Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
July-2018 Volume 16 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2018 Volume 16 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Overexpression of mRNA‑decapping enzyme 1a affects survival rate in colorectal carcinoma

  • Authors:
    • Chuanqing Wu
    • Weizhen Liu
    • Tuo Ruan
    • Xiaojie Zhu
    • Kaixiong Tao
    • Weikang Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China
  • Pages: 1095-1100
    |
    Published online on: May 16, 2018
       https://doi.org/10.3892/ol.2018.8730
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Processing bodies (P‑bodies) are one of the most well understood types of RNA granules, and are associated with a variety of diseases, including cancer. mRNA‑decapping enzyme 1a (DCP1a), which may be used as a marker to analyze P‑bodies, participates in the removal of the 5'‑methylguanosine cap from eukaryotic mRNAs as a cofactor. The aim of the present study was to analyze the association between DCP1a expression and clinical features in colorectal carcinoma (CRC). The levels of DCP1a mRNA expression were detected by reverse transcription‑quantitative polymerase chain reaction assay in carcinoma and non‑carcinoma tissues from 75 patients, while the protein expression levels were evaluated by immunohistochemistry and western blotting. Additional associations between DCP1a expression and clinical characteristics were analyzed by χ2 test and Cox regression analysis. In the 75 cases, the levels of DCP1a mRNA and protein expression were increased in colorectal carcinoma tissues compared with non‑carcinoma tissues. A high expression of DCP1a was significantly associated with lower survival rates in patients with CRC compared with patients with low DCP1a expression (P=0.001). Associations with depth of invasion (P=0.008), lymph node metastasis (P=0.001) and tumor node metastasis stage (P=0.001) were also observed. Additional Cox regression analysis revealed that the DCP1a expression (P=0.012) is an independent factor in survival rate. It was also identified that DCP1a may have high expression in colorectal carcinoma tissues and be associated with poor prognosis. This suggests that DCP1a may be a diagnostic marker or prognostic indicator to assist with patient assessments and therapies.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Center MM, Jemal A, Smith RA and Ward E: Worldwide variations in colorectal cancer. CA Cancer J Clin. 59:366–378. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2016. CA Cancer J Clin. 66:7–30. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Beelman CA and Parker R: Degradation of mRNA in eukaryotes. Cell. 81:179–183. 1995. View Article : Google Scholar : PubMed/NCBI

6 

Ross J: Control of messenger RNA stability in higher eukaryotes. Trends Genet. 12:171–175. 1996. View Article : Google Scholar : PubMed/NCBI

7 

Arribas-Layton M, Wu D, Lykke-Andersen J and Song H: Structural and functional control of the eukaryotic mRNA decapping machinery. Biochim Biophys Acta. 1829:580–589. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Eulalio A, Behm-Ansmant I, Schweizer D and Izaurralde E: P-body formation is a consequence, not the cause, of RNA-mediated gene silencing. Mol Cell Biol. 27:3970–3981. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Franks TM and Lykke-Andersen J: The control of mRNA decapping and P-body formation. Mol Cell. 32:605–615. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Anderson P, Kedersha N and Ivanov P: Stress granules, P-bodies and cancer. Biochim Biophys Acta. 1849:861–870. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Cougot N, Daguenet E, Baguet A, Cavalier A, Thomas D, Bellaud P, Fautrel A, Godey F, Bertrand E, Tomasetto C and Gillet R: Overexpression of MLN51 triggers P-body disassembly and formation of a new type of RNA granules. J Cell Sci. 127:4692–4701. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Anderson P and Kedersha N: RNA granules: Post-transcriptional and epigenetic modulators of gene expression. Nat Rev Mol Cell Biol. 10:430–436. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Hayes J, Peruzzi PP and Lawler S: MicroRNAs in cancer: Biomarkers, functions and therapy. Trends Mol Med. 20:460–469. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Aizer A, Kafri P, Kalo A and Shav-Tal Y: The P body protein Dcp1a is hyper-phosphorylated during mitosis. PLoS One. 8:e497832013. View Article : Google Scholar : PubMed/NCBI

15 

Chen VW, Hsieh MC, Charlton ME, Ruiz BA, Karlitz J, Altekruse SF, Ries LA and Jessup JM: Analysis of stage and clinical/prognostic factors for colon and rectal cancer from SEER registries: AJCC and collaborative stage data collection system. Cancer. 120 Suppl 23:S3793–S3806. 2014. View Article : Google Scholar

16 

Barclay KL, Goh PJ and Jackson TJ: Socio-economic disadvantage and demographics as factors in stage of colorectal cancer presentation and survival. ANZ J Surg. 85:135–139. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Feroci F and Fong Y: Use of clinical score to stage and predict outcome of hepatic resection of metastatic colorectal cancer. J Surg Oncol. 102:914–921. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Yalamati P, Bhongir AV, Karra M and Beedu SR: Comparative analysis of urinary total proteins by bicinchoninic acid and pyrogallol red molybdate methods. J Clin Diagn Res. 9:BC01–BC04. 2015.PubMed/NCBI

20 

Siegel R, Desantis C and Jemal A: Colorectal cancer statistics, 2014. CA Cancer J Clin. 64:104–117. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Edwards BK, Ward E, Kohler BA, Eheman C, Zauber AG, Anderson RN, Jemal A, Schymura MJ, Lansdorp-Vogelaar I, Seeff LC, et al: Annual report to the nation on the status of cancer, 1975–2006, featuring colorectal cancer trends and impact of interventions (risk factors, screening, and treatment) to reduce future rates. Cancer. 116:544–573. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Shimamoto Y, Nukatsuka M, Takechi T and Fukushima M: Association between mRNA expression of chemotherapy-related genes and clinicopathological features in colorectal cancer: A large-scale population analysis. Int J Mol Med. 37:319–328. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Vallazza B, Petri S, Poleganov MA, Eberle F, Kuhn AN and Sahin U: Recombinant messenger RNA technology and its application in cancer immunotherapy, transcript replacement therapies, pluripotent stem cell induction, and beyond. Wiley Interdiscip Rev RNA. 6:471–499. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Gallie DR: The cap and poly(A) tail function synergistically to regulate mRNA translational efficiency. Genes Dev. 5:2108–2116. 1991. View Article : Google Scholar : PubMed/NCBI

25 

Simon E, Camier S and Séraphin B: New insights into the control of mRNA decapping. Trends Biochem Sci. 31:241–243. 2006. View Article : Google Scholar : PubMed/NCBI

26 

Erickson SL and Lykke-Andersen J: Cytoplasmic mRNP granules at a glance. J Cell Sci. 124:293–297. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Polunovsky VA and Bitterman PB: The cap-dependent translation apparatus integrates and amplifies cancer pathways. RNA Biol. 3:10–17. 2006. View Article : Google Scholar : PubMed/NCBI

28 

Wendel HG, De Stanchina E, Fridman JS, Malina A, Ray S, Kogan S, Cordon-Cardo C, Pelletier J and Lowe SW: Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy. Nature. 428:332–337. 2004. View Article : Google Scholar : PubMed/NCBI

29 

Fujimura K, Wright T, Strnadel J, Kaushal S, Metildi C, Lowy AM, Bouvet M, Kelber JA and Klemke RL: A hypusine-eIF5A-PEAK1 switch regulates the pathogenesis of pancreatic cancer. Cancer Res. 74:6671–6681. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Zhang W, Liu H, Yin J, Wu W, Zhu D, Amos CI, Fang S, Lee JE, Li Y, Han J and Wei Q: Genetic variants in the PIWI-piRNA pathway gene DCP1A predict melanoma disease-specific survival. Int J Cancer. 139:2730–2737. 2016. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wu C, Liu W, Ruan T, Zhu X, Tao K and Zhang W: Overexpression of mRNA‑decapping enzyme 1a affects survival rate in colorectal carcinoma. Oncol Lett 16: 1095-1100, 2018.
APA
Wu, C., Liu, W., Ruan, T., Zhu, X., Tao, K., & Zhang, W. (2018). Overexpression of mRNA‑decapping enzyme 1a affects survival rate in colorectal carcinoma. Oncology Letters, 16, 1095-1100. https://doi.org/10.3892/ol.2018.8730
MLA
Wu, C., Liu, W., Ruan, T., Zhu, X., Tao, K., Zhang, W."Overexpression of mRNA‑decapping enzyme 1a affects survival rate in colorectal carcinoma". Oncology Letters 16.1 (2018): 1095-1100.
Chicago
Wu, C., Liu, W., Ruan, T., Zhu, X., Tao, K., Zhang, W."Overexpression of mRNA‑decapping enzyme 1a affects survival rate in colorectal carcinoma". Oncology Letters 16, no. 1 (2018): 1095-1100. https://doi.org/10.3892/ol.2018.8730
Copy and paste a formatted citation
x
Spandidos Publications style
Wu C, Liu W, Ruan T, Zhu X, Tao K and Zhang W: Overexpression of mRNA‑decapping enzyme 1a affects survival rate in colorectal carcinoma. Oncol Lett 16: 1095-1100, 2018.
APA
Wu, C., Liu, W., Ruan, T., Zhu, X., Tao, K., & Zhang, W. (2018). Overexpression of mRNA‑decapping enzyme 1a affects survival rate in colorectal carcinoma. Oncology Letters, 16, 1095-1100. https://doi.org/10.3892/ol.2018.8730
MLA
Wu, C., Liu, W., Ruan, T., Zhu, X., Tao, K., Zhang, W."Overexpression of mRNA‑decapping enzyme 1a affects survival rate in colorectal carcinoma". Oncology Letters 16.1 (2018): 1095-1100.
Chicago
Wu, C., Liu, W., Ruan, T., Zhu, X., Tao, K., Zhang, W."Overexpression of mRNA‑decapping enzyme 1a affects survival rate in colorectal carcinoma". Oncology Letters 16, no. 1 (2018): 1095-1100. https://doi.org/10.3892/ol.2018.8730
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team