DUSP1 enhances the chemoresistance of gallbladder cancer via the modulation of the p38 pathway and DNA damage/repair system

  • Authors:
    • Jun Fang
    • Zhimin Ye
    • Feiying Gu
    • Maohui Yan
    • Qingren Lin
    • Juan Lin
    • Zhun Wang
    • Yaping Xu
    • Yuezhen Wang
  • View Affiliations

  • Published online on: May 29, 2018     https://doi.org/10.3892/ol.2018.8822
  • Pages: 1869-1875
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Abstract

Cisplatin (CDDP) is a commonly used drug for gallbladder cancer (GBC) chemotherapy. However, resistance to CDDP treatment results in relapse. Therefore, there is a need for the development of more effective treatment strategies to overcome chemoresistance. Dual‑specificity phosphatase 1 (DUSP1) was reported to be involved in the resistance of a number of chemotherapeutic agents and was revealed to be highly expressed in CDDP‑resistant GBC cells and CDDP‑treated tumor types compared with normal cells or tissues in the present study. DUSP1 was revealed to inhibit the cytotoxicity of CDDP in two GBC cell lines, SGC996 and GBC‑SD. P38 mitogen‑activated protein kinases may be involved in the mechanism of chemoresistance. Furthermore, the number of DNA double‑strand breaks in SGC996 OE cells was reduced compared with SGC996 vector cells indicating DUSP1 may attenuate the chemotherapeutic efficiency. Due to its potency against CDDP treatment, DUSP1 may be a promising target to overcome chemoresistance in GBC therapy.
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August-2018
Volume 16 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Fang J, Ye Z, Gu F, Yan M, Lin Q, Lin J, Wang Z, Xu Y and Wang Y: DUSP1 enhances the chemoresistance of gallbladder cancer via the modulation of the p38 pathway and DNA damage/repair system. Oncol Lett 16: 1869-1875, 2018
APA
Fang, J., Ye, Z., Gu, F., Yan, M., Lin, Q., Lin, J. ... Wang, Y. (2018). DUSP1 enhances the chemoresistance of gallbladder cancer via the modulation of the p38 pathway and DNA damage/repair system. Oncology Letters, 16, 1869-1875. https://doi.org/10.3892/ol.2018.8822
MLA
Fang, J., Ye, Z., Gu, F., Yan, M., Lin, Q., Lin, J., Wang, Z., Xu, Y., Wang, Y."DUSP1 enhances the chemoresistance of gallbladder cancer via the modulation of the p38 pathway and DNA damage/repair system". Oncology Letters 16.2 (2018): 1869-1875.
Chicago
Fang, J., Ye, Z., Gu, F., Yan, M., Lin, Q., Lin, J., Wang, Z., Xu, Y., Wang, Y."DUSP1 enhances the chemoresistance of gallbladder cancer via the modulation of the p38 pathway and DNA damage/repair system". Oncology Letters 16, no. 2 (2018): 1869-1875. https://doi.org/10.3892/ol.2018.8822