Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
September-2018 Volume 16 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2018 Volume 16 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Decreased expression level and DNA‑binding activity of specificity protein 1 via cyclooxygenase‑2 inhibition antagonizes radiation resistance, cell migration and invasion in radiation‑resistant lung cancer cells

  • Authors:
    • Ruijun Liu
    • Qiang Tan
    • Qingquan Luo
  • View Affiliations / Copyright

    Affiliations: Department of Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3029-3037
    |
    Published online on: June 28, 2018
       https://doi.org/10.3892/ol.2018.9035
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Radiation is able to inhibit tumor growth, promote tumor cell apoptosis and prolong patient survival. However, radiation resistance remains a major impediment to radiotherapy. Local and metastatic recurrences following radiation are still large impediments to overall survival. Although cyclooxygenase‑2 (COX‑2) inhibitors may induce radiation sensitivity in cancer cells, the underlying mechanisms are not fully understood. The present study demonstrated high potential for cell proliferation, migration and invasion in radiation‑resistant lung cancer cell lines. The present study observed the overexpression of specificity protein 1 (Sp1) in these cells, and the overexpression of Sp1 induced upregulation of matrix metalloproteinase (MMP)‑2, MMP‑9, B cell lymphoma‑2, in addition to a high potential for radiation resistance, migration and invasion in these cells. The present study revealed that the COX‑2 selective inhibitor, celecoxib, enhanced radiation sensitivity and inhibited migration and invasion in these cells by inhibiting the expression and DNA‑binding activity of Sp1. Furthermore, celecoxib downregulated Sp1 by inhibiting c‑Jun N‑terminal kinase (JNK). Taken together, the present study demonstrated that Sp1 overexpression in radiation‑resistant cancer cells and COX‑2 inhibitors enhanced radiation sensitivity and inhibited the migration and invasion of cancer cells, at least partially, via inactivation of the JNK/Sp1 signaling pathway and a decrease in Sp1 DNA‑binding activity.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Ferlay J, Parkin DM and Steliarova-Foucher E: Estimates of cancer incidence and mortality in Europe in 2008. Eur J Cancer. 46:765–781. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Ferlay J, Shin HR, Bray F, Forman D, Mathers C and Parkin DM: Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 127:2893–2917. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Jemal A, Siegel R, Ward E, Murray T, Xu J, Smigal C and Thun MJ: Cancer statistics, 2006. CA Cancer J Clin. 56:106–130. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Guan Z, Yu X, Wang H, Wang H, Zhang J, Li G, Cao J and Teng L: Advances in the targeted therapy of liposarcoma. Onco Targets Ther. 8:125–136. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Duong CP, Yong CS, Kershaw MH, Slaney CY and Darcy PK: Cancer immunotherapy utilizing gene-modified T cells: From the bench to the clinic. Mol Immunol. 67:46–57. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Kong FM, Zhao J, Wang J and Faivre-Finn C: Radiation dose effect in locally advanced non-small cell lung cancer. J Thorac Dis. 6:336–347. 2014.PubMed/NCBI

7 

Brady LW, Kramer S, Levitt SH, Parker RG and Powers WE: Radiation oncology: Contributions of the United States in the last years of the 20th century. Radiology. 219:1–5. 2001. View Article : Google Scholar : PubMed/NCBI

8 

Alamanda VK, Song Y, Shinohara E, Schwartz HS and Holt GE: Postoperative radiation boost does not improve local recurrence rates in extremity soft tissue sarcomas. J Med Imaging Radiat Oncol. 58:633–640. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Cao CN, Luo JW, Gao L, Xu GZ, Li SY and Xiao JP: Recurrence of nasopharyngeal carcinoma in the parotid region after definitive intensity-modulated radiotherapy. J Oral Maxillofac Surg. 71:1993–1997. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Milas L, Raju U, Liao Z and Ajani J: Targeting molecular determinants of tumor chemo-radioresistance. Semin Oncol. 32 Suppl 9:S78–S81. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Brach MA, Gruss HJ, Kaisho T, Asano Y, Hirano T and Herrmann F: Ionizing radiation induces expression of interleukin 6 by human fibroblasts involving activation of nuclear factor-kappa B. J Biol Chem. 268:8466–8472. 1993.PubMed/NCBI

12 

Yin ZJ, Jin FG, Liu TG, Fu EQ, Xie YH and Sun RL: Overexpression of STAT3 potentiates growth, survival, and radioresistance of non-small-cell lung cancer (NSCLC) cells. J Surg Res. 171:675–683. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Guerra LE, Smith RM, Kaminski A, Lagios MD and Silverstein MJ: Invasive local recurrence increased after radiation therapy for ductal carcinoma in situ. Am J Surg. 196:552–555. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Wild-Bode C, Weller M, Rimner A, Dichgans J and Wick W: Sublethal irradiation promotes migration and invasiveness of glioma cells: Implications for radiotherapy of human glioblastoma. Cancer Res. 61:2744–2750. 2001.PubMed/NCBI

15 

Cheng JC, Chou CH, Kuo ML and Hsieh CY: Radiation-enhanced hepatocellular carcinoma cell invasion with MMP-9 expression through PI3K/Akt/NF-kappaB signal transduction pathway. Oncogene. 25:7009–7018. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Paquette B, Baptiste C, Therriault H, Arguin G, Plouffe B and Lemay R: In vitro irradiation of basement membrane enhances the invasiveness of breast cancer cells. Br J Cancer. 97:1505–1512. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Qian LW, Mizumoto K, Urashima T, Nagai E, Maehara N, Sato N, Nakajima M and Tanaka M: Radiation-induced increase in invasive potential of human pancreatic cancer cells and its blockade by a matrix metalloproteinase inhibitor, CGS27023. Clin Cancer Res. 8:1223–1227. 2002.PubMed/NCBI

18 

Hsu TI, Wang MC, Chen SY, Yeh YM, Su WC, Chang WC and Hung JJ: Sp1 expression regulates lung tumor progression. Oncogene. 31:3973–3988. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Zannetti A, Del Vecchio S, Carriero MV, Fonti R, Franco P, Botti G, D'Aiuto G, Stoppelli MP and Salvatore M: Coordinate up-regulation of Sp1 DNA-binding activity and urokinase receptor expression in breast carcinoma. Cancer Res. 60:1546–1551. 2000.PubMed/NCBI

20 

Chiefari E, Brunetti A, Arturi F, Bidart JM, Russo D, Schlumberger M and Filetti S: Increased expression of AP2 and Sp1 transcription factors in human thyroid tumors: A role in NIS expression regulation? BMC Cancer. 2:352002. View Article : Google Scholar : PubMed/NCBI

21 

Zhang JP, Zhang H, Wang HB, Li YX, Liu GH, Xing S, Li MZ and Zeng MS: Down-regulation of Sp1 suppresses cell proliferation, clonogenicity and the expressions of stem cell markers in nasopharyngeal carcinoma. J Transl Med. 12:2222014. View Article : Google Scholar : PubMed/NCBI

22 

Cho JJ, Chae JI, Yoon G, Kim KH, Cho JH, Cho SS, Cho YS and Shim JH: Licochalcone A, a natural chalconoid isolated from Glycyrrhiza inflata root, induces apoptosis via Sp1 and Sp1 regulatory proteins in oral squamous cell carcinoma. Int J Oncol. 45:667–674. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Dynan WS and Tjian R: The promoter-specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoter. Cell. 35:79–87. 1983. View Article : Google Scholar : PubMed/NCBI

24 

de Borja Fojas P, Collins NK, Du P, Azizkhan-Clifford J and Mudryj M: Cyclin A-CDK phosphorylates Sp1 and enhances Sp1-mediated transcription. EMBO J. 20:5737–5747. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Chuang JY, Wang SA, Yang WB, Yang HC, Hung CY, Su TP, Chang WC and Hung JJ: Sp1 phosphorylation by cyclin-dependent kinase 1/cyclin B1 represses its DNA-binding activity during mitosis in cancer cells. Oncogene. 31:4946–4959. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Yang HW: COX-2 regulation of prostaglandins in synaptic signaling. Sheng Li Ke Xue Jin Zhan. 40:317–320. 2009.(In Chinese). PubMed/NCBI

27 

Lim HY, Joo HJ, Choi JH, Yi JW, Yang MS, Cho DY, Kim HS, Nam DK, Lee KB and Kim HC: Increased expression of cyclooxygenase-2 protein in human gastric carcinoma. Clin Cancer Res. 6:519–525. 2000.PubMed/NCBI

28 

Tucker ON, Dannenberg AJ, Yang EK, Zhang F, Teng L, Daly JM, Soslow RA, Masferrer JL, Woerner BM, Koki AT and Fahey TJ III: Cyclooxygenase-2 expression is up-regulated in human pancreatic cancer. Cancer Res. 59:987–990. 1999.PubMed/NCBI

29 

Molina MA, Sitja-Arnau M, Lemoine MG, Frazier ML and Sinicrope FA: Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: Growth inhibition by nonsteroidal anti-inflammatory drugs. Cancer Res. 59:4356–4362. 1999.PubMed/NCBI

30 

Brown JR and DuBois RN: Cyclooxygenase as a target in lung cancer. Clin Cancer Res. 10:4266s–4269s. 2004. View Article : Google Scholar : PubMed/NCBI

31 

Pruthi RS, Derksen E and Gaston K: Cyclooxygenase-2 as a potential target in the prevention and treatment of genitourinary tumors: A review. J Urol. 169:2352–2359. 2003. View Article : Google Scholar : PubMed/NCBI

32 

Wang CH, Chang HC and Hung WC: p16 inhibits matrix metalloproteinase-2 expression via suppression of Sp1-mediated gene transcription. J Cell Physiol. 208:246–252. 2006. View Article : Google Scholar : PubMed/NCBI

33 

Meng Z and Gan YH: Activating PTEN by COX-2 inhibitors antagonizes radiation-induced AKT activation contributing to radiosensitization. Biochem Biophys Res Commun. 460:198–204. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Kwon YW, Jang S, Paek JS, Lee JW, Cho HJ, Yang HM and Kim HS: E-Ras improves the efficiency of reprogramming by facilitating cell cycle progression through JNK-Sp1 pathway. Stem Cell Res. 15:481–494. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Ohuchida K, Mizumoto K, Murakami M, Qian LW, Sato N, Nagai E, Matsumoto K, Nakamura T and Tanaka M: Radiation to stromal fibroblasts increases invasiveness of pancreatic cancer cells through tumor-stromal interactions. Cancer Res. 64:3215–3222. 2004. View Article : Google Scholar : PubMed/NCBI

36 

Guo L, Xiao Y, Fan M, Li JJ and Wang Y: Profiling global kinome signatures of the radioresistant MCF-7/C6 breast cancer cells using MRM-based targeted proteomics. J Proteome Res. 14:193–201. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Peng G, Cao RB, Li YH, Zou ZW, Huang J and Ding Q: Alterations of cell cycle control proteins SHP1/2, p16, CDK4 and cyclin D1 in radioresistant nasopharyngeal carcinoma cells. Mol Med Rep. 10:1709–1716. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Kou XX, Hao T, Meng Z, Zhou YH and Gan YH: Acetylated Sp1 inhibits PTEN expression through binding to PTEN core promoter and recruitment of HDAC1 and promotes cancer cell migration and invasion. Carcinogenesis. 34:58–67. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Duan H, Heckman CA and Boxer LM: Histone deacetylase inhibitors down-regulate bcl-2 expression and induce apoptosis in t(14;18) lymphomas. Mol Cell Biol. 25:1608–1619. 2005. View Article : Google Scholar : PubMed/NCBI

40 

Qiu T, Zhou X, Wang J, Du Y, Xu J, Huang Z, Zhu W, Shu Y and Liu P: MiR-145, miR-133a and miR-133b inhibit proliferation, migration, invasion and cell cycle progression via targeting transcription factor Sp1 in gastric cancer. FEBS Lett. 588:1168–1177. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Yang MY, Lee HT, Chen CM, Shen CC and Ma HI: Celecoxib suppresses the phosphorylation of STAT3 protein and can enhance the radiosensitivity of medulloblastoma-derived cancer stem-like cells. Int J Mol Sci. 15:11013–11029. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Kim YM, Jeong IH and Pyo H: Celecoxib enhances the radiosensitizing effect of 7-hydroxystaurosporine (UCN-01) in human lung cancer cell lines. Int J Radiat Oncol Biol Phys. 83:e399–e407. 2012. View Article : Google Scholar : PubMed/NCBI

43 

Wang LW, Hsiao CF, Chen WT, Lee HH, Lin TC, Chen HC, Chen HH, Chien CR, Lin TY and Liu TW: Celecoxib plus chemoradiotherapy for locally advanced rectal cancer: A phase II TCOG study. J Surg Oncol. 109:580–585. 2014. View Article : Google Scholar : PubMed/NCBI

44 

Chuang JY, Wang YT, Yeh SH, Liu YW, Chang WC and Hung JJ: Phosphorylation by c-Jun NH2-terminal kinase 1 regulates the stability of transcription factor Sp1 during mitosis. Mol Biol Cell. 19:1139–1151. 2008. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Liu R, Tan Q and Luo Q: Decreased expression level and DNA‑binding activity of specificity protein 1 via cyclooxygenase‑2 inhibition antagonizes radiation resistance, cell migration and invasion in radiation‑resistant lung cancer cells. Oncol Lett 16: 3029-3037, 2018.
APA
Liu, R., Tan, Q., & Luo, Q. (2018). Decreased expression level and DNA‑binding activity of specificity protein 1 via cyclooxygenase‑2 inhibition antagonizes radiation resistance, cell migration and invasion in radiation‑resistant lung cancer cells. Oncology Letters, 16, 3029-3037. https://doi.org/10.3892/ol.2018.9035
MLA
Liu, R., Tan, Q., Luo, Q."Decreased expression level and DNA‑binding activity of specificity protein 1 via cyclooxygenase‑2 inhibition antagonizes radiation resistance, cell migration and invasion in radiation‑resistant lung cancer cells". Oncology Letters 16.3 (2018): 3029-3037.
Chicago
Liu, R., Tan, Q., Luo, Q."Decreased expression level and DNA‑binding activity of specificity protein 1 via cyclooxygenase‑2 inhibition antagonizes radiation resistance, cell migration and invasion in radiation‑resistant lung cancer cells". Oncology Letters 16, no. 3 (2018): 3029-3037. https://doi.org/10.3892/ol.2018.9035
Copy and paste a formatted citation
x
Spandidos Publications style
Liu R, Tan Q and Luo Q: Decreased expression level and DNA‑binding activity of specificity protein 1 via cyclooxygenase‑2 inhibition antagonizes radiation resistance, cell migration and invasion in radiation‑resistant lung cancer cells. Oncol Lett 16: 3029-3037, 2018.
APA
Liu, R., Tan, Q., & Luo, Q. (2018). Decreased expression level and DNA‑binding activity of specificity protein 1 via cyclooxygenase‑2 inhibition antagonizes radiation resistance, cell migration and invasion in radiation‑resistant lung cancer cells. Oncology Letters, 16, 3029-3037. https://doi.org/10.3892/ol.2018.9035
MLA
Liu, R., Tan, Q., Luo, Q."Decreased expression level and DNA‑binding activity of specificity protein 1 via cyclooxygenase‑2 inhibition antagonizes radiation resistance, cell migration and invasion in radiation‑resistant lung cancer cells". Oncology Letters 16.3 (2018): 3029-3037.
Chicago
Liu, R., Tan, Q., Luo, Q."Decreased expression level and DNA‑binding activity of specificity protein 1 via cyclooxygenase‑2 inhibition antagonizes radiation resistance, cell migration and invasion in radiation‑resistant lung cancer cells". Oncology Letters 16, no. 3 (2018): 3029-3037. https://doi.org/10.3892/ol.2018.9035
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team