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Article

Anti‑Condyloma acuminata mechanism of microRNAs‑375 modulates HPV in cervical cancer cells via the UBE3A and IGF‑1R pathway

  • Authors:
    • Shuying Wu
    • Hong Chen
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, Tianjin Union Medical Center, Tianjin 300121, P.R. China
  • Pages: 3241-3247
    |
    Published online on: June 18, 2018
       https://doi.org/10.3892/ol.2018.8983
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Abstract

The present study aimed to identify the probable anti‑Condyloma acuminata (CA) mechanism of microRNA‑375 (miRNA‑375) in human papillomavirus (HPV). Firstly, the overexpression of miRNA‑375 significantly suppressed cell proliferation, increased lactate dehydrogenase activity and induced apoptosis in HPV‑18(+) cervical cancer cells. The overexpression of miRNA‑375 significantly increased caspase‑3 and caspase‑9 activities, induced B‑cell lymphoma 2 (Bcl‑2)/Bcl‑2‑associated X protein, tumor protein 53 and cyclin‑dependent kinase inhibitor 1 protein expression and suppressed cyclin D1 and survivin protein expression in HPV‑18(+) cervical cancer cells. The overexpression of miRNA‑375 significantly suppressed the levels of protein expression of ubiquitin‑protein ligase E3A (UBE3A) and Insulin‑like growth factor‑1 receptor (IGF‑1R) in HPV‑18(+) cervical cancer cells. To conclude, it was identified that the probable anti‑CA mechanism of miRNA‑375 modulates HPV through the UBE3A and IGF‑1R pathway in cervical cancer cells.
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Copy and paste a formatted citation
Spandidos Publications style
Wu S and Chen H: Anti‑Condyloma acuminata mechanism of microRNAs‑375 modulates HPV in cervical cancer cells via the UBE3A and IGF‑1R pathway. Oncol Lett 16: 3241-3247, 2018.
APA
Wu, S., & Chen, H. (2018). Anti‑Condyloma acuminata mechanism of microRNAs‑375 modulates HPV in cervical cancer cells via the UBE3A and IGF‑1R pathway. Oncology Letters, 16, 3241-3247. https://doi.org/10.3892/ol.2018.8983
MLA
Wu, S., Chen, H."Anti‑Condyloma acuminata mechanism of microRNAs‑375 modulates HPV in cervical cancer cells via the UBE3A and IGF‑1R pathway". Oncology Letters 16.3 (2018): 3241-3247.
Chicago
Wu, S., Chen, H."Anti‑Condyloma acuminata mechanism of microRNAs‑375 modulates HPV in cervical cancer cells via the UBE3A and IGF‑1R pathway". Oncology Letters 16, no. 3 (2018): 3241-3247. https://doi.org/10.3892/ol.2018.8983
Copy and paste a formatted citation
x
Spandidos Publications style
Wu S and Chen H: Anti‑Condyloma acuminata mechanism of microRNAs‑375 modulates HPV in cervical cancer cells via the UBE3A and IGF‑1R pathway. Oncol Lett 16: 3241-3247, 2018.
APA
Wu, S., & Chen, H. (2018). Anti‑Condyloma acuminata mechanism of microRNAs‑375 modulates HPV in cervical cancer cells via the UBE3A and IGF‑1R pathway. Oncology Letters, 16, 3241-3247. https://doi.org/10.3892/ol.2018.8983
MLA
Wu, S., Chen, H."Anti‑Condyloma acuminata mechanism of microRNAs‑375 modulates HPV in cervical cancer cells via the UBE3A and IGF‑1R pathway". Oncology Letters 16.3 (2018): 3241-3247.
Chicago
Wu, S., Chen, H."Anti‑Condyloma acuminata mechanism of microRNAs‑375 modulates HPV in cervical cancer cells via the UBE3A and IGF‑1R pathway". Oncology Letters 16, no. 3 (2018): 3241-3247. https://doi.org/10.3892/ol.2018.8983
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