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Article Open Access

Liver receptor homologue 1, a novel prognostic marker in colon cancer patients

  • Authors:
    • Cong Wu
    • Jin Feng
    • Ling Li
    • Yugang Wu
    • Haibin Xie
    • Yong Yin
    • Jing Ye
    • Zhong Li
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, The First People's Hospital of Changzhou, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu 213000, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2833-2838
    |
    Published online on: June 18, 2018
       https://doi.org/10.3892/ol.2018.8988
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Abstract

Liver receptor homologue 1 (LRH‑1) is an orphan nuclear receptor that is highly expressed in a variety of cancer tissues, promotes tumor cell proliferation and metastasis, and is involved in the tumor cell cycle and apoptosis. The aim of the present study was to assess the association between the expression of LRH‑1 and the prognosis of patients with colon cancer. Immunohistochemistry was used to detect the expression of LRH1 in 128 cases of colon cancer and adjacent tissues. The 5‑year survival rate was obtained from telephone follow‑up data, outpatient review and through access to medical records. Positive expression of LRH‑1 was found in 108/128 colon cancer samples, compared with 17/128 normal tissues. Statistical analysis showed that positive LRH‑1 expression was significantly associated with clinical pathological stage, depth of invasion and lymph node metastasis. The overall survival (OS) rate of patients with positive LRH‑1 expression was significantly lower than that of patients with low expression. Multivariate analysis showed that LRH‑1 expression could be used as an independent predictor of OS. In conclusion, the present findings suggest that LRH‑1 may serve an important role in the development and progression of colon cancer, with potential value as a prognostic molecular marker that could be used to assist in the diagnosis and evaluation of colon cancer. LRH‑1 may become a target for novel therapies for patients with colon cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Wu C, Feng J, Li L, Wu Y, Xie H, Yin Y, Ye J and Li Z: Liver receptor homologue 1, a novel prognostic marker in colon cancer patients. Oncol Lett 16: 2833-2838, 2018.
APA
Wu, C., Feng, J., Li, L., Wu, Y., Xie, H., Yin, Y. ... Li, Z. (2018). Liver receptor homologue 1, a novel prognostic marker in colon cancer patients. Oncology Letters, 16, 2833-2838. https://doi.org/10.3892/ol.2018.8988
MLA
Wu, C., Feng, J., Li, L., Wu, Y., Xie, H., Yin, Y., Ye, J., Li, Z."Liver receptor homologue 1, a novel prognostic marker in colon cancer patients". Oncology Letters 16.3 (2018): 2833-2838.
Chicago
Wu, C., Feng, J., Li, L., Wu, Y., Xie, H., Yin, Y., Ye, J., Li, Z."Liver receptor homologue 1, a novel prognostic marker in colon cancer patients". Oncology Letters 16, no. 3 (2018): 2833-2838. https://doi.org/10.3892/ol.2018.8988
Copy and paste a formatted citation
x
Spandidos Publications style
Wu C, Feng J, Li L, Wu Y, Xie H, Yin Y, Ye J and Li Z: Liver receptor homologue 1, a novel prognostic marker in colon cancer patients. Oncol Lett 16: 2833-2838, 2018.
APA
Wu, C., Feng, J., Li, L., Wu, Y., Xie, H., Yin, Y. ... Li, Z. (2018). Liver receptor homologue 1, a novel prognostic marker in colon cancer patients. Oncology Letters, 16, 2833-2838. https://doi.org/10.3892/ol.2018.8988
MLA
Wu, C., Feng, J., Li, L., Wu, Y., Xie, H., Yin, Y., Ye, J., Li, Z."Liver receptor homologue 1, a novel prognostic marker in colon cancer patients". Oncology Letters 16.3 (2018): 2833-2838.
Chicago
Wu, C., Feng, J., Li, L., Wu, Y., Xie, H., Yin, Y., Ye, J., Li, Z."Liver receptor homologue 1, a novel prognostic marker in colon cancer patients". Oncology Letters 16, no. 3 (2018): 2833-2838. https://doi.org/10.3892/ol.2018.8988
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