Application of contrast‑enhanced ultrasound and enhanced CT in diagnosis of liver cancer and evaluation of radiofrequency ablation

Kong,Shuhong; Yue,Xuewang; Kong,Sheng; Ren,Yujie

doi:10.3892/ol.2018.8898

Application of contrast‑enhanced ultrasound and enhanced CT in diagnosis of liver cancer and evaluation of radiofrequency ablation

Authors:
- Shuhong Kong
- Xuewang Yue
- Sheng Kong
- Yujie Ren
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Affiliations: Department of Computed Tomography, Dongying People's Hospital, Dongying, Shandong 257091, P.R. China, Department of Ultrasound, Laiwu Central Hospital of Xinwen Mineral Group, Laiwu, Shandong 271103, P.R. China
Published online on: June 5, 2018 https://doi.org/10.3892/ol.2018.8898
Pages: 2434-2438
Copyright: © Kong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

This study investigated the application effect of contrast‑enhanced ultrasound (CEUS) and enhanced CT in diagnosis of liver cancer and response evaluation of radiofrequency ablation (RFA). A total of 60 patients with liver cancer were selected in Dongying People's Hospital from April 2016 to May 2017. All patients were subjected to CEUS and enhanced CT. With pathological examination as the gold standard, diagnostic consistency of the two methods was compared. After RFA, patients were subjected to CEUS and enhanced CT to assess the efficacy, and the consistency was compared. There was no significant difference in diagnostic accuracy between CEUS and CT (p>0.05). Area under the ROC curve of CEUS was 0.896, with a sensitivity of 91.2% and a specificity of 88.7%. The area under the ROC curve for enhanced CT diagnosis was 0.907, with a sensitivity of 91.8% and a specificity of 89.7%. No significant difference in the maximal cross sectional area of lesions was found between CEUS and enhanced CT, and there was no significant difference in evaluation of therapeutic efficiency between the methods (p>0.05) before and 1 and 3 months after treatment. Bland‑Altman test showed that there was a strong consistency between CEUS and enhanced CT in the measured maximum cross‑sectional area of lesions at 1 and 3 months after treatment. Linear regression analysis showed that maximum section cross‑sectional area measured by CEUS was significantly correlated with that detected by enhanced CT (r2=0.617). The results suggested that diagnostic efficiency of CEUS was similar to that of enhanced CT, and both showed high sensitivity and specificity. Two methods showed high consistency in evaluating the curative effect of RFA. CEUS can achieve real‑time observation of focal blood flow perfusion, and was more economically affordable and convenient.

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1	Younossi ZM, Otgonsuren M, Henry L, Venkatesan C, Mishra A, Erario M and Hunt S: Association of nonalcoholic fatty liver disease (NAFLD) with hepatocellular carcinoma (HCC) in the United States from 2004 to 2009. Hepatology. 62:1723–1730. 2015. View Article : Google Scholar : PubMed/NCBI
2	Lee JM, Park JW and Choi BI: 2014 KLCSG-NCC Korea Practice Guidelines for the management of hepatocellular carcinoma: HCC diagnostic algorithm. Dig Dis. 32:764–777. 2014. View Article : Google Scholar : PubMed/NCBI
3	Kew MC: Hepatocellular carcinoma: Epidemiology and risk factors. J Hepatocell Carcinoma. 1:115–125. 2014. View Article : Google Scholar : PubMed/NCBI
4	Hann HW, Coben R, Brown D, Needleman L, Rosato E, Min A, Hann RS, Park KB, Dunn S and DiMarino AJ: A long-term study of the effects of antiviral therapy on survival of patients with HBV-associated hepatocellular carcinoma (HCC) following local tumor ablation. Cancer Med. 3:390–396. 2014. View Article : Google Scholar : PubMed/NCBI
5	Vardal J, Salo RA, Larsson C, Dale AM, Holland D, Groote IR and Bjørnerud A: Correction of B0-distortions in echo-planar-imaging-based perfusion-weighted MRI. J Magn Reson Imaging. 39:722–728. 2014. View Article : Google Scholar : PubMed/NCBI
6	Yu MH, Kim JH, Yoon JH, Kim HC, Chung JW, Han JK and Choi BI: Small (≤1-cm) hepatocellular carcinoma: Diagnostic performance and imaging features at gadoxetic acid-enhanced MR imaging. Radiology. 271:748–760. 2014. View Article : Google Scholar : PubMed/NCBI
7	Jiang N, Xie B, Zhang X, He M, Li K, Bai J, Wang Z, He J and Zhang L: Enhancing ablation effects of a microbubble-enhancing contrast agent (‘SonoVue’) in the treatment of uterine fibroids with high-intensity focused ultrasound: A randomized controlled trial. Cardiovasc Intervent Radiol. 37:1321–1328. 2014. View Article : Google Scholar : PubMed/NCBI
8	Bends R, Brössner A, Felberbaum R and Römer T: Myoma in statu nascendi after transcervical radiofrequency ablation of a transmural uterine leiomyoma. Gynakologische Endokrinologie. 14:291–294. 2016.(In German). View Article : Google Scholar
9	Wang W, Liu JY, Yang Z, Wang YF, Shen SL, Yi FL, Huang Y, Xu EJ, Xie XY, Lu MD, et al: Hepatocellular adenoma: Comparison between real-time contrast-enhanced ultrasound and dynamic computed tomography. Springerplus. 5:9512016. View Article : Google Scholar : PubMed/NCBI
10	Sung JY, Baek JH, Jung SL, Kim JH, Kim KS, Lee D, Kim WB and Na DG: Radiofrequency ablation for autonomously functioning thyroid nodules: A multicenter study. Thyroid. 25:112–117. 2015. View Article : Google Scholar : PubMed/NCBI
11	Ikai I, Arii S, Okazaki M, Okita K, Omata M, Kojiro M, Takayasu K, Nakanuma Y, Makuuchi M, Matsuyama Y, et al: Report of the 17th nationwide follow-up survey of primary liver cancer in japan. Hepatol Res. 37:676–691. 2007. View Article : Google Scholar : PubMed/NCBI
12	Hung HH, Chao Y, Chiou YY, Li CP, Lee RC, Huo TI, Huang YH, Chau GY, Su CW, Yeh YC, et al: A comparison of clinical manifestations and prognoses between patients with hepatocellular carcinoma and Child-Pugh scores of 5 or 6. Medicine (Baltimore). 93:e3482014. View Article : Google Scholar : PubMed/NCBI
13	Liu F, Wang J, Chang H, Lu J and Li H: Relevance between HLA-DP gene rs2281388 polymorphism and hepatocellular carcinoma risk. Int J Clin Exp Pathol. 8:7431–7435. 2015.PubMed/NCBI
14	Hong YM, Yoon KT, Cho M, Heo J, Woo HY and Lim W: A case of small hepatocellular carcinoma with an extensive lymph node metastasis at diagnosis. Clin Mol Hepatol. 20:310–312. 2014. View Article : Google Scholar : PubMed/NCBI
15	Chou CT, Chen RC, Lin WC, Ko CJ, Chen CB and Chen YL: Prediction of microvascular invasion of hepatocellular carcinoma: Preoperative CT and histopathologic correlation. AJR Am J Roentgenol. 203:W253–W259. 2014. View Article : Google Scholar : PubMed/NCBI
16	George RT, Mehra VC, Chen MY, Kitagawa K, Arbab-Zadeh A, Miller JM, Matheson MB, Vavere AL, Kofoed KF, Rochitte CE, et al: Myocardial CT perfusion imaging and SPECT for the diagnosis of coronary artery disease: A head-to-head comparison from the CORE320 multicenter diagnostic performance study. Radiology. 272:407–416. 2014. View Article : Google Scholar : PubMed/NCBI
17	Liu J-J, Li H-X, Chen Z-B, Yang W-P, Zhao S-F, Chen J, Bai T, Li H and Li L-Q: Consistency analysis of contrast-enhanced ultrasound and contrast-enhanced CT in diagnosis of small hepatocellular carcinoma. Int J Clin Exp Med. 8:21466–21471. 2015.PubMed/NCBI
18	Trenker C, Neesse A and Görg C: Sonographic patterns of renal lymphoma in B-mode imaging and in contrast-enhanced ultrasound (CEUS) - a retrospective evaluation. Eur J Radiol. 84:807–810. 2015. View Article : Google Scholar : PubMed/NCBI
19	Zhang ZG, Zhang WG, Wu YH, Liang HF, Zhang BX and Chen XP: Incomplete RFA-generated heat shock response provokes colorectal cancer liver metastases (CRLMs) recurrence by inducing cancer cell stemness and invasion. Mol Cancer Res. 13(10 Suppl): Abst B472015. View Article : Google Scholar
20	Bo XW, Xu HX, Sun LP, Zheng SG, Guo LH, Lu F, Wu J and Xu XH: Bipolar radiofrequency ablation for liver tumors: Comparison of contrast-enhanced ultrasound with contrast-enhanced MRI/CT in the posttreatment imaging evaluation. Int J Clin Exp Pathol. 7:6108–6116. 2014.PubMed/NCBI