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Article

Anticancer effect of salidroside reduces viability through autophagy/PI3K/Akt and MMP‑9 signaling pathways in human bladder cancer cells

  • Authors:
    • Tian Li
    • Kewei Xu
    • Yifan Liu
  • View Affiliations / Copyright

    Affiliations: Department of Urology, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510700, P.R. China, Department of Urology, The Second Affiliated Hospital of Sun Yat‑Sen University, Guangzhou, Guangdong 510120, P.R. China
  • Pages: 3162-3168
    |
    Published online on: June 18, 2018
       https://doi.org/10.3892/ol.2018.8982
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Abstract

Salidroside has a wide range of pharmacological activities, including antitumor, anti‑inflammatory, analgesic, antibacterial, antiviral and anti‑fertility abilities. In the present study, the effects of salidroside on the viability and apoptosis of bladder cancer cells, and the potential underlying mechanisms, were examined. In the present study, treatment with salidroside reduced cell viability, and induced apoptosis and caspase‑9/3 activation in the T24 human bladder carcinoma cell line. Salidroside induced autophagy, promoted the protein expression of nucleoporin p62 and the microtubule‑associated proteins 1A/1B light chain 3B, suppressed phosphoinositide 3‑kinase (PI3K) and phosphorylated protein kinase B (p‑Akt) expression, inhibited matrix metalloproteinase‑9 (MMP‑9) expression and increased that of Bcl‑2‑associated X protein, which functions as an apoptosis regulator in T24 cells. In the present study, it was demonstrated that the effect of salidroside reduced the viability and induced the apoptosis of bladder cancer cells through the autophagy/PI3K/Akt and MMP‑9 signaling pathways.
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Copy and paste a formatted citation
Spandidos Publications style
Li T, Xu K and Liu Y: Anticancer effect of salidroside reduces viability through autophagy/PI3K/Akt and MMP‑9 signaling pathways in human bladder cancer cells. Oncol Lett 16: 3162-3168, 2018.
APA
Li, T., Xu, K., & Liu, Y. (2018). Anticancer effect of salidroside reduces viability through autophagy/PI3K/Akt and MMP‑9 signaling pathways in human bladder cancer cells. Oncology Letters, 16, 3162-3168. https://doi.org/10.3892/ol.2018.8982
MLA
Li, T., Xu, K., Liu, Y."Anticancer effect of salidroside reduces viability through autophagy/PI3K/Akt and MMP‑9 signaling pathways in human bladder cancer cells". Oncology Letters 16.3 (2018): 3162-3168.
Chicago
Li, T., Xu, K., Liu, Y."Anticancer effect of salidroside reduces viability through autophagy/PI3K/Akt and MMP‑9 signaling pathways in human bladder cancer cells". Oncology Letters 16, no. 3 (2018): 3162-3168. https://doi.org/10.3892/ol.2018.8982
Copy and paste a formatted citation
x
Spandidos Publications style
Li T, Xu K and Liu Y: Anticancer effect of salidroside reduces viability through autophagy/PI3K/Akt and MMP‑9 signaling pathways in human bladder cancer cells. Oncol Lett 16: 3162-3168, 2018.
APA
Li, T., Xu, K., & Liu, Y. (2018). Anticancer effect of salidroside reduces viability through autophagy/PI3K/Akt and MMP‑9 signaling pathways in human bladder cancer cells. Oncology Letters, 16, 3162-3168. https://doi.org/10.3892/ol.2018.8982
MLA
Li, T., Xu, K., Liu, Y."Anticancer effect of salidroside reduces viability through autophagy/PI3K/Akt and MMP‑9 signaling pathways in human bladder cancer cells". Oncology Letters 16.3 (2018): 3162-3168.
Chicago
Li, T., Xu, K., Liu, Y."Anticancer effect of salidroside reduces viability through autophagy/PI3K/Akt and MMP‑9 signaling pathways in human bladder cancer cells". Oncology Letters 16, no. 3 (2018): 3162-3168. https://doi.org/10.3892/ol.2018.8982
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