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Article

The protective effect of puerarin on angiotensin II‑induced aortic aneurysm formation by the inhibition of NADPH oxidase activation and oxidative stress‑triggered AP‑1 signaling pathways

  • Authors:
    • Jie Yue
    • Shunwu Chang
    • Zhanxiang Xiao
    • Youfei Qi
    • Jianxing He
  • View Affiliations / Copyright

    Affiliations: The First Clinical College, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China, Department of Gastrointestinal Surgery, Hainan Provincial People's Hospital, Guangzhou, Guangdong 510120, P.R. China, Department of Vascular Surgery, Hainan Provincial People's Hospital, Guangzhou, Guangdong 510120, P.R. China
  • Pages: 3327-3332
    |
    Published online on: June 26, 2018
       https://doi.org/10.3892/ol.2018.9021
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Abstract

Puerarin, an active ingredient of Pueraria lobata, has a range of pharmacological effects and excellent pharmacodynamic properties. In the present study, the effect of puerarin on angiotensin II‑induced aortic aneurysm formation and the potential underlying molecular mechanisms were examined. The results revealed that puerarin significantly suppressed the viability, and induced the apoptosis, of aneurysm‑inducing cells in a time‑ and dose‑dependent manner. Furthermore, treatment with puerarin significantly suppressed the production of reactive oxygen species (ROS) and the expression of matrix metalloproteinase‑2 (MMP‑2) protein in aneurysm cells. Puerarin treatment significantly increased caspase‑9 and ‑3 activity, induced the protein expression of phosphorylated (p)‑Jun and inhibited the protein expression of activator protein 1 (AP‑1) in aneurysm cells. It was also demonstrated that Puerarin significantly suppressed the reduced nicotinamide‑adenine dinucleotide phosphate (NADPH) oxidase activity in aneurysm cells. Therefore, it was demonstrated that puerarin on suppressed the cell growth of angiotensin II‑induced aortic aneurysm formation by affecting the rate of apoptosis, the generation of ROS, MMP‑2, AP‑1 and p‑Jun protein expression and NADPH oxidase.
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Copy and paste a formatted citation
Spandidos Publications style
Yue J, Chang S, Xiao Z, Qi Y and He J: The protective effect of puerarin on angiotensin II‑induced aortic aneurysm formation by the inhibition of NADPH oxidase activation and oxidative stress‑triggered AP‑1 signaling pathways. Oncol Lett 16: 3327-3332, 2018.
APA
Yue, J., Chang, S., Xiao, Z., Qi, Y., & He, J. (2018). The protective effect of puerarin on angiotensin II‑induced aortic aneurysm formation by the inhibition of NADPH oxidase activation and oxidative stress‑triggered AP‑1 signaling pathways. Oncology Letters, 16, 3327-3332. https://doi.org/10.3892/ol.2018.9021
MLA
Yue, J., Chang, S., Xiao, Z., Qi, Y., He, J."The protective effect of puerarin on angiotensin II‑induced aortic aneurysm formation by the inhibition of NADPH oxidase activation and oxidative stress‑triggered AP‑1 signaling pathways". Oncology Letters 16.3 (2018): 3327-3332.
Chicago
Yue, J., Chang, S., Xiao, Z., Qi, Y., He, J."The protective effect of puerarin on angiotensin II‑induced aortic aneurysm formation by the inhibition of NADPH oxidase activation and oxidative stress‑triggered AP‑1 signaling pathways". Oncology Letters 16, no. 3 (2018): 3327-3332. https://doi.org/10.3892/ol.2018.9021
Copy and paste a formatted citation
x
Spandidos Publications style
Yue J, Chang S, Xiao Z, Qi Y and He J: The protective effect of puerarin on angiotensin II‑induced aortic aneurysm formation by the inhibition of NADPH oxidase activation and oxidative stress‑triggered AP‑1 signaling pathways. Oncol Lett 16: 3327-3332, 2018.
APA
Yue, J., Chang, S., Xiao, Z., Qi, Y., & He, J. (2018). The protective effect of puerarin on angiotensin II‑induced aortic aneurysm formation by the inhibition of NADPH oxidase activation and oxidative stress‑triggered AP‑1 signaling pathways. Oncology Letters, 16, 3327-3332. https://doi.org/10.3892/ol.2018.9021
MLA
Yue, J., Chang, S., Xiao, Z., Qi, Y., He, J."The protective effect of puerarin on angiotensin II‑induced aortic aneurysm formation by the inhibition of NADPH oxidase activation and oxidative stress‑triggered AP‑1 signaling pathways". Oncology Letters 16.3 (2018): 3327-3332.
Chicago
Yue, J., Chang, S., Xiao, Z., Qi, Y., He, J."The protective effect of puerarin on angiotensin II‑induced aortic aneurysm formation by the inhibition of NADPH oxidase activation and oxidative stress‑triggered AP‑1 signaling pathways". Oncology Letters 16, no. 3 (2018): 3327-3332. https://doi.org/10.3892/ol.2018.9021
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