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Wnt2 contributes to the progression of gastric cancer by promoting cell migration and invasion

  • Authors:
    • Zhaoran Zhang
    • Jinyan Wang
    • Xiang Dong
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Jining First People's Hospital, Jining, Shandong 272000, P.R. China, Department of Gastroenterology, Liaocheng People's Hospital, Liaocheng, Shandong 252000, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2857-2864
    |
    Published online on: June 28, 2018
       https://doi.org/10.3892/ol.2018.9050
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Abstract

Wnt2 plays a pivotal role in human cancer. However, it is not yet known whether Wnt2 contributes to promoting migration and invasion of gastric cancer. The present study aimed to investigate the expression of Wnt2 in gastric cancer tissues and cell lines, and to analyze the effect of Wnt2 on gastric cancer cells. Wnt2 expression level was evaluated in gastric cancer samples and adjacent normal gastric tissues by immunohistochemical and western blot analysis. To investigate the effect of Wnt2 on gastric cancer cells, an in vitro Wnt2 secreting system was established using CHO cells. The results indicated that Wnt2 is overexpressed in gastric cancer and is implicated in metastasis and TNM stage. Additionally, the results of in vitro experiments demonstrated that Wnt2 contributes to enhancing the migration and invasion abilities of gastric cancer cells. These results suggested that Wnt2 may be an effective target of treatment for patients with advanced gastric cancer.
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1 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Chen W, Zheng R, Zeng H, Zhang S and He J: Annual report on status of cancer in China, 2011. Chin J Cancer Res. 27:2–12. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Hu L, Duan YT, Li JF, Su LP, Yan M, Zhu ZG, Liu BY and Yang QM: Biglycan enhances gastric cancer invasion by activating FAK signaling pathway. Oncotarget. 5:1885–1896. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Clevers H and Nusse R: Wnt/β-catenin signaling and disease. Cell. 149:1192–1205. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Baarsma HA, Königshoff M and Gosens R: The WNT signaling pathway from ligand secretion to gene transcription: Molecular mechanisms and pharmacological targets. Pharmacol Ther. 138:66–83. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Polakis P: Wnt signaling in cancer. Cold Spring Harb Perspect Biol. 4:pii: a008052. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Chiurillo MA: Role of the Wnt/β-catenin pathway in gastric cancer: An in-depth literature review. World J Exp Med. 5:84–102. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Ooi CH, Ivanova T, Wu J, Lee M, Tan IB, Tao J, Ward L, Koo JH, Gopalakrishnan V, Zhu Y, et al: Oncogenic pathway combinations predict clinical prognosis in gastric cancer. PLoS Genet. 5:e10006762009. View Article : Google Scholar : PubMed/NCBI

9 

Clements WM, Wang J, Sarnaik A, Kim OJ, MacDonald J, Fenoglio-Preiser C, Groden J and Lowy AM: Beta-catenin mutation is a frequent cause of Wnt pathway activation in gastric cancer. Cancer Res. 62:3503–3506. 2002.PubMed/NCBI

10 

Ikenoue T, Ijichi H, Kato N, Kanai F, Masaki T, Rengifo W, Okamoto M, Matsumura M, Kawabe T, Shiratori Y and Omata M: Analysis of the beta-catenin/T cell factor signaling pathway in 36 gastrointestinal and liver cancer cells. Jpn J Cancer Res. 93:1213–1220. 2002. View Article : Google Scholar : PubMed/NCBI

11 

Fu L, Zhang C, Zhang LY, Dong SS, Lu LH, Chen J, Dai Y, Li Y, Kong KL, Kwong DL and Guan XY: Wnt2 secreted by tumour fibroblasts promotes tumour progression in oesophageal cancer by activation of the Wnt/β-catenin signalling pathway. Gut. 60:1635–1643. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Wu Y, Ginther C, Kim J, Mosher N, Chung S, Slamon D and Vadgama JV: Expression of Wnt3 activates Wnt/β-catenin pathway and promotes EMT-like phenotype in trastuzumab-resistant HER2-overexpressing breast cancer cells. Mol Cancer Res. 10:1597–1606. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Mao J, Fan S, Ma W, Fan P, Wang B, Zhang J, Wang H, Tang B, Zhang Q, Yu X, et al: Roles of Wnt/β-catenin signaling in the gastric cancer stem cells proliferation and salinomycin treatment. Cell Death Dis. 5:e10392014. View Article : Google Scholar : PubMed/NCBI

14 

Cheng XX, Wang ZC, Chen XY, Sun Y, Kong QY, Liu J and Li H: Correlation of Wnt-2 expression and beta-catenin intracellular accumulation in Chinese gastric cancers: Relevance with tumour dissemination. Cancer Lett. 223:339–347. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Vider BZ, Zimber A, Chastre E, Prevot S, Gespach C, Estlein D, Wolloch Y, Tronick SR, Gazit A and Yaniv A: Evidence for the involvement of the Wnt 2 gene in human colorectal cancer. Oncogene. 12:153–158. 1996.PubMed/NCBI

16 

Watanabe O, Imamura H, Shimizu T, Kinoshita J, Okabe T, Hirano A, Yoshimatsu K, Konno S, Aiba M and Ogawa K: Expression of twist and wnt in human breast cancer. Anticancer Res. 24:3851–3856. 2004.PubMed/NCBI

17 

Jiang H, Li Q, He C, Li F, Sheng H, Shen X, Zhang X, Zhu S, Chen H, Chen X, et al: Activation of the Wnt pathway through Wnt2 promotes metastasis in pancreatic cancer. Am J Cancer Res. 4:537–544. 2014.PubMed/NCBI

18 

Mazieres J, You L, He B, Xu Z, Twogood S, Lee AY, Reguart N, Batra S, Mikami I and Jablons DM: Wnt2 as a new therapeutic target in malignant pleural mesothelioma. Int J Cancer. 117:326–332. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Valkenburg KC, Graveel CR, Zylstra-Diegel CR, Zhong Z and Williams BO: Wnt/β-catenin signaling in normal and cancer stem cells. Cancers (Basel). 3:2050–2079. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Katoh M: WNT2 and human gastrointestinal cancer (review). Int J Mol Med. 12:811–816. 2003.PubMed/NCBI

21 

Katoh M: Frequent up-regulation of WNT2 in primary gastric cancer and colorectal cancer. Int J Oncol. 19:1003–1007. 2001.PubMed/NCBI

22 

In H, Solsky I, Palis B, Langdon-Embry M, Ajani J and Sano T: Validation of the 8th edition of the AJCC TNM staging system for gastric cancer using the national cancer database. Ann Surg Oncol. 24:3683–3691. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Huang C, Ma R, Xu Y, Li N, Li Z, Yue J, Li H, Guo Y and Qi D: Wnt2 promotes non-small cell lung cancer progression by activating WNT/β-catenin pathway. Am J Cancer Res. 5:1032–1046. 2015.PubMed/NCBI

24 

Schmittgen TD and Livak KJ: Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc. 3:1101–1108. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Xu Y, Li H, Huang C, Zhao T, Zhang H, Zheng C, Ren H and Hao J: Wnt2 protein plays a role in the progression of pancreatic cancer promoted by pancreatic stellate cells. Med Oncol. 32:972015. View Article : Google Scholar : PubMed/NCBI

26 

Jeong HW, Nam JO and Kim IS: The COOH-terminal end of R-Ras alters the motility and morphology of breast epithelial cells through Rho/Rho-kinase. Cancer Res. 65:507–515. 2005.PubMed/NCBI

27 

Cheng XX, Wang ZC, Chen XY, Sun Y, Kong QY, Liu J, Gao X, Guan HW and Li H: Frequent loss of membranous E-cadherin in gastric cancers: A cross-talk with Wnt in determining the fate of beta-catenin. Clin Exp Metastasis. 22:85–93. 2005. View Article : Google Scholar : PubMed/NCBI

28 

Yilmaz M and Christofori G: EMT, the cytoskeleton, and cancer cell invasion. Cancer Metastasis Rev. 28:15–33. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Peng Z, Wang CX, Fang EH, Wang GB and Tong Q: Role of epithelial-mesenchymal transition in gastric cancer initiation and progression. World J Gastroenterol. 20:5403–5410. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Valastyan S and Weinberg RA: Tumor metastasis: Molecular insights and evolving paradigms. Cell. 147:275–292. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Klapholz-Brown Z, Walmsley GG, Nusse YM, Nusse R and Brown PO: Transcriptional program induced by Wnt protein in human fibroblasts suggests mechanisms for cell cooperativity in defining tissue microenvironments. PLoS One. 2:e9452007. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang Z, Wang J and Dong X: Wnt2 contributes to the progression of gastric cancer by promoting cell migration and invasion. Oncol Lett 16: 2857-2864, 2018.
APA
Zhang, Z., Wang, J., & Dong, X. (2018). Wnt2 contributes to the progression of gastric cancer by promoting cell migration and invasion. Oncology Letters, 16, 2857-2864. https://doi.org/10.3892/ol.2018.9050
MLA
Zhang, Z., Wang, J., Dong, X."Wnt2 contributes to the progression of gastric cancer by promoting cell migration and invasion". Oncology Letters 16.3 (2018): 2857-2864.
Chicago
Zhang, Z., Wang, J., Dong, X."Wnt2 contributes to the progression of gastric cancer by promoting cell migration and invasion". Oncology Letters 16, no. 3 (2018): 2857-2864. https://doi.org/10.3892/ol.2018.9050
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Z, Wang J and Dong X: Wnt2 contributes to the progression of gastric cancer by promoting cell migration and invasion. Oncol Lett 16: 2857-2864, 2018.
APA
Zhang, Z., Wang, J., & Dong, X. (2018). Wnt2 contributes to the progression of gastric cancer by promoting cell migration and invasion. Oncology Letters, 16, 2857-2864. https://doi.org/10.3892/ol.2018.9050
MLA
Zhang, Z., Wang, J., Dong, X."Wnt2 contributes to the progression of gastric cancer by promoting cell migration and invasion". Oncology Letters 16.3 (2018): 2857-2864.
Chicago
Zhang, Z., Wang, J., Dong, X."Wnt2 contributes to the progression of gastric cancer by promoting cell migration and invasion". Oncology Letters 16, no. 3 (2018): 2857-2864. https://doi.org/10.3892/ol.2018.9050
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