MicroRNA‑205 is downregulated in hepatocellular carcinoma and inhibits cell growth and metastasis via directly targeting vascular endothelial growth factor A

Zhao,Xuya; Zhou,Shi; Wang,Dazhi; He,Wei; Li,Junxiang; Zhang,Shuai

doi:10.3892/ol.2018.8933

MicroRNA‑205 is downregulated in hepatocellular carcinoma and inhibits cell growth and metastasis via directly targeting vascular endothelial growth factor A

Authors:
- Xuya Zhao
- Shi Zhou
- Dazhi Wang
- Wei He
- Junxiang Li
- Shuai Zhang
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Affiliations: Department of Interventional Radiology, Guizhou Cancer Hospital, Cancer Hospital of Guizhou Medical University, Guiyang, Guizhou 550003, P.R. China
Published online on: June 8, 2018 https://doi.org/10.3892/ol.2018.8933
Pages: 2207-2214

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Abstract

MicroRNAs (miRs) are an emerging class of non‑coding, endogenous and small RNA molecules that serve important functions in tumorigenesis and development. The present study investigated the expression, functions and molecular mechanism underlying miR‑205 in hepatocellular carcinoma. miR‑205 was downregulated in hepatocellular carcinoma tissues and cell lines. Ectopic miR‑205 expression suppressed hepatocellular carcinoma cell proliferation, migration and invasion in vitro. In addition, vascular endothelial growth factor A (VEGFA) was identified as a functional downstream target of miR‑205 in hepatocellular carcinoma. Furthermore, knockdown of VEGFA revealed the same functions with miR‑205 overexpression in hepatocellular carcinoma cells. These results provided evidence that miR‑205 served important functions in the inhibition of hepatocellular carcinoma cells growth and metastasis via directly targeting VEGFA, which indicated that miR‑205 may have therapeutic value for hepatocellular carcinoma.

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