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Medicinal supplement genipin induces p53 and Bax‑dependent apoptosis in colon cancer cells

  • Authors:
    • Jingwang Ye
    • Jing Li
    • Xiangfeng Wang
    • Ling Li
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Surgery, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, P.R. China, Department of Central Sterile Supply, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, P.R. China, Department of Vasculocardiology, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, P.R. China
    Copyright: © Ye et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2957-2964
    |
    Published online on: June 26, 2018
       https://doi.org/10.3892/ol.2018.9025
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Abstract

Colorectal cancer (CRC) is the third leading cause of cancer‑associated mortality worldwide. Genipin is a medicinal herb compound derived from the gardenia fruit, which has been reported to exhibit antitumor activity against several types of cancer. The aim of the present study was to investigate the antitumor effect of genipin on colon cancer and the underlying molecular mechanisms. Genipin significantly inhibited the viability of HCT116 and SW480 cells in vitro in a dose‑ and time‑dependent manner. Additionally, genipin was able to significantly inhibit tumor growth in nude mice with xenografts of HCT116 and SW480 cells. The inhibition of tumor growth by genipin treatment was coupled with G0/G1 cell cycle arrest, apoptosis induction, increased reactive oxygen species damage and loss of mitochondrial membrane potential. Further investigation of genipin‑treated HCT116 cells revealed that the expression of p53, Bax and cleaved caspase‑3 in genipin‑treated cells was increased compared with the vehicle control, whereas B‑cell lymphoma‑2 expression appeared to be lower in genipin‑treated cells. Collectively, the findings of the present study indicate that genipin was able to decrease proliferation and promote apoptosis in colon cancer cells by inducing the p53/Bax‑mediated signaling pathway. Therefore, genipin may be used as a novel therapeutic agent in the treatment of CRC.
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1 

Siegel RL, Miller KD, Fedewa SA, Ahnen DJ, Meester RGS, Barzi A and Jemal A: Colorectal cancer statistics, 2017. CA Cancer J Clin. 67:177–193. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Jeyamohan S, Moorthy RK, Kannan MK and Arockiam AJ: Parthenolide induces apoptosis and autophagy through the suppression of PI3k/AKT signaling pathway in cervical cancer. Biotechnol Lett. 38:1251–1260. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Ramezanpour M, Da SK and Sanderson BJ: Venom present in sea anemone (heteractis magnifica) induces apoptosis in non-small-cell lung cancer A549 cells through activation of mitochondria-mediated pathway. Biotechnol Lett. 36:489–495. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Koo HJ, Lim KH, Jung HJ and Park EH: Anti-inflammatory evaluation of gardenia extract, geniposide and genipin. J Ethnopharmacol. 103:496–500. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Park EH, Joo MH, Kim SH and Lim CJ: Antiangiogenic activity of gardenia jasminoides fruit. Phytother Res. 17:961–962. 2003. View Article : Google Scholar : PubMed/NCBI

6 

Suzuki Y, Kondo K, Ikeda Y and Umemura K: Antithrombotic effect of geniposide and genipin in the mouse thrombosis model. Planta Medica. 67:807–810. 2001. View Article : Google Scholar : PubMed/NCBI

7 

Kim JM, Ko H, Kim SJ, Shim SH, Ha CH and Chang HI: Chemopreventive properties of genipin on ags cell line via induction of JNK/Nrf2/are signaling pathway. J Biochem Mol Toxicol. 30:45–54. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Kim BC, Kim HG, Lee SA, Lim S, Park EH, Kim SJ and Lim CJ: Genipin-induced apoptosis in hepatoma cells is mediated by reactive oxygen species/c-JUN NH2-terminal kinase-dependent activation of mitochondrial pathway. Biochem Pharmacol. 70:1398–1407. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Kim ES, Jeong CS and Moon A: Genipin, a constituent of gardenia jasminoides ellis, induces apoptosis and inhibits invasion in MDA-MB-231 breast cancer cells. Oncol Rep. 27:567–572. 2012.PubMed/NCBI

10 

Cao HL, Feng QA, Xu W, Li X, Kang Z, Ren Y and Du L: Genipin induced apoptosis associated with activation of the c-JUN NH2-terminal kinase and p53 protein in hela cells. Biol Pharm Bull. 33:1343–1348. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Chang YC, Chou FP, Huang HP, Hsu JD and Wang CJ: Inhibition of cell cycle progression by penta-acetyl geniposide in rat c6 glioma cells. Toxicol Appl Pharmacol. 198:11–20. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Feng Q, Cao, Hl, Xu W, Li XR, Ren YQ and Du LF: Apoptosis induced by genipin in human leukemia k562 cells: Involvement of c-JUN N-terminal kinase in G(2)/M arrest. Acta Pharmacol Sin. 32:519–527. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Simon HU, Haj-Yehia A and Levi-Schaffer F: Role of reactive oxygen species (ROS) in apoptosis induction. Apoptosis. 5:415–418. 2000. View Article : Google Scholar : PubMed/NCBI

14 

Cho YS, Lee JH, Jung KH, Park JW, Moon SH, Choe YS and Lee KH: Molecular mechanism of (18) F-FDG uptake reduction induced by genipin in T47D cancer cell and role of uncoupling protein-2 in cancer cell glucose metabolism. Nucl Med Biol. 43:587–592. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Kuwana T, Mackey MR, Perkins G, Ellisman MH, Latterich M, Schneiter R, Green DR and Newmeyer DD: Bid, bax and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane. Cell. 111:331–342. 2002. View Article : Google Scholar : PubMed/NCBI

16 

Yun N, Kim C, Cha H, Park WJ, Shibayama H, Park IS and Oh YJ: Caspase-3-mediated cleavage of picot in apoptosis. Biochem Biophys Res Commun. 432:533–538. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Jayaraman L and Prives C: Covalent and noncovalent modifiers of the p53 protein. Cell Mol Life Sci. 55:76–87. 1999. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ye J, Li J, Wang X and Li L: Medicinal supplement genipin induces p53 and Bax‑dependent apoptosis in colon cancer cells. Oncol Lett 16: 2957-2964, 2018.
APA
Ye, J., Li, J., Wang, X., & Li, L. (2018). Medicinal supplement genipin induces p53 and Bax‑dependent apoptosis in colon cancer cells. Oncology Letters, 16, 2957-2964. https://doi.org/10.3892/ol.2018.9025
MLA
Ye, J., Li, J., Wang, X., Li, L."Medicinal supplement genipin induces p53 and Bax‑dependent apoptosis in colon cancer cells". Oncology Letters 16.3 (2018): 2957-2964.
Chicago
Ye, J., Li, J., Wang, X., Li, L."Medicinal supplement genipin induces p53 and Bax‑dependent apoptosis in colon cancer cells". Oncology Letters 16, no. 3 (2018): 2957-2964. https://doi.org/10.3892/ol.2018.9025
Copy and paste a formatted citation
x
Spandidos Publications style
Ye J, Li J, Wang X and Li L: Medicinal supplement genipin induces p53 and Bax‑dependent apoptosis in colon cancer cells. Oncol Lett 16: 2957-2964, 2018.
APA
Ye, J., Li, J., Wang, X., & Li, L. (2018). Medicinal supplement genipin induces p53 and Bax‑dependent apoptosis in colon cancer cells. Oncology Letters, 16, 2957-2964. https://doi.org/10.3892/ol.2018.9025
MLA
Ye, J., Li, J., Wang, X., Li, L."Medicinal supplement genipin induces p53 and Bax‑dependent apoptosis in colon cancer cells". Oncology Letters 16.3 (2018): 2957-2964.
Chicago
Ye, J., Li, J., Wang, X., Li, L."Medicinal supplement genipin induces p53 and Bax‑dependent apoptosis in colon cancer cells". Oncology Letters 16, no. 3 (2018): 2957-2964. https://doi.org/10.3892/ol.2018.9025
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