Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
September-2018 Volume 16 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2018 Volume 16 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Comparative analysis of tumor‑associated vascular changes following TACE alone or in combination with sorafenib treatment in HCC: A retrospective study

  • Authors:
    • Ligang Chen
    • Yifei Zheng
    • Hongjian Zhang
    • Heng Pan
    • Qiusong Liu
    • Xu Zhou
    • Wei Wei
    • Yun Liu
    • Maochuan Zhen
    • Jinling Wang
    • Jianyin Zhou
    • Yilin Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Zhongshan Hospital Affiliated to Xiamen University, Xiamen, Fujian 361004, P.R. China, Medical College, Xiamen University, Xiamen, Fujian 361004, P.R. China, Department of Oncology and Vascular Interventional Radiology, Zhongshan Hospital Affiliated to Xiamen University, Xiamen, Fujian 361004, P.R. China, Department of Hepatic Surgery, Zhongshan Hospital Affiliated to Xiamen University, Xiamen, Fujian 361004, P.R. China, Department of Physical Emergency, Zhongshan Hospital Affiliated to Xiamen University, Xiamen, Fujian 361004, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3690-3698
    |
    Published online on: July 2, 2018
       https://doi.org/10.3892/ol.2018.9055
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The objective of the present study was to investigate the tumor‑associated vascular changes in hepatocellular carcinoma (HCC) following treatment with transarterial chemoembolization (TACE) combined with sorafenib. The data of 20 patients were retrospectively analyzed. Patients underwent treatment depending on their chosen regimens (orally administered sorafenib was recommended, however the cost prevented some study articipants from selecting this course). Based on this, the patients were divided into TACE combined with sorafenib (TS) (n=10) and TACE‑only treatment groups (n=10). Digital subtraction angiography images of all patients were analyzed by 2 radiologists who were blind to the type of treatment administered. The diameters of the hepatic and proper hepatic arteries, and hepatic artery branches (tumor‑associated arteries), the splenic, left gastric and gastroduodenal arteries or portal veins (non‑tumor‑associated arteries) and the number of microvascular vessels were compared prior to and following sorafenib treatment in the TS group, between the first and second sessions of TACE in the TACE‑only group and between the TS and TACE‑only groups. In the TS group, the diameters of the hepatic and proper hepatic arteries, their branches and the number of microvascular vessels were significantly decreased following sorafenib treatment (P<0.05), while the diameters of the splenic, gastroduodenal and left gastric arteries were not significantly altered (P>0.05). In the TACE‑only group, the diameters of the hepatic, proper hepatic, splenic, left gastric and gastroduodenal arteries were not significantly different between the first and second TACE sessions (P>0.05), while the diameters of the hepatic artery branches and the number of microvascular vessels were significantly altered (P<0.05). TACE combined with sorafenib significantly decreased the diameters of the tumor‑associated arteries and the number of tumor microvascular vessels when compared with TACE treatment alone (P<0.05). No significant difference in the diameters of the portal vein and its branches between the two groups was observed (P>0.05). Treatment with TACE combined with sorafenib may significantly affect the tumor‑associated vasculature compared with treatment with TACE alone in HCC.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Elserag HB and Rudolph KL: Hepatocellular carcinoma: Epidemiology and molecular carcinogenesis. Gastroenterology. 132:2557–2576. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Wang JS, Huang T, Su J, Liang F, Wei Z, Liang Y, Luo H, Kuang SY, Qian GS, Sun G, et al: Hepatocellular carcinoma and aflatoxin exposure in Zhuqing Village, Fusui County, People's Republic of China. Cancer Epidemiol Biomarkers Prev. 10:143–146. 2001.PubMed/NCBI

3 

Alloatti A, Testero SA and Uttaro AD: Chemical evaluation of fatty acid desaturases as drug targets in Trypanosoma cruzi. Int J Parasitol. 39:985–993. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Burrel M, Reig M, Forner A, Barrufet M, de Lope CR, Tremosini S, Ayuso C, Llovet JM, Real MI and Bruix J: Survival of patients with hepatocellular carcinoma treated by transarterial chemoembolisation (TACE) using drug eluting beads. Implications for clinical practice and trial design. J Hepatol. 56:1330–1335. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Boas FE, Kamaya A, Do B, Desser TS, Beaulieu CF, Vasanawala SS, Hwang GL and Sze DY: Classification of hypervascular liver lesions based on hepatic artery and portal vein blood supply coefficients calculated from triphasic CT scans. J Digit Imaging. 28:213–223. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Brade AM, Ng S, Brierley J, Kim J, Dinniwell R, Ringash J, Wong RR, Cho C, Knox J and Dawson LA: Phase 1 trial of sorafenib and stereotactic body radiation therapy for hepatocellular carcinoma. Int J Radiat Oncol Biol Phys. 94:580–587. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Brock TJ, Browse J and Watts JL: Genetic regulation of unsaturated fatty acid composition in C. elegans. PLoS Genet. 2:e1082006. View Article : Google Scholar : PubMed/NCBI

8 

Jia ZZ, Jiang GM and Feng YL: Serum HIF-1alpha and VEGF levels pre- and post-TACE in patients with primary liver cancer. Chin Med Sci J. 26:158–162. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Chen J, Zhang WJ, Guo Z, Wang HB, Wang DD, Zhou JJ and Chen QW: pH-responsive iron manganese silicate nanoparticles as T1-T2* dual-modal imaging probes for tumor diagnosis. ACS Appl Mater Interfaces. 7:5373–5383. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Das S, Ladell DS, Podgrabinska S, Ponomarev V, Nagi C, Fallon JT and Skobe M: Vascular endothelial growth factor-C induces lymphangitic carcinomatosis, an extremely aggressive form of lung metastases. Cancer Res. 70:1814–1824. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Di Costanzo GG, Tortora R, Morisco F, Addario L, Guarino M, Cordone G, Falco L and Caporaso N: Impact of diabetes on outcomes of sorafenib therapy for hepatocellular carcinoma. Target Oncol. 12:61–67. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Enoch HG, Catalá A and Strittmatter P: Mechanism of rat liver microsomal stearyl-CoA desaturase. Studies of the substrate specificity, enzyme-substrate interactions, and the function of lipid. J Biol Che. 251:5095–5103. 1976.

13 

Funami Y, Okuyama K, Koide Y, Kouzu T, Kinoshita H, Shimada Y and Isono K: Anatomical analysis of small bronchial arteries in front of the trachea by 3D-CT and digital subtraction angiography: Implications for esophageal cancer surgery. Nihon Geka Gakkai Zasshi. 96:207–212. 1995.(In Japanese). PubMed/NCBI

14 

Kim BK, Kim SU, Park JY, Kim DY, Ahn SH, Park MS, Kim EH, Seong J, Lee DY and Han KH: Applicability of BCLC stage for prognostic stratification in comparison with other staging systems: single centre experience from long-term clinical outcomes of 1717 treatment-naïve patients with hepatocellular carcinoma. Liver Int. 32:1120–1127. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Han K and Kim JH: Transarterial chemoembolization in hepatocellular carcinoma treatment: Barcelona clinic liver cancer staging system. World J Gastroenterol. 21:10327–10335. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Iavarone M, Cabibbo G, Piscaglia F, Zavaglia C, Grieco A, Villa E, Cammà C and Colombo M: SOFIA (SOraFenib Italian Assessment) study group: Field-practice study of sorafenib therapy for hepatocellular carcinoma: A prospective multicenter study in Italy. Hepatology. 54:2055–2063. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Park JW, Koh YH, Kim HB, Kim HY, An S, Choi JI, Woo SM and Nam BH: Phase II study of concurrent transarterial chemoembolization and sorafenib in patients with unresectable hepatocellular carcinoma. J Hepatol. 56:1336–1342. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Igal RA: Roles of stearoylCoA desaturase-1 in the regulation of cancer cell growth, survival and tumorigenesis. Cancers (Basel). 3:2462–2477. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Llovet JM, Brã C and Bruix J: Prognosis of hepatocellular carcinoma: The BCLC staging classification. Semin Liver Dis. 19:329–338. 1999. View Article : Google Scholar : PubMed/NCBI

20 

Wang ZL: Research on the security and clinical curative effect of TACE combined with sorafenib in the treatment of hepatocellular carcinoma in the middle and late period. China Foreign Med Treat. 1:126–127. 2016.

21 

Chung YH, Han G, Yoon JH, Yang J, Wang J, Shao GL, Kim BI, Lee TY and Chao Y: Interim analysis of START: Study in Asia of the combination of TACE (transcatheter arterial chemoembolization) with sorafenib in patients with hepatocellular carcinoma trial. Int J Cancer. 132:2448–2458. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Li X, Feng GS, Zheng CS, Zhuo CK and Liu X: Expression of plasma vascular endothelial growth factor in patients with hepatocellular carcinoma and effect of transcatheter arterial chemoembolization therapy on plasma vascular endothelial growth factor level. World J Gastroenterol. 10:2878–2882. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Yamaguchi R, Yano H, Iemura A, Ogasawara S, Haramaki M and Kojiro M: Expression of vascular endothelial growth factor in human hepatocellular carcinoma. Hepatology. 28:68–77. 1998. View Article : Google Scholar : PubMed/NCBI

24 

Poon RT, Lau CP, Ho JW, Yu WC, Fan ST and Wong J: Tissue factor expression correlates with tumor angiogenesis and invasiveness in human hepatocellular carcinoma. Clin Cancer Res. 9:5339–5345. 2003.PubMed/NCBI

25 

Maio MD, Daniele B and Perrone F: Targeted therapies: Role of sorafenib in HCC patients with compromised liver function. Nat Rev Clin Oncol. 6:505–506. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Wilhelm SM, Adnane L, Newell P, Villanueva A, Llovet JM and Lynch M: Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling. Mol Cancer Ther. 7:3129–3140. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Zhang L, Hu P, Chen X and Bie P: Transarterial chemoembolization (TACE) plus sorafenib versus TACE for intermediate or advanced stage hepatocellular carcinoma: A meta-analysis. PLoS One. 9:e1003052014. View Article : Google Scholar : PubMed/NCBI

28 

Ooka Y, Kanai F, Okabe S, Ueda T, Shimofusa R, Ogasawara S, Chiba T, Sato Y, Yoshikawa M and Yokosuka O: Gadoxetic acid-enhanced MRI compared with CT during angiography in the diagnosis of hepatocellular carcinoma. Magn Reson Imaging. 31:748–754. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Rossi S, Garbagnati F, Lencioni R, Allgaier HP, Marchianò A, Fornari F, Quaretti P, Tolla GD, Ambrosi C, Mazzaferro V, et al: Percutaneous radio-frequency thermal ablation of nonresectable hepatocellular carcinoma after occlusion of tumor blood supply. Radiology. 217:119–126. 2000. View Article : Google Scholar : PubMed/NCBI

30 

Numata K, Tanaka K, Kiba T, Saito S, Isozaki T, Hara K, Morimoto M, Sekihara H, Yonezawa H and Kubota T: Using contrast-enhanced sonography to assess the effectiveness of transcatheter arterial embolization for hepatocellular carcinoma. AJR Am J Roentgenol. 176:1199–1205. 2001. View Article : Google Scholar : PubMed/NCBI

31 

Koito K, Namieno T, Ichimura T, Hirokawa N, Syonai T, Hareyama M, Katsuramaki T, Hirata K and Nishi M: Power Doppler sonography: Evaluation of hepatocellular carcinoma after treatment with transarterial embolization or percutaneous ethanol injection therapy. AJR Am J Roentgenol. 174:337–341. 2000. View Article : Google Scholar : PubMed/NCBI

32 

Breedis C and Young G: The blood supply of neoplasms in the liver. Am J Pathol. 30:969–977. 1954.PubMed/NCBI

33 

Yamasaki T, Kurokawa F, Shirahashi H, Kusano N, Hironaka K and Okita K: Percutaneous radiofrequency ablation therapy for patients with hepatocellular carcinoma during occlusion of hepatic blood flow. Comparison with standard percutaneous radiofrequency ablation therapy. Cancer. 95:2353–2360. 2002. View Article : Google Scholar : PubMed/NCBI

34 

Burrel M, Llovet JM, Ayuso C, Iglesias C, Sala M, Miquel R, Caralt T, Ayuso JR, Solé M, Sanchez M, et al: MRI angiography is superior to helical CT for detection of HCC prior to liver transplantation: An explant correlation. Hepatology. 38:1034–1042. 2003. View Article : Google Scholar : PubMed/NCBI

35 

Kudo M: Imaging blood flow characteristics of hepatocellular carcinoma. Oncology. 62 Suppl 1:S48–S56. 2002. View Article : Google Scholar

36 

Woo HY, Heo J, Yoon KT, Kim GH, Kang DH, Song GA and Cho M: Clinical course of sorafenib treatment in patients with hepatocellular carcinoma. Scand J Gastroenterol. 47:809–819. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Tsurusaki M and Murakami T: Surgical and locoregional therapy of HCC: TACE. Liver Cancer. 4:165–175. 2015. View Article : Google Scholar : PubMed/NCBI

38 

Wan X, Zhai X, Yan Z, Yang P, Li J, Wu D, Wang K, Xia Y and Shen F: Retrospective analysis of transarterial chemoembolization and sorafenib in Chinese patients with unresectable and recurrent hepatocellular carcinoma. Oncotarget. 7:83806–83816. 2016. View Article : Google Scholar : PubMed/NCBI

39 

Pressiani T, Boni C, Rimassa L, Labianca R, Fagiuoli S, Salvagni S, Ferrari D, Cortesi E, Porta C, Mucciarini C, et al: Sorafenib in patients with Child-Pugh class A and B advanced hepatocellular carcinoma: A prospective feasibility analysis. Ann Oncol. 24:406–411. 2013. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Chen L, Zheng Y, Zhang H, Pan H, Liu Q, Zhou X, Wei W, Liu Y, Zhen M, Wang J, Wang J, et al: Comparative analysis of tumor‑associated vascular changes following TACE alone or in combination with sorafenib treatment in HCC: A retrospective study. Oncol Lett 16: 3690-3698, 2018.
APA
Chen, L., Zheng, Y., Zhang, H., Pan, H., Liu, Q., Zhou, X. ... Zhao, Y. (2018). Comparative analysis of tumor‑associated vascular changes following TACE alone or in combination with sorafenib treatment in HCC: A retrospective study. Oncology Letters, 16, 3690-3698. https://doi.org/10.3892/ol.2018.9055
MLA
Chen, L., Zheng, Y., Zhang, H., Pan, H., Liu, Q., Zhou, X., Wei, W., Liu, Y., Zhen, M., Wang, J., Zhou, J., Zhao, Y."Comparative analysis of tumor‑associated vascular changes following TACE alone or in combination with sorafenib treatment in HCC: A retrospective study". Oncology Letters 16.3 (2018): 3690-3698.
Chicago
Chen, L., Zheng, Y., Zhang, H., Pan, H., Liu, Q., Zhou, X., Wei, W., Liu, Y., Zhen, M., Wang, J., Zhou, J., Zhao, Y."Comparative analysis of tumor‑associated vascular changes following TACE alone or in combination with sorafenib treatment in HCC: A retrospective study". Oncology Letters 16, no. 3 (2018): 3690-3698. https://doi.org/10.3892/ol.2018.9055
Copy and paste a formatted citation
x
Spandidos Publications style
Chen L, Zheng Y, Zhang H, Pan H, Liu Q, Zhou X, Wei W, Liu Y, Zhen M, Wang J, Wang J, et al: Comparative analysis of tumor‑associated vascular changes following TACE alone or in combination with sorafenib treatment in HCC: A retrospective study. Oncol Lett 16: 3690-3698, 2018.
APA
Chen, L., Zheng, Y., Zhang, H., Pan, H., Liu, Q., Zhou, X. ... Zhao, Y. (2018). Comparative analysis of tumor‑associated vascular changes following TACE alone or in combination with sorafenib treatment in HCC: A retrospective study. Oncology Letters, 16, 3690-3698. https://doi.org/10.3892/ol.2018.9055
MLA
Chen, L., Zheng, Y., Zhang, H., Pan, H., Liu, Q., Zhou, X., Wei, W., Liu, Y., Zhen, M., Wang, J., Zhou, J., Zhao, Y."Comparative analysis of tumor‑associated vascular changes following TACE alone or in combination with sorafenib treatment in HCC: A retrospective study". Oncology Letters 16.3 (2018): 3690-3698.
Chicago
Chen, L., Zheng, Y., Zhang, H., Pan, H., Liu, Q., Zhou, X., Wei, W., Liu, Y., Zhen, M., Wang, J., Zhou, J., Zhao, Y."Comparative analysis of tumor‑associated vascular changes following TACE alone or in combination with sorafenib treatment in HCC: A retrospective study". Oncology Letters 16, no. 3 (2018): 3690-3698. https://doi.org/10.3892/ol.2018.9055
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team