Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
September-2018 Volume 16 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2018 Volume 16 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review

MicroRNA‑21: A promising biomarker for the prognosis and diagnosis of non‑small cell lung cancer (Review)

  • Authors:
    • Wen Zheng
    • Juanjuan Zhao
    • Yijing Tao
    • Mengmeng Guo
    • Zhou Ya
    • Chao Chen
    • Nalin Qin
    • Jing Zheng
    • Junmin Luo
    • Lin Xu
  • View Affiliations / Copyright

    Affiliations: Department of Immunology, Zunyi Medical College, Zunyi, Guizhou 563000, P.R. China, Department of Medical Physics, Zunyi Medical College, Zunyi, Guizhou 563000, P.R. China
  • Pages: 2777-2782
    |
    Published online on: June 15, 2018
       https://doi.org/10.3892/ol.2018.8972
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Non‑small cell lung cancer (NSCLC) is the most common subtype of lung cancer worldwide. The high mortality rate of NSCLC is due to a limited number of diagnosis being made at an early stage of disease. Therefore, the development of a novel biological marker for the diagnosis and prognosis prediction of NSCLC remains urgent. Current literature shows that microRNA‑21 (miRNA‑21/miR‑21), as an oncogenic miRNA, is involved in the growth, metastasis and apoptosis of NSCLC cells through its control of various target molecules and signaling pathways. Notably, a growing body of evidence further shows that miR‑21 is closely associated with the prognosis prediction, recurrence and diagnosis of cancer patients, indicating that miR‑21 may be a novel promising biomarker for the diagnosis and prognosis prediction of NSCLC. The present review aimed to provide a summary of recent findings on the associated progression toward finding a novel biomarker for NSCLC.
View Figures

Figure 1

View References

1 

Lagos-Quintana M, Rauhut R, Lendeckel W and Tuschl T: Identification of novel genes coding for small expressed RNAs. Science. 294:853–858. 2001. View Article : Google Scholar : PubMed/NCBI

2 

Chen Z, Liu H, Jin W, Ding Z, Zheng S and Yu Y: Tissue microRNA-21 expression predicted recurrence and poor survival in patients with colorectal cancer-a meta-analysis. Onco Targets Ther. 9:2615–2624. 2016.PubMed/NCBI

3 

Gao Y, Cai Q, Huang Y, Li S, Yang H, Sun L, Chen K and Wang Y: MicroRNA-21 as a potential diagnostic biomarker for breast cancer patients: A pooled analysis of individual studies. Oncotarget. 7:34498–34506. 2016.PubMed/NCBI

4 

Wu ZH, Tao ZH, Zhang J, Li T, Ni C, Xie J, Zhang JF and Hu XC: MiRNA-21 induces epithelial to mesenchymal transition and gemcitabine resistance via the PTEN/AKT pathway in breast cancer. Tumour Biol. 37:7245–7254. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Hu GY, Tao F, Wang W and Ji KW: Prognostic value of microRNA-21 in pancreatic ductal adenocarcinoma: A meta-analysis. World J Surg Oncol. 14:822016. View Article : Google Scholar : PubMed/NCBI

6 

Jiang S, Wang R, Yan H, Jin L, Dou X and Chen D: MicroRNA-21 modulates radiation resistance through upregulation of hypoxia-inducible factor-1α-promoted glycolysis in non-small cell lung cancer cells. Mol Med Rep. 13:4101–4107. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Yan J, Liu T, Zhou X, Dang Y, Yin C and Zhang G: FZD6, targeted by miR-21, represses gastric cancer cell proliferation and migration via activating non-canonical wnt pathway. Am J Transl Res. 8:2354–2364. 2016.PubMed/NCBI

8 

Tao YJ, Li YJ, Zheng W, Zhao JJ, Guo MM, Zhou Y, Qin NL, Zheng J and Xu L: Antisense oligonucleotides against microRNA-21 reduced the proliferation and migration of human colon carcinoma cells. Cancer Cell Int. 15:772015. View Article : Google Scholar : PubMed/NCBI

9 

Sha M, Ye J, Luan ZY, Guo T, Wang B and Huang JX: Celastrol induces cell cycle arrest by MicroRNA-21-mTOR-mediated inhibition p27 protein degradation in gastric cancer. Cancer Cell Int. 15:1012015. View Article : Google Scholar : PubMed/NCBI

10 

Husakova M: MicroRNAs in the key events of systemic lupus erythematosus pathogenesis. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 160:327–342. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Sanders KA, Benton MC, Lea RA, Maltby VE, Agland S, Griffin N, Scott RJ, Tajouri L and Lechner-Scott J: Next-generation sequencing reveals broad down-regulation of microRNAs in secondary progressive multiple sclerosis CD4+ T cells. Clin Epigenetics. 8:872016. View Article : Google Scholar : PubMed/NCBI

12 

Zhao XY and Shao K: Roles of MicroRNA-21 in the pathogenesis of insulin resistance and diabetic mellitus-induced non-alcoholic fatty liver disease. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 38:144–149. 2016.(In Chinese). PubMed/NCBI

13 

Sekar D, Venugopal B, Sekar P and Ramalingam K: Role of microRNA 21 in diabetes and associated/related diseases. Gene. 582:14–18. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Guo Q, Zhang H, Zhang L, He Y, Weng S, Dong Z, Wang J, Zhang P and Nao R: MicroRNA-21 regulates non-small cell lung cancer cell proliferation by affecting cell apoptosis via COX-19. Int J Clin Exp Med. 8:8835–8841. 2015.PubMed/NCBI

15 

Li X, Zang A, Jia Y, Zhang J, Fan W, Feng J, Duan M, Zhang L, Huo R, Jiao J and Zhu X: Triptolide reduces proliferation and enhances apoptosis of human non-small cell lung cancer cells through PTEN by targeting miR-21. Mol Med Rep. 13:2763–2768. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Yang Y, Meng H, Peng Q, Yang X, Gan R, Zhao L, Chen Z, Lu J and Meng QH: Downregulation of microRNA-21 expression restrains non-small cell lung cancer cell proliferation and migration through upregulation of programmed cell death 4. Cancer Gene Ther. 22:23–29. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Boldrini L, Giordano M, Ali G, Melfi F, Romano G, Lucchi M and Fontanini G: P2X7 mRNA expression in non-small cell lung cancer: MicroRNA regulation and prognostic value. Oncol Lett. 9:449–453. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Yan LX, Liu YH, Xiang JW, Wu QN, Xu LB, Luo XL, Zhu XL, Liu C, Xu FP, Luo DL, et al: PIK3R1 targeting by miR-21 suppresses tumor cell migration and invasion by reducing PI3K/AKT signaling and reversing EMT, and predicts clinical outcome of breast cancer. Int J Oncol. 48:471–484. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Yanaihara N, Caplen N, Bowman E, Seike M, Kumamoto K, Yi M, Stephens RM, Okamoto A, Yokota J, Tanaka T, et al: Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell. 9:189–198. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Saito M, Schetter AJ, Mollerup S, Kohno T, Skaug V, Bowman ED, Mathé EA, Takenoshita S, Yokota J, Haugen A and Harris CC: The association of microRNA expression with prognosis and progression in early-stage, non-small cell lung adenocarcinoma: A retrospective analysis of three cohorts. Clin Cancer Res. 17:1875–1882. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Rami-Porta R, Crowley JJ and Goldstraw P: The revised TNM staging system for lung cancer. Ann Thorac Cardiovasc Surg. 15:4–9. 2009.PubMed/NCBI

22 

Zhu W and Xu B: MicroRNA-21 identified as predictor of cancer outcome: A meta-analysis. PLoS One. 9:e1033732014. View Article : Google Scholar : PubMed/NCBI

23 

Ma XL, Liu L, Liu XX, Li Y, Deng L, Xiao ZL, Liu YT, Shi HS and Wei YQ: Prognostic role of microRNA-21 in non-small cell lung cancer: A meta-analysis. Asian Pac J Cancer Prev. 13:2329–2334. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Cinegaglia NC, Andrade SC, Tokar T, Pinheiro M, Severino FE, Oliveira RA, Hasimoto EN, Cataneo DC, Cataneo AJ, Defaveri J, et al: Integrative transcriptome analysis identifies deregulated microRNA-transcription factor networks in lung adenocarcinoma. Oncotarget. 7:28920–28934. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Tian L, Shan W, Zhang Y, Lv X, Li X and Wei C: Up-regulation of miR-21 expression predicate advanced clinicopathological features and poor prognosis in patients with non-small cell lung cancer. Pathol Oncol Res. 22:161–167. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Vychytilova-Faltejskova P, Radova L, Sachlova M, Kosarova Z, Slaba K, Fabian P, Grolich T, Prochazka V, Kala Z, Svoboda M, et al: Serum-based microRNA signatures in early diagnosis and prognosis prediction of colon cancer. Carcinogenesis. 37:941–950. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Sun L, Jiang R, Li J, Wang B, Ma C, Lv Y and Mu N: MicoRNA-425-5p is a potential prognostic biomarker for cervical cancer. Ann Clin Biochem. 54:127–133. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Jiang X, Du L, Duan W, Wang R, Yan K, Wang L, Li J, Zheng G, Zhang X, Yang Y and Wang C: Serum microRNA expression signatures as novel noninvasive biomarkers for prediction and prognosis of muscle-invasive bladder cancer. Oncotarget. 7:36733–36742. 2016.PubMed/NCBI

29 

Zhu HT, Hasan AM, Liu RB, Zhang ZC, Zhang X, Wang J, Wang HY, Wang F and Shao JY: Serum microRNA profiles as prognostic biomarkers for HBV-positive hepatocellular carcinoma. Oncotarget. 7:45637–45648. 2016.PubMed/NCBI

30 

Wang ZX, Bian HB, Wang JR, Cheng ZX, Wang KM and De W: Prognostic significance of serum miRNA-21 expression in human non-small cell lung cancer. J Surg Oncol. 104:847–851. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Liu XG, Zhu WY, Huang YY, Ma LN, Zhou SQ, Wang YK, Zeng F, Zhou JH and Zhang YK: High expression of serum miR-21 and tumor miR-200c associated with poor prognosis in patients with lung cancer. Med Oncol. 29:618–626. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Zhao W, Zhao JJ, Zhang L, Xu QF, Zhao YM, Shi XY and Xu AG: Serum miR-21 level: A potential diagnostic and prognostic biomarker for non-small cell lung cancer. Int J Clin Exp Med. 8:14759–14763. 2015.PubMed/NCBI

33 

Yang M, Shen H, Qiu C, Ni Y, Wang L, Dong W, Liao Y and Du J: High expression of miR-21 and miR-155 predicts recurrence and unfavourable survival in non-small cell lung cancer. Eur J Cancer. 49:604–615. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Wang Y, Li J, Tong L, Zhang J, Zhai A, Xu K, Wei L and Chu M: The prognostic value of miR-21 and miR-155 in non-small-cell lung cancer: A meta-analysis. Jpn J Clin Oncol. 43:813–820. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Munagala R, Aqil F and Gupta RC: Exosomal miRNAs as biomarkers of recurrent lung cancer. Tumour Biol. 37:10703–10714. 2016. View Article : Google Scholar : PubMed/NCBI

36 

Stenvold H, Donnem T, Andersen S, Al-Saad S, Valkov A, Pedersen MI, Busund LT and Bremnes RM: High tumor cell expression of microRNA-21 in node positive non-small cell lung cancer predicts a favorable clinical outcome. BMC Clin Pathol. 14:92014. View Article : Google Scholar : PubMed/NCBI

37 

Wu R, Jiang Y, Wu Q, Li Q, Cheng D, Xu L, Zhang C, Zhang M and Ye L: Diagnostic value of microRNA-21 in the diagnosis of lung cancer: Evidence from a meta-analysis involving 11 studies. Tumour Biol. 35:8829–8836. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Meng X, Xiao C, Zhao Y, Jia L, Tang Y and Li D: Meta-analysis of microarrays: Diagnostic value of microRNA-21 as a biomarker for lung cancer. Int J Biol Markers. 30:e282–e285. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Tang D, Shen Y, Wang M, Yang R, Wang Z, Sui A, Jiao W and Wang Y: Identification of plasma microRNAs as novel noninvasive biomarkers for early detection of lung cancer. Eur J Cancer Prev. 22:540–548. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Geng Q, Fan T, Zhang B, Wang W, Xu Y and Hu H: Five microRNAs in plasma as novel biomarkers for screening of early-stage non-small cell lung cancer. Respir Res. 15:1492014. View Article : Google Scholar : PubMed/NCBI

41 

Kim JO, Gazala S, Razzak R, Guo L, Ghosh S, Roa WH and Bedard ELR: Non-small cell lung cancer detection using microRNA expression profiling of bronchoalveolar lavage fluid and sputum. Anticancer Res. 35:1873–1880. 2015.PubMed/NCBI

42 

Razzak R, Bédard EL, Kim JO, Gazala S, Guo L, Ghosh S, Joy A, Nijjar T, Wong E and Roa WH: MicroRNA expression profiling of sputum for the detection of early and locally advanced non-small-cell lung cancer: A prospective case-control study. Curr Oncol. 23:e86–e94. 2016. View Article : Google Scholar : PubMed/NCBI

43 

Yang JS, Li BJ, Lu HW, Chen Y, Lu C, Zhu RX, Liu SH, Yi QT, Li J and Song CH: Serum miR-152, miR-148a, miR-148b, and miR-21 as novel biomarkers in non-small cell lung cancer screening. Tumour Biol. 36:3035–3042. 2015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zheng W, Zhao J, Tao Y, Guo M, Ya Z, Chen C, Qin N, Zheng J, Luo J, Xu L, Xu L, et al: MicroRNA‑21: A promising biomarker for the prognosis and diagnosis of non‑small cell lung cancer (Review). Oncol Lett 16: 2777-2782, 2018.
APA
Zheng, W., Zhao, J., Tao, Y., Guo, M., Ya, Z., Chen, C. ... Xu, L. (2018). MicroRNA‑21: A promising biomarker for the prognosis and diagnosis of non‑small cell lung cancer (Review). Oncology Letters, 16, 2777-2782. https://doi.org/10.3892/ol.2018.8972
MLA
Zheng, W., Zhao, J., Tao, Y., Guo, M., Ya, Z., Chen, C., Qin, N., Zheng, J., Luo, J., Xu, L."MicroRNA‑21: A promising biomarker for the prognosis and diagnosis of non‑small cell lung cancer (Review)". Oncology Letters 16.3 (2018): 2777-2782.
Chicago
Zheng, W., Zhao, J., Tao, Y., Guo, M., Ya, Z., Chen, C., Qin, N., Zheng, J., Luo, J., Xu, L."MicroRNA‑21: A promising biomarker for the prognosis and diagnosis of non‑small cell lung cancer (Review)". Oncology Letters 16, no. 3 (2018): 2777-2782. https://doi.org/10.3892/ol.2018.8972
Copy and paste a formatted citation
x
Spandidos Publications style
Zheng W, Zhao J, Tao Y, Guo M, Ya Z, Chen C, Qin N, Zheng J, Luo J, Xu L, Xu L, et al: MicroRNA‑21: A promising biomarker for the prognosis and diagnosis of non‑small cell lung cancer (Review). Oncol Lett 16: 2777-2782, 2018.
APA
Zheng, W., Zhao, J., Tao, Y., Guo, M., Ya, Z., Chen, C. ... Xu, L. (2018). MicroRNA‑21: A promising biomarker for the prognosis and diagnosis of non‑small cell lung cancer (Review). Oncology Letters, 16, 2777-2782. https://doi.org/10.3892/ol.2018.8972
MLA
Zheng, W., Zhao, J., Tao, Y., Guo, M., Ya, Z., Chen, C., Qin, N., Zheng, J., Luo, J., Xu, L."MicroRNA‑21: A promising biomarker for the prognosis and diagnosis of non‑small cell lung cancer (Review)". Oncology Letters 16.3 (2018): 2777-2782.
Chicago
Zheng, W., Zhao, J., Tao, Y., Guo, M., Ya, Z., Chen, C., Qin, N., Zheng, J., Luo, J., Xu, L."MicroRNA‑21: A promising biomarker for the prognosis and diagnosis of non‑small cell lung cancer (Review)". Oncology Letters 16, no. 3 (2018): 2777-2782. https://doi.org/10.3892/ol.2018.8972
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team