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Article Open Access

miR‑210 promotes human osteosarcoma cell migration and invasion by targeting FGFRL1

  • Authors:
    • Xiangjun Liu
    • Chengfeng Zhang
    • Cunhua Wang
    • Jianwei Sun
    • Deliang Wang
    • Yansheng Zhao
    • Xiaohui Xu
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, The People's Hospital of Qingdao West Coast New Area, Qingdao, Shandong 266400, P.R. China
  • Pages: 2229-2236
    |
    Published online on: June 11, 2018
       https://doi.org/10.3892/ol.2018.8939
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Abstract

Osteosarcoma is a common bone tumor and a frequently occuring cancer‑associated threat to children. Notably, the prognosis of osteosarcoma is very poor when it is diagnosed with metastasis. A growing number of studies have indicated that various microRNAs (miRs) serve important regulatory roles in the pathogeny of different types of cancer. However, the functions of miR‑210 in osteosarcoma need to be elucidated comprehensively. The aim of the present study was to investigate the potential roles of miR‑210 in osteosarcoma by targeting fibroblast growth factor receptor‑like 1 (FGFRL1). Reverse transcription‑quantitative polymerase chain reaction results revealed that the expression of miR‑210 was highly elevated while FGFRL1 expression was reduced inversely in osteosarcoma tissues compared with matched normal tissues. The results of Transwell assays showed that miR‑210 promoted osteosarcoma cell migration and invasion. Furthermore, the luciferase reporter assay results suggested that miR‑210 could directly bind to FGFRL1 in osteosarcoma cells. In addition, the present findings demonstrated that miR‑210 could negatively regulate FGFRL1 expression by targeting the 3'untranslated region. In conclusion, the findings of the present study suggested that miR‑210 exerted tumor carcinogenic functions in osteosarcoma by targeting FGFRL1. The findings of this study demonstrated that FGFRL1 was a direct target of miR‑210 in osteosarcoma involved in the promoting functions mediated by miR‑210 in the invasion and migration of osteosarcoma, suggesting that miR‑210/FGFRL1 may be promising for discovering diagnostic and prognostic biomarkers for the therapies of osteosarcoma.
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Copy and paste a formatted citation
Spandidos Publications style
Liu X, Zhang C, Wang C, Sun J, Wang D, Zhao Y and Xu X: miR‑210 promotes human osteosarcoma cell migration and invasion by targeting FGFRL1. Oncol Lett 16: 2229-2236, 2018.
APA
Liu, X., Zhang, C., Wang, C., Sun, J., Wang, D., Zhao, Y., & Xu, X. (2018). miR‑210 promotes human osteosarcoma cell migration and invasion by targeting FGFRL1. Oncology Letters, 16, 2229-2236. https://doi.org/10.3892/ol.2018.8939
MLA
Liu, X., Zhang, C., Wang, C., Sun, J., Wang, D., Zhao, Y., Xu, X."miR‑210 promotes human osteosarcoma cell migration and invasion by targeting FGFRL1". Oncology Letters 16.2 (2018): 2229-2236.
Chicago
Liu, X., Zhang, C., Wang, C., Sun, J., Wang, D., Zhao, Y., Xu, X."miR‑210 promotes human osteosarcoma cell migration and invasion by targeting FGFRL1". Oncology Letters 16, no. 2 (2018): 2229-2236. https://doi.org/10.3892/ol.2018.8939
Copy and paste a formatted citation
x
Spandidos Publications style
Liu X, Zhang C, Wang C, Sun J, Wang D, Zhao Y and Xu X: miR‑210 promotes human osteosarcoma cell migration and invasion by targeting FGFRL1. Oncol Lett 16: 2229-2236, 2018.
APA
Liu, X., Zhang, C., Wang, C., Sun, J., Wang, D., Zhao, Y., & Xu, X. (2018). miR‑210 promotes human osteosarcoma cell migration and invasion by targeting FGFRL1. Oncology Letters, 16, 2229-2236. https://doi.org/10.3892/ol.2018.8939
MLA
Liu, X., Zhang, C., Wang, C., Sun, J., Wang, D., Zhao, Y., Xu, X."miR‑210 promotes human osteosarcoma cell migration and invasion by targeting FGFRL1". Oncology Letters 16.2 (2018): 2229-2236.
Chicago
Liu, X., Zhang, C., Wang, C., Sun, J., Wang, D., Zhao, Y., Xu, X."miR‑210 promotes human osteosarcoma cell migration and invasion by targeting FGFRL1". Oncology Letters 16, no. 2 (2018): 2229-2236. https://doi.org/10.3892/ol.2018.8939
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