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Enhanced motility and proliferation by miR‑10b/FUT8/p‑AKT axis in breast cancer cells

  • Authors:
    • Dong Guo
    • Jia Guo
    • Xiang Li
    • Feng Guan
  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu 214122, P.R. China, Wuxi Medical School, Jiangnan University, Wuxi, Jiangsu 214122, P.R. China
    Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2097-2104
    |
    Published online on: June 4, 2018
       https://doi.org/10.3892/ol.2018.8891
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Abstract

Upregulation of microRNA (miR)‑10b has been confirmed in multiple types of cancer, however, the role of miR‑10b in glycosylation remains unclear. Protein core‑fucosylation is an important N‑linked glycosylation modification and serves important roles in cancer progression. In a previous study, a glycogene array was applied to profile the alterations of glycogene expression in miR‑10b‑overexpressed MCF10A cells. Notably, fucosyltranferase 8 (FUT8), which is responsible for the addition of core‑fucose to N‑glycan, was significantly upregulated by miR‑10b. In the present study, increased motility and proliferation were observed in miR‑10b‑overexpressed MCF10A cells. To assess the mechanism involved, the role of FUT8 in MCF10A cells was studied and it was confirmed that miR‑10b promotes motility and proliferation by regulating FUT8 and activating the protein kinase B (AKT) signaling pathway. Consistent with the aforementioned result, decreased motility and proliferation were detected when miR‑10b expression was inhibited in MDA‑MB‑231 cells, transforming growth factor‑β‑induced and Twist‑overexpressed MCF10A cells. To conclude, the findings from the present study indicate that miR‑10b promotes motility and proliferation by increasing FUT8 and activating AKT in breast cancer cells.
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Copy and paste a formatted citation
Spandidos Publications style
Guo D, Guo J, Li X and Guan F: Enhanced motility and proliferation by miR‑10b/FUT8/p‑AKT axis in breast cancer cells. Oncol Lett 16: 2097-2104, 2018.
APA
Guo, D., Guo, J., Li, X., & Guan, F. (2018). Enhanced motility and proliferation by miR‑10b/FUT8/p‑AKT axis in breast cancer cells. Oncology Letters, 16, 2097-2104. https://doi.org/10.3892/ol.2018.8891
MLA
Guo, D., Guo, J., Li, X., Guan, F."Enhanced motility and proliferation by miR‑10b/FUT8/p‑AKT axis in breast cancer cells". Oncology Letters 16.2 (2018): 2097-2104.
Chicago
Guo, D., Guo, J., Li, X., Guan, F."Enhanced motility and proliferation by miR‑10b/FUT8/p‑AKT axis in breast cancer cells". Oncology Letters 16, no. 2 (2018): 2097-2104. https://doi.org/10.3892/ol.2018.8891
Copy and paste a formatted citation
x
Spandidos Publications style
Guo D, Guo J, Li X and Guan F: Enhanced motility and proliferation by miR‑10b/FUT8/p‑AKT axis in breast cancer cells. Oncol Lett 16: 2097-2104, 2018.
APA
Guo, D., Guo, J., Li, X., & Guan, F. (2018). Enhanced motility and proliferation by miR‑10b/FUT8/p‑AKT axis in breast cancer cells. Oncology Letters, 16, 2097-2104. https://doi.org/10.3892/ol.2018.8891
MLA
Guo, D., Guo, J., Li, X., Guan, F."Enhanced motility and proliferation by miR‑10b/FUT8/p‑AKT axis in breast cancer cells". Oncology Letters 16.2 (2018): 2097-2104.
Chicago
Guo, D., Guo, J., Li, X., Guan, F."Enhanced motility and proliferation by miR‑10b/FUT8/p‑AKT axis in breast cancer cells". Oncology Letters 16, no. 2 (2018): 2097-2104. https://doi.org/10.3892/ol.2018.8891
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