Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
September-2018 Volume 16 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2018 Volume 16 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Association between AKT rs2494752 single nucleotide polymorphism and the risk of metastasis in hepatocellular carcinoma

  • Authors:
    • Zhaohui Wang
    • Huiling Fu
    • Wei Li
  • View Affiliations / Copyright

    Affiliations: Department of Hepatology, Qingdao Sixth People's Hospital, Qingdao, Shandong 266033, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3699-3705
    |
    Published online on: July 2, 2018
       https://doi.org/10.3892/ol.2018.9060
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Hepatocellular carcinoma (HCC) is one of the most common types of human tumors, which is characterized by high morbidity and mortality rates. AKT1 transcriptional activity is implicated in HCC initiation and development. In the present study, the effects of rs2494752 single nucleotide polymorphism (SNP) on AKT1 transcriptional activity in the progression of HCC cells were investigated. A case‑control study was analyzed in 1,056 HCC patients and 1,080 healthy individuals using the PCR assay method. Results indicated AKT1 expression levels were up‑regulated in HCC tissue compared to adjacent normal tissues. Furthermore, a higher frequency of AKT rs2494752 AG and AA genotypes were observed in HCC cases (P=0.0046). Gene polymorphism identified C and T alleles were frequency in HCC patients compared to healthy individuals. Individuals harboring AKT rs2494752 AG/AA genotype had a vital increased susceptibility to HCC in the dominant model (P=0.0028). In addition, AKT1 rs2494752 GG genotype showed an increasing of AKT1 promoter activity determined by the luciferase assay. Furthermore, it was demonstrated that AKT1 rs2494752 GG and C polymorphism was more aggressive than other AKT1 rs2494752 cancer cells. Moreover, AKT1 rs2494752 GG markedly increased rates of response to NCT chemotherapy. Additionally, results revealed that AKT1 rs2494752 GG and C increased the risk factors of HCC. In conclusion, these results indicate that AKT1 rs2494752 polymorphisms may be regarded as a candidate gene in assessing the susceptibility, metastasis and responses to chemotherapy in the progression of hepatocellular carcinoma.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Muto J, Shirabe K, Sugimachi K and Maehara Y: Review of angiogenesis in hepatocellular carcinoma. Hepatol Res. 45:1–9. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Pang Q, Qu K, Bi JB, Liu SS, Zhang JY, Song SD, Lin T, Xu XS, Wan Y, Tai MH, et al: Thrombocytopenia for prediction of hepatocellular carcinoma recurrence: Systematic review and meta-analysis. World J Gastroenterol. 21:7895–7906. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Parikh ND, Waljee AK and Singal AG: Downstaging hepatocellular carcinoma: A systematic review and pooled analysis. Liver Transpl. 21:1142–1152. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Qi X, Liu L, Wang D, Li H, Su C and Guo X: Hepatic resection alone versus in combination with pre- and post-operative transarterial chemoembolization for the treatment of hepatocellular carcinoma: A systematic review and meta-analysis. Oncotarget. 6:36838–36859. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Seshadri RM, Baker EH, Templin M, Swan RZ, Martinie JB, Vrochides D and Iannitti DA: Outcomes of surgical resection and loco-regional therapy in patients with stage 3A hepatocellular carcinoma: A retrospective review from the national cancer database. HPB (Oxford). 17:964–968. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Yang XD, Pan LH, Wang L, Ke Y, Cao J, Yang C, Zhong JH, Luo W, Guo J and Li LQ: Systematic review of single large and/or multinodular hepatocellular carcinoma: Surgical resection improves survival. Asian Pac J Cancer Prev. 16:5541–5547. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Zhu GQ, Shi KQ, Yu HJ, He SY, Braddock M, Zhou MT, Chen YP and Zheng MH: Optimal adjuvant therapy for resected hepatocellular carcinoma: A systematic review with network meta-analysis. Oncotarget. 6:18151–18161. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Simonetti RG, Cammà C, Fiorello F, Politi F, D'Amico G and Pagliaro L: Hepatocellular carcinoma. A worldwide problem and the major risk factors. Dig Dis Sci. 36:962–972. 1991. View Article : Google Scholar : PubMed/NCBI

9 

Zidan A, Scheuerlein H, Schüle S, Settmacher U and Rauchfuss F: Epidemiological pattern of hepatitis B and hepatitis C as etiological agents for hepatocellular carcinoma in iran and worldwide. Hepat Mon. 12:e68942012.PubMed/NCBI

10 

Suo GJ and Zhao ZX: Association of the interleukin-28B gene polymorphism with development of hepatitis virus-related hepatocellular carcinoma and liver cirrhosis: A meta-analysis. Genet Mol Res. 12:3708–3717. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Park MS, Kim SK, Shin HP, Lee SM and Chung JH: TXNDC5 gene polymorphism contributes to increased risk of hepatocellular carcinoma in the Korean male population. Anticancer Res. 33:3983–3987. 2013.PubMed/NCBI

12 

Yeh CT, Liang KH, Lin CC, Chang ML, Hsu CL and Hung CF: A single nucleotide polymorphism on the GALNT14 gene as an effective predictor of response to chemotherapy in advanced hepatocellular carcinoma. Int J Cancer. 134:1214–1224. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Duan C, Zhang W, Lu J, Wu H, Liu M and Zhu W: DNA repair gene XRCC3 Thr241Met polymorphism and hepatocellular carcinoma risk. Tumour Biol. 34:2827–2834. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Liu T, Gulinaer A, Shi X, Wang F, An H, Cui W and Li Q: Gene polymorphisms in the PI3K/AKT/mTOR signaling pathway contribute to prostate cancer susceptibility in Chinese men. Oncotarget. 8:61305–61317. 2017.PubMed/NCBI

15 

Piao Y, Li Y, Xu Q, Liu JW, Xing CZ, Xie XD and Yuan Y: Association of MTOR and AKT gene polymorphisms with susceptibility and survival of gastric cancer. PLoS One. 10:e01364472015. View Article : Google Scholar : PubMed/NCBI

16 

He ML, Wu Y, Zhao JM, Wang Z and Chen YB: PIK3CA and AKT gene polymorphisms in susceptibility to osteosarcoma in a Chinese population. Asian Pac J Cancer Prev. 14:5117–5122. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Yin P, Zhao C, Li Z, Mei C, Yao W, Liu Y, Li N, Qi J, Wang L, Shi Y, et al: Sp1 is involved in regulation of cystathionine γ-lyase gene expression and biological function by PI3K/Akt pathway in human hepatocellular carcinoma cell lines. Cell Signal. 24:1229–1240. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Xu J, Jia L, Ma H, Li Y, Ma Z and Zhao Y: Axl gene knockdown inhibits the metastasis properties of hepatocellular carcinoma via PI3K/Akt-PAK1 signal pathway. Tumour Biol. 35:3809–3817. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Mde Almeida A, Pizzini CV, Damasceno LS, Mde Muniz M, Almeida-Paes R, Peralta RH, Peralta JM, Rde Oliveira V, Vizzoni AG, de Andrade CL and Zancopé-Oliveira RM: Validation of western blot for Histoplasma capsulatum antibody detection assay. BMC Infect Dis. 16:872016. View Article : Google Scholar : PubMed/NCBI

21 

Dirani M, Nasreddine W, Abdulla F and Beydoun A: Seizure control and improvement of neurological dysfunction in Lafora disease with perampanel. Epilepsy Behav Case Rep. 2:164–166. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Santin I, Castellanos-Rubio A, Hualde I, Castaño L, Vitoria JC and Bilbao JR: Toll-like receptor 4 (TLR4) gene polymorphisms in celiac disease. Tissue Antigens. 70:495–498. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Suzuki S, Hosomichi K, Yokoyama K, Tsuda K, Hara H, Yoshida Y, Fujiwara A, Mizutani M, Shiina T, Kono T and Hanzawa K: Primary analysis of DNA polymorphisms in the TRIM region (MHC subregion) of the Japanese quail, Coturnix japonica. Anim Sci J. 84:90–96. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Balogh J, Victor D III, Asham EH, Burroughs SG, Boktour M, Saharia A, Li X, Ghobrial RM and Monsour HP Jr: Hepatocellular carcinoma: A review. J Hepatocell Carcinoma. 3:41–53. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Wu X, Xin Z, Zhang W, Zheng S, Wu J, Chen K, Wang H, Zhu X, Li Z, Duan Z, et al: A missense polymorphism in ATF6 gene is associated with susceptibility to hepatocellular carcinoma probably by altering ATF6 level. Int J Cancer. 135:61–68. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Li X, Zhang R, Liu Z, Li S and Xu H: The genetic variants in the PTEN/PI3K/AKT pathway predict susceptibility and CE(A)F chemotherapy response to breast cancer and clinical outcomes. Oncotarget. 8:20252–20265. 2017.PubMed/NCBI

27 

Dai X, Zhang X, Wang B, Wang C, Jiang J and Wu C: Association between polymorphism rs678653 in human cyclin D1 gene (CCND1) and susceptibility to cancer: A meta-analysis. Med Sci Monit. 22:863–874. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Kowal A, Wiśniewski A, Kuśnierczyk P and Jankowska R: Human leukocyte antigen (HLA)-G gene polymorphism in patients with non-small cell lung cancer. Thorac Cancer. 6:613–619. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Azimzadeh P, Romani S, Mirtalebi H, Fatemi SR, Kazemian S, Khanyaghma M and Mohebbi SR: Association of co-stimulatory human B-lymphocyte antigen B7-2 (CD86) gene polymorphism with colorectal cancer risk. Gastroenterol Hepatol Bed Bench. 6:86–91. 2013.PubMed/NCBI

30 

Wang MY, He J, Zhu ML, Teng XY, Li QX, Sun MH, Wang XF, Yang YJ, Wang JC, Jin L, et al: A functional polymorphism (rs2494752) in the AKT1 promoter region and gastric adenocarcinoma risk in an eastern chinese population. Sci Rep. 6:200082016. View Article : Google Scholar : PubMed/NCBI

31 

Wu J, Lv S, An J and Lu C: Pre-miR-149 rs71428439 polymorphism is associated with increased cancer risk and AKT1/cyclinD1 signaling in hepatocellular carcinoma. Int J Clin Exp Med. 8:13628–13633. 2015.PubMed/NCBI

32 

Salati U, Barry A, Chou FY, Ma R and Liu DM: State of the ablation nation: A review of ablative therapies for cure in the treatment of hepatocellular carcinoma. Future Oncol. 13:1437–1448. 2017. View Article : Google Scholar : PubMed/NCBI

33 

Wu L, Zheng J, Chen P, Liu Q and Yuan Y: Small nucleolar RNA ACA11 promotes proliferation, migration and invasion in hepatocellular carcinoma by targeting the PI3K/AKT signaling pathway. Biomed Pharmacother. 90:705–712. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Gong L, Di C, Xia X, Wang J, Chen G, Shi J, Chen P, Xu H and Zhang W: AKT/mTOR signaling pathway is involved in salvianolic acid B-induced autophagy and apoptosis in hepatocellular carcinoma cells. Int J Oncol. 49:2538–2548. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Wang Z, Huang Y and Zhang J: Molecularly targeting the PI3K-Akt-mTOR pathway can sensitize cancer cells to radiotherapy and chemotherapy. Cell Mol Biol Lett. 19:233–242. 2014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang Z, Fu H and Li W: Association between AKT rs2494752 single nucleotide polymorphism and the risk of metastasis in hepatocellular carcinoma. Oncol Lett 16: 3699-3705, 2018.
APA
Wang, Z., Fu, H., & Li, W. (2018). Association between AKT rs2494752 single nucleotide polymorphism and the risk of metastasis in hepatocellular carcinoma. Oncology Letters, 16, 3699-3705. https://doi.org/10.3892/ol.2018.9060
MLA
Wang, Z., Fu, H., Li, W."Association between AKT rs2494752 single nucleotide polymorphism and the risk of metastasis in hepatocellular carcinoma". Oncology Letters 16.3 (2018): 3699-3705.
Chicago
Wang, Z., Fu, H., Li, W."Association between AKT rs2494752 single nucleotide polymorphism and the risk of metastasis in hepatocellular carcinoma". Oncology Letters 16, no. 3 (2018): 3699-3705. https://doi.org/10.3892/ol.2018.9060
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Z, Fu H and Li W: Association between AKT rs2494752 single nucleotide polymorphism and the risk of metastasis in hepatocellular carcinoma. Oncol Lett 16: 3699-3705, 2018.
APA
Wang, Z., Fu, H., & Li, W. (2018). Association between AKT rs2494752 single nucleotide polymorphism and the risk of metastasis in hepatocellular carcinoma. Oncology Letters, 16, 3699-3705. https://doi.org/10.3892/ol.2018.9060
MLA
Wang, Z., Fu, H., Li, W."Association between AKT rs2494752 single nucleotide polymorphism and the risk of metastasis in hepatocellular carcinoma". Oncology Letters 16.3 (2018): 3699-3705.
Chicago
Wang, Z., Fu, H., Li, W."Association between AKT rs2494752 single nucleotide polymorphism and the risk of metastasis in hepatocellular carcinoma". Oncology Letters 16, no. 3 (2018): 3699-3705. https://doi.org/10.3892/ol.2018.9060
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team