Correlation between miR‑222 and uterine cancer and its prognostic value
Affiliations: Department of Obstetrics and Gynecology, Dongying People's Hospital, Dongying, Shandong 257091, P.R. China
- Published online on: May 25, 2018 https://doi.org/10.3892/ol.2018.8815
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Relationship between the expression of miR‑222 and uterine cancer was investigated to explore its prognostic value. A total of 66 patients with uterine cancer diagnosed by pathological examination in Dongying People's Hospital were enrolled from March 2014 to October 2016. Uterine cancer and adjacent tissues were collected, and the expression of miR‑222 in the tissues was detected by stem‑loop RT‑PCR. The relationship between miR‑222 expression and various clinicopathological features of uterine cancer was analyzed. All the patients were followed up to record the survival conditions. The results revealed that stem‑loop RT‑PCR method could specifically amplify miR‑222. The expression of miR‑222 in uterine cancer tissues was significantly upregulated compared with that in adjacent tissues (p<0.05). The expression level of miR‑222 was significantly increased with the increase of degree of tumor differentiation (p<0.05). The expression of miR‑222 in uterine cancer tissue was not significantly correlated with patients' age, tumor size, gross tumor type, pathological type and FIGO stage (p>0.05). There was a significant negative correlation between the expression of miR‑222 and the survival of patients with uterine cancer. In conclusion, the expression of miR‑222 in uterine cancer tissues was significantly upregulated in uterine cancer and negatively correlated with prognosis. miR‑222 may play a pivotal role in the development and progression of uterine cancer. It is expected that miR‑222 will be an indicator and target for the treatment and prognosis of uterine cancer.