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Dual targeting of survivin and X‑linked inhibitor of apoptosis protein suppresses the growth and promotes the apoptosis of gastric cancer HGC‑27 cells

  • Authors:
    • Yanfeng Li
    • Wenbo Gao
    • Yan Ma
    • Guanyu Zhu
    • Fuhui Chen
    • Hongyan Qu
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Surgery, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang 150040, P.R. China, Department of Respiratory Medicine, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150081, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3489-3498
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    Published online on: July 5, 2018
       https://doi.org/10.3892/ol.2018.9081
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Abstract

Gastric cancer can be a fatal tumor and therefore represents one of the primary challenges in modern oncology. Survivin and X‑linked inhibitor of apoptosis protein (XIAP) are members of the IAP family, which exerts a strong inhibitory effect on cellular apoptosis. In previous studies, the expression levels of survivin and XIAP have been demonstrated to influence the prognosis of patients with gastric cancer; therefore, the present study investigated the effect of silencing survivin and XIAP on the biological activity of the gastric cancer HGC‑27 cell line. It was demonstrated that the expression levels of survivin and XIAP were significantly increased in gastric cancer tissues, compared with the adjacent non‑tumor tissues. Furthermore, it was observed that the expression levels of survivin and XIAP were similarly elevated in gastric cancer HGC‑27 cells, compared with normal gastric epithelial GES‑1cells. Furthermore, small interfering RNA‑mediated surviving‑ or XIAP‑knockdown, in addition to the dual knockdown of survivin and XIAP, inhibited the proliferation and promoted the apoptosis of HGC‑27 cells. Simultaneous inhibition of XIAP and survivin expression was more effective, compared with inhibition of XIAP or survivin alone. These results indicated that the dual knockdown of survivin and XIAP may be an effective strategy for treating gastric cancer in the future.
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Copy and paste a formatted citation
Spandidos Publications style
Li Y, Gao W, Ma Y, Zhu G, Chen F and Qu H: Dual targeting of survivin and X‑linked inhibitor of apoptosis protein suppresses the growth and promotes the apoptosis of gastric cancer HGC‑27 cells . Oncol Lett 16: 3489-3498, 2018.
APA
Li, Y., Gao, W., Ma, Y., Zhu, G., Chen, F., & Qu, H. (2018). Dual targeting of survivin and X‑linked inhibitor of apoptosis protein suppresses the growth and promotes the apoptosis of gastric cancer HGC‑27 cells . Oncology Letters, 16, 3489-3498. https://doi.org/10.3892/ol.2018.9081
MLA
Li, Y., Gao, W., Ma, Y., Zhu, G., Chen, F., Qu, H."Dual targeting of survivin and X‑linked inhibitor of apoptosis protein suppresses the growth and promotes the apoptosis of gastric cancer HGC‑27 cells ". Oncology Letters 16.3 (2018): 3489-3498.
Chicago
Li, Y., Gao, W., Ma, Y., Zhu, G., Chen, F., Qu, H."Dual targeting of survivin and X‑linked inhibitor of apoptosis protein suppresses the growth and promotes the apoptosis of gastric cancer HGC‑27 cells ". Oncology Letters 16, no. 3 (2018): 3489-3498. https://doi.org/10.3892/ol.2018.9081
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Gao W, Ma Y, Zhu G, Chen F and Qu H: Dual targeting of survivin and X‑linked inhibitor of apoptosis protein suppresses the growth and promotes the apoptosis of gastric cancer HGC‑27 cells . Oncol Lett 16: 3489-3498, 2018.
APA
Li, Y., Gao, W., Ma, Y., Zhu, G., Chen, F., & Qu, H. (2018). Dual targeting of survivin and X‑linked inhibitor of apoptosis protein suppresses the growth and promotes the apoptosis of gastric cancer HGC‑27 cells . Oncology Letters, 16, 3489-3498. https://doi.org/10.3892/ol.2018.9081
MLA
Li, Y., Gao, W., Ma, Y., Zhu, G., Chen, F., Qu, H."Dual targeting of survivin and X‑linked inhibitor of apoptosis protein suppresses the growth and promotes the apoptosis of gastric cancer HGC‑27 cells ". Oncology Letters 16.3 (2018): 3489-3498.
Chicago
Li, Y., Gao, W., Ma, Y., Zhu, G., Chen, F., Qu, H."Dual targeting of survivin and X‑linked inhibitor of apoptosis protein suppresses the growth and promotes the apoptosis of gastric cancer HGC‑27 cells ". Oncology Letters 16, no. 3 (2018): 3489-3498. https://doi.org/10.3892/ol.2018.9081
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