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Case Report Open Access

Complete cure of a patient with HBV‑associated hepatocellular carcinoma with lung metastasis using interferon and survival up to 108 months: A case report and literature review

  • Authors:
    • Fang Wang
    • Hongmin Lv
    • Yan Li
    • Tao Han
    • Hui Liu
    • Kefeng Jia
    • Fang Liu
    • Yanying Gao
    • Fengmei Wang
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology and Hepatology, The Third Central Hospital of Tianjin, Hedong, Tianjin 300170, P.R. China, Tianjin Institute of Hepatobiliary Disease, Hedong, Tianjin 300170, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2979-2988
    |
    Published online on: June 28, 2018
       https://doi.org/10.3892/ol.2018.9033
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Abstract

Hepatocellular carcinoma (HCC) has a poor prognosis due to its asymptomatic onset and susceptibility to metastasis. The survival of patients with advanced HCC is 6‑12 months. As a first‑line medicine for the control of hepatitis B virus, interferon (IFN) is also capable of inhibiting tumor growth and modulating immunity. However, treatment of HCC with lung metastasis using IFN has been rarely reported. The present study reports the case of one patient with HCC having lung metastasis who underwent a one‑time treatment with transcatheter arterial chemoembolization (TACE) and was subsequently completely cured by single peginterferon α 2a (PEG‑IFNα2a); and has survived up to 108 months. A 53‑year‑old male patient diagnosed with HBV‑related HCC with lung metastasis underwent TACE using floxuridine (FUDR) 500 mg, cisdiamine dichloroplatinum (CDDP) 20 mg, mitomycin 10 mg, and ultrafluid lipiodol 10 ml, together with local thoracic aorta chemotherapy using FUDR 250 mg and CDDP 20 mg. His metastatic lung cancer aggravated. However, after 9 months of treatment with subcutaneous injections of PEG‑IFNα 2a once per week, the metastatic lung foci gradually shrunk until disappearance and the HCC lesion stabilized without progression. According to the World Health Organization criteria for the efficacy of solid tumors, this was a case of complete response. Upon follow‑up up to 108 months his metastatic lung cancer had disappeared and HCC did not recur. Therefore, IFN intervention may be an appropriate novel adjuvant therapy for patients with HCC with lung metastasis and requires further attention and study.
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1 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Natsuizaka M, Omura T, Akaike T, Kuwata Y, Yamazaki K, Sato T, Karino Y, Toyota J, Suga T and Asaka M: Clinical features of hepatocellular carcinoma with extrahepatic metastases. J Gastroenterol Hepatol. 20:1781–1787. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Chen F, Sato K, Fujinaga T, Sonobe M, Shoji T, Sakai H, Miyahara R, Bando T, Okubo K, Hirata T and Date H: Pulmonary resection for metastases from hepatocellular carcinoma. World J Surg. 32:2213–2217. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Hu HH, Liu J, Lin YL, Luo WS, Chu YJ, Chang CL, Jen CL, Lee MH, Lu SN, Wang LY, et al: The rs2296651 (S267F) variant on NTCP (SLC10A1) is inversely associated with chronic hepatitis B and progression to cirrhosis and hepatocellular carcinoma in patients with chronic hepatitis B. Gut. 65:1514–1521. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Yau T, Chan P, Ng KK, Chok SH, Cheung TT, Fan ST and Poon RT: Phase 2 open-label study of single-agent sorafenib in treating advanced hepatocellular carcinoma in a hepatitis B-endemic Asian population: Presence of lung metastasis predicts poor response. Cancer. 115:428–436. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Zhu GQ, Shi KQ, Yu HJ, He SY, Braddock M, Zhou MT, Chen YP and Zheng MH: Optimal adjuvant therapy for resected hepatocellular carcinoma: A systematic review with network meta-analysis. Oncotarget. 6:18151–18161. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Ono T, Yamanoi A, El Assal Nazmy O, Kohno H and Nagasue N: Adjuvant chemotherapy after resection of hepatocellular carcinoma causes deterioration of long-term prognosis in cirrhotic patients: Metaanalysis of three randomized controlled trials. Cancer. 91:2378–2385. 2001. View Article : Google Scholar : PubMed/NCBI

8 

Katsura Y, Wada H, Kobayashi S, Marubashi S, Eguchi H, Tanemura M, Umeshita K, Wakasa K, Doki Y, Mori M and Nagano H: [A case of complete response to interferon-alpha and S-1 combination therapy for multiple pulmonary recurrences of hepatocellular carcinoma after hepatic resection]. Gan To Kagaku Ryoho. 38:2487–2489. 2011.PubMed/NCBI

9 

Oh YJ, Park YM, Kim BH, Kim MJ, Cho JH, Cha CW, Park SJ and Yeon JW: A case of hepatocellular carcinoma with pulmonary metastases treated successfully with a combination of repeated hepatic arterial infusion epirubicin and Cisplatin chemotherapy and systemic low-dose infusion of 5-Fluorouracil. Gut Liver. 3:343–348. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Kilickap S, Kars A, Hamaloglu E and Simsek H: A case of recurrent metastatic hepatocellular cancer controlled with immunotherapy and antiviral therapy following resection. Med Oncol. 26:501–505. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Tanaka K, Yamada K, Sasaki H, Kishi K, Noura S, Takachi K, Eguchi H, Miyashiro I, Ohue M, Ohigashi H, Yano M, Ishikawa O and Imaoka S: [A surgical case of solitary lymph node metastatic recurrence of hepatocellular carcinoma after hepatectomy]. Gan To Kagaku Ryoho. 33:1938–1940. 2006.PubMed/NCBI

12 

Nakamura M, Nagano H, Wada H, Ota H, Damdinsuren B, Marubashi S, Miyamoto A, Takeda Y, Umeshita K, Dono K and Monden M: A case of hepatocellular carcinoma with multiple lung, spleen, and remnant liver metastasis successfully treated by combination chemotherapy with the novel oral DPD-inhibiting chemotherapeutic drug S-1 and interferon-alpha. J Gastroenterol. 41:1120–1125. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Nakamura M, Nagano H, Sakon M, Yamamoto T, Ota H, Wada H, Yoshioka S, Kato H, Damdinsuren B, Marubashi S, et al: [A case of HCC with inferior caval vein tumor thrombus and multiple pulmonary metastases that remarkably responded to combination therapy of TS-1 and interferon-alpha]. Gan To Kagaku Ryoho. 32:1824–1828. 2005.PubMed/NCBI

14 

Nakamura M, Nagano H, Sakon M, Kondo M, Yamamoto T, Ota H, Wada H, Damdinsuren B, Yang Y, Marubashi S, et al: [A case of long-term survivor with multiple pulmonary metastases of HCC after hepatic resection]. Gan To Kagaku Ryoho. 31:1939–1942. 2004.PubMed/NCBI

15 

Kanda Y, Akazawa S, Futatsugi K, Fujiki T, Saifuku K, Yamamoto K, Suzuki F, Nakajima T, Naoi Y, Muraoka M, et al: [A case of hepatocellular carcinoma (HCC) with lung metastasis which responded to chemotherapy with a single use of 1-hexylcarbamoyl-5-fluorouracil (HCFU)]. Gan To Kagaku Ryoho. 16:269–272. 1989.PubMed/NCBI

16 

Akita H, Marubashi S, Wada H, Hama N, Kawamoto K, Kobayashi S, Eguchi H, Doki Y, Mori M and Nagano H: Combination therapy with S-1 and interferon-α in hepatocellular carcinoma patients with lung metastasis. Mol Clin Oncol. 3:322–328. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Jiang S, Liu Y, Wang L, Duan C and Liu M: A meta-analysis and systematic review: Adjuvant interferon therapy for patients with viral hepatitis-related hepatocellular carcinoma. World J Surg Oncol. 11:2402013. View Article : Google Scholar : PubMed/NCBI

18 

Zhang W, Song TQ, Zhang T, Wu Q, Kong DL, Li Q and Sun HC: Adjuvant interferon for early or late recurrence of hepatocellular carcinoma and mortality from hepatocellular carcinoma following curative treatment: A meta-analysis with comparison of different types of hepatitis. Mol Clin Oncol. 2:1125–1134. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Huang TS, Shyu YC, Chen HY, Yuan SS, Shih JN and Chen PJ: A systematic review and meta-analysis of adjuvant interferon therapy after curative treatment for patients with viral hepatitis-related hepatocellular carcinoma. J Viral Hepat. 20:729–743. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Yang S, Lin Q, Lin W, Hu W and Wang G: Effect of adjuvant interferon therapy on hepatitis B virus-related hepatocellular carcinoma: A systematic review. World J Surg Oncol. 14:1592016. View Article : Google Scholar : PubMed/NCBI

21 

Eun JR, Lee HJ, Moon HJ, Kim TN, Kim JW and Chang JC: Hepatic arterial infusion chemotherapy using high-dose 5-fluorouracil and cisplatin with or without interferon-alpha for the treatment of advanced hepatocellular carcinoma with portal vein tumor thrombosis. Scand J Gastroenterol. 44:1477–1486. 2009. View Article : Google Scholar : PubMed/NCBI

22 

O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB and Laurence A: The JAK-STAT pathway: Impact on human disease and therapeutic intervention. Annu Rev Med. 66:311–328. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Quiroga AD, de Lujan Alvarez M, Parody JP, Ronco MT, Carnovale CE and Carrillo MC: Interferon-alpha2b (IFN-alpha2b)-induced apoptosis is mediated by p38 MAPK in hepatocytes from rat preneoplastic liver via activation of NADPH oxidase. Growth Factors. 27:214–227. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Maeda S, Wada H, Naito Y, Nagano H, Simmons S, Kagawa Y, Naito A, Kikuta J, Ishii T, Tomimaru Y, et al: Interferon-α acts on the S/G2/M phases to induce apoptosis in the G1 phase of an IFNAR2-expressing hepatocellular carcinoma cell line. J Biol Chem. 289:23786–23795. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Schmeisser H, Bekisz J and Zoon KC: New function of type I IFN: Induction of autophagy. J Interferon Cytokine Res. 34:71–78. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Comet NR, Aguiló JI, Rathoré MG, Catalán E, Garaude J, Uzé G, Naval J, Pardo J, Villalba M and Anel A: IFNα signaling through PKC-θ is essential for antitumor NK cell function. Oncoimmunology. 3:e9487052014. View Article : Google Scholar : PubMed/NCBI

27 

Lapenta C, Donati S, Spadaro F, Castaldo P, Belardelli F, Cox MC and Santini SM: NK cell activation in the antitumor response induced by IFN-α dendritic cells loaded with apoptotic cells from follicular lymphoma patients. J Immunol. 197:795–806. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Hervas-Stubbs S, Mancheño U, Riezu-Boj JI, Larraga A, Ochoa MC, Alignani D, Alfaro C, Morales-Kastresana A, Gonzalez I, Larrea E, et al: CD8 T cell priming in the presence of IFN-α renders CTLs with improved responsiveness to homeostatic cytokines and recall antigens: Important traits for adoptive T cell therapy. J Immunol. 189:3299–3310. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Pacella I, Timperi E, Accapezzato D, Martire C, Labbadia G, Cavallari EN, D'Ettorre G, Calvo L, Rizzo F, Severa M, et al: IFN-α promotes rapid human Treg contraction and late Th1-like Treg decrease. J Leukoc Biol. 100:613–623. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Wang J, Zhu CP, Hu PF, Qian H, Ning BF, Zhang Q, Chen F, Liu J, Shi B, Zhang X and Xie WF: FOXA2 suppresses the metastasis of hepatocellular carcinoma partially through matrix metalloproteinase-9 inhibition. Carcinogenesis. 35:2576–2583. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Martin MD, Carter KJ, Jean-Philippe SR, Chang M, Mobashery S, Thiolloy S, Lynch CC, Matrisian LM and Fingleton B: Effect of ablation or inhibition of stromal matrix metalloproteinase-9 on lung metastasis in a breast cancer model is dependent on genetic background. Cancer Res. 68:6251–6259. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Wang L, Wu WZ, Sun HC, Wu XF, Qin LX, Liu YK, Liu KD and Tang ZY: Mechanism of interferon alpha on inhibition of metastasis and angiogenesis of hepatocellular carcinoma after curative resection in nude mice. J Gastrointest Surg. 7:587–594. 2003. View Article : Google Scholar : PubMed/NCBI

33 

Sun HC, Tang ZY, Wang L, Qin LX, Ma ZC, Ye QH, Zhang BH, Qian YB, Wu ZQ, Fan J, et al: Postoperative interferon alpha treatment postponed recurrence and improved overall survival in patients after curative resection of HBV-related hepatocellular carcinoma: A randomized clinical trial. J Cancer Res Clin Oncol. 132:458–465. 2006. View Article : Google Scholar : PubMed/NCBI

34 

Gong W, Zhang GM, Liu Y, Lei Z, Li D, Yuan Y, Huang B and Feng ZH: IFN-gamma withdrawal after immunotherapy potentiates B16 melanoma invasion and metastasis by intensifying tumor integrin alphavbeta3 signaling. Int J Cancer. 123:702–708. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Hiramatsu N, Yamada R and Takehara T: The suppressive effect of nucleos(t)ide analogue treatment on the incidence of hepatocellular carcinoma in chronic hepatitis B patients. J Gastroenterol Hepatol. 31:546–552. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang F, Lv H, Li Y, Han T, Liu H, Jia K, Liu F, Gao Y and Wang F: Complete cure of a patient with HBV‑associated hepatocellular carcinoma with lung metastasis using interferon and survival up to 108 months: A case report and literature review. Oncol Lett 16: 2979-2988, 2018.
APA
Wang, F., Lv, H., Li, Y., Han, T., Liu, H., Jia, K. ... Wang, F. (2018). Complete cure of a patient with HBV‑associated hepatocellular carcinoma with lung metastasis using interferon and survival up to 108 months: A case report and literature review. Oncology Letters, 16, 2979-2988. https://doi.org/10.3892/ol.2018.9033
MLA
Wang, F., Lv, H., Li, Y., Han, T., Liu, H., Jia, K., Liu, F., Gao, Y., Wang, F."Complete cure of a patient with HBV‑associated hepatocellular carcinoma with lung metastasis using interferon and survival up to 108 months: A case report and literature review". Oncology Letters 16.3 (2018): 2979-2988.
Chicago
Wang, F., Lv, H., Li, Y., Han, T., Liu, H., Jia, K., Liu, F., Gao, Y., Wang, F."Complete cure of a patient with HBV‑associated hepatocellular carcinoma with lung metastasis using interferon and survival up to 108 months: A case report and literature review". Oncology Letters 16, no. 3 (2018): 2979-2988. https://doi.org/10.3892/ol.2018.9033
Copy and paste a formatted citation
x
Spandidos Publications style
Wang F, Lv H, Li Y, Han T, Liu H, Jia K, Liu F, Gao Y and Wang F: Complete cure of a patient with HBV‑associated hepatocellular carcinoma with lung metastasis using interferon and survival up to 108 months: A case report and literature review. Oncol Lett 16: 2979-2988, 2018.
APA
Wang, F., Lv, H., Li, Y., Han, T., Liu, H., Jia, K. ... Wang, F. (2018). Complete cure of a patient with HBV‑associated hepatocellular carcinoma with lung metastasis using interferon and survival up to 108 months: A case report and literature review. Oncology Letters, 16, 2979-2988. https://doi.org/10.3892/ol.2018.9033
MLA
Wang, F., Lv, H., Li, Y., Han, T., Liu, H., Jia, K., Liu, F., Gao, Y., Wang, F."Complete cure of a patient with HBV‑associated hepatocellular carcinoma with lung metastasis using interferon and survival up to 108 months: A case report and literature review". Oncology Letters 16.3 (2018): 2979-2988.
Chicago
Wang, F., Lv, H., Li, Y., Han, T., Liu, H., Jia, K., Liu, F., Gao, Y., Wang, F."Complete cure of a patient with HBV‑associated hepatocellular carcinoma with lung metastasis using interferon and survival up to 108 months: A case report and literature review". Oncology Letters 16, no. 3 (2018): 2979-2988. https://doi.org/10.3892/ol.2018.9033
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