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Clinical significance of cytokeratin in the cervical lymph nodes of patients with mandibular gingival squamous cell carcinoma

  • Authors:
    • Qingyun Duan
    • Mei Xu
    • Xiong Zhang
    • Muyun Jia
    • Rongtao Yuan
    • Min Gan
  • View Affiliations / Copyright

    Affiliations: Oral and Maxillofacial Surgery, Hangzhou First People's Hospital, Nanjing Medical University, Hangzhou, Zhejiang 310006, P.R. China, Department of Ophtalmology, Hangzhou Jianggan District People's Hospital, Hangzhou, Zhejiang 310016, P.R. China, Oral and Maxillofacial Surgery, The Affiliated Hospital of Qingdao University Medical College, Qingdao, Shandong 266003, P.R. China
    Copyright: © Duan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3135-3139
    |
    Published online on: June 21, 2018
       https://doi.org/10.3892/ol.2018.9005
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Abstract

The present study aims to analyze the expression of broad spectrum cytokeratin in the cervical lymph nodes of patients with mandibular gingival squamous cell carcinoma and explore the metastasis of mandibular gingival squamous cell carcinoma in cervical lymph nodes. This study included 42 patients with mandibular gingival squamous cell carcinoma, which was staged according to the clinical staging criteria by International Union Against Cancer 2002 (UICC) and the Level staging method of cervical lymph node by American Academy of Otolaryngology-Head and Neck Surgery 1991. Monoclonal mouse anti-human cytokeratin (AE1/AE3) antibody was used in immunohistochemical examination and hematoxylin and eosin (H&E) staining. All positive sections by H&E staining were also positive by immunohistochemistry (IHC). The positive rate of routine H&E staining and serial‑section H&E staining was 8.03 and 9.57%, respectively, the positive rate of IHC was 12.82%. The positive rate of IHC was significantly different with that of routine H&E staining (χ2=7.17, P<0.01), yet not significantly different with that of serial-section H&E staining (χ2=3.10, P>0.05). Lymph node metastasis was mainly in level I, II and III, both serial-section H&E staining and IHC showed lymph node metastasis in level IV for advanced patients. IHC showed 19 lymph node micrometastasis in 12 patients, while neither serial-section nor routine H&E staining showed micrometastasis. Lymph node dissection of hyoid bone (mainly in level I, II and III) could be used for early patients, and the dissection could be expanded to level IV for advanced patients.
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View References

1 

Benson JR: Management of breast-cancer patients with sentinel-node micrometastases. Lancet Oncol. 14:266–267. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Atula T, Hunter KD, Cooper LA, Shoaib T, Ross GL and Soutar DS: Micrometastases and isolated tumour cells in sentinel lymph nodes in oral and oropharyngeal squamous cell carcinoma. Eur J Surg Oncol. 35:532–538. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Argiris A, Karamouzis MV, Johnson JT, Heron DE, Myers E, Eibling D, Cano E, Urba S, Gluckman J, Grandis JR, et al: Long-term results of a phase III randomized trial of postoperative radiotherapy with or without carboplatin in patients with high-risk head and neck cancer. Laryngoscope. 118:444–449. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Tai SK, Li WY, Yang MH, Chang SY, Chu PY, Tsai TL, Wang YF and Chang PM: Treatment for T1-2 oral squamous cell carcinoma with or without perineural invasion: Neck dissection and postoperative adjuvant therapy. Ann Surg Oncol. 19:1995–2002. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Taylor BE, Leibman NF, Luong R, Loar AS and Craft DM: Detection of carcinoma micrometastases in bone marrow of dogs and cats using conventional and cell block cytology. Vet Clin Pathol. 42:85–91. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Hirano C, Nagata M, Noman AA, Kitamura N, Ohnishi M, Ohyama T, Kobayashi T, Suzuki K, Yoshizawa M, Izumi N, et al: Tetraspanin gene expression levels as potential biomarkers for malignancy of gingival squamous cell carcinoma. Int J Cancer. 124:2911–2916. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Givi B, Linkov G, Ganly I, Patel SG, Wong RJ, Singh B, Boyle JO, Shaha AR, Shah JP and Kraus DH: Selective neck dissection in node-positive squamous cell carcinoma of the head and neck. Otolaryngol Head Neck Surg. 147:707–715. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Mahalingam M, Richards JE, Selim MA, Muzikansky A and Hoang MP: An immunohistochemical comparison of cytokeratin 7, cytokeratin 15, cytokeratin 19, CAM 5.2, carcinoembryonic antigen, and nestin in differentiating porocarcinoma from squamous cell carcinoma. Hum Pathol. 43:1265–1272. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Alshareeda AT, Soria D, Garibaldi JM, Rakha E, Nolan C, Ellis IO and Green AR: Characteristics of basal cytokeratin expression in breast cancer. Breast Cancer Res Treat. 139:23–37. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Guerra A, Marotta V, Deandrea M, Motta M, Limone PP, Caleo A, Zeppa P, Esposito S, Fulciniti F and Vitale M: BRAF (V600E) associates with cytoplasmatic localization of p27kip1 and higher cytokeratin 19 expression in papillary thyroid carcinoma. Endocrine. 44:165–171. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Elalfy H, Basheer T, El-Hussiny AB, Alsayed SAM and Alhaware G: 639 cytokeratin 18 as a potential marker predicts early local recurrence of hepatocellular carcinoma after curative local ablation. J Hepatol. 58:S260–S261. 2013. View Article : Google Scholar

12 

Ichikawa E, Ohnishi T and Watanabe S: Expression of keratin and involucrin in keratoacanthoma: An immunohistochemical aid to diagnosis. J Dermatol Sci. 34:115–117. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Helfand BT, Chang L and Goldman RD: Intermediate filaments are dynamic and motile elements of cellular architecture. J Cell Sci. 117:133–141. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Shuto M, Warigaya K, Watanabe H, Shimizu M, Fukuda T and Murata S: Correlation analysis of nuclear morphology, cytokeratin and Ki-67 expression of urothelial carcinoma cells. Pathol Int. 63:311–317. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Wang Y, Zhu JF, Liu YY and Han GP: An analysis of cyclin D1, cytokeratin 5/6 and cytokeratin 8/18 expression in breast papillomas and papillary carcinomas. Diagn Pathol. 8:82013. View Article : Google Scholar : PubMed/NCBI

16 

Lee CW, Kuo WL, Yu MC, Chen TC, Tsai CN, Lee WC and Chen MF: The expression of cytokeratin 19 in lymph nodes was a poor prognostic factor for hepatocellular carcinoma after hepatic resection. World J Surg Oncol. 11:1362013. View Article : Google Scholar : PubMed/NCBI

17 

Negm H, Mosleh M, Fathy H, Hareedy A and Elbattawy A: Cytokeratin immunohistochemically detected nodal micrometastases in N0 laryngeal cancer: Impact on the overall occult metastases. Eur Arch Otorhinolaryngol. 270:1085–1092. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Gazquez C, Ribal MJ, Marín-Aguilera M, Kayed H, Fernández PL, Mengual L and Alcaraz A: Biomarkers vs conventional histological analysis to detect lymph node micrometastases in bladder cancer: A real improvement? BJU Int. 110:1310–1316. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Märkl B, Herbst C, Cacchi C, Schaller T, Krammer I, Schenkirsch G, Probst A and Spatz H: Prognostic significance of histologically detected lymph node micrometastases of sizes between 0.2 and 2 mm in colorectal cancer. Int J Colorectal Dis. 28:977–983. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Chong Loong CY, Mirbagheri N, Harris M and Fox J: Sentinel node micrometastases in breast cancer: A survey of Australian and New Zealand breast surgeons. ANZ J Surg. 82:766–767. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Seethala RR: Current state of neck dissection in the United States. Head Neck Pathol. 3:238–245. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Patel RS, Clark JR, Gao K and OBrien CJ: Effectiveness of selective neck dissection in the treatment of the clinically positive neck. Head Neck. 30:1231–1236. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Melkane AE, Mamelle G, Wycisk G, Temam S, Janot F, Casiraghi O and Lumbroso J: Sentinel node biopsy in early oral squamous cell carcinomas: A 10-year experience. Laryngoscope. 122:1782–1788. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Duan Q, Xu M, Zhang X, Jia M, Yuan R and Gan M: Clinical significance of cytokeratin in the cervical lymph nodes of patients with mandibular gingival squamous cell carcinoma. Oncol Lett 16: 3135-3139, 2018.
APA
Duan, Q., Xu, M., Zhang, X., Jia, M., Yuan, R., & Gan, M. (2018). Clinical significance of cytokeratin in the cervical lymph nodes of patients with mandibular gingival squamous cell carcinoma. Oncology Letters, 16, 3135-3139. https://doi.org/10.3892/ol.2018.9005
MLA
Duan, Q., Xu, M., Zhang, X., Jia, M., Yuan, R., Gan, M."Clinical significance of cytokeratin in the cervical lymph nodes of patients with mandibular gingival squamous cell carcinoma". Oncology Letters 16.3 (2018): 3135-3139.
Chicago
Duan, Q., Xu, M., Zhang, X., Jia, M., Yuan, R., Gan, M."Clinical significance of cytokeratin in the cervical lymph nodes of patients with mandibular gingival squamous cell carcinoma". Oncology Letters 16, no. 3 (2018): 3135-3139. https://doi.org/10.3892/ol.2018.9005
Copy and paste a formatted citation
x
Spandidos Publications style
Duan Q, Xu M, Zhang X, Jia M, Yuan R and Gan M: Clinical significance of cytokeratin in the cervical lymph nodes of patients with mandibular gingival squamous cell carcinoma. Oncol Lett 16: 3135-3139, 2018.
APA
Duan, Q., Xu, M., Zhang, X., Jia, M., Yuan, R., & Gan, M. (2018). Clinical significance of cytokeratin in the cervical lymph nodes of patients with mandibular gingival squamous cell carcinoma. Oncology Letters, 16, 3135-3139. https://doi.org/10.3892/ol.2018.9005
MLA
Duan, Q., Xu, M., Zhang, X., Jia, M., Yuan, R., Gan, M."Clinical significance of cytokeratin in the cervical lymph nodes of patients with mandibular gingival squamous cell carcinoma". Oncology Letters 16.3 (2018): 3135-3139.
Chicago
Duan, Q., Xu, M., Zhang, X., Jia, M., Yuan, R., Gan, M."Clinical significance of cytokeratin in the cervical lymph nodes of patients with mandibular gingival squamous cell carcinoma". Oncology Letters 16, no. 3 (2018): 3135-3139. https://doi.org/10.3892/ol.2018.9005
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