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Review

Interplay between inflammatory tumor microenvironment and cancer stem cells (Review)

  • Authors:
    • Shijian Zhang
    • Xi Yang
    • Lei Wang
    • Chenping Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial‑Head and Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, P.R. China
  • Pages: 679-686
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    Published online on: May 16, 2018
       https://doi.org/10.3892/ol.2018.8716
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Abstract

Cancer stem cells (CSCs), which have a close connection with tumor microenvironment, play a pivotal role in tumorigenesis, tumor progression, and metastasis. The inflammatory microenvironment is an essential component of tumor microenvironment. In the recent years, many studies have demonstrated that the inflammatory microenvironment induces the initiation of tumors, and contributes to the process of the progression of tumors, as well as metastasis. In this review, we summarize the relationship between CSCs and inflammatory components, such as inflammatory cytokines (IFNs, TNF, IL‑6, IL‑17) and inflammatory cells (myeloid‑derived suppressor cells, tumor‑associated macrophages). To illuminate the key factors that exert important actions in the tumor process would be important to improve the clinical outcome of the treatment for different types of cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang S, Yang X, Wang L and Zhang C: Interplay between inflammatory tumor microenvironment and cancer stem cells (Review). Oncol Lett 16: 679-686, 2018.
APA
Zhang, S., Yang, X., Wang, L., & Zhang, C. (2018). Interplay between inflammatory tumor microenvironment and cancer stem cells (Review). Oncology Letters, 16, 679-686. https://doi.org/10.3892/ol.2018.8716
MLA
Zhang, S., Yang, X., Wang, L., Zhang, C."Interplay between inflammatory tumor microenvironment and cancer stem cells (Review)". Oncology Letters 16.1 (2018): 679-686.
Chicago
Zhang, S., Yang, X., Wang, L., Zhang, C."Interplay between inflammatory tumor microenvironment and cancer stem cells (Review)". Oncology Letters 16, no. 1 (2018): 679-686. https://doi.org/10.3892/ol.2018.8716
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang S, Yang X, Wang L and Zhang C: Interplay between inflammatory tumor microenvironment and cancer stem cells (Review). Oncol Lett 16: 679-686, 2018.
APA
Zhang, S., Yang, X., Wang, L., & Zhang, C. (2018). Interplay between inflammatory tumor microenvironment and cancer stem cells (Review). Oncology Letters, 16, 679-686. https://doi.org/10.3892/ol.2018.8716
MLA
Zhang, S., Yang, X., Wang, L., Zhang, C."Interplay between inflammatory tumor microenvironment and cancer stem cells (Review)". Oncology Letters 16.1 (2018): 679-686.
Chicago
Zhang, S., Yang, X., Wang, L., Zhang, C."Interplay between inflammatory tumor microenvironment and cancer stem cells (Review)". Oncology Letters 16, no. 1 (2018): 679-686. https://doi.org/10.3892/ol.2018.8716
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