Open Access

Hint1 expression inhibits proliferation and promotes radiosensitivity of human SGC7901 gastric cancer cells

  • Authors:
    • Xiaowei Wei
    • Jin Zhou
    • Lingzhi Hong
    • Zhi Xu
    • Huanyu Zhao
    • Xiaomin Wu
    • Jinfei Chen
  • View Affiliations

  • Published online on: June 5, 2018     https://doi.org/10.3892/ol.2018.8900
  • Pages: 2135-2142
  • Copyright: © Wei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Gastric cancer is a prevalent, malignant tumor that frequently escapes treatment. Histidine triad nucleotide‑binding protein 1 (Hint1) is a haploinsufficient tumor suppressor gene which contributes to intercellular communication, helps to regulate cell proliferation and survival, and is frequently underexpressed in gastric cancer. To examine the involvement of Hint1 in gastric cancer, small interfering RNA was used to knock down Hint1 expression in the human gastric cancer cell line SGC‑7901. The data revealed that Hint1 inhibited cell proliferation, reduced radiation‑induced DNA damage repair and caused G1 phase arrest, which increased the radiosensitivity of gastric cancer cells. Further mechanistic studies revealed a novel function of Hint1, whereby it acted as a negative regulator of extracellular signal‑regulated kinase. These results demonstrated the critical function of Hint1 in the biology of human gastric cancer. Acting as a tumor growth suppressor and a radiosensitive agent, this protein is a potential biomarker and may be an attractive target for specific therapeutic interventions against gastric cancer.
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August-2018
Volume 16 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Wei X, Zhou J, Hong L, Xu Z, Zhao H, Wu X and Chen J: Hint1 expression inhibits proliferation and promotes radiosensitivity of human SGC7901 gastric cancer cells. Oncol Lett 16: 2135-2142, 2018
APA
Wei, X., Zhou, J., Hong, L., Xu, Z., Zhao, H., Wu, X., & Chen, J. (2018). Hint1 expression inhibits proliferation and promotes radiosensitivity of human SGC7901 gastric cancer cells. Oncology Letters, 16, 2135-2142. https://doi.org/10.3892/ol.2018.8900
MLA
Wei, X., Zhou, J., Hong, L., Xu, Z., Zhao, H., Wu, X., Chen, J."Hint1 expression inhibits proliferation and promotes radiosensitivity of human SGC7901 gastric cancer cells". Oncology Letters 16.2 (2018): 2135-2142.
Chicago
Wei, X., Zhou, J., Hong, L., Xu, Z., Zhao, H., Wu, X., Chen, J."Hint1 expression inhibits proliferation and promotes radiosensitivity of human SGC7901 gastric cancer cells". Oncology Letters 16, no. 2 (2018): 2135-2142. https://doi.org/10.3892/ol.2018.8900