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Article Open Access

Expression of miR-30c and miR-29b in prostate cancer and its diagnostic significance

  • Authors:
    • Chuanan Zhu
    • Xiumei Hou
    • Jiabin Zhu
    • Chunxiao Jiang
    • Wei Wei
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory, Jining First People's Hospital, Jining, Shandong 272000, P.R. China, Nursing Department, Jining Psychiatric Hospital, Jining, Shandong 272051, P.R. China, Department of Neurology, The General Hospital of Ningxia Medical University, Yinchuan, Ningxia 750000, P.R. China
    Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3140-3144
    |
    Published online on: June 21, 2018
       https://doi.org/10.3892/ol.2018.9007
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Abstract

This study aimed to investigate the expression of miR-30c and miR-29b in prostate cancer (PCa) and its clinical significance. The expression of miR-30c and miR-29b was detected by RT-qPCR in 187 cases of PCa and their adjacent tissues. Combined with clinical information, the correlation between the expression of miR-29b and miR-30c and the clinical features of PCa was analyzed, and ROC curve was plotted. The expression of miR-30c and miR-29b detected by RT-qPCR showed that the expression of miR-29b and miR-30c in PCa tissues was significantly lower than that in adjacent cancerous tissues (p<0.05). By comparing the expression and clinical data of miR-29b and miR-30c in the cancer tissues of PCa patients, it was observed that age, smoking, and TNM staging were not related to miR-29b and miR-30c expression (p>0.05), while lymph node metastasis, bone metastasis, and Gleason score were related to the expression of miR-29b and miR-30c (p<0.01). The ROC curve showed that miR-29b AUC, 0.924; 95% CI, 0.824-0.967, and miR-30c AUC, 0.944; 95% CI, 0.798-0.972. miR-30c and miR-29b are clinically relevant to PCa. In conclusion, detecting the expression of miR-30c and miR-29b not only can differentiate between PCa and paracancerous tissues, but it is also anticipated to become a new biomarker for the diagnosis of PCa.
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Copy and paste a formatted citation
Spandidos Publications style
Zhu C, Hou X, Zhu J, Jiang C and Wei W: Expression of miR-30c and miR-29b in prostate cancer and its diagnostic significance. Oncol Lett 16: 3140-3144, 2018.
APA
Zhu, C., Hou, X., Zhu, J., Jiang, C., & Wei, W. (2018). Expression of miR-30c and miR-29b in prostate cancer and its diagnostic significance. Oncology Letters, 16, 3140-3144. https://doi.org/10.3892/ol.2018.9007
MLA
Zhu, C., Hou, X., Zhu, J., Jiang, C., Wei, W."Expression of miR-30c and miR-29b in prostate cancer and its diagnostic significance". Oncology Letters 16.3 (2018): 3140-3144.
Chicago
Zhu, C., Hou, X., Zhu, J., Jiang, C., Wei, W."Expression of miR-30c and miR-29b in prostate cancer and its diagnostic significance". Oncology Letters 16, no. 3 (2018): 3140-3144. https://doi.org/10.3892/ol.2018.9007
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu C, Hou X, Zhu J, Jiang C and Wei W: Expression of miR-30c and miR-29b in prostate cancer and its diagnostic significance. Oncol Lett 16: 3140-3144, 2018.
APA
Zhu, C., Hou, X., Zhu, J., Jiang, C., & Wei, W. (2018). Expression of miR-30c and miR-29b in prostate cancer and its diagnostic significance. Oncology Letters, 16, 3140-3144. https://doi.org/10.3892/ol.2018.9007
MLA
Zhu, C., Hou, X., Zhu, J., Jiang, C., Wei, W."Expression of miR-30c and miR-29b in prostate cancer and its diagnostic significance". Oncology Letters 16.3 (2018): 3140-3144.
Chicago
Zhu, C., Hou, X., Zhu, J., Jiang, C., Wei, W."Expression of miR-30c and miR-29b in prostate cancer and its diagnostic significance". Oncology Letters 16, no. 3 (2018): 3140-3144. https://doi.org/10.3892/ol.2018.9007
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