Open Access

Wnt2 contributes to the progression of gastric cancer by promoting cell migration and invasion

  • Authors:
    • Zhaoran Zhang
    • Jinyan Wang
    • Xiang Dong
  • View Affiliations

  • Published online on: June 28, 2018     https://doi.org/10.3892/ol.2018.9050
  • Pages: 2857-2864
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Wnt2 plays a pivotal role in human cancer. However, it is not yet known whether Wnt2 contributes to promoting migration and invasion of gastric cancer. The present study aimed to investigate the expression of Wnt2 in gastric cancer tissues and cell lines, and to analyze the effect of Wnt2 on gastric cancer cells. Wnt2 expression level was evaluated in gastric cancer samples and adjacent normal gastric tissues by immunohistochemical and western blot analysis. To investigate the effect of Wnt2 on gastric cancer cells, an in vitro Wnt2 secreting system was established using CHO cells. The results indicated that Wnt2 is overexpressed in gastric cancer and is implicated in metastasis and TNM stage. Additionally, the results of in vitro experiments demonstrated that Wnt2 contributes to enhancing the migration and invasion abilities of gastric cancer cells. These results suggested that Wnt2 may be an effective target of treatment for patients with advanced gastric cancer.
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September-2018
Volume 16 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhang Z, Wang J and Dong X: Wnt2 contributes to the progression of gastric cancer by promoting cell migration and invasion. Oncol Lett 16: 2857-2864, 2018
APA
Zhang, Z., Wang, J., & Dong, X. (2018). Wnt2 contributes to the progression of gastric cancer by promoting cell migration and invasion. Oncology Letters, 16, 2857-2864. https://doi.org/10.3892/ol.2018.9050
MLA
Zhang, Z., Wang, J., Dong, X."Wnt2 contributes to the progression of gastric cancer by promoting cell migration and invasion". Oncology Letters 16.3 (2018): 2857-2864.
Chicago
Zhang, Z., Wang, J., Dong, X."Wnt2 contributes to the progression of gastric cancer by promoting cell migration and invasion". Oncology Letters 16, no. 3 (2018): 2857-2864. https://doi.org/10.3892/ol.2018.9050