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Article Open Access

miR-185 inhibits cell migration and invasion of hepatocellular carcinoma through CDC42

Erratum in: /10.3892/ol.2019.11186
  • Authors:
    • Qingjun Zhang
    • Yun Chen
    • Ke Liu
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary Surgery, Central Hospital of Zibo, Zibo, Shandong 255000, P.R. China, Central Sterile Supply Department, Central Hospital of Zibo, Zibo, Shandong 255000, P.R. China
  • Pages: 3101-3107
    |
    Published online on: June 15, 2018
       https://doi.org/10.3892/ol.2018.8971
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Abstract

Hepatocellular carcinoma (HCC) is a primary liver cancer with high incidence and mortality. miR-185, a microRNA with appriximately 22-28 nucleotides, was reported to be involved in many cancers. The potential mechanism of miR-185 on HCC through cell division cycle 42 (CDC42) was investigated. RT-qPCR was used to measure the RNA level of miR-185 and CDC42 in HCC tissues and cells. The dual luciferase reporter assay was used to verify whether CDC42 was a target gene for miR-185. Transwell assay was employed to detect the ability of migration and invasion to change miR-185. miR-185 expression was low in HCC and negatively correlated with CDC42. miR-185 inhibited HCC migration, invasion and miR-185 low expression predicted poor prognosis. CDC42 was predicted to be a target gene for miR-185, and regulated by miR-185. miR-185 suspressed the ability of cell migration and invasion through CDC42 in HCC. In conclusion, miR-185 suspressed migration and invasion of HCC cells by directly targeting CDC42. It is suggested that miR-185/CDC42 axis may present a novel target for HCC treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang Q, Chen Y and Liu K: miR-185 inhibits cell migration and invasion of hepatocellular carcinoma through CDC42 Erratum in /10.3892/ol.2019.11186. Oncol Lett 16: 3101-3107, 2018.
APA
Zhang, Q., Chen, Y., & Liu, K. (2018). miR-185 inhibits cell migration and invasion of hepatocellular carcinoma through CDC42 Erratum in /10.3892/ol.2019.11186. Oncology Letters, 16, 3101-3107. https://doi.org/10.3892/ol.2018.8971
MLA
Zhang, Q., Chen, Y., Liu, K."miR-185 inhibits cell migration and invasion of hepatocellular carcinoma through CDC42 Erratum in /10.3892/ol.2019.11186". Oncology Letters 16.3 (2018): 3101-3107.
Chicago
Zhang, Q., Chen, Y., Liu, K."miR-185 inhibits cell migration and invasion of hepatocellular carcinoma through CDC42 Erratum in /10.3892/ol.2019.11186". Oncology Letters 16, no. 3 (2018): 3101-3107. https://doi.org/10.3892/ol.2018.8971
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Q, Chen Y and Liu K: miR-185 inhibits cell migration and invasion of hepatocellular carcinoma through CDC42 Erratum in /10.3892/ol.2019.11186. Oncol Lett 16: 3101-3107, 2018.
APA
Zhang, Q., Chen, Y., & Liu, K. (2018). miR-185 inhibits cell migration and invasion of hepatocellular carcinoma through CDC42 Erratum in /10.3892/ol.2019.11186. Oncology Letters, 16, 3101-3107. https://doi.org/10.3892/ol.2018.8971
MLA
Zhang, Q., Chen, Y., Liu, K."miR-185 inhibits cell migration and invasion of hepatocellular carcinoma through CDC42 Erratum in /10.3892/ol.2019.11186". Oncology Letters 16.3 (2018): 3101-3107.
Chicago
Zhang, Q., Chen, Y., Liu, K."miR-185 inhibits cell migration and invasion of hepatocellular carcinoma through CDC42 Erratum in /10.3892/ol.2019.11186". Oncology Letters 16, no. 3 (2018): 3101-3107. https://doi.org/10.3892/ol.2018.8971
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