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Loss of Raf kinase inhibitor protein expression is associated with human papillomavirus 16 infection in anal tumors

  • Authors:
    • Lucas Tadeu Bidinotto
    • Carlos A. R. Véo
    • Edgar Aleman Loaiza
    • Guilherme G. Ribeiro
    • Adriana T. Lorenzi
    • Luciana Albina Reis Rosa
    • Cristina Mendes de Oliveira
    • José Eduardo Levi
    • Cristovam Scapulatempo‑Neto
    • Adhemar Longatto‑Filho
    • Rui Manuel Reis

  • View Affiliations

  • Published online on: May 30, 2018     https://doi.org/10.3892/ol.2018.8828
  • Pages: 1785-1790
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Abstract

There has been an increase in the incidence of anal cancer in the past two decades, with squamous cell carcinoma (SCC) being the most frequent histological type identified. Among the risk factors, high‑risk human papillomavirus (HPV) infection is the most pervasive. Raf kinase inhibitor protein (RKIP) is expressed in a number of normal human tissues and previous studies have demonstrated the prognostic value of the loss of RKIP expression in several gastrointestinal tumors. Therefore, the present study aimed to evaluate the clinical implications of RKIP expression in a series of neoplastic lesions of the anal canal. The resected tumors of 48 patients [8 high‑grade intraepithelial lesions (HSILs), 14 adenocarcinomas and 26 squamous cell carcinomas (SCCs)] were immunohistochemically evaluated for RKIP expression, and the results were correlated with clinicopathological data. The results identified a decreased 5‑year overall survival rate in patients with adenocarcinoma (40.8%) compared with patients with SCC (76.7%), and a decreased 5‑year disease‑free survival rate in patients at clinical stages III/IV (37.3 vs. 62.5 and 82.6% for clinical stages 0 and I/II, respectively). Low RKIP expression was revealed in 62.5% of HSILs, 88.5% of SCCs and 100.0% of the adenocarcinomas. High RKIP expression was associated with patient ethnicity (37.5% in non‑Caucasians vs. 7.5% in Caucasians) and patient age (33.3% in younger patients vs. 0.0% in older patients). Finally, high RKIP expression was correlated with HPV16 infection status (40% in HPV‑ vs. 5.3% in HPV+ patients). A correlation was identified between high RKIP expression and lesions with a generally improved prognosis, such as those diagnosed in younger patients, in situ lesions and lesions of lower clinical grades; there was also a negative correlation between high RKIP expression and HPV16 positivity in patients.
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August-2018
Volume 16 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Bidinotto LT, Véo CA, Loaiza EA, Ribeiro GG, Lorenzi AT, Reis Rosa LA, de Oliveira CM, Levi JE, Scapulatempo‑Neto C, Longatto‑Filho A, Longatto‑Filho A, et al: Loss of Raf kinase inhibitor protein expression is associated with human papillomavirus 16 infection in anal tumors. Oncol Lett 16: 1785-1790, 2018
APA
Bidinotto, L.T., Véo, C.A., Loaiza, E.A., Ribeiro, G.G., Lorenzi, A.T., Reis Rosa, L.A. ... Reis, R.M. (2018). Loss of Raf kinase inhibitor protein expression is associated with human papillomavirus 16 infection in anal tumors. Oncology Letters, 16, 1785-1790. https://doi.org/10.3892/ol.2018.8828
MLA
Bidinotto, L. T., Véo, C. A., Loaiza, E. A., Ribeiro, G. G., Lorenzi, A. T., Reis Rosa, L. A., de Oliveira, C. M., Levi, J. E., Scapulatempo‑Neto, C., Longatto‑Filho, A., Reis, R. M."Loss of Raf kinase inhibitor protein expression is associated with human papillomavirus 16 infection in anal tumors". Oncology Letters 16.2 (2018): 1785-1790.
Chicago
Bidinotto, L. T., Véo, C. A., Loaiza, E. A., Ribeiro, G. G., Lorenzi, A. T., Reis Rosa, L. A., de Oliveira, C. M., Levi, J. E., Scapulatempo‑Neto, C., Longatto‑Filho, A., Reis, R. M."Loss of Raf kinase inhibitor protein expression is associated with human papillomavirus 16 infection in anal tumors". Oncology Letters 16, no. 2 (2018): 1785-1790. https://doi.org/10.3892/ol.2018.8828