptosis and increased radiosensitivity. These findings suggest that targeting of IGF‑1R may represent a novel approach for lung SCC radiation treatment.
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View References

1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2016. CA Cancer J Clin. 66:7–30. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Dong JC, Gao H, Zuo SY, Zhang HQ, Zhao G, Sun SL, Han HL, Jin LL, Shao LH, Wei W and Jin SZ: Neuropilin 1 expression correlates with the Radio-resistance of human non-small-cell lung cancer cells. J Cell Mol Med. 19:2286–2295. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Juchum M, Gunther M and Laufer SA: Fighting cancer drug resistance: Opportunities and challenges for mutation-specific EGFR inhibitors. Drug Resist Updat. 20:12–28. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Kumarakulasinghe NB, van Zanwijk N and Soo RA: Molecular targeted therapy in the treatment of advanced stage non-small cell lung cancer (NSCLC). Respirology. 20:370–378. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Valenciano A, Henríquez-Hernández LA, Moreno M, Lloret M and Lara PC: Role of IGF-1 receptor in radiation response. Transl Oncol. 5:1–9. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Cao H, Dong W, Shen H, Xu J, Zhu L, Liu Q and Du J: Combinational therapy enhances the effects of anti-IGF-1R mAb figitumumab to target small cell lung cancer. PLoS One. 10:e01358442015. View Article : Google Scholar : PubMed/NCBI

7 

Takahashi T, Uehara H, Ogawa H, Umemoto H, Bando Y and Izumi K: Inhibition of EP2/EP4 signaling abrogates IGF-1R-mediated cancer cell growth: Involvement of protein kinase C-θ activation. Oncotarget. 6:4829–4844. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Kim JS, Kim ES, Liu D, Lee JJ, Behrens C, Lippman SM, Hong WK, Wistuba II, Lee E and Lee HY: Activation of insulin-like growth factor 1 receptor in patients with non-small cell lung cancer. Oncotarget. 6:16746–16756. 2015.PubMed/NCBI

9 

Iwasa T, Okamoto I, Suzuki M, Hatashita E, Yamada Y, Fukuoka M, Ono K and Nakagawa K: Inhibition of insulin-like growth factor 1 receptor by CP-751,871 radiosensitizes non-small cell lung cancer cells. Clin Cancer Res. 15:5117–5125. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Morgan MA and Lawrence TS: Molecular pathways: Overcoming radiation resistance by targeting DNA damage response pathways. Clin Cancer Res. 21:2898–2904. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Wakasugi M, Sasaki T, Matsumoto M, Nagaoka M, Inoue K, Inobe M, Horibata K, Tanaka K and Matsunaga T: Nucleotide excision repair-dependent DNA double-strand break formation and ATM signaling activation in mammalian quiescent cells. J Biol Chem. 289:28730–28737. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Sears CR, Cooney SA, Chin-Sinex H, Mendonca MS and Turchi JJ: DNA damage response (DDR) pathway engagement in cisplatin radiosensitization of non-small cell lung cancer. DNA Repair (Amst). 40:35–46. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Wang Z, Lu P, Liang Z, Zhang Z, Shi W, Cai X and Chen C: Increased insulin-like growth factor 1 receptor (IGF1R) expression in small cell lung cancer and the effect of inhibition of IGF1R expression by RNAi on growth of human small cell lung cancer NCI-H446 cell. Growth Factors. 33:337–346. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Cao H, Dong W, Qu X, Shen H, Xu J, Zhu L, Liu Q and Du J: Metformin enhances the therapy effects of anti-IGF-1R mAb figitumumab to NSCLC. Sci Rep. 6:310722016. View Article : Google Scholar : PubMed/NCBI

15 

Furukawa J, Wraight CJ, Freier SM, Peralta E, Atley LM, Monia BP, Gleave ME and Cox ME: Antisense oligonucleotide targeting of insulin-like growth factor-1 receptor (IGF-1R) in prostate cancer. Prostate. 70:206–218. 2010.PubMed/NCBI

16 

Wang J, Huang F, Bai Z, Chi B, Wu J and Chen X: Curcumol inhibits growth and induces apoptosis of colorectal cancer LoVo cell line via IGF-1R and p38 MAPK pathway. Int J Mol Sci. 16:19851–19867. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Zhou X, Shen F, Ma P, Hui H, Pei S, Chen M, Wang Z, Zhou W and Jin B: GSK1838705A, an IGF-1R inhibitor, inhibits glioma cell proliferation and suppresses tumor growth in vivo. Mol Med Rep. 12:5641–5646. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Ramcharan R, Aleksic T, Kamdoum WP, Gao S, Pfister SX, Tanner J, Bridges E, Asher R, Watson AJ, Margison GP, et al: IGF-1R inhibition induces schedule-dependent sensitization of human melanoma to temozolomide. Oncotarget. 6:39877–39890. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Chen Y, Zhu C, Peng Z, Dai Y and Gu Y: Lentivirus-mediated short-hairpin RNA targeting IGF-1R inhibits growth and lymphangiogenesis in breast cancer. Oncol Rep. 28:1778–1784. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Zhao H and Gu X: Silencing of insulin-like growth factor-1 receptor enhances the radiation sensitivity of human esophageal squamous cell carcinoma in vitro and in vivo. World J Surg Oncol. 12:3252014. View Article : Google Scholar : PubMed/NCBI

21 

Sahlberg SH, Gustafsson AS, Pendekanti PN, Glimelius B and Stenerlöw B: The influence of AKT isoforms on radiation sensitivity and DNA repair in colon cancer cell lines. Tumour Biol. 35:3525–3534. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Héron-Milhavet L, Karas M, Goldsmith CM, Baum BJ and LeRoith D: Insulin-like growth factor-I (IGF-I) receptor activation rescues UV-damaged cells through a p38 signaling pathway. Potential role of the IGF-I receptor in DNA repair. J Biol Chem. 276:18185–18192. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Héron-Milhavet L and LeRoith D: Insulin-like growth factor I induces MDM2-dependent degradation of p53 via the p38 MAPK pathway in response to DNA damage. J Biol Chem. 277:15600–15606. 2002. View Article : Google Scholar : PubMed/NCBI

24 

Osipov AN, Pustovalova M, Grekhova A, Eremin P, Vorobyova N, Pulin A, Zhavoronkov A, Roumiantsev S, Klokov DY and Eremin I: Low doses of X-rays induce prolonged and ATM-independent persistence of γH2AX foci in human gingival mesenchymal stem cells. Oncotarget. 6:27275–27287. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Kurashige T, Shimamura M and Nagayama Y: Differences in quantification of DNA double-strand breaks assessed by 53BP1/γH2AX focus formation assays and the comet assay in mammalian cells treated with irradiation and N-acetyl-L-cysteine. J Radiat Res. 57:312–317. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Baldock RA, Day M, Wilkinson OJ, Cloney R, Jeggo PA, Oliver AW, Watts FZ and Pearl LH: ATM localization and heterochromatin repair depend on direct interaction of the 53BP1-BRCT2 domain with γH2AX. Cell Rep. 13:2081–2089. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Lima M, Bouzid H, Soares DG, Selle F, Morel C, Galmarini CM, Henriques JA, Larsen AK and Escargueil AE: Dual inhibition of ATR and ATM potentiates the activity of trabectedin and lurbinectedin by perturbing the DNA damage response and homologous recombination repair. Oncotarget. 7:25885–25901. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Ghattass K, Assah R, El-Sabban M and Gali-Muhtasib H: Targeting hypoxia for sensitization of tumors to radio- and chemotherapy. Curr Cancer Drug Targets. 13:670–685. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Pei J, Lou Y, Zhong R and Han B: MMP9 activation triggered by epidermal growth factor induced FoxO1 nuclear exclusion in non-small cell lung cancer. Tumour Biol. 35:6673–6678. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Miyasaka A, Oda K, Ikeda Y, Sone K, Fukuda T, Inaba K, Makii C, Enomoto A, Hosoya N, Tanikawa M, et al: PPI3K/mTOR pathway inhibition overcomes radioresistance via suppression of the HIF1-α/VEGF pathway in endometrial cancer. Gynecol Oncol. 138:174–180. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Harada H: Hypoxia-inducible factor 1-mediated characteristic features of cancer cells for tumor radioresistance. J Radiat Res. 57(Suppl 1): i99–i105. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Helbig L, Koi L, Brüchner K, Gurtner K, Hess-Stumpp H, Unterschemmann K, Pruschy M, Baumann M, Yaromina A and Zips D: Hypoxia-inducible factor pathway inhibition resolves tumor hypoxia and improves local tumor control after single-dose irradiation. Int J Radiat Oncol Biol Phys. 88:159–166. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Fotia C, Massa A, Boriani F, Baldini N and Granchi D: Hypoxia enhances proliferation and stemness of human adipose-derived mesenchymal stem cells. Cytotechnology. 67:1073–1084. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Fu Z, Chen D, Cheng H and Wang F: Hypoxia-inducible factor-1α protects cervical carcinoma cells from apoptosis induced by radiation via modulation of vascular endothelial growth factor and p53 under hypoxia. Med Sci Monit. 21:318–325. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Gao Q, Guo M, Zeng W, Wang Y, Yang L, Pang X, Li H, Suo Y, Jiang X and Yu C: Matrix metalloproteinase 9 secreted by hypoxia cardiac fibroblasts triggers cardiac stem cell migration in vitro. Stem Cells Int. 2015:8363902015. View Article : Google Scholar : PubMed/NCBI

36 

Ondrej M, Cechakova L, Durisova K, Pejchal J and Tichy A: To live or let die: Unclear task of autophagy in the radiosensitization battle. Radiother Oncol. 119:265–275. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Milczarek M, Wiktorska K, Mielczarek L, Koronkiewicz M, Dąbrowska A, Lubelska K, Matosiuk D and Chilmonczyk Z: Autophagic cell death and premature senescence: New mechanism of 5-fluorouracil and sulforaphane synergistic anticancer effect in MDA-MB-231 triple negative breast cancer cell line. Food Chem Toxicol. 111:1–8. 2018. View Article : Google Scholar : PubMed/NCBI

38 

Jo GH, Bögler O, Chwae YJ, Yoo H, Lee SH, Park JB, Kim YJ, Kim JH and Gwak HS: Radiation-induced autophagy contributes to cell death and induces apoptosis partly in malignant glioma cells. Cancer Res Treat. 47:221–241. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Ryan F, Khodagholi F, Dargahi L, Minai-Tehrani D and Ahmadiani A: Temporal pattern and crosstalk of necroptosis markers with autophagy and apoptosis associated proteins in ischemic hippocampus. Neurotox Res. Jan 8. 2018, (Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

40 

Suzuki R, Kang Y, Li X, Roife D, Zhang R and Fleming JB: Genistein potentiates the antitumor effect of 5-Fluorouracil by inducing apoptosis and autophagy in human pancreatic cancer cells. Anticancer Res. 34:4685–4692. 2014.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liu X, Chen H, Xu X, Ye M, Cao H, Xu L, Hou Y, Tang J, Zhou D, Bai Y, Bai Y, et al: Insulin‑like growth factor‑1 receptor knockdown enhances radiosensitivity via the HIF‑1α pathway and attenuates ATM/H2AX/53BP1 DNA repair activation in human lung squamous carcinoma cells. Oncol Lett 16: 1332-1340, 2018.
APA
Liu, X., Chen, H., Xu, X., Ye, M., Cao, H., Xu, L. ... Ma, X. (2018). Insulin‑like growth factor‑1 receptor knockdown enhances radiosensitivity via the HIF‑1α pathway and attenuates ATM/H2AX/53BP1 DNA repair activation in human lung squamous carcinoma cells. Oncology Letters, 16, 1332-1340. https://doi.org/10.3892/ol.2018.8705
MLA
Liu, X., Chen, H., Xu, X., Ye, M., Cao, H., Xu, L., Hou, Y., Tang, J., Zhou, D., Bai, Y., Ma, X."Insulin‑like growth factor‑1 receptor knockdown enhances radiosensitivity via the HIF‑1α pathway and attenuates ATM/H2AX/53BP1 DNA repair activation in human lung squamous carcinoma cells". Oncology Letters 16.1 (2018): 1332-1340.
Chicago
Liu, X., Chen, H., Xu, X., Ye, M., Cao, H., Xu, L., Hou, Y., Tang, J., Zhou, D., Bai, Y., Ma, X."Insulin‑like growth factor‑1 receptor knockdown enhances radiosensitivity via the HIF‑1α pathway and attenuates ATM/H2AX/53BP1 DNA repair activation in human lung squamous carcinoma cells". Oncology Letters 16, no. 1 (2018): 1332-1340. https://doi.org/10.3892/ol.2018.8705
Copy and paste a formatted citation
x
Spandidos Publications style
Liu X, Chen H, Xu X, Ye M, Cao H, Xu L, Hou Y, Tang J, Zhou D, Bai Y, Bai Y, et al: Insulin‑like growth factor‑1 receptor knockdown enhances radiosensitivity via the HIF‑1α pathway and attenuates ATM/H2AX/53BP1 DNA repair activation in human lung squamous carcinoma cells. Oncol Lett 16: 1332-1340, 2018.
APA
Liu, X., Chen, H., Xu, X., Ye, M., Cao, H., Xu, L. ... Ma, X. (2018). Insulin‑like growth factor‑1 receptor knockdown enhances radiosensitivity via the HIF‑1α pathway and attenuates ATM/H2AX/53BP1 DNA repair activation in human lung squamous carcinoma cells. Oncology Letters, 16, 1332-1340. https://doi.org/10.3892/ol.2018.8705
MLA
Liu, X., Chen, H., Xu, X., Ye, M., Cao, H., Xu, L., Hou, Y., Tang, J., Zhou, D., Bai, Y., Ma, X."Insulin‑like growth factor‑1 receptor knockdown enhances radiosensitivity via the HIF‑1α pathway and attenuates ATM/H2AX/53BP1 DNA repair activation in human lung squamous carcinoma cells". Oncology Letters 16.1 (2018): 1332-1340.
Chicago
Liu, X., Chen, H., Xu, X., Ye, M., Cao, H., Xu, L., Hou, Y., Tang, J., Zhou, D., Bai, Y., Ma, X."Insulin‑like growth factor‑1 receptor knockdown enhances radiosensitivity via the HIF‑1α pathway and attenuates ATM/H2AX/53BP1 DNA repair activation in human lung squamous carcinoma cells". Oncology Letters 16, no. 1 (2018): 1332-1340. https://doi.org/10.3892/ol.2018.8705
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