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Article

HMGN5 promotes proliferation and invasion via the activation of Wnt/β-catenin signaling pathway in pancreatic ductal adenocarcinoma

  • Authors:
    • Jianwen Zhao
    • Yong Wang
    • Xinglong Wu
  • View Affiliations / Copyright

    Affiliations: Scientific Research Center of LanLing County Hospital, Linyi, Shandong 277700, P.R. China, Oncology Department of LanLing County Hospital, Linyi, Shandong 277700, P.R. China, Laboratory of Scientific Research Center of LanLing County Hospital, Linyi, Shandong 277700, P.R. China
  • Pages: 4013-4019
    |
    Published online on: July 5, 2018
       https://doi.org/10.3892/ol.2018.9090
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Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive carcinoma with a poor prognosis. A recent study has demonstrated that high mobility group nucleosome binding domain 5 (HMGN5) was involved in tumorigenesis and progression of multiple types of human cancers. However, the role of HMGN5 in PDAC is unknown. The objective of the present study was to analyze the function and novel mechanism of HMGN5 involved in PDAC cell progression. It was firstly revealed that the expression of HMGN5 was significantly upregulated in PDAC cell lines and tissues, when compared with that in normal pancreatic duct epithelial cells and adjacent normal pancreatic tissues. In vitro assay revealed that HMGN5 silencing impaired PDAC cell viability, proliferation, migration and invasion. Similarly, tumor growth rate was also decreased in vivo following HMGN5 silencing. Furthermore, it was demonstrated that HMGN5 silencing significantly inhibited epithelial-mesenchymal transition in vitro. Notably, HMGN5-medicated Wnt/β-catenin signaling pathway activation was observed to be one of the critical signal transduction pathways that associates HMGN5 with EMT activation. Collectively, the results indicated the important role of HMGN5 in PDAC cell proliferation and metastasis, and provide a promising target against the transcriptional program of PDAC.
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1 

Siegel RL, Miller KD and Jemal A: Cancer Statistics, 2017. CA Cancer J Clin. 67:7–30. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Melisi D and Budillon A: Pancreatic cancer: Between bench and bedside. Curr Drug Targets. 13:729–730. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Nistico P, Bissell MJ and Radisky DC: Epithelial-mesenchymal transition: General principles and pathological relevance with special emphasis on the role of matrix metalloproteinases. Cold Spring Harb Perspect Biol. 4:pii: a011908. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Gaianigo N, Melisi D and Carbone C: EMT and treatment resistance in pancreatic cancer. Cancers. 9:pii: E122. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Rochman M, Malicet C and Bustin M: HMGN5/NSBP1: A new member of the HMGN protein family that affects chromatin structure and function. Biochim Biophys Acta. 1799:86–92. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Ji SQ, Yao L, Zhang XY, Li XS and Zhou LQ: Knockdown of the nucleosome binding protein 1 inhibits the growth and invasion of clear cell renal cell carcinoma cells in vitro and in vivo. J Exp Clin Cancer Res. 31:222012. View Article : Google Scholar : PubMed/NCBI

7 

Chen P, Wang XL, Ma ZS, Xu Z, Jia B, Ren J, Hu YX, Zhang QH, Ma TG, Yan BD, et al: Knockdown of HMGN5 expression by RNA interference induces cell cycle arrest in human lung cancer cells. Asian Pac J Cancer Prev. 13:3223–3228. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Su B, Shi B, Tang Y, Guo Z, Yu X, He X, Li X, Gao X and Zhou L: HMGN5 knockdown sensitizes prostate cancer cells to ionizing radiation. Prostate. 75:33–44. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Jiang W, Zheng J, Yu T and Wang J: Overexpression of microRNA-495 suppresses the proliferation and invasion and induces the apoptosis of osteosarcoma cells by targeting high-mobility group nucleosome-binding domain 5. Oncol Rep. 38:1099–1107. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Cao Y, Zhang L, Wei M, Jiang X and Jia D: MicroRNA-409-3p represses glioma cell invasion and proliferation by targeting high-mobility group nucleosome-binding domain 5. Oncol Res. 25:1097–1107. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Weng M, Song F, Chen J, Wu J, Qin J, Jin T and Xu J: The high-mobility group nucleosome-binding domain 5 is highly expressed in breast cancer and promotes the proliferation and invasion of breast cancer cells. Tumour Biol. 36:959–966. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Gan Y, He L, Yao K, Tan J, Zeng Q, Dai Y, Liu J and Tang Y: Knockdown of HMGN5 increases the chemosensitivity of human urothelial bladder cancer cells to cisplatin by targeting PI3K/Akt signaling. Oncol Lett. 14:6463–6470. 2017.PubMed/NCBI

13 

Liu X, Ma W, Yan Y and Wu S: Silencing HMGN5 suppresses cell growth and promotes chemosensitivity in esophageal squamous cell carcinoma. J Biochem Mol Toxicol. 31:2017. View Article : Google Scholar

14 

Shi Z, Tang R, Wu D and Sun X: Research advances in HMGN5 and cancer. Tumour Biol. 37:1531–1539. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Nusse R and Clevers H: Wnt/β-catenin signaling, disease, and emerging therapeutic modalities. Cell. 169:985–999. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Huang L, Wu RL and Xu AM: Epithelial-mesenchymal transition in gastric cancer. Am J Transl Res. 7:2141–2158. 2015.PubMed/NCBI

17 

Peng L, Liu Z, Xiao J, Tu Y, Wan Z, Xiong H, Li Y and Xiao W: MicroRNA-148a suppresses epithelial-mesenchymal transition and invasion of pancreatic cancer cells by targeting Wnt10b and inhibiting the Wnt/β-catenin signaling pathway. Oncol Rep. 38:301–308. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Bao Z, Xu X, Liu Y, Chao H, Lin C, Li Z, You Y, Liu N and Ji J: CBX7 negatively regulates migration and invasion in glioma via Wnt/β-catenin pathway inactivation. Oncotarget. 8:39048–39063. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Nakamoto M and Hisaoka M: Clinicopathological Implications of Wingless/int1 (WNT) signaling pathway in pancreatic ductal adenocarcinoma. J UOEH. 38:1–8. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhao J, Wang Y and Wu X: HMGN5 promotes proliferation and invasion via the activation of Wnt/β-catenin signaling pathway in pancreatic ductal adenocarcinoma. Oncol Lett 16: 4013-4019, 2018.
APA
Zhao, J., Wang, Y., & Wu, X. (2018). HMGN5 promotes proliferation and invasion via the activation of Wnt/β-catenin signaling pathway in pancreatic ductal adenocarcinoma. Oncology Letters, 16, 4013-4019. https://doi.org/10.3892/ol.2018.9090
MLA
Zhao, J., Wang, Y., Wu, X."HMGN5 promotes proliferation and invasion via the activation of Wnt/β-catenin signaling pathway in pancreatic ductal adenocarcinoma". Oncology Letters 16.3 (2018): 4013-4019.
Chicago
Zhao, J., Wang, Y., Wu, X."HMGN5 promotes proliferation and invasion via the activation of Wnt/β-catenin signaling pathway in pancreatic ductal adenocarcinoma". Oncology Letters 16, no. 3 (2018): 4013-4019. https://doi.org/10.3892/ol.2018.9090
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao J, Wang Y and Wu X: HMGN5 promotes proliferation and invasion via the activation of Wnt/β-catenin signaling pathway in pancreatic ductal adenocarcinoma. Oncol Lett 16: 4013-4019, 2018.
APA
Zhao, J., Wang, Y., & Wu, X. (2018). HMGN5 promotes proliferation and invasion via the activation of Wnt/β-catenin signaling pathway in pancreatic ductal adenocarcinoma. Oncology Letters, 16, 4013-4019. https://doi.org/10.3892/ol.2018.9090
MLA
Zhao, J., Wang, Y., Wu, X."HMGN5 promotes proliferation and invasion via the activation of Wnt/β-catenin signaling pathway in pancreatic ductal adenocarcinoma". Oncology Letters 16.3 (2018): 4013-4019.
Chicago
Zhao, J., Wang, Y., Wu, X."HMGN5 promotes proliferation and invasion via the activation of Wnt/β-catenin signaling pathway in pancreatic ductal adenocarcinoma". Oncology Letters 16, no. 3 (2018): 4013-4019. https://doi.org/10.3892/ol.2018.9090
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