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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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August-2018 Volume 16 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Article

Expression of ZEBs in gliomas is associated with invasive properties and histopathological grade

  • Authors:
    • Keiko Suzuki
    • Tomoyuki Kawataki
    • Kaori Endo
    • Keiji Miyazawa
    • Hiroyuki Kinouchi
    • Masao Saitoh
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo, Yamanashi 409‑3898, Japan, Department of Biochemistry, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo, Yamanashi 409‑3898, Japan
  • Pages: 1758-1764
    |
    Published online on: May 31, 2018
       https://doi.org/10.3892/ol.2018.8852
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Abstract

The invasiveness of glioma cells is the predominant clinical problem associated with this tumor type, and is correlated with pathological malignant grade. ZEB1 is highly expressed in glioma cells and associated with the aggressiveness of various types of cancer. In the present study, the expression of ZEB1 and ZEB2 was examined with the aim of determining the role of ZEBs in glioma. ZEB1 and ZEB2 were highly expressed in all glioma cells used in this study. Double knockdown of ZEB1 and ZEB2 suppressed tumor invasiveness more effectively than knockdown of either alone, in both in vitro and in vivo experiments. ZEB1 and ZEB2 were marginally expressed in grade II, but expressed at higher levels in grade IV. Importantly, ZEB‑positive cells were more abundant in recurrent glioma with malignant transformation than in initial grade II tissue from the same case. These results indicate that the levels of ZEB1 and ZEB2 are positively correlated with histopathological grade and invasiveness of glioma, suggesting that δEF1 family proteins (ZEB1 and ZEB2) could be useful as prognostic markers and therapeutic targets in patients with glioma.
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Copy and paste a formatted citation
Spandidos Publications style
Suzuki K, Kawataki T, Endo K, Miyazawa K, Kinouchi H and Saitoh M: Expression of ZEBs in gliomas is associated with invasive properties and histopathological grade. Oncol Lett 16: 1758-1764, 2018.
APA
Suzuki, K., Kawataki, T., Endo, K., Miyazawa, K., Kinouchi, H., & Saitoh, M. (2018). Expression of ZEBs in gliomas is associated with invasive properties and histopathological grade. Oncology Letters, 16, 1758-1764. https://doi.org/10.3892/ol.2018.8852
MLA
Suzuki, K., Kawataki, T., Endo, K., Miyazawa, K., Kinouchi, H., Saitoh, M."Expression of ZEBs in gliomas is associated with invasive properties and histopathological grade". Oncology Letters 16.2 (2018): 1758-1764.
Chicago
Suzuki, K., Kawataki, T., Endo, K., Miyazawa, K., Kinouchi, H., Saitoh, M."Expression of ZEBs in gliomas is associated with invasive properties and histopathological grade". Oncology Letters 16, no. 2 (2018): 1758-1764. https://doi.org/10.3892/ol.2018.8852
Copy and paste a formatted citation
x
Spandidos Publications style
Suzuki K, Kawataki T, Endo K, Miyazawa K, Kinouchi H and Saitoh M: Expression of ZEBs in gliomas is associated with invasive properties and histopathological grade. Oncol Lett 16: 1758-1764, 2018.
APA
Suzuki, K., Kawataki, T., Endo, K., Miyazawa, K., Kinouchi, H., & Saitoh, M. (2018). Expression of ZEBs in gliomas is associated with invasive properties and histopathological grade. Oncology Letters, 16, 1758-1764. https://doi.org/10.3892/ol.2018.8852
MLA
Suzuki, K., Kawataki, T., Endo, K., Miyazawa, K., Kinouchi, H., Saitoh, M."Expression of ZEBs in gliomas is associated with invasive properties and histopathological grade". Oncology Letters 16.2 (2018): 1758-1764.
Chicago
Suzuki, K., Kawataki, T., Endo, K., Miyazawa, K., Kinouchi, H., Saitoh, M."Expression of ZEBs in gliomas is associated with invasive properties and histopathological grade". Oncology Letters 16, no. 2 (2018): 1758-1764. https://doi.org/10.3892/ol.2018.8852
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