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Hypermethylation of normal mucosa of esophagus‑specific 1 is associated with an unfavorable prognosis in patients with non‑small cell lung cancer

  • Authors:
    • Dong Sun Kim
    • Won Kee Lee
    • Jae Yong Park
  • View Affiliations / Copyright

    Affiliations: Department of Anatomy, BK21 Plus KNU Biomedical Convergence Program, School of Medicine, Kyungpook National University, Daegu 702‑422, Republic of Korea, Department of Preventive Medicine, School of Medicine, Kyungpook National University, Daegu 702‑422, Republic of Korea, Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu 702‑422, Republic of Korea
    Copyright: © Kim et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2409-2415
    |
    Published online on: June 6, 2018
       https://doi.org/10.3892/ol.2018.8915
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Abstract

Lung cancer is the leading cause of cancer‑associated mortality due to high incidence and poor survival rates, irrespective of global variations in its biology and treatment. Changes in DNA methylation are frequent in cancer and constitute an important mechanism in tumorigenesis. Normal mucosa of esophagus‑specific 1 (NMES1) is expressed in epithelial tissue and is believed to be a tumor suppressor gene. The present study investigated the methylation status of the NMES1 promoter in 178 cases of primary non‑small cell lung cancer (NSCLC) by pyrosequencing and evaluated the prognostic value of this methylation. NMES1 methylation‑positive tumors above the background threshold for non‑malignant tissue were found in 15 cases (8.4%) and were detected exclusively in malignant tissues. In addition, univariate and multivariate analyses showed that methylation‑positive patients experienced worse overall survival rate (OSR) compared with methylation‑negative patients (adjusted hazard ratio, 2.62; 95% confidence interval, 1.20‑5.69; P=0.02). Notably, within the methylation‑positive group, patients with strong methylation tended to experience worse OSR compared with those with weak methylation (adjusted hazard ratio, 2.45 vs. 3.05; Ptrend=0.02). These findings suggest that NMES1 may serve an important role in lung cancer pathogenesis, and its methylation could be considered a prognostic marker for NSCLC. Further studies with large numbers of samples are required to confirm this conclusion.
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Copy and paste a formatted citation
Spandidos Publications style
Kim DS, Lee WK and Park JY: Hypermethylation of normal mucosa of esophagus‑specific 1 is associated with an unfavorable prognosis in patients with non‑small cell lung cancer. Oncol Lett 16: 2409-2415, 2018.
APA
Kim, D.S., Lee, W.K., & Park, J.Y. (2018). Hypermethylation of normal mucosa of esophagus‑specific 1 is associated with an unfavorable prognosis in patients with non‑small cell lung cancer. Oncology Letters, 16, 2409-2415. https://doi.org/10.3892/ol.2018.8915
MLA
Kim, D. S., Lee, W. K., Park, J. Y."Hypermethylation of normal mucosa of esophagus‑specific 1 is associated with an unfavorable prognosis in patients with non‑small cell lung cancer". Oncology Letters 16.2 (2018): 2409-2415.
Chicago
Kim, D. S., Lee, W. K., Park, J. Y."Hypermethylation of normal mucosa of esophagus‑specific 1 is associated with an unfavorable prognosis in patients with non‑small cell lung cancer". Oncology Letters 16, no. 2 (2018): 2409-2415. https://doi.org/10.3892/ol.2018.8915
Copy and paste a formatted citation
x
Spandidos Publications style
Kim DS, Lee WK and Park JY: Hypermethylation of normal mucosa of esophagus‑specific 1 is associated with an unfavorable prognosis in patients with non‑small cell lung cancer. Oncol Lett 16: 2409-2415, 2018.
APA
Kim, D.S., Lee, W.K., & Park, J.Y. (2018). Hypermethylation of normal mucosa of esophagus‑specific 1 is associated with an unfavorable prognosis in patients with non‑small cell lung cancer. Oncology Letters, 16, 2409-2415. https://doi.org/10.3892/ol.2018.8915
MLA
Kim, D. S., Lee, W. K., Park, J. Y."Hypermethylation of normal mucosa of esophagus‑specific 1 is associated with an unfavorable prognosis in patients with non‑small cell lung cancer". Oncology Letters 16.2 (2018): 2409-2415.
Chicago
Kim, D. S., Lee, W. K., Park, J. Y."Hypermethylation of normal mucosa of esophagus‑specific 1 is associated with an unfavorable prognosis in patients with non‑small cell lung cancer". Oncology Letters 16, no. 2 (2018): 2409-2415. https://doi.org/10.3892/ol.2018.8915
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