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Article

Irreversible electroporation of malignant liver tumors: Effect on laboratory values

  • Authors:
    • Mohammed Alnaggar
    • Ammar M. Qaid
    • Jibing Chen
    • Lizhi Niu
    • Kecheng Xu
  • View Affiliations / Copyright

    Affiliations: Biomedical Translational Research Institute and The First Affiliated Hospital, Jinan University, Guangzhou, Guangdong 510632, P.R. China, Department of Oncology, Affiliated Union Hospital of Fujian Medical University, Fuzhou, Fujian 350001, P.R. China, Department of Oncology, Guangzhou Fuda Cancer Hospital, School of Medicine, Jinan University, Guangzhou, Guangdong 510665, P.R. China
  • Pages: 3881-3888
    |
    Published online on: July 2, 2018
       https://doi.org/10.3892/ol.2018.9058
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Abstract

Liver cancer is often associated with chronic liver diseases. Treatment with percutaneous irreversible electroporation (IRE) may preserve liver function. In the present study, the clinical data of 29 patients with liver tumors between July 2015 and December 2016, all of whom underwent liver IRE at Fuda Cancer Hospital, Guangzhou, China was retrospectively reviewed. All the patients survived the treatment. Of the 29 patients, 7 were positive for hepatitis B, 15 had hepatocellular carcinoma (HCC) and 7 had pancreatic cancer with liver metastases. All patients survived IRE. Despite liver‑protective treatment prior to IRE, the mean alanine transaminase (ALT) and aspartate transaminase (AST) levels were significantly elevated 1‑2 days after IRE, to 540 and 712 U/l, respectively; however they had returned to the preoperative values by 2 weeks following IRE. Prior to IRE, the mean total bilirubin and direct bilirubin measurement levels were normal; however, 8‑10 days after IRE, they had increased to 24 U/l and 12 µmol/l, respectively, and had returned back to the preoperative levels by 2 weeks after IRE. This first group included all patients. The result of the 4 subgroups of cancer patients demonstrated a variation between different measurement days and recovery with patients positive for the hepatitis B virus taking the longest duration to recover (17±3 days) meanwhile patients with pancreatic cancer with liver metastases took the shortest time to achieve recovery (10.78±2 days). The findings of the present study indicate that hepatic injury caused by IRE is transient and self‑limiting in patients with liver tumors.
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1 

Ali AM, Lizhi N, Jialiang L, Fei Y, Yuan W, Jianying Z, Jin Y, Jibing C, Feng M and Kecheng X: Cryoprotective therapy for hepatocellular carcinoma: Study of 51 patients with a single lesion. Cryobiology. 69:61–67. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Alnaggar M, Niu L, Li J, Yao F, Wang Y, Zeng J, Ye J, Chen J, Mu F and Xu K: Cryoprotective therapy for huge hepatocellular carcinoma: A study of 14 patients with a single lesion. Cryobiology. 69:457–461. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Pearson AS, Izzo F, Fleming RY, Ellis LM, Delrio P, Roh MS, Granchi J and Curley SA: Intraoperative radiofrequency ablation or cryoablation for hepatic malignancies. Am J Surg. 178:592–599. 1999. View Article : Google Scholar : PubMed/NCBI

4 

Chung CD, Lau LL, Ko KL, Wong AC, Wong S, Chan AC, Poon RT, Lo CM and Fan ST: Laparoscopic liver resection for hepatocellular carcinoma. Asian J Surg. 33:168–172. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Ravikumar TS, Kane R, Cady B, Jenkins R, Clouse M and Steele G Jr: A 5-year study of cryosurgery in the treatment of liver tumors. Arch Surg. 126:1520–1524. 1991. View Article : Google Scholar : PubMed/NCBI

6 

Sarantou T, Bilchik A and Ramming KP: Complications of hepatic cryosurgery. Semin Surg Oncol. 14:156–162. 1998. View Article : Google Scholar : PubMed/NCBI

7 

Seifert JK and Morris DL: World survey on the complications of hepatic and prostate cryotherapy. World J Surg. 23:109–114. 1999. View Article : Google Scholar : PubMed/NCBI

8 

Shafir M, Shapiro R, Sung M, Warner R, Sicular A and Klipfel A: Cryoablation of unresectable malignant liver tumors. Am J Surg. 171:27–31. 1996. View Article : Google Scholar : PubMed/NCBI

9 

Schweitzer A, Horn J, Mikolajczyk RT, Krause G and Ott JJ: Estimations of worldwide prevalence of chronic hepatitis B virus infection: A systematic review of data published between 1965 and 2013. Lancet. 386:1546–1555. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Al-Sakere B, André F, Bernat C, Connault E, Opolon P, Davalos RV, Rubinsky B and Mir LM: Tumor ablation with irreversible electroporation. PloS One. 2:e11352007. View Article : Google Scholar : PubMed/NCBI

11 

Edd JF, Horowitz L, Davalos RV, Mir LM and Rubinsky B: In vivo results of a new focal tissue ablation technique: Irreversible electroporation. IEEE Trans Biomed Eng. 53:1409–1415. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Charpentier KP, Wolf F, Noble L, Winn B, Resnick M and Dupuy DE: Irreversible electroporation of the liver and liver hilum in swine. HPB (Oxford). 13:168–173. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Péus D, Newcomb N and Hofer S: Appraisal of the karnofsky performance status and proposal of a simple algorithmic system for its evaluation. BMC Med Inform Decis Mak. 13:722013. View Article : Google Scholar : PubMed/NCBI

14 

Cholongitas E, Papatheodoridis GV, Vangeli M, Terreni N, Patch D and Burroughs AK: Systematic review: The model for end-stage liver disease-should it replace Child-Pugh's classification for assessing prognosis in cirrhosis? Aliment Pharmacol Ther. 22:1079–1089. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Xu HM, Chen Y, Xu J and Zhou Q: Drug-induced liver injury in hospitalized patients with notably elevated alanine aminotransferase. World J Gastroenterol. 18:5972–5978. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Kos B, Voigt P, Miklavcic D and Moche M: Careful treatment planning enables safe ablation of liver tumors adjacent to major blood vessels by percutaneous irreversible electroporation (IRE). Radiol Oncol. 49:234–241. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Dollinger M, Muller-Wille R, Zeman F, Haimerl M, Niessen C, Beyer LP, Lang SA, Teufel A, Stroszczynski C and Wiggermann P: Irreversible electroporation of malignant hepatic tumors-alterations in venous structures at subacute follow-up and evolution at mid-term follow-up. PloS One. 10:e01357732015. View Article : Google Scholar : PubMed/NCBI

18 

Dollinger M, Zeman F, Niessen C, Lang SA, Beyer LP, Müller M, Stroszczynski C and Wiggermann P: Bile duct injury after irreversible electroporation of hepatic malignancies: Evaluation of MR imaging findings and laboratory values. J Vasc Interv Radiol. 27:96–103. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Dollinger M, Beyer LP, Haimerl M, Niessen C, Jung EM, Zeman F, Stroszczynski C and Wiggermann P: Adverse effects of irreversible electroporation of malignant liver tumors under CT fluoroscopic guidance: A single-center experience. Diagn Interv Radiol. 21:471–475. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Scheffer HJ, Nielsen K, de Jong MC, van Tilborg AA, Vieveen JM, Bouwman AR, Meijer S, van Kuijk C, van den Tol PM and Meijerink MR: Irreversible electroporation for nonthermal tumor ablation in the clinical setting: A systematic review of safety and efficacy. J Vasc Interv Radiol. 25:997–1011; quiz 1011. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Cohen EI, Field D, Lynskey GE and Kim AY: Technology of irreversible electroporation and review of its clinical data on liver cancers. Expert Rev Med Devices. 15:99–106. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Ryan MJ, Willatt J, Majdalany BS, Kielar AZ, Chong S, Ruma JA and Pandya A: Ablation techniques for primary and metastatic liver tumors. World J Hepatol. 8:191–199. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Chen X, Ren Z, Zhu T, Zhang X, Peng Z, Xie H, Zhou L, Yin S, Sun J and Zheng S: Electric ablation with irreversible electroporation (IRE) in vital hepatic structures and follow-up investigation. Sci Rep. 5:162332015. View Article : Google Scholar : PubMed/NCBI

24 

Min JH, Waters P, Vincent A, Lee S, Shin Y H, Lee H K and Kim BJ: Reduced serum uric acid levels in neuromyelitis optica: Serum uric acid levels are reduced during relapses in NMO. Acta Neurol Scand. 126:287–291. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Lord J, Willis S, Eatock J, Tappenden P, Trapero-Bertran M, Miners A, Crossan C, Westby M, Anagnostou A, Taylor S, et al: Economic modelling of diagnostic and treatment pathways in National Institute for Health and Care Excellence clinical guidelines: The modelling algorithm pathways in guidelines (MAPGuide) project. Health Technol Assess. 17(v-vi): 1–192. 2013.

26 

Wichtowski M, Nowaczyk P, Kocur J and Murawa D: Irreversible electroporation in the treatment of locally advanced pancreas and liver metastases of colorectal carcinoma. Contemp Oncol (Pozn). 20:39–44. 2016.PubMed/NCBI

27 

Froud T, Venkat SR, Barbery KJ, Gunjan A and Narayanan G: Liver function tests following irreversible electroporation of liver tumors: Experience in 174 procedures. Techn Vasc Interv Radiol. 18:140–146. 2015. View Article : Google Scholar

28 

Silk MT, Wimmer T, Lee KS, Srimathveeravalli G, Brown KT, Kingham PT, Fong Y, Durack JC, Sofocleous CT and Solomon SB: Percutaneous ablation of peribiliary tumors with irreversible electroporation. J Vasc Interv Radiol. 25:112–118. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Kingham TP, Karkar AM, D'Angelica MI, Allen PJ, Dematteo RP, Getrajdman GI, Sofocleous CT, Solomon SB, Jarnagin WR and Fong Y: Ablation of perivascular hepatic malignant tumors with irreversible electroporation. J Am Coll Surg. 215:379–387. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Thomson KR, Cheung W, Ellis SJ, Federman D, Kavnoudias H, Loader-Oliver D, Roberts S, Evans P, Ball C and Haydon A: Investigation of the safety of irreversible electroporation in humans. J Vasc Interv Radiol. 22:611–621. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Sugimoto K, Moriyasu F, Kobayashi Y, Saito K, Takeuchi H, Ogawa S, Ando M, Sano T, Mori T, Furuichi Y and Nakamura I: Irreversible electroporation for nonthermal tumor ablation in patients with hepatocellular carcinoma: Initial clinical experience in Japan. Jpn J Radiol. 33:424–432. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Cannon R, Ellis S, Hayes D, Narayanan G and Martin RC II: Safety and early efficacy of irreversible electroporation for hepatic tumors in proximity to vital structures. J Surg Oncol. 107:544–549. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Hosein PJ, Echenique A, Loaiza-Bonilla A, Froud T, Barbery K, Lima Rocha CM, Yrizarry JM and Narayanan G: Percutaneous irreversible electroporation for the treatment of colorectal cancer liver metastases with a proposal for a new response evaluation system. J Vasc Interv Radiol. 25(1233–1239): e22014.

34 

Distelmaier M, Barabasch A, Heil P, Kraemer NA, Isfort P, Keil S, Kuhl CK and Bruners P: Midterm safety and efficacy of irreversible electroporation of malignant liver tumors located close to major portal or hepatic veins. Radiology. 285:1023–1031. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Zhang Q and Teng G: Interventional therapy of colorectal liver metastasis. Zhonghua Wei Chang Wai Ke Za Zhi. 20:621–624. 2017.(In Chinese). PubMed/NCBI

36 

Lyu T, Wang X, Su Z, Shangguan J, Sun C, Figini M, Wang J, Yaghmai V, Larson AC and Zhang Z: Irreversible electroporation in primary and metastatic hepatic malignancies: A review. Medicine (Baltimore). 96:e63862017. View Article : Google Scholar : PubMed/NCBI

37 

Washington K: 7th edition of the AJCC cancer staging manual: Stomach. Ann Surg Oncol. 17:3077–3079. 2010. View Article : Google Scholar : PubMed/NCBI

38 

Edge SB and Compton CC: The American Joint Committee on Cancer: The 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol. 17:1471–1474. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Alnaggar M, Qaid AM, Chen J, Niu L and Xu K: Irreversible electroporation of malignant liver tumors: Effect on laboratory values. Oncol Lett 16: 3881-3888, 2018.
APA
Alnaggar, M., Qaid, A.M., Chen, J., Niu, L., & Xu, K. (2018). Irreversible electroporation of malignant liver tumors: Effect on laboratory values. Oncology Letters, 16, 3881-3888. https://doi.org/10.3892/ol.2018.9058
MLA
Alnaggar, M., Qaid, A. M., Chen, J., Niu, L., Xu, K."Irreversible electroporation of malignant liver tumors: Effect on laboratory values". Oncology Letters 16.3 (2018): 3881-3888.
Chicago
Alnaggar, M., Qaid, A. M., Chen, J., Niu, L., Xu, K."Irreversible electroporation of malignant liver tumors: Effect on laboratory values". Oncology Letters 16, no. 3 (2018): 3881-3888. https://doi.org/10.3892/ol.2018.9058
Copy and paste a formatted citation
x
Spandidos Publications style
Alnaggar M, Qaid AM, Chen J, Niu L and Xu K: Irreversible electroporation of malignant liver tumors: Effect on laboratory values. Oncol Lett 16: 3881-3888, 2018.
APA
Alnaggar, M., Qaid, A.M., Chen, J., Niu, L., & Xu, K. (2018). Irreversible electroporation of malignant liver tumors: Effect on laboratory values. Oncology Letters, 16, 3881-3888. https://doi.org/10.3892/ol.2018.9058
MLA
Alnaggar, M., Qaid, A. M., Chen, J., Niu, L., Xu, K."Irreversible electroporation of malignant liver tumors: Effect on laboratory values". Oncology Letters 16.3 (2018): 3881-3888.
Chicago
Alnaggar, M., Qaid, A. M., Chen, J., Niu, L., Xu, K."Irreversible electroporation of malignant liver tumors: Effect on laboratory values". Oncology Letters 16, no. 3 (2018): 3881-3888. https://doi.org/10.3892/ol.2018.9058
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