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Monitoring immunoglobulin heavy chain and T‑cell receptor gene rearrangement in cfDNA as minimal residual disease detection for patients with acute myeloid leukemia

  • Authors:
    • Ling Zhong
    • Jiao Chen
    • Xiaobing Huang
    • Yanxing Li
    • Tao Jiang
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory, Sichuan Academy of Medical Science, Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, P.R. China, Department of Hematology, Sichuan Academy of Medical Science, Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, P.R. China
    Copyright: © Zhong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2279-2288
    |
    Published online on: June 13, 2018
       https://doi.org/10.3892/ol.2018.8966
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Abstract

The present study aimed to examine whether monoclonal immunoglobulin heavy chain (IGH) or T‑cell receptor (TCR) gene rearrangement in cell‑free DNA (cfDNA) may be used for minimal residual disease (MRD) monitoring in patients with acute myeloid leukemia (AML). Monoclonal IGH and TCR rearrangement in cfDNA were monitored in patients with AML. A total of 94 (40%) patients had monoclonal IGH or TCR rearrangements in cfDNA at diagnosis; 84% of these patients (79 cases) achieved complete remission following 1‑3 courses of induction chemotherapy. Among these cases, 89.9% were negative for monoclonal IGH or TCR rearrangement in cfDNA following consolidation chemotherapies. A total of 8 patients with consistently positive monoclonal IGH or TCR rearrangement in cfDNA relapsed within 6‑10 months. During follow up, 39 patients demonstrated positive monoclonal IGH or TCR rearrangement in cfDNA and relapsed. Recurrence of monoclonal IGH or TCR rearrangement in cfDNA was observed 1‑3 months earlier than bone marrow relapse and 11 patients with solitary extramedullary relapse demonstrated positive monoclonal IGH or TCR rearrangement recurrence in cfDNA. In conclusion, the detection of monoclonal IGH and TCR rearrangement in cfDNA may represent a useful tool for MRD monitoring in patients with AML.
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Copy and paste a formatted citation
Spandidos Publications style
Zhong L, Chen J, Huang X, Li Y and Jiang T: Monitoring immunoglobulin heavy chain and T‑cell receptor gene rearrangement in cfDNA as minimal residual disease detection for patients with acute myeloid leukemia. Oncol Lett 16: 2279-2288, 2018.
APA
Zhong, L., Chen, J., Huang, X., Li, Y., & Jiang, T. (2018). Monitoring immunoglobulin heavy chain and T‑cell receptor gene rearrangement in cfDNA as minimal residual disease detection for patients with acute myeloid leukemia. Oncology Letters, 16, 2279-2288. https://doi.org/10.3892/ol.2018.8966
MLA
Zhong, L., Chen, J., Huang, X., Li, Y., Jiang, T."Monitoring immunoglobulin heavy chain and T‑cell receptor gene rearrangement in cfDNA as minimal residual disease detection for patients with acute myeloid leukemia". Oncology Letters 16.2 (2018): 2279-2288.
Chicago
Zhong, L., Chen, J., Huang, X., Li, Y., Jiang, T."Monitoring immunoglobulin heavy chain and T‑cell receptor gene rearrangement in cfDNA as minimal residual disease detection for patients with acute myeloid leukemia". Oncology Letters 16, no. 2 (2018): 2279-2288. https://doi.org/10.3892/ol.2018.8966
Copy and paste a formatted citation
x
Spandidos Publications style
Zhong L, Chen J, Huang X, Li Y and Jiang T: Monitoring immunoglobulin heavy chain and T‑cell receptor gene rearrangement in cfDNA as minimal residual disease detection for patients with acute myeloid leukemia. Oncol Lett 16: 2279-2288, 2018.
APA
Zhong, L., Chen, J., Huang, X., Li, Y., & Jiang, T. (2018). Monitoring immunoglobulin heavy chain and T‑cell receptor gene rearrangement in cfDNA as minimal residual disease detection for patients with acute myeloid leukemia. Oncology Letters, 16, 2279-2288. https://doi.org/10.3892/ol.2018.8966
MLA
Zhong, L., Chen, J., Huang, X., Li, Y., Jiang, T."Monitoring immunoglobulin heavy chain and T‑cell receptor gene rearrangement in cfDNA as minimal residual disease detection for patients with acute myeloid leukemia". Oncology Letters 16.2 (2018): 2279-2288.
Chicago
Zhong, L., Chen, J., Huang, X., Li, Y., Jiang, T."Monitoring immunoglobulin heavy chain and T‑cell receptor gene rearrangement in cfDNA as minimal residual disease detection for patients with acute myeloid leukemia". Oncology Letters 16, no. 2 (2018): 2279-2288. https://doi.org/10.3892/ol.2018.8966
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