MicroRNA‑21: A promising biomarker for the prognosis and diagnosis of non‑small cell lung cancer (Review)

  • Authors:
    • Wen Zheng
    • Juanjuan Zhao
    • Yijing Tao
    • Mengmeng Guo
    • Zhou Ya
    • Chao Chen
    • Nalin Qin
    • Jing Zheng
    • Junmin Luo
    • Lin Xu
  • View Affiliations

  • Published online on: June 15, 2018     https://doi.org/10.3892/ol.2018.8972
  • Pages: 2777-2782
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Abstract

Non‑small cell lung cancer (NSCLC) is the most common subtype of lung cancer worldwide. The high mortality rate of NSCLC is due to a limited number of diagnosis being made at an early stage of disease. Therefore, the development of a novel biological marker for the diagnosis and prognosis prediction of NSCLC remains urgent. Current literature shows that microRNA‑21 (miRNA‑21/miR‑21), as an oncogenic miRNA, is involved in the growth, metastasis and apoptosis of NSCLC cells through its control of various target molecules and signaling pathways. Notably, a growing body of evidence further shows that miR‑21 is closely associated with the prognosis prediction, recurrence and diagnosis of cancer patients, indicating that miR‑21 may be a novel promising biomarker for the diagnosis and prognosis prediction of NSCLC. The present review aimed to provide a summary of recent findings on the associated progression toward finding a novel biomarker for NSCLC.
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September-2018
Volume 16 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Zheng W, Zhao J, Tao Y, Guo M, Ya Z, Chen C, Qin N, Zheng J, Luo J, Xu L, Xu L, et al: MicroRNA‑21: A promising biomarker for the prognosis and diagnosis of non‑small cell lung cancer (Review). Oncol Lett 16: 2777-2782, 2018
APA
Zheng, W., Zhao, J., Tao, Y., Guo, M., Ya, Z., Chen, C. ... Xu, L. (2018). MicroRNA‑21: A promising biomarker for the prognosis and diagnosis of non‑small cell lung cancer (Review). Oncology Letters, 16, 2777-2782. https://doi.org/10.3892/ol.2018.8972
MLA
Zheng, W., Zhao, J., Tao, Y., Guo, M., Ya, Z., Chen, C., Qin, N., Zheng, J., Luo, J., Xu, L."MicroRNA‑21: A promising biomarker for the prognosis and diagnosis of non‑small cell lung cancer (Review)". Oncology Letters 16.3 (2018): 2777-2782.
Chicago
Zheng, W., Zhao, J., Tao, Y., Guo, M., Ya, Z., Chen, C., Qin, N., Zheng, J., Luo, J., Xu, L."MicroRNA‑21: A promising biomarker for the prognosis and diagnosis of non‑small cell lung cancer (Review)". Oncology Letters 16, no. 3 (2018): 2777-2782. https://doi.org/10.3892/ol.2018.8972