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Article Open Access

High PKM2 expression is independently correlated with decreased overall survival in hepatocellular carcinoma

  • Authors:
    • Dong‑Hui Lu
    • Wen‑Wen Lv
    • Wen‑Xing Li
    • Yue‑Dong Gao
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, People's Liberation Army 105 Hospital, Hefei, Anhui 230031, P.R. China, Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P.R. China, Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, P.R. China
    Copyright: © Lu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3603-3610
    |
    Published online on: July 6, 2018
       https://doi.org/10.3892/ol.2018.9100
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Abstract

Hepatocellular carcinoma (HCC) is one of the most lethal and malignant types of cancer that affects global human health. The present study aimed to investigate the effect of pyruvate kinase muscle isozyme M2 (PKM2) expression on the clinical features and prognosis of HCC. The present study employed univariate logistic regression to investigate the correlation between PKM2 expression and clinical features. Univariate and multivariate Cox regression analyses were performed to estimate the independent effect of PKM2 expression on survival status. The results revealed that patients in the high PKM2 group (≥11.25) exhibited significantly lower creatinine levels (P=0.043), higher fetoprotein levels (P<0.001), advanced stage (P<0.001) and higher grade (P=0.004) compared with patients with low PKM2 expression levels (<11.25). In addition, patients with high PKM2 expression exhibited poor prognosis compared with patients with low PKM2 expression. After correcting the covariates, PKM2 expression remains significantly associated with reduced overall survival (P<0.05). These findings suggested that PKM2 is an independent risk factor for HCC and provides valuable information for future studies on the pathogenesis of HCC and drug discovery.
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Copy and paste a formatted citation
Spandidos Publications style
Lu DH, Lv WW, Li WX and Gao YD: High PKM2 expression is independently correlated with decreased overall survival in hepatocellular carcinoma. Oncol Lett 16: 3603-3610, 2018.
APA
Lu, D., Lv, W., Li, W., & Gao, Y. (2018). High PKM2 expression is independently correlated with decreased overall survival in hepatocellular carcinoma. Oncology Letters, 16, 3603-3610. https://doi.org/10.3892/ol.2018.9100
MLA
Lu, D., Lv, W., Li, W., Gao, Y."High PKM2 expression is independently correlated with decreased overall survival in hepatocellular carcinoma". Oncology Letters 16.3 (2018): 3603-3610.
Chicago
Lu, D., Lv, W., Li, W., Gao, Y."High PKM2 expression is independently correlated with decreased overall survival in hepatocellular carcinoma". Oncology Letters 16, no. 3 (2018): 3603-3610. https://doi.org/10.3892/ol.2018.9100
Copy and paste a formatted citation
x
Spandidos Publications style
Lu DH, Lv WW, Li WX and Gao YD: High PKM2 expression is independently correlated with decreased overall survival in hepatocellular carcinoma. Oncol Lett 16: 3603-3610, 2018.
APA
Lu, D., Lv, W., Li, W., & Gao, Y. (2018). High PKM2 expression is independently correlated with decreased overall survival in hepatocellular carcinoma. Oncology Letters, 16, 3603-3610. https://doi.org/10.3892/ol.2018.9100
MLA
Lu, D., Lv, W., Li, W., Gao, Y."High PKM2 expression is independently correlated with decreased overall survival in hepatocellular carcinoma". Oncology Letters 16.3 (2018): 3603-3610.
Chicago
Lu, D., Lv, W., Li, W., Gao, Y."High PKM2 expression is independently correlated with decreased overall survival in hepatocellular carcinoma". Oncology Letters 16, no. 3 (2018): 3603-3610. https://doi.org/10.3892/ol.2018.9100
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