Suppression of Hiwi inhibits the growth and epithelial‑mesenchymal transition of cervical cancer cells

Pei,Guangjun; Li,Baojian; Ma,Anjun

doi:10.3892/ol.2018.9056

Suppression of Hiwi inhibits the growth and epithelial‑mesenchymal transition of cervical cancer cells

Authors:
- Guangjun Pei
- Baojian Li
- Anjun Ma
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Affiliations: Department of Radiotherapy, The First Hospital of Lanzhou University, Lanzhou, Gansu 730000, P.R. China, Department of Oncology, Zaozhuang Mining Group Center Hospital, Zaozhuang, Shandong 277800, P.R. China, Department of Gynecology, The Second People's Hospital of Liaocheng, Linqing, Shandong 252600, P.R. China
Published online on: July 2, 2018 https://doi.org/10.3892/ol.2018.9056
Pages: 3874-3880

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Abstract

Cervical cancer is a common gynecological malignancy. Hiwi exhibits a high level of expression in cervical cancer cells. However, the effects of Hiwi expression in cervical cancer cells remain unresolved. In the present study, the effects of Hiwi downregulation on the growth and epithelial‑mesenchymal transition of cervical cancer cells were investigated. The results of the present study revealed that the suppression of Hiwi was able to inhibit the proliferation of cervical cancer cells and arrest cell cycle at G1 phase. The downregulation of Hiwi was also revealed to inhibit the epithelial‑mesenchymal transition process of cervical cancer cells by regulating the expression of E‑cadherin, N‑cadherin, vimentin, and snail. The present study demonstrated that the suppression of Hiwi was able to inhibit the growth and epithelial‑mesenchymal transition of cervical cancer cells. Therefore, the results suggest that Hiwi may function as an oncogene in cervical cancer cells and may become a potential target for cervical cancer therapy.

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